AtherosclerosisPESANCT01410318
Progression of Early Subclinical Atherosclerosis
An observational study of Atherosclerosis, run by Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III at 1 site in Spain.
Trial summary
The overall objective of this study is to characterize the prevalence and progression rate of subclinical atherosclerotic lesions and to study their association to the imaging characteristics of atheroma plaques and to the presence of genetic, epigenetic, metabolomic, and environmental factors, including dietary… Read more about this study
- Who is it for?
- Ages 40 to 54 yearsHealthy volunteers can take part
- Conditions the study is for
- Atherosclerosis
- How many people
- 4,184 participants
- Where
- 1 siteSpain
- Study dates
- 14 Jun 2010to Jun 2030
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 54 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: The target population of the study consists of employees (N= 4,184) of the Banco de Santander Group in the Madrid region (65% males and 35% females, aged 40-54 years).
Who may be able to join
- Employees of the Banco de Santander Group
- Age between 40-54 years.
Who cannot join
- Myocardial Infarction
- Angina pectoris
- Stroke, either transient or with sequelae
- Peripheral vascular disease
- Prior angioplasty or heart surgery
- Atrial fibrillation
Show all 15Show fewer
- Other heart diseases
- Subjects with the following conditions will also be excluded:
- Pregnancy
- Active treatment for any cancer
- Morbid obesity (BMI ≥40)
- Renal failure with creatinine clearance <60 mL/min, as estimated by the Cockcroft and Gault formula
- Any disease that decreases life expectation to ≤6 years
- Pacemaker, implantable automatic defibrillator, or any implanted device that contraindicates MRI
- A chest CT in the previous year
Trial locations and contacts
1 site in 1 country.
Spain1 site
Ciudad Financiera del Grupo Santander
Boadilla del Monte, Madrid, 28660
About this study
Official title: Early Detection and Progression of Subclinical Atherosclerosis and Its Relationship to Coronary Risk Factors
The overall objective of this study is to characterize the prevalence and progression rate of subclinical atherosclerotic lesions and to study their association to the imaging characteristics of atheroma plaques and to the presence of genetic, epigenetic, metabolomic, and environmental factors, including dietary habits, physical activity, biorhythms, psychosocial characteristics, and exposure to environmental pollutants
Read the detailed description
Atherosclerosis is the most common cardiovascular disease and accounts for the greatest number of deaths. Atherosclerotic disease starts at an early age and follows a subclinical course for decades, becoming apparent in the fifth or sixth decades of life in men and approximately 10 years later in women. Its main clinical signs include myocardial infarction, angina pectoris, sudden death, or stroke. Disease occurrence and progression are conditioned by the presence of the so-called risk factors: smoking, dyslipidemia, hypertension, and diabetes, among others. From these factors, a number of equations have been developed for predicting the risk of an individual to suffer the disease, in order to apply adequate prevention measures such as lifestyle changes or drug treatment. However, despite the proven efficacy of such interventions, cardiovascular prevention has many limitations due to three significant problems:
- The ability to predict risk from current equations is very limited because other genetic or environmental factors that may influence the course of disease are still unknown.
- The ability for early prediction of cardiovascular risk from current equations is even more limited in individuals under 55 years of age.
- Atherosclerotic disease is diagnosed too late, usually when the condition is very advanced and lesions are already irreversible, or when it has caused clinical signs or events in organs or territories vascularized by the diseased arteries. Clinical procedures currently used for detection of myocardial ischemia are however poorly sensitive and specific in the asymptomatic general population.
Technological advances made in the past decade in both laboratory tests and medical imaging have opened up new expectations for detection and treatment of atherosclerotic disease. Current research is focused on two aspects:
- To improve the ability to predict the disease by incorporating risk factors obtained from the laboratory such as C-reactive protein, homocysteine, fibrinogen, myeloperoxidase, or lipoprotein-associated phospholipase A2. At the same time, development of genetics and the new so-called "omics" techniques allows for exploring the genetic variability of individuals and its contribution to development of the disease and its complications. Such technologies include genomics, epigenetics, transcriptomics, proteomics, and metabolomics.
- To detect the disease at an early stage using the advanced imaging techniques, which may be used with no or minimal risks in large population groups. Use of magnetic resonance imaging (MRI) with and without contrast, computed tomography (CT), and positron emission tomography (PET) allows not only for identifying subclinical lesions, but also for studying the mechanisms of disease and for monitoring its course.
Very few population studies making combined use of some of these procedures are available. The actual potential of this approach and the impact it may have on early diagnosis of subclinical atherosclerosis, its progression, and its relationship to risk factors have not been assessed to date.
- Conditions
- Atherosclerosis
- Keywords
- Atherosclerosis, PESA, Subclinical, Cardiovascular diseases, Coronary disease, Heart diseases, Heart Failure, Myocardial Infarction, Stroke, Arteriosclerosis
- Medical subject headings
- Atherosclerosis, Cardiovascular Diseases, Coronary Disease, Heart Diseases, Heart Failure, Myocardial Infarction, Stroke, Arteriosclerosis
What is being measured
The primary outcome is the main question the study is designed to answer.
To assess the prevalence and 6-year progression rate of subclinical atherosclerotic disease in a population aged 40-54 years using basic and advanced cardiovascular imaging techniques.
The basic imaging tests consist of vascular 2D and 3D ultrasound in carotid, aorta and ilio-femoral arteries and computed tomography (CT) for coronary artery calcification. The advanced imaging test consist of magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose-positron emission tomography (18FDG PET) in carotid and ilio-femoral territories.
These imaging techniques enable early detection of subclinical atherosclerosis, characterization of the atherosclerotic burden, and monitoring of disease progression.
Measured: 20 years
Secondary outcomes (1)
To assess the association of both emerging and traditional cardiovascular risk factors with progression of subclinical atherosclerotic disease.
The main emerging risk factors to be investigated will be genetic markers (using genome-wide association scans), epigenetic markers (by genome-wide analysis of DNA methylation), and metabolomic markers (metabolomic profile in serum). Conventional factors are defined as those included in the prediction equations (European SCORE equation for Mediterranean countries and REGICOR), dietary habits, physical activity, and psychosocial characteristics.
Measured: 20 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Aug 2011 (estimated)
- Study start14 Jun 2010
- Primary completionJun 2030 (estimated)
- Study completionJun 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (33)Papers the sponsor has linked to this study.
- Other trials for AtherosclerosisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 4,184 participants (actual)
Sponsor and investigators
- Lead sponsor
- Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
- Sponsor type
- University, hospital or other
- Collaborators
- Grupo Santander
- Responsible party
- Sponsor
- Investigators
- Valentín Fuster, PhD, Principal investigator, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos IIIAntonio I Fernández Ortiz, PhD, Study director, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos IIIBorja Ibañez, PhD, Study chair, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos IIIGinés Sanz, PhD, Study chair, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos IIIJose María Ordovás, PhD, Study chair, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos IIILuis Jesús Jiménez Borreguero, MD, Study chair, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos IIIJose Luis Peñalvo, PhD, Study chair, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos IIIMartín Laclaustra, PhD, Study chair, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01410318
- Sponsor's protocol ID
- PESA CNIC-SANTANDER
- Acronym
- PESA
- Status last verified
- Apr 2021
- First submitted
- 2 Aug 2011
- Last updated
- 29 Apr 2021
- Results posted
- No
- Data monitoring committee
- Yes
- Individual data sharing
- Undecided
Publications
Fernandez-Ortiz A, Jimenez-Borreguero LJ, Penalvo JL, Ordovas JM, Mocoroa A, Fernandez-Friera L, Laclaustra M, Garcia L, Molina J, Mendiguren JM, Lopez-Melgar B, de Vega VM, Alonso-Farto JC, Guallar E, Sillesen H, Rudd JH, Fayad ZA, Ibanez B, Sanz G, Fuster V. The Progression and Early detection of Subclinical Atherosclerosis (PESA) study: rationale and design. Am Heart J. 2013 Dec;166(6):990-8. doi: 10.1016/j.ahj.2013.08.024. Epub 2013 Oct 10.
PubMed 24268213Fernandez-Friera L, Ibanez B, Fuster V. Imaging subclinical atherosclerosis: is it ready for prime time? A review. J Cardiovasc Transl Res. 2014 Oct;7(7):623-34. doi: 10.1007/s12265-014-9582-4. Epub 2014 Aug 14.
PubMed 25119855Fernandez-Friera L, Penalvo JL, Fernandez-Ortiz A, Ibanez B, Lopez-Melgar B, Laclaustra M, Oliva B, Mocoroa A, Mendiguren J, Martinez de Vega V, Garcia L, Molina J, Sanchez-Gonzalez J, Guzman G, Alonso-Farto JC, Guallar E, Civeira F, Sillesen H, Pocock S, Ordovas JM, Sanz G, Jimenez-Borreguero LJ, Fuster V. Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study. Circulation. 2015 Jun 16;131(24):2104-13. doi: 10.1161/CIRCULATIONAHA.114.014310. Epub 2015 Apr 16.
PubMed 25882487Fernandez-Alvira JM, Fuster V, Dorado B, Soberon N, Flores I, Gallardo M, Pocock S, Blasco MA, Andres V. Short Telomere Load, Telomere Length, and Subclinical Atherosclerosis: The PESA Study. J Am Coll Cardiol. 2016 May 31;67(21):2467-76. doi: 10.1016/j.jacc.2016.03.530.
PubMed 27230041Lopez-Melgar B, Fernandez-Friera L, Sanchez-Gonzalez J, Vilchez JP, Cecconi A, Mateo J, Penalvo JL, Oliva B, Garcia-Ruiz JM, Kauffman S, Jimenez-Borreguero LJ, Ruiz-Cabello J, Fernandez-Ortiz A, Ibanez B, Fuster V. Accurate quantification of atherosclerotic plaque volume by 3D vascular ultrasound using the volumetric linear array method. Atherosclerosis. 2016 May;248:230-7. doi: 10.1016/j.atherosclerosis.2016.03.002. Epub 2016 Mar 15.
PubMed 27038420Penalvo JL, Fernandez-Friera L, Lopez-Melgar B, Uzhova I, Oliva B, Fernandez-Alvira JM, Laclaustra M, Pocock S, Mocoroa A, Mendiguren JM, Sanz G, Guallar E, Bansilal S, Vedanthan R, Jimenez-Borreguero LJ, Ibanez B, Ordovas JM, Fernandez-Ortiz A, Bueno H, Fuster V. Association Between a Social-Business Eating Pattern and Early Asymptomatic Atherosclerosis. J Am Coll Cardiol. 2016 Aug 23;68(8):805-14. doi: 10.1016/j.jacc.2016.05.080.
PubMed 27539172Hurtado-Roca Y, Bueno H, Fernandez-Ortiz A, Ordovas JM, Ibanez B, Fuster V, Rodriguez-Artalejo F, Laclaustra M. Oxidized LDL Is Associated With Metabolic Syndrome Traits Independently of Central Obesity and Insulin Resistance. Diabetes. 2017 Feb;66(2):474-482. doi: 10.2337/db16-0933. Epub 2016 Dec 19.
PubMed 27993926Coffeng JK, van der Ploeg HP, Castellano JM, Fernandez-Alvira JM, Ibanez B, Garcia-Lunar I, van der Beek AJ, Fernandez-Ortiz A, Mocoroa A, Garcia-Leal L, Cardenas E, Rojas C, Martinez-Castro MI, Santiago-Sacristan S, Fernandez-Gallardo M, Mendiguren JM, Bansilal S, van Mechelen W, Fuster V. A 30-month worksite-based lifestyle program to promote cardiovascular health in middle-aged bank employees: Design of the TANSNIP-PESA randomized controlled trial. Am Heart J. 2017 Feb;184:121-132. doi: 10.1016/j.ahj.2016.11.002. Epub 2016 Nov 10.
PubMed 28224926Lopez-Melgar B, Fernandez-Friera L, Oliva B, Garcia-Ruiz JM, Penalvo JL, Gomez-Talavera S, Sanchez-Gonzalez J, Mendiguren JM, Ibanez B, Fernandez-Ortiz A, Sanz J, Fuster V. Subclinical Atherosclerosis Burden by 3D Ultrasound in Mid-Life: The PESA Study. J Am Coll Cardiol. 2017 Jul 18;70(3):301-313. doi: 10.1016/j.jacc.2017.05.033.
PubMed 28705310Uzhova I, Fuster V, Fernandez-Ortiz A, Ordovas JM, Sanz J, Fernandez-Friera L, Lopez-Melgar B, Mendiguren JM, Ibanez B, Bueno H, Penalvo JL. The Importance of Breakfast in Atherosclerosis Disease: Insights From the PESA Study. J Am Coll Cardiol. 2017 Oct 10;70(15):1833-1842. doi: 10.1016/j.jacc.2017.08.027.
PubMed 28982495Fernandez-Alvira JM, Fuster V, Pocock S, Sanz J, Fernandez-Friera L, Laclaustra M, Fernandez-Jimenez R, Mendiguren J, Fernandez-Ortiz A, Ibanez B, Bueno H. Predicting Subclinical Atherosclerosis in Low-Risk Individuals: Ideal Cardiovascular Health Score and Fuster-BEWAT Score. J Am Coll Cardiol. 2017 Nov 14;70(20):2463-2473. doi: 10.1016/j.jacc.2017.09.032.
PubMed 29145946Fernandez-Friera L, Fuster V, Lopez-Melgar B, Oliva B, Garcia-Ruiz JM, Mendiguren J, Bueno H, Pocock S, Ibanez B, Fernandez-Ortiz A, Sanz J. Normal LDL-Cholesterol Levels Are Associated With Subclinical Atherosclerosis in the Absence of Risk Factors. J Am Coll Cardiol. 2017 Dec 19;70(24):2979-2991. doi: 10.1016/j.jacc.2017.10.024.
PubMed 29241485Dominguez F, Fuster V, Fernandez-Alvira JM, Fernandez-Friera L, Lopez-Melgar B, Blanco-Rojo R, Fernandez-Ortiz A, Garcia-Pavia P, Sanz J, Mendiguren JM, Ibanez B, Bueno H, Lara-Pezzi E, Ordovas JM. Association of Sleep Duration and Quality With Subclinical Atherosclerosis. J Am Coll Cardiol. 2019 Jan 22;73(2):134-144. doi: 10.1016/j.jacc.2018.10.060.
PubMed 30654884Tsilingiri K, de la Fuente H, Relano M, Sanchez-Diaz R, Rodriguez C, Crespo J, Sanchez-Cabo F, Dopazo A, Alonso-Lebrero JL, Vara A, Vazquez J, Casasnovas JM, Alfonso F, Ibanez B, Fuster V, Martinez-Gonzalez J, Martin P, Sanchez-Madrid F. Oxidized Low-Density Lipoprotein Receptor in Lymphocytes Prevents Atherosclerosis and Predicts Subclinical Disease. Circulation. 2019 Jan 8;139(2):243-255. doi: 10.1161/CIRCULATIONAHA.118.034326.
PubMed 30586697Fernandez-Friera L, Fuster V, Lopez-Melgar B, Oliva B, Sanchez-Gonzalez J, Macias A, Perez-Asenjo B, Zamudio D, Alonso-Farto JC, Espana S, Mendiguren J, Bueno H, Garcia-Ruiz JM, Ibanez B, Fernandez-Ortiz A, Sanz J. Vascular Inflammation in Subclinical Atherosclerosis Detected by Hybrid PET/MRI. J Am Coll Cardiol. 2019 Apr 2;73(12):1371-1382. doi: 10.1016/j.jacc.2018.12.075.
PubMed 30922468
Study at a glance
From the registry record, last updated by the sponsor on 29 Apr 2021. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Early Detection and Progression of Subclinical Atherosclerosis and Its Relationship to Coronary Risk Factors
- ClinicalTrials.gov ID
- NCT01410318
- Acronym / sponsor ID
- PESA / PESA CNIC-SANTANDER
- Conditions
- Atherosclerosis
- Keywords
- Atherosclerosis, PESA, Subclinical, Cardiovascular diseases, Coronary disease, Heart diseases, Heart Failure, Myocardial Infarction
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 4,184 participants (actual)
- Lead sponsor
- Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos IIIUniversity, hospital or other
- Collaborators
- Grupo Santander
- Study start
- 14 Jun 2010 (actual)
- Primary completion
- Jun 2030 (estimated)
- Study completion
- Jun 2030 (estimated)
- First posted
- 5 Aug 2011 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The overall objective of this study is to characterize the prevalence and progression rate of subclinical atherosclerotic lesions and to study their association to the imaging characteristics of atheroma plaques and to the presence of genetic, epigenetic, metabolomic, and environmental factors, including dietary habits, physical activity, biorhythms, psychosocial characteristics, and exposure to environmental pollutants
Detailed description
Atherosclerosis is the most common cardiovascular disease and accounts for the greatest number of deaths. Atherosclerotic disease starts at an early age and follows a subclinical course for decades, becoming apparent in the fifth or sixth decades of life in men and approximately 10 years later in women. Its main clinical signs include myocardial infarction, angina pectoris, sudden death, or stroke. Disease occurrence and progression are conditioned by the presence of the so-called risk factors: smoking, dyslipidemia, hypertension, and diabetes, among others. From these factors, a number of equations have been developed for predicting the risk of an individual to suffer the disease, in order to apply adequate prevention measures such as lifestyle changes or drug treatment. However, despite the proven efficacy of such interventions, cardiovascular prevention has many limitations due to three significant problems:
- The ability to predict risk from current equations is very limited because other genetic or environmental factors that may influence the course of disease are still unknown.
- The ability for early prediction of cardiovascular risk from current equations is even more limited in individuals under 55 years of age.
- Atherosclerotic disease is diagnosed too late, usually when the condition is very advanced and lesions are already irreversible, or when it has caused clinical signs or events in organs or territories vascularized by the diseased arteries. Clinical procedures currently used for detection of myocardial ischemia are however poorly sensitive and specific in the asymptomatic general population.
Technological advances made in the past decade in both laboratory tests and medical imaging have opened up new expectations for detection and treatment of atherosclerotic disease. Current research is focused on two aspects:
- To improve the ability to predict the disease by incorporating risk factors obtained from the laboratory such as C-reactive protein, homocysteine, fibrinogen, myeloperoxidase, or lipoprotein-associated phospholipase A2. At the same time, development of genetics and the new so-called "omics" techniques allows for exploring the genetic variability of individuals and its contribution to development of the disease and its complications. Such technologies include genomics, epigenetics, transcriptomics, proteomics, and metabolomics.
- To detect the disease at an early stage using the advanced imaging techniques, which may be used with no or minimal risks in large population groups. Use of magnetic resonance imaging (MRI) with and without contrast, computed tomography (CT), and positron emission tomography (PET) allows not only for identifying subclinical lesions, but also for studying the mechanisms of disease and for monitoring its course.
Very few population studies making combined use of some of these procedures are available. The actual potential of this approach and the impact it may have on early diagnosis of subclinical atherosclerosis, its progression, and its relationship to risk factors have not been assessed to date.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 40 to 54 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- The target population of the study consists of employees (N= 4,184) of the Banco de Santander Group in the Madrid region (65% males and 35% females, aged 40-54 years).
Key inclusion criteria (2 listed)
- Employees of the Banco de Santander Group
- Age between 40-54 years.
Key exclusion criteria (15 listed)
- Myocardial Infarction
- Angina pectoris
- Stroke, either transient or with sequelae
- Peripheral vascular disease
- Prior angioplasty or heart surgery
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
To assess the prevalence and 6-year progression rate of subclinical atherosclerotic disease in a population aged 40-54 years using basic and advanced cardiovascular imaging techniques.
Time frame: 20 years
The basic imaging tests consist of vascular 2D and 3D ultrasound in carotid, aorta and ilio-femoral arteries and computed tomography (CT) for coronary artery calcification. The advanced imaging test consist of magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose-positron emission tomography (18FDG PET) in carotid and ilio-femoral territories. These imaging techniques enable early detection of subclinical atherosclerosis, characterization of the atherosclerotic burden, and monitoring of disease progression.
1 secondary outcome
To assess the association of both emerging and traditional cardiovascular risk factors with progression of subclinical atherosclerotic disease.
Time frame: 20 years
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Apr 2021.
- Background: PubMed 24268213Fernandez-Ortiz A, Jimenez-Borreguero LJ, Penalvo JL, Ordovas JM, Mocoroa A, Fernandez-Friera L, Laclaustra M, Garcia L, Molina J, Mendiguren JM, Lopez-Melgar B, de Vega VM, Alonso-Farto JC, Guallar E, Sillesen H, Rudd JH, Fayad ZA, Ibanez B, Sanz G, Fuster V. The Progression and Early detection of Subclinical Atherosclerosis (PESA) study: rationale and design. Am Heart J. 2013 Dec;166(6):990-8. doi: 10.1016/j.ahj.2013.08.024. Epub 2013 Oct 10.
- Background: PubMed 25119855Fernandez-Friera L, Ibanez B, Fuster V. Imaging subclinical atherosclerosis: is it ready for prime time? A review. J Cardiovasc Transl Res. 2014 Oct;7(7):623-34. doi: 10.1007/s12265-014-9582-4. Epub 2014 Aug 14.
- Results publication: PubMed 25882487Fernandez-Friera L, Penalvo JL, Fernandez-Ortiz A, Ibanez B, Lopez-Melgar B, Laclaustra M, Oliva B, Mocoroa A, Mendiguren J, Martinez de Vega V, Garcia L, Molina J, Sanchez-Gonzalez J, Guzman G, Alonso-Farto JC, Guallar E, Civeira F, Sillesen H, Pocock S, Ordovas JM, Sanz G, Jimenez-Borreguero LJ, Fuster V. Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study. Circulation. 2015 Jun 16;131(24):2104-13. doi: 10.1161/CIRCULATIONAHA.114.014310. Epub 2015 Apr 16.
- Results publication: PubMed 27230041Fernandez-Alvira JM, Fuster V, Dorado B, Soberon N, Flores I, Gallardo M, Pocock S, Blasco MA, Andres V. Short Telomere Load, Telomere Length, and Subclinical Atherosclerosis: The PESA Study. J Am Coll Cardiol. 2016 May 31;67(21):2467-76. doi: 10.1016/j.jacc.2016.03.530.
- Results publication: PubMed 27038420Lopez-Melgar B, Fernandez-Friera L, Sanchez-Gonzalez J, Vilchez JP, Cecconi A, Mateo J, Penalvo JL, Oliva B, Garcia-Ruiz JM, Kauffman S, Jimenez-Borreguero LJ, Ruiz-Cabello J, Fernandez-Ortiz A, Ibanez B, Fuster V. Accurate quantification of atherosclerotic plaque volume by 3D vascular ultrasound using the volumetric linear array method. Atherosclerosis. 2016 May;248:230-7. doi: 10.1016/j.atherosclerosis.2016.03.002. Epub 2016 Mar 15.
- Results publication: PubMed 27539172Penalvo JL, Fernandez-Friera L, Lopez-Melgar B, Uzhova I, Oliva B, Fernandez-Alvira JM, Laclaustra M, Pocock S, Mocoroa A, Mendiguren JM, Sanz G, Guallar E, Bansilal S, Vedanthan R, Jimenez-Borreguero LJ, Ibanez B, Ordovas JM, Fernandez-Ortiz A, Bueno H, Fuster V. Association Between a Social-Business Eating Pattern and Early Asymptomatic Atherosclerosis. J Am Coll Cardiol. 2016 Aug 23;68(8):805-14. doi: 10.1016/j.jacc.2016.05.080.
- Results publication: PubMed 27993926Hurtado-Roca Y, Bueno H, Fernandez-Ortiz A, Ordovas JM, Ibanez B, Fuster V, Rodriguez-Artalejo F, Laclaustra M. Oxidized LDL Is Associated With Metabolic Syndrome Traits Independently of Central Obesity and Insulin Resistance. Diabetes. 2017 Feb;66(2):474-482. doi: 10.2337/db16-0933. Epub 2016 Dec 19.
- Results publication: PubMed 28224926Coffeng JK, van der Ploeg HP, Castellano JM, Fernandez-Alvira JM, Ibanez B, Garcia-Lunar I, van der Beek AJ, Fernandez-Ortiz A, Mocoroa A, Garcia-Leal L, Cardenas E, Rojas C, Martinez-Castro MI, Santiago-Sacristan S, Fernandez-Gallardo M, Mendiguren JM, Bansilal S, van Mechelen W, Fuster V. A 30-month worksite-based lifestyle program to promote cardiovascular health in middle-aged bank employees: Design of the TANSNIP-PESA randomized controlled trial. Am Heart J. 2017 Feb;184:121-132. doi: 10.1016/j.ahj.2016.11.002. Epub 2016 Nov 10.
- Results publication: PubMed 28705310Lopez-Melgar B, Fernandez-Friera L, Oliva B, Garcia-Ruiz JM, Penalvo JL, Gomez-Talavera S, Sanchez-Gonzalez J, Mendiguren JM, Ibanez B, Fernandez-Ortiz A, Sanz J, Fuster V. Subclinical Atherosclerosis Burden by 3D Ultrasound in Mid-Life: The PESA Study. J Am Coll Cardiol. 2017 Jul 18;70(3):301-313. doi: 10.1016/j.jacc.2017.05.033.
- Results publication: PubMed 28982495Uzhova I, Fuster V, Fernandez-Ortiz A, Ordovas JM, Sanz J, Fernandez-Friera L, Lopez-Melgar B, Mendiguren JM, Ibanez B, Bueno H, Penalvo JL. The Importance of Breakfast in Atherosclerosis Disease: Insights From the PESA Study. J Am Coll Cardiol. 2017 Oct 10;70(15):1833-1842. doi: 10.1016/j.jacc.2017.08.027.
- Results publication: PubMed 29145946Fernandez-Alvira JM, Fuster V, Pocock S, Sanz J, Fernandez-Friera L, Laclaustra M, Fernandez-Jimenez R, Mendiguren J, Fernandez-Ortiz A, Ibanez B, Bueno H. Predicting Subclinical Atherosclerosis in Low-Risk Individuals: Ideal Cardiovascular Health Score and Fuster-BEWAT Score. J Am Coll Cardiol. 2017 Nov 14;70(20):2463-2473. doi: 10.1016/j.jacc.2017.09.032.
- Results publication: PubMed 29241485Fernandez-Friera L, Fuster V, Lopez-Melgar B, Oliva B, Garcia-Ruiz JM, Mendiguren J, Bueno H, Pocock S, Ibanez B, Fernandez-Ortiz A, Sanz J. Normal LDL-Cholesterol Levels Are Associated With Subclinical Atherosclerosis in the Absence of Risk Factors. J Am Coll Cardiol. 2017 Dec 19;70(24):2979-2991. doi: 10.1016/j.jacc.2017.10.024.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Valentín Fuster, PhD principal investigator
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Antonio I Fernández Ortiz, PhD study director
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Borja Ibañez, PhD study chair
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Atherosclerosis, run by Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III at 1 site in Spain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 15 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 29 Apr 2021. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
To assess the prevalence and 6-year progression rate of subclinical atherosclerotic disease in a population aged 40-54 years using basic and advanced cardiovascular imaging techniques. (time frame: 20 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT01410318, which also lists 33 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Apr 2021.