HypertensionPhase 4NCT01570686
8-week Randomized, Open-label Study to Evaluate Food Effect on Efficacy and Safety of Oral Aliskiren 300 mg in Patients With Hypertension
A Phase 4 study testing Aliskiren in people with Hypertension, run by Novartis Pharmaceuticals at 83 sites in 7 countries.
Trial summary
The purpose of this study is to evaluate the effect of food on aliskiren's efficacy, pharmacokinetics and safety following an oral dose of 300 mg, given once daily under light meal versus fasted conditions. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Hypertension
- What is being tested?
- Aliskiren
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 589 participants
- Where
- 83 sitesin 7 countries
- Study dates
- Apr 2012to Nov 2012
- Phase
- Phase 4
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients with essential hypertension, untreated or currently taking antihypertensive therapy (monotherapy or combination therapy).
- Patients with an office BP ≥ 140/90 mmHg and < 180/110mmHg at the randomization visit and the preceding visit
- Patients must have an absolute difference of ≤ 10 mmHg in both their msSBP and their msDBP between the randomization visit and the preceding visit
Who cannot join
- Malignant hypertension or severe hypertension (grade 3 of WHO classification; msSBP ≥180 mmHg or msDBP ≥110 mmHg)
- History or evidence of a secondary form of hypertension, such as renal parenchymal hypertension, renovascular hypertension, coarctation of the aorta, primary hyperaldosteronism, Cushing's disease, drug-induced hypertension, unilateral or bilateral renal artery stenosis, pheochromocytoma, polycystic kidney disease (PKD).
- Type 1 or Type 2 diabetes mellitus with a fasting glycosylated hemoglobin (HbA1c) > 8%
- Evidence of renal impairment as determined by one of the following: serum creatinine >1.5 x ULN or eGFR < 30 ml/min/1.73m2 at Visit 1, a history of dialysis, or a history of nephrotic syndrome
- Other protocol-defined inclusion/exclusion criteria may apply.
- -
Trial locations and contacts
83 sites in 7 countries.
83 sites in 7 countries
United States43 sites
Novartis Investigative Site
Arlington, Virginia, 22203
Novartis Investigative Site
Beaumont, Texas, 77702
Novartis Investigative Site
Centerville, Utah, 84104
Novartis Investigative Site
Charlotte, North Carolina, 28209
Novartis Investigative Site
Chaska, Minnesota, 55318
Novartis Investigative Site
Chicago, Illinois, 60607
Novartis Investigative Site
Chicago, Illinois, 60610
Novartis Investigative Site
Cincinnati, Ohio, 45246
Novartis Investigative Site
Columbus, Ohio, 43213
Novartis Investigative Site
Coral Gables, Florida, 33134
Novartis Investigative Site
Edina, Minnesota, 55435
Novartis Investigative Site
Ettrick, Virginia, 23803
Novartis Investigative Site
Eugene, Oregon, 97404
Novartis Investigative Site
Evansville, Indiana, 47712
Novartis Investigative Site
Greensboro, North Carolina, 27401
Novartis Investigative Site
Greensboro, North Carolina, 27408
Novartis Investigative Site
Houston, Texas, 77081
Novartis Investigative Site
Jackson, Mississippi, 39209
Novartis Investigative Site
Knoxville, Tennessee, 37920
Novartis Investigative Site
Lake Jackson, Texas, 77566
Novartis Investigative Site
Los Angeles, California, 90057
Novartis Investigative Site
Lyndhurst, Ohio, 44124
Novartis Investigative Site
Marion, Ohio, 43302
Novartis Investigative Site
Miami, Florida, 33169
Novartis Investigative Site
Midlothian, Virginia, 23114
Novartis Investigative Site
Norman, Oklahoma, 73069
Novartis Investigative Site
Opelousas, Louisiana, 70570
Novartis Investigative Site
Oregon City, Oregon, 97045
Novartis Investigative Site
Pasadena, Texas, 77504
Novartis Investigative Site
Picayune, Mississippi, 39466
Novartis Investigative Site
Port Orchard, Washington, 98366
Novartis Investigative Site
Portland, Oregon, 97239
Novartis Investigative Site
Riverside, California, 92506
Novartis Investigative Site
Saint Paul, Minnesota, 55114
Novartis Investigative Site
Salisbury, North Carolina, 28144
Novartis Investigative Site
Santa Monica, California, 90404
Novartis Investigative Site
Shelby, North Carolina, 28152
Novartis Investigative Site
South Miami, Florida, 33143
Novartis Investigative Site
St Louis, Missouri, 63141
Novartis Investigative Site
Topeka, Kansas, 66606
Novartis Investigative Site
Walnut Creek, California, 94598
Novartis Investigative Site
Westlake Village, California, 91361
Novartis Investigative Site
Winston-Salem, North Carolina, 27103
Slovakia15 sites
Novartis Investigative Site
Banská Bystrica, Slovak Republic, 97405
Novartis Investigative Site
Bratislava, Slovak Republic, 83299
Novartis Investigative Site
Bratislava, Slovakia, 821 07
Novartis Investigative Site
Košice, Slovak Republic, 040 11
Novartis Investigative Site
Košice, Slovak Republic, 04001
Novartis Investigative Site
Martin, Slovakia, 036 01
Novartis Investigative Site
Nitra, Slovak Republic, 95201
Novartis Investigative Site
Prešov, Slovakia, 080 01
Novartis Investigative Site
Rimavská Sobota, Slovak Republic, 97901
Novartis Investigative Site
Šaľa, Slovakia, 927 03
Novartis Investigative Site
Senec, Slovak Republic, 90301
Novartis Investigative Site
Snina, Slovak Republic, 09601
Novartis Investigative Site
Svidník, Slovak Republic, 08901
Novartis Investigative Site
Trnava, Slovak Republic, 91701
Novartis Investigative Site
Zvolen, Slovakia, 960 01
Spain8 sites
Novartis Investigative Site
Alzira, Valencia, 46600
Novartis Investigative Site
Barcelona, Catalonia, 08905
Novartis Investigative Site
Centelles, Catalonia, 08540
Novartis Investigative Site
Corbera de Llobregat, Catalonia, 08757
Novartis Investigative Site
Hostalets de Balenya, Catalonia, 08550
Novartis Investigative Site
Madrid, Madrid, 28009
Novartis Investigative Site
Quart de Poblet, Valencia, 46930
Novartis Investigative Site
Vic, Catalonia, 08500
Canada6 sites
Novartis Investigative Site
Brampton, Ontario, L6T 0G1
Novartis Investigative Site
Mirabel, Quebec, J7J 2K8
Novartis Investigative Site
Moncton, New Brunswick, E1G 1A7
Novartis Investigative Site
Sainte-Foy, Quebec, G1W 4R4
Novartis Investigative Site
St. John's, Newfoundland and Labrador, A1A 3R5
Novartis Investigative Site
Toronto, Ontario, M9W 4L6
Taiwan5 sites
Novartis Investigative Site
Changhua, 500
Novartis Investigative Site
Taichung, Taiwan, 40447
Novartis Investigative Site
Taipei, Taiwan, 10002
Novartis Investigative Site
Taipei, Taiwan, 114
Novartis Investigative Site
Taipei, Taiwan, ROC, 112
Italy3 sites
Novartis Investigative Site
Pavia, PV, 27100
Novartis Investigative Site
Pozzilli, IS, 86077
Novartis Investigative Site
Sassari, SS, 07100
Puerto Rico3 sites
Novartis Investigative Site
Carolina, 00983
Novartis Investigative Site
Cidra, 00739
Novartis Investigative Site
Manati, 00674
About this study
Official title: An 8-week Randomized, Open-label, Multi-center Study to Evaluate the Efficacy and Safety of Oral Aliskiren 300 mg Once Daily Under Light Meal Versus Fasted Condition in Patients With Hypertension
The purpose of this study is to evaluate the effect of food on aliskiren's efficacy, pharmacokinetics and safety following an oral dose of 300 mg, given once daily under light meal versus fasted conditions.
- Conditions
- Hypertension
- Being tested
- Aliskiren
- Keywords
- Food effect, hypertension, aliskiren
- Medical subject headings
- Hypertension
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AliskirenDrug
Also called Tekturna, rasilez
Aliskiren 300 mg once daily
| Study group | Role | What they receive |
|---|---|---|
| Aliskiren: Fed | Experimental | Aliskiren 300 mg once daily, taken 30 minutes after start of light breakfast Receives: Drug: Aliskiren |
| Aliskiren: Fasting | Experimental | Aliskiren 300 mg once daily taken after after an overnight fast Receives: Drug: Aliskiren |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change From Baseline (Visit 3) to End of Study (Week 8) in Mean 24 Hour Ambulatory Systolic Blood Pressure (maSBP)
24 hour ambulatory blood pressure measurement (ABPM) were taken twice, at baseline and at the end of 8 weeks. An Ambulatory Blood Pressure Monitoring device (ABPM) was attached to the non-dominant arm. The mean change of 24 hours maSBP from baseline to week 8 was estimated using an Analysis of Covariance (ANCOVA) model by using treatment, region as factors, and baseline as covariate.
Measured: Baseline, week 8
Secondary outcomes (10)
Change From Baseline (Visit 3) to End of Study (Week 8) in Mean 24 Hour Ambulatory Diastolic Blood Pressure (maDBP)
24 hour ambulatory blood pressure measurement (ABPM) were taken twice, at baseline and at the end of 8 weeks. An Ambulatory Blood Pressure Monitoring device (ABPM) was attached to the non-dominant arm. The mean change of 24 hours maDBP from baseline to week 8 was estimated using an Analysis of Covariance (ANCOVA) model by using treatment, region as factors, and baseline as covariate.
Measured: Baseline, week 8
Percentage of Patients Achieving Blood Pressure Control
Patients achieving blood pressure control were patients who, at week 8, had a mean sitting systolic blood pressure (msSBP)/ mean sitting diastolic blood pressure (msDBP) < 140/90 mmHg
Measured: 8 weeks
Change From Baseline (Visit 3) to End of Study (8 Weeks) in Mean Sitting Systolic Blood Pressure (msSBP) and Mean Sitting Diastolic Blood Pressure (msDBP)
Sitting blood pressure (BP) was measured at trough (approximately 24 hours ± 3 hours post dose) and recorded at all study visits. At the first study visit, the BP was checked in both arms and the arm with higher systolic BP (SBP) was used for all subsequent readings throughout the study. At each study visit, after the patient had been sitting for five minutes, systolic and diastolic blood pressures (msSBP and msDBP) were measured four times using a standard mercury sphygmomanometer and appropriate size cuff. The repeat sitting measurements were made at 2 minute intervals and the mean of all four sitting blood pressure measurements was used as the average sitting office blood pressure for that visit. The analysis of covariance (ANCOVA) model used treatment, region as factors, and baseline as covariate.
Measured: Baseline, Week 8
Percentage of Patients Achieving a Successful Response in Systolic Blood Pressure Reduction
Successful response in systolic blood pressure reduction at end of 8-week treatment was defined as msSBP <140 mmHg or a reduction in msSBP ≥ 20 mmHg from baseline.
Measured: Baseline, Week 8
Pharmacokinetic (PK) of Aliskiren: The Observed Maximum Plasma Concentration (Cmax) Following Drug Administration in Fasted vs. Fed
Blood samples were collected at Week 4 and Week 8 in a subset of patients (approximately 15% of each treatment group) for PK analysis.
Measured: Week 4 (0, 0.5, 1, 1.5, 2, 4, 6 and 24 hrs post-dose) and week 8 (0, 0.5, 1, 1.5, 2, 4, 6 and 24 hrs post-dose)
Pharmacokinetic of Aliskiren: The Area Under the Plasma Concentration-time Curve From Time Zero to the End of the Dosing Interval Tau (AUCtau) in Fasted vs. Fed
Blood samples were collected at Week 4 and Week 8 in a subset of patients (approximately 15% of each treatment group) for PK analysis.
Measured: Week 4 (0, 0.5, 1, 1.5, 2, 4, 6 and 24 hrs post-dose) and week 8 (0, 0.5, 1, 1.5, 2, 4, 6 and 24 hrs post-dose)
Pharmacokinetic of Aliskiren: Time to Reach the Maximum Concentration (Tmax) After Drug Administration in Fasted vs. Fed
Blood samples were collected at Week 4 and Week 8 in a subset of patients (approximately 15% of each treatment group) for PK analysis.
Measured: Week 4 (0, 0.5, 1, 1.5, 2, 4, 6 and 24 hrs post-dose) and week 8 (0, 0.5, 1, 1.5, 2, 4, 6 and 24 hrs post-dose)
Change From Baseline to Week 8 in Plasma Renin Activity (PRA)
Biomarkers related to hypertension-related pathophysiology were evaluated in this study, such as plasma renin activity (PRA) . Blood samples were taken at Visit 3 (baseline) and Visit 6 (week 8).The difference between baseline and week 8 was calculated.
Measured: Baseline, Week 8
Change From Baseline to Week 8 in Plasma Renin Concentration (PRC)
Biomarkers related to hypertension-related pathophysiology were evaluated in this study, such as plasma renin concentration (PRC). Blood samples were taken at Visit 3 (baseline) and Visit 6 (week 8). The difference between baseline and week 8 was calculated.
Measured: Baseline, Week 8
Number of Patients With Adverse Events, Serious Adverse Events and Death
Measured: 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Apr 2012 (estimated)
- Study startApr 2012
- Primary completionNov 2012
- Study completionNov 2012
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Other trials for HypertensionStudies of the same condition, open and under way.
- More trials run by Novartis PharmaceuticalsThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 4
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 589 participants (actual)
Sponsor and investigators
- Lead sponsor
- Novartis Pharmaceuticals
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Novartis Pharmaceuticals, Study director, Novartis Pharmaceuticals
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01570686
- Sponsor's protocol ID
- CSPP100A2413
- Other IDs
- 2011-005297-36
- Status last verified
- Jan 2014
- First submitted
- 2 Apr 2012
- Last updated
- 22 Jan 2014
- Results posted
- Yes, on ClinicalTrials.gov
Study at a glance
From the registry record, last updated by the sponsor on 22 Jan 2014. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- An 8-week Randomized, Open-label, Multi-center Study to Evaluate the Efficacy and Safety of Oral Aliskiren 300 mg Once Daily Under Light Meal Versus Fasted Condition in Patients With Hypertension
- ClinicalTrials.gov ID
- NCT01570686
- Acronym / sponsor ID
- CSPP100A2413
- Conditions
- Hypertension
- Keywords
- Food effect, hypertension, aliskiren
- Phase
- Phase 4
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 589 participants (actual)
- Lead sponsor
- Novartis PharmaceuticalsIndustry (pharma, biotech, devices)
- Study start
- Apr 2012
- Primary completion
- Nov 2012 (actual)
- Study completion
- Nov 2012 (actual)
- First posted
- 4 Apr 2012 (estimated)
- Results
- Posted 1 Jan 2014
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to evaluate the effect of food on aliskiren's efficacy, pharmacokinetics and safety following an oral dose of 300 mg, given once daily under light meal versus fasted conditions.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Aliskiren: Fed | Experimental | Drug: AliskirenAliskiren 300 mg once daily, taken 30 minutes after start of light breakfast |
| Aliskiren: Fasting | Experimental | Drug: AliskirenAliskiren 300 mg once daily taken after after an overnight fast |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Patients with essential hypertension, untreated or currently taking antihypertensive therapy (monotherapy or combination therapy).
- Patients with an office BP ≥ 140/90 mmHg and < 180/110mmHg at the randomization visit and the preceding visit
- Patients must have an absolute difference of ≤ 10 mmHg in both their msSBP and their msDBP between the randomization visit and the preceding visit
Key exclusion criteria (6 listed)
- Malignant hypertension or severe hypertension (grade 3 of WHO classification; msSBP ≥180 mmHg or msDBP ≥110 mmHg)
- History or evidence of a secondary form of hypertension, such as renal parenchymal hypertension, renovascular hypertension, coarctation of the aorta, primary hyperaldosteronism, Cushing's disease, drug-induced hypertension, unilateral or bilateral renal artery stenosis, pheochromocytoma, polycystic kidney disease (PKD).
- Type 1 or Type 2 diabetes mellitus with a fasting glycosylated hemoglobin (HbA1c) > 8%
- Evidence of renal impairment as determined by one of the following: serum creatinine >1.5 x ULN or eGFR < 30 ml/min/1.73m2 at Visit 1, a history of dialysis, or a history of nephrotic syndrome
- Other protocol-defined inclusion/exclusion criteria may apply.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| AliskirenAlso: Tekturna, rasilezAliskiren 300 mg once daily | Drug | Aliskiren: Fasting, Aliskiren: Fed |
Primary outcome
Change From Baseline (Visit 3) to End of Study (Week 8) in Mean 24 Hour Ambulatory Systolic Blood Pressure (maSBP)
Time frame: Baseline, week 8
24 hour ambulatory blood pressure measurement (ABPM) were taken twice, at baseline and at the end of 8 weeks. An Ambulatory Blood Pressure Monitoring device (ABPM) was attached to the non-dominant arm. The mean change of 24 hours maSBP from baseline to week 8 was estimated using an Analysis of Covariance (ANCOVA) model by using treatment, region as factors, and baseline as covariate.
10 secondary outcomes
Change From Baseline (Visit 3) to End of Study (Week 8) in Mean 24 Hour Ambulatory Diastolic Blood Pressure (maDBP)
Time frame: Baseline, week 8
Percentage of Patients Achieving Blood Pressure Control
Time frame: 8 weeks
Change From Baseline (Visit 3) to End of Study (8 Weeks) in Mean Sitting Systolic Blood Pressure (msSBP) and Mean Sitting Diastolic Blood Pressure (msDBP)
Time frame: Baseline, Week 8
Percentage of Patients Achieving a Successful Response in Systolic Blood Pressure Reduction
Time frame: Baseline, Week 8
Pharmacokinetic (PK) of Aliskiren: The Observed Maximum Plasma Concentration (Cmax) Following Drug Administration in Fasted vs. Fed
Time frame: Week 4 (0, 0.5, 1, 1.5, 2, 4, 6 and 24 hrs post-dose) and week 8 (0, 0.5, 1, 1.5, 2, 4, 6 and 24 hrs post-dose)
Pharmacokinetic of Aliskiren: The Area Under the Plasma Concentration-time Curve From Time Zero to the End of the Dosing Interval Tau (AUCtau) in Fasted vs. Fed
Time frame: Week 4 (0, 0.5, 1, 1.5, 2, 4, 6 and 24 hrs post-dose) and week 8 (0, 0.5, 1, 1.5, 2, 4, 6 and 24 hrs post-dose)
Pharmacokinetic of Aliskiren: Time to Reach the Maximum Concentration (Tmax) After Drug Administration in Fasted vs. Fed
Time frame: Week 4 (0, 0.5, 1, 1.5, 2, 4, 6 and 24 hrs post-dose) and week 8 (0, 0.5, 1, 1.5, 2, 4, 6 and 24 hrs post-dose)
Change From Baseline to Week 8 in Plasma Renin Activity (PRA)
Time frame: Baseline, Week 8
Change From Baseline to Week 8 in Plasma Renin Concentration (PRC)
Time frame: Baseline, Week 8
Number of Patients With Adverse Events, Serious Adverse Events and Death
Time frame: 8 weeks
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Jan 2014.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Novartis Pharmaceuticals study director
Novartis Pharmaceuticals
83 sites in 7 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 4 study testing Aliskiren in people with Hypertension, run by Novartis Pharmaceuticals at 83 sites in 7 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Jan 2014. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 83 sites in United States, Slovakia, Spain, Canada, Taiwan and 2 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 4 studies take place after a treatment is approved, to learn more about its long-term benefits and risks in everyday use.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
Yes. Results are posted in the registry (first posted 1 Jan 2014). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change From Baseline (Visit 3) to End of Study (Week 8) in Mean 24 Hour Ambulatory Systolic Blood Pressure (maSBP) (time frame: Baseline, week 8). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Jan 2014.