Unilateral Knee OsteoarthritisISOGONCT01586130
Assessing the Impact of Isokinetic Muscular Strengthening in Eccentric Mode in the Medical Treatment of Knee Osteoarthritis
A study testing Exercise in eccentric or concentric mode in people with Unilateral Knee Osteoarthritis, run by University Hospital, Clermont-Ferrand at 1 site in France.
Trial summary
Knee osteoarthritis (O.A. from now on) is associated to muscular weakness of inferior limbs, especially the quadriceps; leading to disease progression. Advantages of muscular strength training for the treatment of this kind of O.A. is now well established. Read more about this study
- Who is it for?
- Ages 40 to 70 years
- Conditions the study is for
- Unilateral Knee Osteoarthritis
- What is being tested?
- Exercise in eccentric or concentric mode
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteFrance
- Study dates
- Feb 2012to 31 Dec 2018
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patient male or female, age ranging from 40 to 70 years old
- Patient suffering from one-sided knee O.A. regarding criteria of the American College of Rheumatology (A.C.R.), with radiologic score ranging from 2 to 3 according to the Kellgren \& Lawrence classification.
- Patient receiving medical support
- Patient that did not receive any infiltration on knee within two months before randomisation.
- Patient free from any disease that could be a contraindication to the study treatment
- Patient able to understand the protocol and willing to comply with its rules.
- Patient willing to give consent.
- Patient affiliated to the french social secu
Who cannot join
- Patient carrying prosthesis.
- Patient suffering from inflammatory arthritis, or flare of arthritis.
- Patient suffering from symptomatic patellofemoral osteoarthritis.
- Patient suffering from cardio-vascular or pneumologic disease that could a contraindication to the study treatment.
- Patient suffering from any pathology that could cause muscular weakness (myopathy, neuropathy, hemiplegia...)
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Assessing the Impact of Isokinetic Muscular Strengthening in Eccentric Mode in the Medical Treatment of Knee Osteoarthritis.
Knee osteoarthritis (O.A. from now on) is associated to muscular weakness of inferior limbs, especially the quadriceps; leading to disease progression. Advantages of muscular strength training for the treatment of this kind of O.A. is now well established. In this therapeutic field, isokinetic exercises seem to have a better efficiency than other, more frequently used, kinds of exercises such as isometric or isotonic exercises.
Functional impairment caused by knee O.A. is mainly affecting walking. Walking induces muscles to work in eccentric mode.
The hypothesis of this study is that muscular strengthening using isokinetic exercises in eccentric mode would have a more important benefit than isokinetic exercises in concentric mode. Such an hypothesis, if verified, could lead to a better management of rehabilitative knee exercises in the treatment of knee O.A.
Read the detailed description
Knee osteoarthritis (O.A. from now on) is associated to muscular weakness of inferior limbs, especially the quadriceps; leading to disease progression. Advantages of muscular strength training for the treatment of this kind of O.A. is now well established. In this therapeutic field, isokinetic exercises seem to have a better efficiency than other, more frequently used, kinds of exercises such as isometric or isotonic exercises.
Functional impairment caused by knee O.A. is mainly affecting walking. Walking induces muscles to work in eccentric mode.
The hypothesis of this study is that muscular strengthening using isokinetic exercises in eccentric mode would have a more important benefit than isokinetic exercises in concentric mode. Such an hypothesis, if verified, could lead to a better management of rehabilitative knee exercises in the treatment of knee O.A.
- Conditions
- Unilateral Knee Osteoarthritis
- Being tested
- Exercise in eccentric or concentric mode
- Keywords
- Knee Osteoarthritis, Exercise, Isokinetic, Muscle strength, Rehabilitation
- Medical subject headings
- Osteoarthritis, Knee, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Exercise in eccentric or concentric modeOther
In this therapeutic field, isokinetic exercises seem to have a better efficiency than other, more frequently used, kinds of exercises such as isometric or isotonic exercises.
| Study group | Role | What they receive |
|---|---|---|
| isokinetic exercises in eccentric mode | Other | Not described Receives: Other: Exercise in eccentric or concentric mode |
| isokinetic exercises in concentric mode | Other | Not described Receives: Other: Exercise in eccentric or concentric mode |
What is being measured
The primary outcome is the main question the study is designed to answer.
Difference of peak torque of quadriceps
Measured: 6 months after treatment start
Secondary outcomes (7)
Walk speed (50 meters and 200 meters)
Measured: at day 1, 6 weeks, and 6 months :
Knee pain (via analogic visual scales)
Measured: at day 1, 6 weeks, and 6 months
Posture parameters (posturography)
Measured: at day 1, 6 weeks, and 6 months
WOMAC Scores
Measured: at day 1, 6 weeks, and 6 months
Knee perimeter
Measured: at day 1, 6 weeks, and 6 months
Knee range of motion (goniometer)
Measured: at day 1, 6 weeks, and 6 months
Kellgren & Lawrence scores
Measured: at day 1, 6 weeks, and 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Apr 2012 (estimated)
- Study startFeb 2012
- Primary completionAug 2014
- Study completion31 Dec 2018
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Unilateral Knee OsteoarthritisStudies of the same condition, open and under way.
- More trials run by University Hospital, Clermont-FerrandThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- University Hospital, Clermont-Ferrand
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Emmanuel COUDEYRE, Principal investigator, University Hospital, Clermont-Ferrand
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01586130
- Sponsor's protocol ID
- CHU-0114
- Acronym
- ISOGO
- Status last verified
- Apr 2026
- First submitted
- 16 Feb 2012
- Last updated
- 21 Apr 2026
- Results posted
- No
Publications
Coudeyre E, Pereira B, Lechauve JB, Girold S, Richard R, Dobija L, Lanhers C. Eccentric Muscle Strengthening Using Maximal Contractions Is Deleterious in Knee Osteoarthritis: A Randomized Clinical Trial. J Clin Med. 2024 Jun 4;13(11):3318. doi: 10.3390/jcm13113318.
PubMed 38893028Jegu AG, Pereira B, Andant N, Coudeyre E. Effect of eccentric isokinetic strengthening in the rehabilitation of patients with knee osteoarthritis: Isogo, a randomized trial. Trials. 2014 Apr 2;15:106. doi: 10.1186/1745-6215-15-106.
PubMed 24693988
Study at a glance
From the registry record, last updated by the sponsor on 21 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Assessing the Impact of Isokinetic Muscular Strengthening in Eccentric Mode in the Medical Treatment of Knee Osteoarthritis.
- ClinicalTrials.gov ID
- NCT01586130
- Acronym / sponsor ID
- ISOGO / CHU-0114
- Conditions
- Unilateral Knee Osteoarthritis
- Keywords
- Knee Osteoarthritis, Exercise, Isokinetic, Muscle strength, Rehabilitation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- University Hospital, Clermont-FerrandUniversity, hospital or other
- Study start
- Feb 2012
- Primary completion
- Aug 2014 (actual)
- Study completion
- 31 Dec 2018 (actual)
- First posted
- 26 Apr 2012 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Knee osteoarthritis (O.A. from now on) is associated to muscular weakness of inferior limbs, especially the quadriceps; leading to disease progression. Advantages of muscular strength training for the treatment of this kind of O.A. is now well established. In this therapeutic field, isokinetic exercises seem to have a better efficiency than other, more frequently used, kinds of exercises such as isometric or isotonic exercises.
Functional impairment caused by knee O.A. is mainly affecting walking. Walking induces muscles to work in eccentric mode.
The hypothesis of this study is that muscular strengthening using isokinetic exercises in eccentric mode would have a more important benefit than isokinetic exercises in concentric mode. Such an hypothesis, if verified, could lead to a better management of rehabilitative knee exercises in the treatment of knee O.A.
Detailed description
Knee osteoarthritis (O.A. from now on) is associated to muscular weakness of inferior limbs, especially the quadriceps; leading to disease progression. Advantages of muscular strength training for the treatment of this kind of O.A. is now well established. In this therapeutic field, isokinetic exercises seem to have a better efficiency than other, more frequently used, kinds of exercises such as isometric or isotonic exercises.
Functional impairment caused by knee O.A. is mainly affecting walking. Walking induces muscles to work in eccentric mode.
The hypothesis of this study is that muscular strengthening using isokinetic exercises in eccentric mode would have a more important benefit than isokinetic exercises in concentric mode. Such an hypothesis, if verified, could lead to a better management of rehabilitative knee exercises in the treatment of knee O.A.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| isokinetic exercises in eccentric mode | Other | Other: Exercise in eccentric or concentric mode |
| isokinetic exercises in concentric mode | Other | Other: Exercise in eccentric or concentric mode |
Who may qualify
- Ages
- 40 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Patient male or female, age ranging from 40 to 70 years old
- Patient suffering from one-sided knee O.A. regarding criteria of the American College of Rheumatology (A.C.R.), with radiologic score ranging from 2 to 3 according to the Kellgren \& Lawrence classification.
- Patient receiving medical support
- Patient that did not receive any infiltration on knee within two months before randomisation.
- Patient free from any disease that could be a contraindication to the study treatment
Key exclusion criteria (5 listed)
- Patient carrying prosthesis.
- Patient suffering from inflammatory arthritis, or flare of arthritis.
- Patient suffering from symptomatic patellofemoral osteoarthritis.
- Patient suffering from cardio-vascular or pneumologic disease that could a contraindication to the study treatment.
- Patient suffering from any pathology that could cause muscular weakness (myopathy, neuropathy, hemiplegia...)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Exercise in eccentric or concentric modeIn this therapeutic field, isokinetic exercises seem to have a better efficiency than other, more frequently used, kinds of exercises such as isometric or isotonic exercises. | Other | isokinetic exercises in concentric mode, isokinetic exercises in eccentric mode |
Primary outcome
Difference of peak torque of quadriceps
Time frame: 6 months after treatment start
7 secondary outcomes
Walk speed (50 meters and 200 meters)
Time frame: at day 1, 6 weeks, and 6 months :
Knee pain (via analogic visual scales)
Time frame: at day 1, 6 weeks, and 6 months
Posture parameters (posturography)
Time frame: at day 1, 6 weeks, and 6 months
WOMAC Scores
Time frame: at day 1, 6 weeks, and 6 months
Knee perimeter
Time frame: at day 1, 6 weeks, and 6 months
Knee range of motion (goniometer)
Time frame: at day 1, 6 weeks, and 6 months
Kellgren & Lawrence scores
Time frame: at day 1, 6 weeks, and 6 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Apr 2026.
- Results publication: PubMed 38893028Coudeyre E, Pereira B, Lechauve JB, Girold S, Richard R, Dobija L, Lanhers C. Eccentric Muscle Strengthening Using Maximal Contractions Is Deleterious in Knee Osteoarthritis: A Randomized Clinical Trial. J Clin Med. 2024 Jun 4;13(11):3318. doi: 10.3390/jcm13113318.
- Derived from this study: PubMed 24693988Jegu AG, Pereira B, Andant N, Coudeyre E. Effect of eccentric isokinetic strengthening in the rehabilitation of patients with knee osteoarthritis: Isogo, a randomized trial. Trials. 2014 Apr 2;15:106. doi: 10.1186/1745-6215-15-106.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Emmanuel COUDEYRE principal investigator
University Hospital, Clermont-Ferrand
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Exercise in eccentric or concentric mode in people with Unilateral Knee Osteoarthritis, run by University Hospital, Clermont-Ferrand at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 21 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Difference of peak torque of quadriceps (time frame: 6 months after treatment start). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT01586130, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Apr 2026.