Uric Acid and Hypertension in PregnancyNCT01523327
Study of Association Between Maternal Uric Acid , Maternal and Fetal Outcome in Pregnant Women With Hypertension
An observational study of Uric Acid and Hypertension in Pregnancy, run by Ain Shams Maternity Hospital at 1 site in Egypt.
Trial summary
Association of maternal uric acid with maternal condition and fetal outcome in pregnant women with hypertension. Read more about this study
- Who is it for?
- Ages 18 to 40 years, women only
- Conditions the study is for
- Uric Acid and Hypertension in Pregnancy
- What is being tested?
- measuring protein creatinin ratio,serum uric acid
- How many people
- 80 participants
- Where
- 1 siteEgypt
- Study dates
- Oct 2011to Oct 2012
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- Women only
- No healthy volunteers
- Adult
Study population: The study will include 80 pregnant ladies with hypertension admitted to the maternity ward of the hospital who will be divided into two groups according to their uric acid level.
Who may be able to join
- Age:18-40 years old
- Gestational age:28-42 weeks gestation singleton pregnancy of living fetus
- Non smoker
Who cannot join
- women who refuse the study
- Any medical or obstetric disorders especially D.M.,renal disease,hepatic, cardiac disorders or gout arthritis, other than hypertension if present.
- Previously elevated uric acid level.
- Hemolytic or sickle cell anemia,urinary tract infection.
- Use of diuretics or anti-inflammatory drugs.
Trial locations and contacts
1 site in 1 country.
Egypt1 site, 1 recruiting
- Recruiting
Ain shams maternity hospital
Cairo, 11117
nermin marzouk touma, M.B.,B.Ch
About this study
Official title: Association of Maternal Uric Acid With Maternal Condition and Fetal Outcome in Pregnant Women With Hypertension
Association of maternal uric acid with maternal condition and fetal outcome in pregnant women with hypertension.
Read the detailed description
Association of maternal uric acid with maternal condition(renal function,liver function,...ect.) and fetal outcome(birth weight,APGER score) in pregnant women with hypertension.
- Conditions
- Uric Acid and Hypertension in Pregnancy
- Being tested
- measuring protein creatinin ratio,serum uric acid
- Keywords
- Uric acid
- Medical subject headings
- Hypertension, Pregnancy-Induced
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
measuring protein creatinin ratio,serum uric acidOther
A non-deproteinized Jaffe reaction is employed to measure creatinine and urinary protein measured by an automated colorimetric assay using pyrogallol red and sodium molybdate.
Measuring of serum uric acid by(2,4,6-tribromo-3-hydroxybenzoic acid)TBHBA by uricase method.
| Study group | Role | What they receive |
|---|---|---|
| A | 40 pregnant Women with hypertension who have uric acid level more than 6 mg per dL. Receives: Other: measuring protein creatinin ratio,serum uric acid | |
| B | 40 pregnant women with hypertension who have uric acid level less than 6 mg per dl. Receives: Other: measuring protein creatinin ratio,serum uric acid |
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Feb 2012 (estimated)
- Study startOct 2011
- Primary completionNov 2011
- Study completionOct 2012 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Uric Acid and Hypertension in PregnancyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Time perspective
- Cross-sectional
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ain Shams Maternity Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, nermin marzouk agaibi, Ain Shams Maternity Hospital
- Investigators
- Mohamed Saeedeldin Elsafty, assistant lecture, Study director, Ain Shams Maternity Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01523327
- Sponsor's protocol ID
- ainshamsMH
- Status last verified
- Jan 2012
- First submitted
- 30 Jan 2012
- Last updated
- 1 Feb 2012
- Results posted
- No
- Data monitoring committee
- Yes
Publications
MATSELIUKH BP. [TRANSMISSION OF CERTAIN BIOCHEMICAL PROPERTIES IN ACTINOMYCETES BY MEANS OF DNA UNDER CONDITIONS OF HETEROTRANSFORMATION]. Mikrobiol Zh. 1963;25:3-6. No abstract available. Russian.
PubMed 14071979Paula LG, da Costa BE, Poli-de-Figueiredo CE, Antonello IC. Does uric acid provide information about maternal condition and fetal outcome in pregnant women with hypertension? Hypertens Pregnancy. 2008;27(4):413-20. doi: 10.1080/10641950801955709.
PubMed 19003642
Study at a glance
From the registry record, last updated by the sponsor on 1 Feb 2012. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Association of Maternal Uric Acid With Maternal Condition and Fetal Outcome in Pregnant Women With Hypertension
- ClinicalTrials.gov ID
- NCT01523327
- Acronym / sponsor ID
- ainshamsMH
- Conditions
- Uric Acid and Hypertension in Pregnancy
- Keywords
- Uric acid
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- Ain Shams Maternity HospitalUniversity, hospital or other
- Study start
- Oct 2011
- Primary completion
- Nov 2011 (actual)
- Study completion
- Oct 2012 (estimated)
- First posted
- 1 Feb 2012 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Association of maternal uric acid with maternal condition and fetal outcome in pregnant women with hypertension.
Detailed description
Association of maternal uric acid with maternal condition(renal function,liver function,...ect.) and fetal outcome(birth weight,APGER score) in pregnant women with hypertension.
Study design
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| A | – | Other: measuring protein creatinin ratio,serum uric acid40 pregnant Women with hypertension who have uric acid level more than 6 mg per dL. |
| B | – | Other: measuring protein creatinin ratio,serum uric acid40 pregnant women with hypertension who have uric acid level less than 6 mg per dl. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- The study will include 80 pregnant ladies with hypertension admitted to the maternity ward of the hospital who will be divided into two groups according to their uric acid level.
Key inclusion criteria (3 listed)
- Age:18-40 years old
- Gestational age:28-42 weeks gestation singleton pregnancy of living fetus
- Non smoker
Key exclusion criteria (5 listed)
- women who refuse the study
- Any medical or obstetric disorders especially D.M.,renal disease,hepatic, cardiac disorders or gout arthritis, other than hypertension if present.
- Previously elevated uric acid level.
- Hemolytic or sickle cell anemia,urinary tract infection.
- Use of diuretics or anti-inflammatory drugs.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| measuring protein creatinin ratio,serum uric acidA non-deproteinized Jaffe reaction is employed to measure creatinine and urinary protein measured by an automated colorimetric assay using pyrogallol red and sodium molybdate. Measuring of serum uric acid by(2,4,6-tribromo-3-hydroxybenzoic acid)TBHBA by uricase method. | Other | A, B |
Primary outcome
Not reported in the source record.
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Feb 2012.
- Results publication: PubMed 14071979MATSELIUKH BP. [TRANSMISSION OF CERTAIN BIOCHEMICAL PROPERTIES IN ACTINOMYCETES BY MEANS OF DNA UNDER CONDITIONS OF HETEROTRANSFORMATION]. Mikrobiol Zh. 1963;25:3-6. No abstract available. Russian.
- Results publication: PubMed 19003642Paula LG, da Costa BE, Poli-de-Figueiredo CE, Antonello IC. Does uric acid provide information about maternal condition and fetal outcome in pregnant women with hypertension? Hypertens Pregnancy. 2008;27(4):413-20. doi: 10.1080/10641950801955709.
- does+uric+acid+provide+information+about+maternal+condition+and+fetal+outcome+in+pregnant+women+with+hypertension\&TransSchema=title\&cmd=detailssearchLink provided by the sponsor.
- does+uric+acid+provide+information+about+maternal+condition+and+fetal+outcome+in+pregnant+women+with+hypertension\&TransSchema=title\&cmd=detailssearchLink provided by the sponsor.
Related trials for Uric Acid and Hypertension in Pregnancy
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Multiparametric Assessment of Maternal Vascular Function in the Prediction of Hypertensive Disorders of Pregnancy
Preeclampsia, Hypertensive Disorder of Pregnancy
RecruitingObservational study
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Hypertension, Left Ventricular Hypertrophy
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Mohamed Saeedeldin Elsafty, assistant lecture study director
Ain Shams Maternity Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Uric Acid and Hypertension in Pregnancy, run by Ain Shams Maternity Hospital at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 1 Feb 2012. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Nermin marzouk touma, M.B.,B.Ch (01222740182 ext. 002, nermindave@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT01523327, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Feb 2012.