AzTrials
AzTrials

Atherosclerotic Cardiovascular DiseasePhase 3NCT01663402

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab

A Phase 3 study testing Alirocumab and LMT in people with Atherosclerotic Cardiovascular Disease, run by Sanofi at 1,388 sites in 57 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
Search all trials

Trial summary

Primary Objective: To compare the effect of alirocumab with placebo on the occurrence of cardiovascular (CV) events (composite endpoint of coronary heart disease (CHD) death, non-fatal myocardial infarction (MI), fatal and non-fatal ischemic stroke, unstable angina (UA) requiring hospitalization) in participants who… Read more about this study

Who is it for?
Ages 40 years and older
Conditions the study is for
Atherosclerotic Cardiovascular Disease
What is being tested?
Alirocumab and LMT
Type of treatment
Injection or infusion
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
18,924 participants
Where
1,388 sitesin 57 countries
Study dates
Oct 2012to 23 Jan 2018
Phase
Phase 3
Are there results?
Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 40 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Recently (< 52 weeks) hospitalized for ACS.

Who cannot join

  • Age < 40 years.
  • ACS event occurring more than 52 weeks prior to randomization visit.
  • LDL-C likely to be <70 mg/dL (<1.81 mmo/L), and apolipoprotein B (ApoB) <80 mg/dL (<0.8 g/L), and non - high-density lipoprotein cholesterol (HDL-C) <100 mg/dL (<2.59 mmol/L) with evidence-based medical and dietary management of dyslipidemia.
  • The above information is not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.

Trial locations and contacts

1,388 sites in 57 countries.

1388 sites in 57 countries

United States273 sites
  • Investigational Site Number 840364

    Akron, Ohio, 44304

  • Investigational Site Number 840254

    Alexandria, Louisiana, 71301

  • Investigational Site Number 840133

    Allentown, Pennsylvania, 18102

  • Investigational Site Number 840347

    Altamonte Springs, Florida, 32714

  • Investigational Site Number 840205

    Amarillo, Texas, 79106

  • Investigational Site Number 840352

    Amarillo, Texas, 79106

  • Investigational Site Number 840154

    Ames, Iowa, 50010

  • Investigational Site Number 840118

    Anderson, South Carolina, 29621

  • Investigational Site Number 840351

    Annapolis, Maryland, 21401

  • Investigational Site Number 840237

    Arlington Heights, Illinois, 60005

  • Investigational Site Number 840075

    Atlanta, Georgia

  • Investigational Site Number 840332

    Atlantis, Arizona, 33462

  • Investigational Site Number 840142

    Auburn, Maine, 04210

  • Investigational Site Number 840148

    Auburn, Maine

  • Investigational Site Number 840176

    Augusta, Georgia, 30901

  • Investigational Site Number 840096

    Aurora, Colorado, 80012

  • Investigational Site Number 840135

    Austin, Texas, 78756

  • Investigational Site Number 840097

    Bangor, Maine, 04401

  • Investigational Site Number 840139

    Banning, California

  • Investigational Site Number 840104

    Beaver, Pennsylvania, 15009

  • Investigational Site Number 840025

    Bellevue, Washington, 98004

  • Investigational Site Number 840072

    Beltsville, Maryland

  • Investigational Site Number 840193

    Bethesda, Maryland, 20817

  • Investigational Site Number 840286

    Beverly Hills, California, 90210

  • Investigational Site Number 840246

    Beverly Hills, California, 90211

  • Investigational Site Number 840353

    Beverly Hills, California, 90211

  • Investigational Site Number 840163

    Birmingham, Alabama, 35235

  • Investigational Site Number 840060

    Birmingham, Alabama, 35294

  • Investigational Site Number 840056

    Boston, Massachusetts, 02111

  • Investigational Site Number 840122

    Bridgeport, Connecticut, 06606

  • Investigational Site Number 840077

    Bridgewater, New Jersey, 08807

  • Investigational Site Number 840173

    Bridgewater, New Jersey

  • Investigational Site Number 840322

    Buffalo, New York, 14215

  • Investigational Site Number 840053

    Burlington, Vermont, 05401

  • Investigational Site Number 840262

    Burlington, Wisconsin, 53105

  • Investigational Site Number 840170

    Camp Hill, Pennsylvania, 17011

  • Investigational Site Number 840341

    Carmichael, California, 95608

  • Investigational Site Number 840049

    Charlottesville, Virginia, 22908-0679

  • Investigational Site Number 840260

    Charlottesville, Virginia

  • Investigational Site Number 840285

    Chattanooga, Tennessee, 37421

  • Investigational Site Number 840292

    Chicago, Illinois, 60612

  • Investigational Site Number 840299

    Chula Vista, California, 91910

  • Investigational Site Number 840131

    Cincinnati, Ohio

  • Investigational Site Number 840066

    Clearwater, Florida, 33756

  • Investigational Site Number 840037

    Colorado Springs, Colorado, 80909

  • Investigational Site Number 840200

    Columbia, Maryland, 21044

  • Investigational Site Number 840046

    Columbia, Missouri, 65201

  • Investigational Site Number 840045

    Columbus, Ohio, 43210

  • Investigational Site Number 840265

    Columbus, Ohio, 43210

  • Investigational Site Number 840048

    Covington, Georgia, 30014

  • Investigational Site Number 840065

    Cumming, Georgia, 30041

  • Investigational Site Number 840301

    Dallas, Texas, 75226

  • Investigational Site Number 840152

    Dallas, Texas, 75231

  • Investigational Site Number 840157

    Dallas, Texas, 75390

  • Investigational Site Number 840079

    Daytona Beach, Florida, 32114

  • Investigational Site Number 840051

    Daytona Beach, Florida, 32117

  • Investigational Site Number 840368

    Delray Beach, Florida, 33484

  • Investigational Site Number 840189

    Denver, Colorado, 80220

  • Investigational Site Number 840020

    Doylestown, Pennsylvania, 18901

  • Investigational Site Number 840199

    Duluth, Minnesota, 55805

  • Investigational Site Number 840116

    Edina, Minnesota, 55435

  • Investigational Site Number 840070

    Elizabeth City, North Carolina, 27909

  • Investigational Site Number 840358

    Elkhart, Indiana, 46514

  • Investigational Site Number 840016

    Erie, Pennsylvania, 16502-4604

  • Investigational Site Number 840321

    Everett, Washington, 98201

  • Investigational Site Number 840214

    Fargo, North Dakota

  • Investigational Site Number 840127

    Flemington, New Jersey, 08822

  • Investigational Site Number 840144

    Flint, Michigan, 48532

  • Investigational Site Number 840242

    Fort Lauderdale, Florida, 33308

  • Investigational Site Number 840229

    Fort Worth, Texas, 76104

  • Investigational Site Number 840120

    Fort Worth, Texas, 76107

  • Investigational Site Number 840258

    Fort Worth, Texas

  • Investigational Site Number 840234

    Framingham, Maine, 01702

  • Investigational Site Number 840164

    Fresno, California, 93721

  • Investigational Site Number 840076

    Fullerton, California, 92835

  • Investigational Site Number 840134

    Gainesville, Florida, 32608

  • Investigational Site Number 840306

    Glasston, North Dakota, 21229

  • Investigational Site Number 840329

    Goodyear, Pennsylvania, 85395

  • Investigational Site Number 840033

    Grand Island, Nebraska, 68803

  • Investigational Site Number 840365

    Grandville, Michigan, 49418

  • Investigational Site Number 840298

    Green Bay, Wisconsin, 54303

  • Investigational Site Number 840059

    Green Bay, Wisconsin

  • Investigational Site Number 840303

    Greenville, North Carolina, 27834

  • Investigational Site Number 840182

    Greenville, North Carolina

  • Investigational Site Number 840190

    Greenwood, South Carolina

  • Investigational Site Number 840219

    Guilford, Connecticut, 06437

  • Investigational Site Number 840359

    Hackensack, New Jersey, 07601

  • Investigational Site Number 840036

    Hammond, Indiana, 46320

  • Investigational Site Number 840350

    Harrisonburg, Virginia, 22801

  • Investigational Site Number 840146

    Harvey, Illinois, 60426

  • Investigational Site Number 840327

    Hollywood, Florida, 33021

  • Investigational Site Number 840153

    Hudson, Florida, 34667

  • Investigational Site Number 840105

    Hudson, Florida

  • Investigational Site Number 840073

    Huntington Beach, California, 92648

  • Investigational Site Number 840117

    Huntsville, Alabama, 35801

  • Investigational Site Number 840192

    Huntsville, Alabama, 35801

  • Investigational Site Number 840211

    Idaho Falls, Idaho, 83404

  • Investigational Site Number 840180

    Independence, Missouri, 64057

  • Investigational Site Number 840026

    Indianapolis, Indiana

  • Investigational Site Number 840345

    Iowa City, Iowa

  • Investigational Site Number 840287

    Jackson, Tennessee, 38301

  • Investigational Site Number 840253

    Jacksonville, Florida, 32204

  • Investigational Site Number 840141

    Jacksonville, Florida, 32209

  • Investigational Site Number 840042

    Jacksonville, Florida, 32216

  • Investigational Site Number 840206

    Jacksonville, Florida, 32216

  • Investigational Site Number 840063

    Jacksonville, Florida, 32258

  • Investigational Site Number 840040

    Johnson City, Tennessee, 37604

  • Investigational Site Number 840340

    Joliet, Illinois, 60435

  • Investigational Site Number 840002

    Jupiter, Florida, 33458

  • Investigational Site Number 840093

    Kalamazoo, Michigan

  • Investigational Site Number 840032

    Kalispell, Montana, 59901

  • Investigational Site Number 840335

    Kansas City, Kansas, 64116

  • Investigational Site Number 840089

    Kansas City, Kansas, 66160-7321

  • Investigational Site Number 840218

    Kansas City, Kansas

  • Investigational Site Number 840136

    Kingwood, Texas, 77339

  • Investigational Site Number 840126

    Knoxville, Pennsylvania

  • Investigational Site Number 840238

    Knoxville, Tennessee, 37917-4524

  • Investigational Site Number 840177

    La Crosse, Wisconsin, 54601

  • Investigational Site Number 840092

    La Jolla, California, 92093

  • Investigational Site Number 840344

    Lafayette, Louisiana, 70503

  • Investigational Site Number 840187

    Lake Charles, Louisiana, 70601

  • Investigational Site Number 840249

    Lancaster, Pennsylvania, 17603

  • Investigational Site Number 840150

    Lancaster, Pennsylvania

  • Investigational Site Number 840360

    Lancaster, South Carolina, 29720

  • Investigational Site Number 840198

    Lansing, Michigan, 48910

  • Investigational Site Number 840119

    Largo, Florida

  • Investigational Site Number 840221

    Las Vegas, Nevada, 89146

  • Investigational Site Number 840215

    Leesburg, Virginia

  • Investigational Site Number 840030

    Lexington, Kentucky

  • Investigational Site Number 840208

    Long Beach, California, 90801

  • Investigational Site Number 840068

    Long Beach, California, 90822

  • Investigational Site Number 840113

    Lorain, Ohio, 44053

  • Investigational Site Number 840115

    Lorain, Ohio, 44053

  • Investigational Site Number 840269

    Los Alamitos, California, 90720

  • Investigational Site Number 840009

    Los Angeles, California, 90073

  • Investigational Site Number 840282

    Los Angeles, California, 90095

  • Investigational Site Number 840023

    Louisville, Kentucky, 40205

  • Investigational Site Number 840007

    Louisville, Kentucky, 40207

  • Investigational Site Number 840027

    Lubbock, Texas, 79410

  • Investigational Site Number 840202

    Lufkin, Texas, 75904

  • Investigational Site Number 840010

    Lynchburg, Virginia, 24501

  • Investigational Site Number 840225

    Manassas, Virginia, 20109

  • Investigational Site Number 840300

    Manitowoc, Wisconsin, 54220

  • Investigational Site Number 840013

    Marquette, Missouri

  • Investigational Site Number 840309

    Maumee, Ohio, 43537

  • Investigational Site Number 840241

    Miami Beach, Florida, 33140

  • Investigational Site Number 840291

    Minden, Louisiana, 71055

  • Investigational Site Number 840281

    Minneapolis, Minnesota, 55407

  • Investigational Site Number 840095

    Minot, North Dakota, 58701

  • Investigational Site Number 840019

    Mission Viejo, California, 92691

  • Investigational Site Number 840121

    Mobile, Alabama, 36604

  • Investigational Site Number 840319

    Mobile, Alabama, 36695

  • Investigational Site Number 840348

    Moorestown, New Jersey, 08057

  • Investigational Site Number 840336

    Moreno Valley, California, 92553

  • Investigational Site Number 840210

    Mount Clemens, Florida

  • Investigational Site Number 840257

    Mountain Lakes, North Dakota

  • Investigational Site Number 840102

    Muncie, Indiana, 47303-3400

  • Investigational Site Number 840314

    Myrtle Beach, South Carolina, 29572

  • Investigational Site Number 840062

    Nashua, New Hampshire, 03060

  • Investigational Site Number 840128

    New Brunswick, New Jersey, 08903-0019

  • Investigational Site Number 840278

    New Orleans, Louisiana, 70112

  • Investigational Site Number 840366

    New Port Richey, Florida, 34653

  • Investigational Site Number 840248

    New York, New York, 10016

  • Investigational Site Number 840371

    New York, New York

  • Investigational Site Number 840333

    Newburgh, New York, 47630

  • Investigational Site Number 840320

    Newport Beach, Arizona, 92663

  • Investigational Site Number 840124

    Northridge, California, 91325

  • Investigational Site Number 840195

    Oak Ridge, Tennessee, 37830

  • Investigational Site Number 840270

    Odessa, Texas, 79761

  • Investigational Site Number 840334

    Oklahoma City, Oklahoma, 73104

  • Investigational Site Number 840337

    Oklahoma City, Oklahoma, 73120

  • Investigational Site Number 840015

    Omaha, Nebraska, 68122

  • Investigational Site Number 840021

    Omaha, Nebraska, 68122

  • Investigational Site Number 840001

    Omaha, Nebraska

  • Investigational Site Number 840256

    Orem, Utah, 84058

  • Investigational Site Number 840179

    Overland, Missouri

  • Investigational Site Number 840140

    Overland Park, Kansas, 66209

  • Investigational Site Number 840279

    Owensboro, Kentucky, 42303

  • Investigational Site Number 840311

    Palm Beach Gardens, Florida, 33410

  • Investigational Site Number 840280

    Palm Harbor, Florida, 34684

  • Investigational Site Number 840054

    Panama City, Florida, 32401

  • Investigational Site Number 840251

    Pasadena, California, 91105

  • Investigational Site Number 840289

    Pasadena, California, 91105

  • Investigational Site Number 840129

    Pawtucket, Rhode Island, 02860

  • Investigational Site Number 840239

    Pembroke Pines, Florida, 33024

  • Investigational Site Number 840044

    Pensacola, Florida, 32501

  • Investigational Site Number 840196

    Peoria, Illinois, 61614

  • Investigational Site Number 840231

    Philadelphia, Pennsylvania, 19085

  • Investigational Site Number 840339

    Philadelphia, Pennsylvania, 19104

  • Investigational Site Number 840308

    Pikeville, Kentucky, 41501

  • Investigational Site Number 840230

    Pittsburgh, Pennsylvania, 15240

  • Investigational Site Number 840367

    Plantation, Florida, 33317

  • Investigational Site Number 840167

    Pomona, New Jersey, 08240

  • Investigational Site Number 840312

    Port Hueneme, California, 93041

  • Investigational Site Number 840184

    Portland, Oregon, 97239

  • Investigational Site Number 840017

    Poughkeepsie, New York, 12601

  • Investigational Site Number 840243

    Raleigh, North Carolina, 27610

  • Investigational Site Number 840342

    Raleigh, North Carolina, 27610

  • Investigational Site Number 840008

    Rapid City, South Dakota, 57701

  • Investigational Site Number 840022

    Richmond, Virginia, 23225

  • Investigational Site Number 840078

    Richmond, Virginia, 23249

  • Investigational Site Number 840110

    Richmond, Virginia, 23298

  • Investigational Site Number 840067

    Ridgewood, New Jersey, 07506

  • Investigational Site Number 840149

    Roanoke, Virginia, 24014

  • Investigational Site Number 840087

    Rochester Hills, Michigan, 48085

  • Investigational Site Number 840081

    Rock Island, Illinois, 61201

  • Investigational Site Number 840090

    Rock Island, Illinois, 61201

  • Investigational Site Number 840349

    Rockville, Maryland, 20850

  • Investigational Site Number 840293

    Rocky Mount, North Carolina, 27804

  • Investigational Site Number 840132

    Safety Harbor, Florida, 34695

  • Investigational Site Number 840061

    Safety Harbor, Florida

  • Investigational Site Number 840094

    Saint Cloud, Minnesota, 56303

  • Investigational Site Number 840181

    Saint Paul, Kentucky, 55102

  • Investigational Site Number 840324

    Saint Paul, Minnesota, 55101

  • Investigational Site Number 840296

    Salt Lake City, Utah, 84124

  • Investigational Site Number 840162

    San Antonio, Texas, 78229

  • Investigational Site Number 840232

    San Antonio, Texas, 78229

  • Investigational Site Number 840261

    San Diego, California, 92120

  • Investigational Site Number 840310

    San Diego, California, 92120

  • Investigational Site Number 840024

    San Diego, California

  • Investigational Site Number 840071

    Santa Ana, California, 92704

  • Investigational Site Number 840236

    Santa Rosa, California, 95405

  • Investigational Site Number 840247

    Sarasota, Florida, 34239

  • Investigational Site Number 840028

    Sayre, Pennsylvania, 18840

  • Investigational Site Number 840276

    Scarborough, Maine, 04074

  • Investigational Site Number 840328

    Schertz, Texas, 78154

  • Investigational Site Number 840069

    Scranton, Pennsylvania, 18503

  • Investigational Site Number 840316

    Scranton, Pennsylvania, 18510

  • Investigational Site Number 840273

    Seven Fields, Pennsylvania, 16046

  • Investigational Site Number 840290

    Shreveport, Louisiana, 71103

  • Investigational Site Number 840250

    Somerset, New Jersey, 08873

  • Investigational Site Number 840145

    South Bend, Indiana, 46601-1075

  • Investigational Site Number 840326

    Spokane, Washington, 99204

  • Investigational Site Number 840004

    Springfield, Michigan, 65807

  • Investigational Site Number 840267

    Springfield, Michigan

  • Investigational Site Number 840297

    Springfield, Ohio, 45505

  • Investigational Site Number 840228

    St Louis, Missouri, 63128

  • Investigational Site Number 840233

    St Louis, Missouri, 63128

  • Investigational Site Number 840235

    St Louis, Missouri, 63128

  • Investigational Site Number 840175

    St Louis, Missouri, 63136

  • Investigational Site Number 840125

    St Louis, Missouri, 63141

  • Investigational Site Number 840168

    St Louis, Missouri

  • Investigational Site Number 840088

    Statesville, North Carolina, 28627

  • Investigational Site Number 840086

    Tacoma, Washington, 98415-0299

  • Investigational Site Number 840264

    Tampa, Florida, 33606

  • Investigational Site Number 840082

    Tampa, Florida, 33613

  • Investigational Site Number 840222

    The Bronx, New York, 10467

  • Investigational Site Number 840356

    Thomasville, Georgia, 31792

  • Investigational Site Number 840274

    Thomure, Missouri

  • Investigational Site Number 840172

    Toledo, Ohio, 43623

  • Investigational Site Number 840012

    Torrance, California

  • Investigational Site Number 840213

    Trinity, Florida, 34655

  • Investigational Site Number 840114

    Tucker, Georgia, 30084

  • Investigational Site Number 840103

    Tucson, Arizona, 85724

  • Investigational Site Number 840084

    Tucson, Arizona

  • Investigational Site Number 840018

    Tulsa, Oklahoma, 74104

  • Investigational Site Number 840158

    Tyler, Texas, 75701

  • Investigational Site Number 840166

    Valhalla, New York, 10595

  • Investigational Site Number 840318

    Victoria, Texas, 77901

  • Investigational Site Number 840277

    Voorhees Township, New Jersey, 08043

  • Investigational Site Number 840295

    Walla Walla, Washington, 99362

  • Investigational Site Number 840227

    Washington, Pennsylvania

  • Investigational Site Number 840165

    Wellington, Florida, 33449

  • Investigational Site Number 840283

    West Des Moines, Iowa, 50266

  • Investigational Site Number 840323

    West Palm Beach, Florida, 33401

  • Investigational Site Number 840083

    Westwood, New Jersey

  • Investigational Site Number 840245

    Wichita Falls, Texas

  • Investigational Site Number 840354

    Williamsville, New York, 14221

  • Investigational Site Number 840052

    Wilmington, North Carolina, 28401

  • Investigational Site Number 840223

    Winchester, Virginia, 22601

  • Investigational Site Number 840111

    Winfield, Maryland

  • Investigational Site Number 840263

    Youngstown, Ohio, 44501

  • Investigational Site Number 840035

    Ypsilanti, Michigan, 48197

Other trials in United States

China63 sites
  • Investigational Site Number 156022

    Baotou, 014010

  • Investigational Site Number 156004

    Beijing, 100020

  • Investigational Site Number 156005

    Beijing, 100029

  • Investigational Site Number 156006

    Beijing, 100029

  • Investigational Site Number 156001

    Beijing, 100034

  • Investigational Site Number 156082

    Beijing, 100048

  • Investigational Site Number 156009

    Beijing, 100049

  • Investigational Site Number 156003

    Beijing, 100730

  • Investigational Site Number 156002

    Beijing, 100853

  • Investigational Site Number 156013

    Changchun, 130021

  • Investigational Site Number 156064

    Changchun, 130021

  • Investigational Site Number 156052

    Changsha, 410005

  • Investigational Site Number 156053

    Changsha, 410011

  • Investigational Site Number 156088

    Changsha, 410013

  • Investigational Site Number 156057

    Chongqing, 400037

  • Investigational Site Number 156070

    Fuzhou, 350005

  • Investigational Site Number 156079

    Fuzhou, 354200

  • Investigational Site Number 156059

    Guangzhou, 510080

  • Investigational Site Number 156060

    Guangzhou, 510080

  • Investigational Site Number 156071

    Guangzhou, 510120

  • Investigational Site Number 156061

    Guangzhou, 510515

  • Investigational Site Number 156072

    Guiyang, 550002

  • Investigational Site Number 156047

    Hangzhou, 310003

  • Investigational Site Number 156077

    Hangzhou, 310006

  • Investigational Site Number 156048

    Hangzhou, 310009

  • Investigational Site Number 156068

    Hangzhou, 310013

  • Investigational Site Number 156078

    Hangzhou, 310014

  • Investigational Site Number 156046

    Hangzhou, 310016

  • Investigational Site Number 156020

    Hohhot, 010017

  • Investigational Site Number 156032

    Jinan, 250013

  • Investigational Site Number 156031

    Jinan, 250033

  • Investigational Site Number 156027

    Lanzhou, 730000

  • Investigational Site Number 156074

    Lanzhou, 730030

  • Investigational Site Number 156081

    Luzhou, 646000

  • Investigational Site Number 156054

    Nanchang, 330006

  • Investigational Site Number 156055

    Nanchang, 330006

  • Investigational Site Number 156034

    Nanjing, 210008

  • Investigational Site Number 156035

    Nanjing, 210009

  • Investigational Site Number 156039

    Shanghai, 200025

  • Investigational Site Number 156076

    Shanghai, 200030

  • Investigational Site Number 156044

    Shanghai, 200032

  • Investigational Site Number 156043

    Shanghai, 200080

  • Investigational Site Number 156038

    Shanghai, 200120

  • Investigational Site Number 156040

    Shanghai, 200233

  • Investigational Site Number 156016

    Shenyang, 110001

  • Investigational Site Number 156017

    Shenyang, 110004

  • Investigational Site Number 156073

    Shenzhen, 518020

  • Investigational Site Number 156084

    Shenzhen, 518036

  • Investigational Site Number 156063

    Siping, 136000

  • Investigational Site Number 156037

    Suzhou, 215006

  • Investigational Site Number 156066

    Tianjin, 300052

  • Investigational Site Number 156067

    Tianjin, 300121

  • Investigational Site Number 156083

    Tianjin, 300140

  • Investigational Site Number 156025

    Tianjin, 300457

  • Investigational Site Number 156065

    Wenzhou, 325000

  • Investigational Site Number 156051

    Wuhan, 430022

  • Investigational Site Number 156087

    Wuhan, 430033

  • Investigational Site Number 156029

    Xi'an, 710061

  • Investigational Site Number 156086

    Xi'an, 710068

  • Investigational Site Number 156062

    Xuzhou, 221002

  • Investigational Site Number 156014

    Yanji, 133000

  • Investigational Site Number 156075

    Yueyang, 414000

  • Investigational Site Number 156080

    Zhanjiang, 524001

Other trials in China

India56 sites
  • Investigational Site Number 356060

    Ahmedabad, 380008

  • Investigational Site Number 356025

    Bangalore, 560017

  • Investigational Site Number 356028

    Bangalore, 560034

  • Investigational Site Number 356083

    Bangalore, 560038

  • Investigational Site Number 356018

    Bangalore, 560052

  • Investigational Site Number 356026

    Bangalore, 560054

  • Investigational Site Number 356084

    Bangalore, 560102

  • Investigational Site Number 356103

    Belagavi, 590010

  • Investigational Site Number 356019

    Bikaner

  • Investigational Site Number 356013

    Chennai, 600 037

  • Investigational Site Number 356012

    Chennai, 600006

  • Investigational Site Number 356081

    Chennai, 603203

  • Investigational Site Number 356056

    Chhatrapati Sambhajinagar, 431005

  • Investigational Site Number 356093

    Delhi, 110060

  • Investigational Site Number 356038

    Delhi, 110088

  • Investigational Site Number 356101

    Gūrgaon, 122001

  • Investigational Site Number 356100

    Gūrgaon, 122002

  • Investigational Site Number 356035

    Hyderabad, 500004

  • Investigational Site Number 356082

    Hyderabad, 50063

  • Investigational Site Number 356015

    Jaipur, 302001

  • Investigational Site Number 356053

    Karad, 415110

  • Investigational Site Number 356102

    Karamsad, 388325

  • Investigational Site Number 356022

    Kochi, 682018

  • Investigational Site Number 356106

    Kolhāpur, 416012

  • Investigational Site Number 356067

    Kolkata, 700020

  • Investigational Site Number 356079

    Kolkata, 700027

  • Investigational Site Number 356069

    Kolkata

  • Investigational Site Number 356089

    Ludhiana, 141003

  • Investigational Site Number 356095

    Mangalore, 575002

  • Investigational Site Number 356071

    Mumbai, 400022

  • Investigational Site Number 356057

    Mumbai

  • Investigational Site Number 356007

    Mysore, 570001

  • Investigational Site Number 356087

    Nagpur, 440010

  • Investigational Site Number 356098

    Nagpur, 440012

  • Investigational Site Number 356097

    Nagpur

  • Investigational Site Number 356096

    Nashik, 422005

  • Investigational Site Number 356055

    New Delhi, 110017

  • Investigational Site Number 356031

    New Delhi, 122001

  • Investigational Site Number 356041

    Panjim, 403001

  • Investigational Site Number 356077

    Pune, 411001

  • Investigational Site Number 356099

    Pune, 411001

  • Investigational Site Number 356048

    Pune, 411004

  • Investigational Site Number 356049

    Pune, 411004

  • Investigational Site Number 356050

    Pune, 411004

  • Investigational Site Number 356045

    Pune, 411011

  • Investigational Site Number 356046

    Pune, 411013

  • Investigational Site Number 356094

    Pune, 411019

  • Investigational Site Number 356009

    Secunderabad, 500 003

  • Investigational Site Number 356032

    Secunderabad, 500003

  • Investigational Site Number 356042

    Secunderabad, Hyderabad, 500003

  • Investigational Site Number 356091

    Surat, 395002

  • Investigational Site Number 356002

    Vijayawada, 520008

  • Investigational Site Number 356105

    Vijaywada, 520002

  • Investigational Site Number 356033

    Visakhapatnam, 530002

  • Investigational Site Number 356039

    Vishkhapattanam, 530013

  • Investigational Site Number 356104

    Wardha, 442004

Other trials in India

Argentina52 sites
  • Investigational Site Number 032012

    Adrogué, B1846DSK

  • Investigational Site Number 032018

    Bahía Blanca, B8000AKK

  • Investigational Site Number 032050

    Caba, C1093AAS

  • Investigational Site Number 032048

    Caba, C1118AAE

  • Investigational Site Number 032023

    Caba, C1119ACN

  • Investigational Site Number 032020

    Caba, C1180AAX

  • Investigational Site Number 032041

    Caba, C1181ACH

  • Investigational Site Number 032011

    Caba, C1425AGC

  • Investigational Site Number 032045

    Caba, C1426EGR

  • Investigational Site Number 032010

    Ciudad de Buenos Aires, C1428DCO

  • Investigational Site Number 032046

    Ciudadela, B1702BML

  • Investigational Site Number 032032

    Córdoba, X5000AAW

  • Investigational Site Number 032019

    Córdoba, X5000AAX

  • Investigational Site Number 032021

    Córdoba, X5000EPU

  • Investigational Site Number 032026

    Córdoba, X5000JHQ

  • Investigational Site Number 032008

    Córdoba, X5002AOQ

  • Investigational Site Number 032049

    Córdoba, X5003DCE

  • Investigational Site Number 032042

    Córdoba, X5004BAL

  • Investigational Site Number 032038

    Córdoba, X5006IKK

  • Investigational Site Number 032031

    Córdoba, X5016KEH

  • Investigational Site Number 032017

    Coronel Suárez, B7540GHD

  • Investigational Site Number 032009

    Corrientes, W3400AMZ

  • Investigational Site Number 032005

    Junín, B6000BHA

  • Investigational Site Number 032001

    La Plata, B1900AXI

  • Investigational Site Number 032040

    La Plata, B1906ESC

  • Investigational Site Number 032033

    Mar del Plata, B7600FYK

  • Investigational Site Number 032014

    Mar del Plata, B7600FZN

  • Investigational Site Number 032016

    Mendoza, 5500

  • Investigational Site Number 032030

    Merlo, B1722COV

  • Investigational Site Number 032036

    Morón, B1708CGU

  • Investigational Site Number 032007

    Olivos, 1638

  • Investigational Site Number 032044

    Olivos, B1605DSX

  • Investigational Site Number 032004

    Quilmes, B1878DKF

  • Investigational Site Number 032025

    Rafaela, S2300MMA

  • Investigational Site Number 032035

    Ramos Mejía, B1704ETD

  • Investigational Site Number 032039

    Resistencia, H3500CDM

  • Investigational Site Number 032028

    Rosario, S2000DEJ

  • Investigational Site Number 032024

    Rosario, S2000DSR

  • Investigational Site Number 032053

    Salta, 4400

  • Investigational Site Number 032037

    San Isidro, B1642DCB

  • Investigational Site Number 032052

    San Martin, B1650NBN

  • Investigational Site Number 032013

    San Martin, B1685CSQ

  • Investigational Site Number 032002

    San Miguel de Tucumán, T4000ICL

  • Investigational Site Number 032034

    San Miguel de Tucumán, T4000IFL

  • Investigational Site Number 032006

    San Nicolás, B2900DMH

  • Investigational Site Number 032043

    Santa Fe, S3000EOZ

  • Investigational Site Number 032003

    Santa Fe, S3000FWO

  • Investigational Site Number 032051

    Santa Rosa, L6300DSD

  • Investigational Site Number 032047

    Santiago del Estero, G4200AQK

  • Investigational Site Number 032029

    Venado Tuerto, S2600KUE

  • Investigational Site Number 032022

    Villa María, X5900JKA

  • Investigational Site Number 032015

    Zárate, B2800DGH

Other trials in Argentina

Russia43 sites
  • Investigational Site Number 643027

    Barnaul, 656055

  • Investigational Site Number 643037

    Kazan', 420012

  • Investigational Site Number 643013

    Kemerovo, 650002

  • Investigational Site Number 643020

    Krasnodar, 350042

  • Investigational Site Number 643053

    Krasnodar, 350086

  • Investigational Site Number 643033

    Moscow, 101990

  • Investigational Site Number 643002

    Moscow, 111539

  • Investigational Site Number 643011

    Moscow, 117292

  • Investigational Site Number 643029

    Moscow, 121356

  • Investigational Site Number 643028

    Moscow, 121552

  • Investigational Site Number 643004

    Moscow, 125284

  • Investigational Site Number 643016

    Moscow, 125284

  • Investigational Site Number 643023

    Moscow, 127473

  • Investigational Site Number 643044

    Moscow, 127644

  • Investigational Site Number 643022

    Moscow, 129301

  • Investigational Site Number 643031

    Moscow, 129327

  • Investigational Site Number 643043

    Nizhny Novgorod, 603005

  • Investigational Site Number 643034

    Novosibirsk, 630075

  • Investigational Site Number 643052

    Novosibirsk, 630089

  • Investigational Site Number 643050

    Novosibirsk

  • Investigational Site Number 643035

    Omsk, 644112

  • Investigational Site Number 643039

    Perm, 614077

  • Investigational Site Number 643008

    Rostov-on-Don, 344068

  • Investigational Site Number 643017

    Ryazan, 390026

  • Investigational Site Number 643006

    Saint Petersburg, 190013

  • Investigational Site Number 643015

    Saint Petersburg, 190013

  • Investigational Site Number 643051

    Saint Petersburg, 192242

  • Investigational Site Number 643001

    Saint Petersburg, 194044

  • Investigational Site Number 643030

    Saint Petersburg, 194044

  • Investigational Site Number 643010

    Saint Petersburg, 194291

  • Investigational Site Number 643042

    Saint Petersburg, 194354

  • Investigational Site Number 643007

    Saint Petersburg, 196601

  • Investigational Site Number 643040

    Saint Petersburg, 197022

  • Investigational Site Number 643054

    Saint Petersburg, 199106

  • Investigational Site Number 643012

    Saratov, 410028

  • Investigational Site Number 643021

    Saratov, 410028

  • Investigational Site Number 643003

    Saratov, 410053

  • Investigational Site Number 643014

    Saratov, 410054

  • Investigational Site Number 643049

    Tomsk, 634012

  • Investigational Site Number 643019

    Tyumen, 625000

  • Investigational Site Number 643025

    Tyumen, 625026

  • Investigational Site Number 643045

    Voronezh, 394065

  • Investigational Site Number 643009

    Yaroslavl, 150029

Other trials in Russia

Canada42 sites
  • Investigational Site Number 124033

    Calgary, T2N 2T8

  • Investigational Site Number 124017

    Cambridge, N1R 7R1

  • Investigational Site Number 124013

    Cambridge, N3H 3R8

  • Investigational Site Number 124026

    Edmonton, T5H 3V9

  • Investigational Site Number 124019

    Edmonton, T6G 2B7

  • Investigational Site Number 124016

    Edmonton, T6L 5X8

  • Investigational Site Number 124027

    Granby, J2G 1T7

  • Investigational Site Number 124002

    Halifax, B3H 3A7

  • Investigational Site Number 124051

    Hamilton, L8L 2X2

  • Investigational Site Number 124043

    Joliette, J6E 6J2

  • Investigational Site Number 124045

    Kitchener, N2M 1B2

  • Investigational Site Number 124053

    Lévis, G6V4Z5

  • Investigational Site Number 124015

    Longueuil, J4M 2X1

  • Investigational Site Number 124004

    Moncton, E1C 4B7

  • Investigational Site Number 124040

    Montreal, H1T 1C8

  • Investigational Site Number 124032

    Montreal, H2K 4L5

  • Investigational Site Number 124036

    Montreal, H2R 1V6

  • Investigational Site Number 124042

    Montreal, H3G 1A4

  • Investigational Site Number 124028

    New Westminster, V3L 3W4

  • Investigational Site Number 124008

    Newmarket, L3Y 8C3

  • Investigational Site Number 124005

    Oshawa, L1J 2K1

  • Investigational Site Number 124007

    Ottawa, K1Y4W7

  • Investigational Site Number 124006

    Penticton, V2A 3G6

  • Investigational Site Number 124012

    Red Deer, T4N 4E7

  • Investigational Site Number 124054

    Saint-Jérôme, J7Z 5T3

  • Investigational Site Number 124024

    Sainte-Foy, G1V 4G5

  • Investigational Site Number 124035

    Scarborough, M1E 5E9

  • Investigational Site Number 124047

    Sherbrooke, J1H 5N4

  • Investigational Site Number 124044

    St. Catherines, L2N 7L6

  • Investigational Site Number 124025

    St. Georges, G5Y 4T8

  • Investigational Site Number 124034

    St. John's, A1B 3V6

  • Investigational Site Number 124021

    St. John's, NBE 2L4

  • Investigational Site Number 124009

    Surrey, V3V 1N1

  • Investigational Site Number 124022

    Sydney, B1P 1P3

  • Investigational Site Number 124048

    Thetford-Mines, G6G 2V4

  • Investigational Site Number 124037

    Thunder Bay, P7B 6V4

  • Investigational Site Number 124001

    Toronto, M5B 1W8

  • Investigational Site Number 124049

    Trois-Rivières, G8Z 3R6

  • Investigational Site Number 124039

    Vancouver, V5Z 1M9

  • Investigational Site Number 124023

    Victoria, V8R 4R2

  • Investigational Site Number 124041

    Victoria, V8T 5G4

  • Investigational Site Number 124038

    Winnipeg, R2H 2A6

Other trials in Canada

Germany42 sites
  • Investigational Site Number 276013

    Aachen, 52074

  • Investigational Site Number 276019

    Bad Krozingen, 79189

  • Investigational Site Number 276008

    Berlin, 10789

  • Investigational Site Number 276040

    Berlin, 12203

  • Investigational Site Number 276051

    Berlin, 12559

  • Investigational Site Number 276039

    Berlin, 13347

  • Investigational Site Number 276025

    Berlin, 13509

  • Investigational Site Number 276054

    Bernau, 16321

  • Investigational Site Number 276037

    Bielefeld, 33604

  • Investigational Site Number 276016

    Bonn, 53127

  • Investigational Site Number 276009

    Bonn, 53225

  • Investigational Site Number 276001

    Dortmund, 44137

  • Investigational Site Number 276006

    Dortmund, 44137

  • Investigational Site Number 276031

    Dortmund, 44137

  • Investigational Site Number 276050

    Dresden, 01099

  • Investigational Site Number 276024

    Eschweiler, 52249

  • Investigational Site Number 276028

    Essen, 45219

  • Investigational Site Number 276036

    Frankfurt am Main, 60594

  • Investigational Site Number 276012

    Freiburg im Breisgau, 79106

  • Investigational Site Number 276030

    Halle, 06120

  • Investigational Site Number 276032

    Hamburg, 20099

  • Investigational Site Number 276017

    Hamburg, 20246

  • Investigational Site Number 276027

    Hamburg, 22041

  • Investigational Site Number 276029

    Hamm, 59071

  • Investigational Site Number 276052

    Haßloch, 67454

  • Investigational Site Number 276014

    Heidelberg, 69115

  • Investigational Site Number 276023

    Homburg/Saar, 66421

  • Investigational Site Number 276035

    Kassel, 34121

  • Investigational Site Number 276046

    Leipzig, 04103

  • Investigational Site Number 276020

    Limburg, 65549

  • Investigational Site Number 276026

    Lippstadt, 59555

  • Investigational Site Number 276044

    Lübeck, 23560

  • Investigational Site Number 276021

    Magdeburg, 39120

  • Investigational Site Number 276015

    Mainz, 55131

  • Investigational Site Number 276010

    Marburg, 35043

  • Investigational Site Number 276018

    Münster, 48149

  • Investigational Site Number 276042

    Nuremberg, 90402

  • Investigational Site Number 276048

    Peine, 31224

  • Investigational Site Number 276053

    Rotenburg an der Fulda, 36199

  • Investigational Site Number 276045

    Rüdersdorf Bei Berlin, 15562

  • Investigational Site Number 276002

    Stuttgart, 70376

  • Investigational Site Number 276033

    Warendorf, 48231

Other trials in Germany

Brazil41 sites
  • Investigational Site Number 076029

    Aparecida de Goiânia, 74905-410

  • Investigational Site Number 076032

    Belém, 66087-660

  • Investigational Site Number 076017

    Belo Horizonte, 30140-062

  • Investigational Site Number 076004

    Belo Horizonte, 30150-221

  • Investigational Site Number 076022

    Belo Horizonte, 30150-320

  • Investigational Site Number 076038

    Belo Horizonte, 31110-580

  • Investigational Site Number 076002

    Blumenau, 89010906

  • Investigational Site Number 076011

    Brasília, 70390-903

  • Investigational Site Number 076007

    Brasília, 70710-100

  • Investigational Site Number 076003

    Campina Grande do Sul, 83430-000

  • Investigational Site Number 076006

    Campinas, 13015-001

  • Investigational Site Number 076040

    Canoas, 92200-000

  • Investigational Site Number 076033

    Curitiba, 80430-100

  • Investigational Site Number 076005

    Curitiba, 80730-150

  • Investigational Site Number 076009

    Fortaleza, 60110-110

  • Investigational Site Number 076008

    Fortaleza, 60170-320

  • Investigational Site Number 076012

    Goiânia, 74223-130

  • Investigational Site Number 076021

    Goiânia, 74605-020

  • Investigational Site Number 076019

    Passo Fundo, 99010-180

  • Investigational Site Number 076018

    Pelotas, 96015290

  • Investigational Site Number 076024

    Porto Alegre, 90020-090

  • Investigational Site Number 076026

    Porto Alegre, 90110270

  • Investigational Site Number 076014

    Porto Alegre, 90610-000

  • Investigational Site Number 076001

    Porto Alegre, 90620-001

  • Investigational Site Number 076027

    Porto Alegre, 91350-250

  • Investigational Site Number 076035

    Riberao Preto, 14048-900

  • Investigational Site Number 076010

    Rio de Janeiro, 22271-100

  • Investigational Site Number 076015

    Salvador, 40050-410

  • Investigational Site Number 076041

    Salvador, 40050-410

  • Investigational Site Number 076036

    Santo André, 18270170

  • Investigational Site Number 076031

    São Bernardo do Campo, 9780000

  • Investigational Site Number 076030

    São José do Rio Preto, 15015-210

  • Investigational Site Number 076020

    São José do Rio Preto, 15090-000

  • Investigational Site Number 076025

    São Paulo, 01244-030

  • Investigational Site Number 076042

    São Paulo, 01308-050

  • Investigational Site Number 076039

    São Paulo, 01327010

  • Investigational Site Number 076013

    São Paulo, 01418-100

  • Investigational Site Number 076023

    São Paulo, 04024-002

  • Investigational Site Number 076028

    São Paulo, 05403-000

  • Investigational Site Number 076016

    Tatuí, 18270-170

  • Investigational Site Number 076034

    Uberlândia, 38400-368

Other trials in Brazil

Spain40 sites
  • Investigational Site Number 724010

    Alcalá de Henares, 28805

  • Investigational Site Number 724007

    Almería, 04120

  • Investigational Site Number 724037

    Barcelona, 08003

  • Investigational Site Number 724041

    Barcelona, 08025

  • Investigational Site Number 724038

    Barcelona, 08035

  • Investigational Site Number 724008

    Barcelona, 08036

  • Investigational Site Number 724039

    Cáceres, 10003

  • Investigational Site Number 724042

    Córdoba, 14004

  • Investigational Site Number 724027

    Fuenlabrada, 28942

  • Investigational Site Number 724002

    Girona, 17007

  • Investigational Site Number 724013

    Granada, 18014

  • Investigational Site Number 724032

    Guadalajara, 19002

  • Investigational Site Number 724003

    Huelva, 21005

  • Investigational Site Number 724025

    L'Hospitalet de Llobregat, 08907

  • Investigational Site Number 724021

    León, 24071

  • Investigational Site Number 724026

    Lleida, 25198

  • Investigational Site Number 724006

    Lugo, 27003

  • Investigational Site Number 724030

    Madrid, 28006

  • Investigational Site Number 724020

    Madrid, 28031

  • Investigational Site Number 724015

    Madrid, 28034

  • Investigational Site Number 724031

    Madrid, 28040

  • Investigational Site Number 724033

    Madrid, 28040

  • Investigational Site Number 724017

    Madrid, 28922

  • Investigational Site Number 724035

    Majadahonda, 28222

  • Investigational Site Number 724016

    Málaga, 29010

  • Investigational Site Number 724043

    Málaga, 29010

  • Investigational Site Number 724036

    Murcia, 30120

  • Investigational Site Number 724001

    Oviedo, 33011

  • Investigational Site Number 724022

    Sabadell, 08208

  • Investigational Site Number 724029

    San Sebastián de los Reyes, 28702

  • Investigational Site Number 724028

    Santander, 39008

  • Investigational Site Number 724034

    Santiago de Compostela, 15706

  • Investigational Site Number 724014

    Seville, 41071

  • Investigational Site Number 724024

    Tarragona, 43007

  • Investigational Site Number 724019

    Valencia, 46010

  • Investigational Site Number 724009

    Valencia, 46015

  • Investigational Site Number 724011

    Valencia, 46017

  • Investigational Site Number 724023

    Valladolid, 47005

  • Investigational Site Number 724005

    Vigo, 36312

  • Investigational Site Number 724040

    Zaragoza, 50009

Other trials in Spain

Japan39 sites
  • Investigational Site Number 392013

    Amagasaki-Shi

  • Investigational Site Number 392041

    Amagasaki-Shi

  • Investigational Site Number 392029

    Fukuoka

  • Investigational Site Number 392019

    Hachioji-Shi

  • Investigational Site Number 392026

    Higashihiroshima-Shi

  • Investigational Site Number 392024

    Higashiibaraki-Gun

  • Investigational Site Number 392003

    Hiroshima

  • Investigational Site Number 392033

    Izumisano

  • Investigational Site Number 392020

    Kanazawa

  • Investigational Site Number 392015

    Kitakyushu-Shi

  • Investigational Site Number 392017

    Kobe

  • Investigational Site Number 392028

    Kobe

  • Investigational Site Number 392037

    Kobe

  • Investigational Site Number 392025

    Koga-Shi

  • Investigational Site Number 392010

    Komatsu-Shi

  • Investigational Site Number 392035

    Komatsushima-Shi

  • Investigational Site Number 392023

    Kumamoto

  • Investigational Site Number 392031

    Kumamoto

  • Investigational Site Number 392039

    Kure-Shi

  • Investigational Site Number 392012

    Kurume-Shi

  • Investigational Site Number 392032

    Kusatsu-Shi

  • Investigational Site Number 392001

    Kyoto

  • Investigational Site Number 392027

    Minatoku

  • Investigational Site Number 392016

    Morioka

  • Investigational Site Number 392005

    Nagoya

  • Investigational Site Number 392022

    Nerima-Ku

  • Investigational Site Number 392009

    Osaka

  • Investigational Site Number 392011

    Osaka

  • Investigational Site Number 392040

    Osaka

  • Investigational Site Number 392004

    Sagamihara-Shi

  • Investigational Site Number 392036

    Sapporo

  • Investigational Site Number 392034

    Shinagawa-Ku

  • Investigational Site Number 392018

    Suita-Shi

  • Investigational Site Number 392002

    tabashi City

  • Investigational Site Number 392014

    tabashi City

  • Investigational Site Number 392030

    Tokushima

  • Investigational Site Number 392008

    Urasoe-Shi

  • Investigational Site Number 392006

    Yokohama

  • Investigational Site Number 392021

    Yokohama

Other trials in Japan

Poland36 sites
  • Investigational Site Number 616026

    Bydgoszcz, 85-094

  • Investigational Site Number 616029

    Bydgoszcz, 85-681

  • Investigational Site Number 616010

    Chrzanów, 40-635

  • Investigational Site Number 616036

    Czeladź, 41-250

  • Investigational Site Number 616034

    Gdansk, 80-462

  • Investigational Site Number 616015

    Gdansk, 80-952

  • Investigational Site Number 616035

    Gdynia, 81-394

  • Investigational Site Number 616005

    Gdynia, 81-402

  • Investigational Site Number 616033

    Gdynia, 81-472

  • Investigational Site Number 616037

    Grodzisk Mazowiecki, 05-825

  • Investigational Site Number 616030

    Jelenia Góra, 58-506

  • Investigational Site Number 616031

    Krakow, 30-901

  • Investigational Site Number 616002

    Krakow, 31-121

  • Investigational Site Number 616012

    Łęczna, 21-010

  • Investigational Site Number 616017

    Legnica, 59-220

  • Investigational Site Number 616019

    Lodz, 91-078

  • Investigational Site Number 616016

    Lubin, 59-301

  • Investigational Site Number 616021

    Oława, 55-200

  • Investigational Site Number 616039

    Olsztyn, 10-561

  • Investigational Site Number 616003

    Płock, 09-402

  • Investigational Site Number 616011

    Poznan, 61-289

  • Investigational Site Number 616018

    Puławy, 24-100

  • Investigational Site Number 616006

    Skierniewice, 96-100

  • Investigational Site Number 616027

    Sobótka, 55-050

  • Investigational Site Number 616007

    Sokółka, 16-100

  • Investigational Site Number 616022

    Świdnik, 21-040

  • Investigational Site Number 616024

    Szczecin, 70-506

  • Investigational Site Number 616004

    Torun, 87-100

  • Investigational Site Number 616013

    Torun, 87-100

  • Investigational Site Number 616025

    Torun, 87-100

  • Investigational Site Number 616032

    W?Grów, 07-100

  • Investigational Site Number 616040

    Warsaw, 00-444

  • Investigational Site Number 616020

    Warsaw, 01-142

  • Investigational Site Number 616038

    Warsaw, 02-672

  • Investigational Site Number 616008

    Warsaw, 04-073

  • Investigational Site Number 616041

    Wroclaw, 50-315

Other trials in Poland

United Kingdom35 sites
  • Investigational Site Number 826018

    Basildon, SS16 5NL

  • Investigational Site Number 826015

    Birmingham, B18 7QH

  • Investigational Site Number 826030

    Birmingham, B9 5SS

  • Investigational Site Number 826038

    Bournemouth, BH7 7DW

  • Investigational Site Number 826025

    Bradford, BD9 6RJ

  • Investigational Site Number 826027

    Burton-on-Trent, DE13 0RB

  • Investigational Site Number 826017

    Cardiff, CF14 4XW

  • Investigational Site Number 826010

    Chertsey, KT16 0PZ

  • Investigational Site Number 826012

    Chesterfield, S44 5BL

  • Investigational Site Number 826039

    Chichester, PO19 4SE

  • Investigational Site Number 826024

    Cumbria, LA14 4LF

  • Investigational Site Number 826041

    Dudley, DY1 2HQ

  • Investigational Site Number 826021

    Harrow, HA1 3UJ

  • Investigational Site Number 826026

    High Wycombe, HP11 2TT

  • Investigational Site Number 826028

    Hull, HU16 5JQ

  • Investigational Site Number 826034

    London, E2 9JX

  • Investigational Site Number 826004

    Manchester, M13 9WL

  • Investigational Site Number 826011

    Newcastle upon Tyne, NE7 7DN

  • Investigational Site Number 826036

    Northampton, NN1 5BD

  • Investigational Site Number 826019

    Peterborough, PE3 9GZ

  • Investigational Site Number 826020

    Plymouth, PL6 8DH

  • Investigational Site Number 826040

    Portadown, BT63 5QQ

  • Investigational Site Number 826016

    Portsmouth, PO6 3LY

  • Investigational Site Number 826014

    Redhill, RH1 5RH

  • Investigational Site Number 826007

    Rhyl, LL18 5UJ

  • Investigational Site Number 826001

    Romford, RM7 0AG

  • Investigational Site Number 826009

    Rotherham, S60 2UD

  • Investigational Site Number 826002

    Sheffield, S10 2RX

  • Investigational Site Number 826032

    South Shields, NE34 0PL

  • Investigational Site Number 826013

    St Leonards, TN37 7RD

  • Investigational Site Number 826005

    Stoke-on-Trent, ST4 6QG

  • Investigational Site Number 826031

    Sunderland, SR4 7TP

  • Investigational Site Number 826022

    Truro, TR1 3LJ

  • Investigational Site Number 826035

    Wigan, WN1 2NN

  • Investigational Site Number 826003

    Worcester, WR5 1DD

Other trials in United Kingdom

Netherlands32 sites
  • Investigational Site Number 528006

    Alkmaar, 1815 JD

  • Investigational Site Number 528022

    Amsterdam, 1061 AE

  • Investigational Site Number 528026

    Amsterdam, 1091 AC

  • Investigational Site Number 528021

    Apeldoorn, 7314 ET

  • Investigational Site Number 528029

    Arnhem, 6815 AD

  • Investigational Site Number 528004

    Breda, 4818 CK

  • Investigational Site Number 528002

    Delft, 2625 AD

  • Investigational Site Number 528007

    Eindhoven, 5602 ZA

  • Investigational Site Number 528032

    Goes, 4462 RA

  • Investigational Site Number 528012

    Gouda, 2803 HH

  • Investigational Site Number 528001

    Groningen, 9728 NT

  • Investigational Site Number 528025

    Haarlem, 2035 RC

  • Investigational Site Number 528023

    Hardenberg, 7702 SE

  • Investigational Site Number 528024

    Heerenveen, 8441PW

  • Investigational Site Number 528016

    Hoorn, 1624 NP

  • Investigational Site Number 528019

    Leeuwarden, 8934 AD

  • Investigational Site Number 528008

    Leiden, 2333 ZA

  • Investigational Site Number 528017

    Meppel, 7943 KA

  • Investigational Site Number 528030

    Nieuwegein, 3435 CM

  • Investigational Site Number 528011

    Nijmegen, 6500 HB

  • Investigational Site Number 528015

    Purmerend, 1441RN

  • Investigational Site Number 528018

    Roosendaal, 4708 AE

  • Investigational Site Number 528014

    Rotterdam, 3045 PM

  • Investigational Site Number 528027

    Rotterdam, 3079

  • Investigational Site Number 528005

    Sneek, 8601

  • Investigational Site Number 528034

    Tiel, 4002 WP

  • Investigational Site Number 528013

    Tilburg, 5022 GC

  • Investigational Site Number 528028

    Uden, 5406 PT

  • Investigational Site Number 528009

    Venlo, 5912 BL

  • Investigational Site Number 528033

    Zaandam, 1502 DV

  • Investigational Site Number 528031

    Zutphen, 7207 AE

  • Investigational Site Number 528020

    Zwolle, 8011 JW

Other trials in Netherlands

Ukraine32 sites
  • Investigational Site Number 804015

    Chernivtsi, 58013

  • Investigational Site Number 804018

    Dnipropetrovsk

  • Investigational Site Number 804027

    Donetsk, 83114

  • Investigational Site Number 804012

    Donetsk

  • Investigational Site Number 804010

    Ivano-Frankivsk, 76018

  • Investigational Site Number 804006

    Kharkiv, 61002

  • Investigational Site Number 804003

    Kharkiv, 61176

  • Investigational Site Number 804009

    Kharkiv

  • Investigational Site Number 804020

    Khmelnytskyi, 29000

  • Investigational Site Number 804001

    Kiev, 02091

  • Investigational Site Number 804002

    Kiev, 02660

  • Investigational Site Number 804011

    Kyiv, 01601

  • Investigational Site Number 804014

    Kyiv, 01601

  • Investigational Site Number 804025

    Kyiv, 03049

  • Investigational Site Number 804034

    Kyiv, 03110

  • Investigational Site Number 804036

    Kyiv, 03115

  • Investigational Site Number 804016

    Kyiv, 03680

  • Investigational Site Number 804030

    Kyiv, 04050

  • Investigational Site Number 804028

    Lutsk, 43024

  • Investigational Site Number 804033

    Lviv, 79010

  • Investigational Site Number 804031

    Lviv, 79059

  • Investigational Site Number 804029

    Mykolaiv, 54003

  • Investigational Site Number 804004

    Odesa, 65014

  • Investigational Site Number 804013

    Odesa, 65025

  • Investigational Site Number 804017

    Simferopol, 95026

  • Investigational Site Number 804035

    Sumy, 40021

  • Investigational Site Number 804007

    Uzhhorod, 88014

  • Investigational Site Number 804005

    Vinnitsya, 21100

  • Investigational Site Number 804008

    Vinnytsia, 21018

  • Investigational Site Number 804026

    Zaporizhia, 69005

  • Investigational Site Number 804024

    Zhytomyr, 10002

  • Investigational Site Number 804032

    Zhytomyr, 10002

Other trials in Ukraine

Israel27 sites
  • Investigational Site Number 376006

    Afula, 18101

  • Investigational Site Number 376024

    Afula, 18101

  • Investigational Site Number 376009

    Ashkelon, 78278

  • Investigational Site Number 376012

    Beersheba, 84101

  • Investigational Site Number 376011

    Haifa, 31048

  • Investigational Site Number 376017

    Haifa, 31048

  • Investigational Site Number 376025

    Haifa, 31048

  • Investigational Site Number 376018

    Haifa, 31096

  • Investigational Site Number 376007

    Holon, 58100

  • Investigational Site Number 376021

    Holon, 58100

  • Investigational Site Number 376016

    Jerusalem, 91031

  • Investigational Site Number 376005

    Jerusalem, 91120

  • Investigational Site Number 376027

    Jerusalem, 91120

  • Investigational Site Number 376002

    Kfar Saba, 44281

  • Investigational Site Number 376013

    Kfar Saba, 44281

  • Investigational Site Number 376004

    Nahariya, 22100

  • Investigational Site Number 376015

    Nazareth, 16100

  • Investigational Site Number 376001

    Petah Tikva, 49100

  • Investigational Site Number 376019

    Petah Tikva, 49100

  • Investigational Site Number 376020

    Rehovot, 76100

  • Investigational Site Number 376003

    Safed, 13100

  • Investigational Site Number 376008

    Safed, 13100

  • Investigational Site Number 376010

    Tel Aviv, 64239

  • Investigational Site Number 376014

    Tel Aviv, 64239

  • Investigational Site Number 376022

    Tel HaShomer, 52621

  • Investigational Site Number 376023

    Tiberias, 15208

  • Investigational Site Number 376026

    Tzrifin, 70300

Other trials in Israel

Australia25 sites
  • Investigational Site Number 036002

    Ashford, 5035

  • Investigational Site Number 036023

    Auchenflower, 4066

  • Investigational Site Number 036024

    Ballarat, 3353

  • Investigational Site Number 036020

    Bedford Park, 5042

  • Investigational Site Number 036015

    Bruce, 2617

  • Investigational Site Number 036026

    Cairns, 4870

  • Investigational Site Number 036005

    Chermside, 4032

  • Investigational Site Number 036008

    Chermside, 4032

  • Investigational Site Number 036011

    Coffs Harbour, 2450

  • Investigational Site Number 036003

    Concord, 2137

  • Investigational Site Number 036017

    Elizabeth Vale, 5112

  • Investigational Site Number 036006

    Fullarton, 5063

  • Investigational Site Number 036004

    Gosford, 2250

  • Investigational Site Number 036019

    Heidelberg West, 3081

  • Investigational Site Number 036027

    Hobart, 7001

  • Investigational Site Number 036009

    Kogarah, 2217

  • Investigational Site Number 036012

    Mildura, 3500

  • Investigational Site Number 036028

    Nambour, 4560

  • Investigational Site Number 036013

    New Lambton, 2305

  • Investigational Site Number 036010

    Perth, 6000

  • Investigational Site Number 036014

    Prahran, 3004

  • Investigational Site Number 036018

    Redcliffe, 4020

  • Investigational Site Number 036022

    Richmond, 3121

  • Investigational Site Number 036025

    Woodville South, 5011

  • Investigational Site Number 036021

    Woolloongabba, 4102

Other trials in Australia

Italy24 sites
  • Investigational Site Number 380019

    Augusta, 96100

  • Investigational Site Number 380017

    Bergamo, 24127

  • Investigational Site Number 380026

    Brescia, 25123

  • Investigational Site Number 380008

    Brescia, 25124

  • Investigational Site Number 380012

    Ferrara, 44100

  • Investigational Site Number 380027

    Forlì, 47100

  • Investigational Site Number 380015

    Livorno, 57125

  • Investigational Site Number 380033

    Massa, 54100

  • Investigational Site Number 380030

    Milan, 20132

  • Investigational Site Number 380005

    Milan, 20138

  • Investigational Site Number 380003

    Milan, 20148

  • Investigational Site Number 380025

    Monza, 20900

  • Investigational Site Number 380001

    Naples, 80100

  • Investigational Site Number 380002

    Naples, 80131

  • Investigational Site Number 380021

    Novara, 28100

  • Investigational Site Number 380009

    Osio Sotto, 24040

  • Investigational Site Number 380007

    Palermo, 90127

  • Investigational Site Number 380013

    Perugia, 06132

  • Investigational Site Number 380031

    Rho, 20017

  • Investigational Site Number 380014

    Rimini, 47900

  • Investigational Site Number 380024

    Roma, 00152

  • Investigational Site Number 380028

    Seriate, 24068

  • Investigational Site Number 380032

    Treviso, 31100

  • Investigational Site Number 380020

    Vittorio Veneto, 31029

Other trials in Italy

Czechia22 sites
  • Investigational Site Number 203003

    Brno, 62500

  • Investigational Site Number 203020

    Česká Lípa, 470 01

  • Investigational Site Number 203025

    Český Krumlov, 38101

  • Investigational Site Number 203023

    Hodonín, 695 01

  • Investigational Site Number 203006

    Hradec Králové, 50005

  • Investigational Site Number 203019

    Kladno, 272 59

  • Investigational Site Number 203005

    Kladno, 272 80

  • Investigational Site Number 203008

    Kroměříž, 767 01

  • Investigational Site Number 203015

    Liberec, 46063

  • Investigational Site Number 203024

    Mariánské Lázně, 353 01

  • Investigational Site Number 203013

    Olomouc, 77520

  • Investigational Site Number 203016

    Ostrava, 72880

  • Investigational Site Number 203014

    Pardubice, 53203

  • Investigational Site Number 203018

    Pilsen, 30599

  • Investigational Site Number 203011

    Prague, 10034

  • Investigational Site Number 203017

    Prague, 12808

  • Investigational Site Number 203004

    Prague, 14021

  • Investigational Site Number 203021

    Prague, 14059

  • Investigational Site Number 203012

    Prague, 15030

  • Investigational Site Number 203007

    Praha 5 - Motol, 15006

  • Investigational Site Number 203009

    Rakovník, 269 01

  • Investigational Site Number 203010

    Zlín, 76275

Other trials in Czechia

France22 sites
  • Investigational Site Number 250003

    Besançon, 25000

  • Investigational Site Number 250007

    Brest, 29609

  • Investigational Site Number 250010

    Cambrai, 59409

  • Investigational Site Number 250018

    Clermont-Ferrand, 63003

  • Investigational Site Number 250021

    Compiègne, 60321

  • Investigational Site Number 250002

    Dijon, 21000

  • Investigational Site Number 250001

    Grenoble, 38043

  • Investigational Site Number 250009

    Limoges, 87042

  • Investigational Site Number 250019

    Marseille, 13015

  • Investigational Site Number 250008

    Massy, 91300

  • Investigational Site Number 250005

    Montfermeil, 93370

  • Investigational Site Number 250023

    Montpellier, 34295

  • Investigational Site Number 250025

    Nantes, 44093

  • Investigational Site Number 250017

    Nice, 06002

  • Investigational Site Number 250020

    Paris, 75013

  • Investigational Site Number 250012

    Paris, 75015

  • Investigational Site Number 250004

    Paris, 75018

  • Investigational Site Number 250015

    Paris, 75571

  • Investigational Site Number 250011

    Pau, 64000

  • Investigational Site Number 250016

    Pessac, 33600

  • Investigational Site Number 250026

    Rouen, 76000

  • Investigational Site Number 250022

    Strasbourg, 67091

Other trials in France

Belgium21 sites
  • Investigational Site Number 056016

    Aalst, 9300

  • Investigational Site Number 056003

    Antwerp, 2060

  • Investigational Site Number 056002

    Antwerp, B-2020

  • Investigational Site Number 056008

    Bonheiden, 2820

  • Investigational Site Number 056014

    Brasschaat, 2930

  • Investigational Site Number 056005

    Brussels, 1000

  • Investigational Site Number 056021

    Brussels, 1070

  • Investigational Site Number 056004

    Brussels, 1200

  • Investigational Site Number 056017

    Edegem, B-2650

  • Investigational Site Number 056024

    Genk, 3600

  • Investigational Site Number 056007

    Ghent, 9000

  • Investigational Site Number 056018

    Ghent, 9000

  • Investigational Site Number 056020

    La Louvière, 7100

  • Investigational Site Number 056009

    Leuven, 3000

  • Investigational Site Number 056015

    Liège, 4000

  • Investigational Site Number 056010

    Mechelen, 2800

  • Investigational Site Number 056013

    Mol, 2400

  • Investigational Site Number 056001

    Ottignies, 1340

  • Investigational Site Number 056012

    Overpelt, 3900

  • Investigational Site Number 056006

    Roeselare, 8800

  • Investigational Site Number 056019

    Tienen, 3300

Other trials in Belgium

South Africa21 sites
  • Investigational Site Number 710017

    Alberton, 1450

  • Investigational Site Number 710007

    Bellville, 7530

  • Investigational Site Number 710015

    Bloemfontein, 9300

  • Investigational Site Number 710009

    Cape Town, 7405

  • Investigational Site Number 710010

    Cape Town, 7925

  • Investigational Site Number 710005

    Chatsworth, 4091

  • Investigational Site Number 710006

    Durban, 4001

  • Investigational Site Number 710004

    Durban, 4052

  • Investigational Site Number 710002

    Durban, 4320

  • Investigational Site Number 710012

    Johannesburg, 2193

  • Investigational Site Number 710014

    Johannesburg

  • Investigational Site Number 710019

    Kempton Park, 1619

  • Investigational Site Number 710011

    Kimberley, 8301

  • Investigational Site Number 710021

    Kuils River, 7580

  • Investigational Site Number 710018

    Parow, 7500

  • Investigational Site Number 710008

    Pretoria, 0040

  • Investigational Site Number 710016

    Pretoria, 0157

  • Investigational Site Number 710020

    Stellenbosch, 7600

  • Investigational Site Number 710013

    Tongaat, 4400

  • Investigational Site Number 710022

    Western Cape, 7500

  • Investigational Site Number 710003

    Worcester, 6850

Other trials in South Africa

Mexico20 sites
  • Investigational Site Number 484005

    Aguascalientes, 20230

  • Investigational Site Number 484015

    Aguascalientes, 20230

  • Investigational Site Number 484004

    Culiacán, 80020

  • Investigational Site Number 484003

    Durango, 34000

  • Investigational Site Number 484010

    Guadalajara, 44100

  • Investigational Site Number 484006

    Guadalajara, 44210

  • Investigational Site Number 484008

    Jalapa, 91020

  • Investigational Site Number 484027

    México, 06720

  • Investigational Site Number 484023

    Mexico City, 11850

  • Investigational Site Number 484019

    Mexico City, 14080

  • Investigational Site Number 484013

    Monterrey, 64020

  • Investigational Site Number 484018

    Monterrey, 64060

  • Investigational Site Number 484011

    Monterrey, 64460

  • Investigational Site Number 484007

    Monterrey, 64710

  • Investigational Site Number 484017

    Morelia, 58260

  • Investigational Site Number 484012

    Oaxaca City, 68000

  • Investigational Site Number 484014

    Querétaro, 76000

  • Investigational Site Number 484009

    San Luis Potosí City, 72244

  • Investigational Site Number 484002

    Tijuana, 22500

  • Investigational Site Number 484020

    Toluca, 50130

Other trials in Mexico

Peru20 sites
  • Investigational Site Number 604018

    Arequipa

  • Investigational Site Number 604004

    Callao, CALLAO 02

  • Investigational Site Number 604025

    Callao, Callao 02

  • Investigational Site Number 604022

    Cuzco

  • Investigational Site Number 604013

    Ica, 11001

  • Investigational Site Number 604010

    Lima, 051

  • Investigational Site Number 604008

    Lima, 27

  • Investigational Site Number 604001

    Lima, LIMA 01

  • Investigational Site Number 604007

    Lima, LIMA 01

  • Investigational Site Number 604005

    Lima, LIMA 10

  • Investigational Site Number 604006

    Lima, Lima 11

  • Investigational Site Number 604015

    Lima, LIMA 18

  • Investigational Site Number 604016

    Lima, Lima 18

  • Investigational Site Number 604017

    Lima, Lima 27

  • Investigational Site Number 604019

    Lima, Lima 27

  • Investigational Site Number 604003

    Lima, LIMA 29

  • Investigational Site Number 604024

    Lima, LIMA 31

  • Investigational Site Number 604012

    Lima, LIMA 32

  • Investigational Site Number 604020

    Piura, 20001

  • Investigational Site Number 604023

    Trujillo, 13001

Other trials in Peru

Slovakia19 sites
  • Investigational Site Number 703001

    Bardejov, 085 01

  • Investigational Site Number 703008

    Bratislava, 821 01

  • Investigational Site Number 703020

    Bratislava, 821 01

  • Investigational Site Number 703014

    Bratislava, 826 06

  • Investigational Site Number 703013

    Bratislava, 841 08

  • Investigational Site Number 703023

    Dolný Kubín, 02601

  • Investigational Site Number 703002

    Košice, 040 01

  • Investigational Site Number 703009

    Košice, 040 01

  • Investigational Site Number 703016

    Košice, 040 01

  • Investigational Site Number 703019

    Košice, 04001

  • Investigational Site Number 703007

    Košice

  • Investigational Site Number 703012

    Kráľovský Chlmec, 077 01

  • Investigational Site Number 703006

    Lučenec, 984 39

  • Investigational Site Number 703010

    Lučenec, 98401

  • Investigational Site Number 703003

    Nitra, 950 01

  • Investigational Site Number 703004

    Prešov, 080 01

  • Investigational Site Number 703018

    Svidník, 089 01

  • Investigational Site Number 703022

    Trebišov, 075 01

  • Investigational Site Number 703005

    Žilina, 01001

Other trials in Slovakia

Bulgaria18 sites
  • Investigational Site Number 100020

    Blagoevgrad, 2700

  • Investigational Site Number 100012

    Burgas, 8000

  • Investigational Site Number 100011

    Pazardzhik, 4400

  • Investigational Site Number 100013

    Pleven, 5800

  • Investigational Site Number 100018

    Pleven, 5800

  • Investigational Site Number 100005

    Plovdiv, 4002

  • Investigational Site Number 100015

    Sandanski, 2800

  • Investigational Site Number 100023

    Smolyan, 4700

  • Investigational Site Number 100017

    Sofia, 1142

  • Investigational Site Number 100007

    Sofia, 1202

  • Investigational Site Number 100001

    Sofia, 1233

  • Investigational Site Number 100004

    Sofia, 1233

  • Investigational Site Number 100010

    Sofia, 1309

  • Investigational Site Number 100019

    Sofia, 1336

  • Investigational Site Number 100016

    Sofia, 1431

  • Investigational Site Number 100003

    Sofia, 1527

  • Investigational Site Number 100022

    Varna, 9000

  • Investigational Site Number 100014

    Veliko Tarnovo, 5000

Other trials in Bulgaria

Chile18 sites
  • Investigational Site Number 152013

    Concepción, 4070038

  • Investigational Site Number 152003

    Osorno, 5311092

  • Investigational Site Number 152017

    Punta Arenas, 6210005

  • Investigational Site Number 152004

    Santiago, 7500710

  • Investigational Site Number 152014

    Santiago, 7500710

  • Investigational Site Number 152001

    Santiago, 7500922

  • Investigational Site Number 152019

    Santiago, 7650018

  • Investigational Site Number 152007

    Santiago, 7650568

  • Investigational Site Number 152012

    Santiago, 8053095

  • Investigational Site Number 152011

    Santiago, 832 0000

  • Investigational Site Number 152006

    Santiago, 8380456

  • Investigational Site Number 152016

    Santiago, 8900085

  • Investigational Site Number 152015

    Santiago

  • Investigational Site Number 152009

    Talca

  • Investigational Site Number 152002

    Temuco, 4781156

  • Investigational Site Number 152008

    Valdivia, 5090145

  • Investigational Site Number 152010

    Viña del Mar, 2520000

  • Investigational Site Number 152018

    Viña del Mar, 2520997

Other trials in Chile

Serbia18 sites
  • Investigational Site Number 688003

    Belgrade, 11000

  • Investigational Site Number 688005

    Belgrade, 11000

  • Investigational Site Number 688006

    Belgrade, 11000

  • Investigational Site Number 688007

    Belgrade, 11000

  • Investigational Site Number 688008

    Belgrade, 11000

  • Investigational Site Number 688010

    Belgrade, 11000

  • Investigational Site Number 688011

    Belgrade, 11000

  • Investigational Site Number 688013

    Belgrade, 11000

  • Investigational Site Number 688015

    Belgrade, 11050

  • Investigational Site Number 688002

    Belgrade, 11080

  • Investigational Site Number 688009

    Kamenitz, 21204

  • Investigational Site Number 688012

    Kragujevac, 34000

  • Investigational Site Number 688016

    Leskovac, 16000

  • Investigational Site Number 688004

    Niš, 18000

  • Investigational Site Number 688001

    Niška Banja, 18205

  • Investigational Site Number 688018

    Pančevo, 26 000

  • Investigational Site Number 688017

    Sremska Mitrovica, 22000

  • Investigational Site Number 688014

    Valjevo, 14000

Other trials in Serbia

Colombia17 sites
  • Investigational Site Number 170006

    Armenia, 630004

  • Investigational Site Number 170003

    Barranquilla, 08013

  • Investigational Site Number 170011

    Barranquilla

  • Investigational Site Number 170013

    Barranquilla

  • Investigational Site Number 170018

    Bogotá, 11001000

  • Investigational Site Number 170016

    Bogotá, 111211

  • Investigational Site Number 170022

    Bogota D.C.

  • Investigational Site Number 170010

    Cali, 572

  • Investigational Site Number 170001

    Cali

  • Investigational Site Number 170017

    Cartagena, 130010

  • Investigational Site Number 170004

    Cartagena

  • Investigational Site Number 170008

    Espinal - Tolima

  • Investigational Site Number 170005

    Floridablanca, 681004

  • Investigational Site Number 170002

    Manizales, 170004

  • Investigational Site Number 170007

    Medellín, 050012

  • Investigational Site Number 170009

    Medellín

  • Investigational Site Number 170021

    Medellín

Other trials in Colombia

Denmark17 sites
  • Investigational Site Number 208016

    Aabenraa, 6200

  • Investigational Site Number 208012

    Aalborg, 9000

  • Investigational Site Number 208011

    Aarhus N, 8200

  • Investigational Site Number 208002

    Copenhagen, 2100

  • Investigational Site Number 208003

    Glostrup Municipality, 2600

  • Investigational Site Number 208007

    Hellerup, 2900

  • Investigational Site Number 208006

    Herning, 7400

  • Investigational Site Number 208018

    Hillerød, 3400

  • Investigational Site Number 208014

    Holbæk, 4300

  • Investigational Site Number 208013

    Hvidovre, 2650

  • Investigational Site Number 208004

    Køge, 4600

  • Investigational Site Number 208017

    Næstved, 4700

  • Investigational Site Number 208009

    Odense C, 5000

  • Investigational Site Number 208015

    Silkeborg, 8600

  • Investigational Site Number 208008

    Slagelse, 4200

  • Investigational Site Number 208001

    Vejle, 7100

  • Investigational Site Number 208010

    Viborg, 8800

Other trials in Denmark

Romania17 sites
  • Investigational Site Number 642001

    Brăila, 810249

  • Investigational Site Number 642003

    Bucharest, 010242

  • Investigational Site Number 642012

    Bucharest, 011234

  • Investigational Site Number 642021

    Bucharest, 011461

  • Investigational Site Number 642007

    Bucharest, 014461

  • Investigational Site Number 642008

    Bucharest, 10416

  • Investigational Site Number 642005

    Buzău, 120203

  • Investigational Site Number 642013

    Codlea, 505100

  • Investigational Site Number 642004

    Constanța, 900591

  • Investigational Site Number 642002

    Craiova, 200147

  • Investigational Site Number 642016

    Craiova, 200642

  • Investigational Site Number 642010

    Focşani, 620034

  • Investigational Site Number 642017

    Iași, 700786

  • Investigational Site Number 642006

    Targoviste, 130083

  • Investigational Site Number 642019

    Târgu Mureş, 540136

  • Investigational Site Number 642015

    Târgu Mureş, 540143

  • Investigational Site Number 642018

    Timișoara, 300736

Other trials in Romania

Croatia16 sites
  • Investigational Site Number 191013

    Dubrovnik, 20000

  • Investigational Site Number 191017

    Krapinske Toplice, 49217

  • Investigational Site Number 191009

    Opatija, 51410

  • Investigational Site Number 191006

    Rijeka

  • Investigational Site Number 191012

    Slavonski Brod, 35000

  • Investigational Site Number 191003

    Varaždin, 42000

  • Investigational Site Number 191001

    Zagreb, 10000

  • Investigational Site Number 191002

    Zagreb, 10000

  • Investigational Site Number 191005

    Zagreb, 10000

  • Investigational Site Number 191007

    Zagreb, 10000

  • Investigational Site Number 191008

    Zagreb, 10000

  • Investigational Site Number 191010

    Zagreb, 10000

  • Investigational Site Number 191011

    Zagreb, 10000

  • Investigational Site Number 191015

    Zagreb, 10000

  • Investigational Site Number 191016

    Zagreb, 10000

  • Investigational Site Number 191018

    Zagreb, 10000

Other trials in Croatia

Hungary13 sites
  • Investigational Site Number 348013

    Balatonfüred, 8230

  • Investigational Site Number 348002

    Budapest, 1023

  • Investigational Site Number 348012

    Budapest, 1106

  • Investigational Site Number 348005

    Budapest, 1122

  • Investigational Site Number 348006

    Budapest, 1134

  • Investigational Site Number 348008

    Debrecen, 4032

  • Investigational Site Number 348004

    Eger, 3300

  • Investigational Site Number 348003

    Gyula, 5700

  • Investigational Site Number 348010

    Pécs, 7624

  • Investigational Site Number 348009

    Szeged, 6725

  • Investigational Site Number 348007

    Székesfehérvár, 8000

  • Investigational Site Number 348011

    Szombathely, 9700

  • Investigational Site Number 348001

    Zalaegerszeg, 8900

Other trials in Hungary

Philippines13 sites
  • Investigational Site Number 608012

    Cavite

  • Investigational Site Number 608003

    Cebu City, 6000

  • Investigational Site Number 608013

    Cebu City, 6000

  • Investigational Site Number 608010

    Davao City, 8000

  • Investigational Site Number 608011

    Davao City, 8000

  • Investigational Site Number 608006

    Iloilo City, 5000

  • Investigational Site Number 608002

    Makati City, 1218

  • Investigational Site Number 608004

    Manila, 1000

  • Investigational Site Number 608014

    Manila, 1000

  • Investigational Site Number 608005

    Quezon, 1102

  • Investigational Site Number 608001

    Quezon City, 1100

  • Investigational Site Number 608009

    Quezon City, 1109

  • Investigational Site Number 608008

    San Juan City, 1500

Other trials in Philippines

South Korea13 sites
  • Investigational Site Number 410013

    Busan, 602-715

  • Investigational Site Number 410003

    Busan, 602-739

  • Investigational Site Number 410002

    Daegu, 700-721

  • Investigational Site Number 410012

    Goyang-si, 10326

  • Investigational Site Number 410001

    Gwangju, 501-757

  • Investigational Site Number 410008

    Seongnam, 463-707

  • Investigational Site Number 410004

    Seoul, 06591

  • Investigational Site Number 410007

    Seoul, 07061

  • Investigational Site Number 410010

    Seoul, 110-744

  • Investigational Site Number 410011

    Seoul, 134-727

  • Investigational Site Number 410006

    Seoul, 152-703

  • Investigational Site Number 410009

    Suwon, 443-721

  • Investigational Site Number 410005

    Wŏnju, 220-701

Other trials in South Korea

Sweden13 sites
  • Investigational Site Number 752001

    Falun, 791 82

  • Investigational Site Number 752016

    Gothenburg, 41345

  • Investigational Site Number 752011

    Halmstad, 30185

  • Investigational Site Number 752006

    Karlshamn, 378 00

  • Investigational Site Number 752008

    Karlskrona, 371 85

  • Investigational Site Number 752013

    Köping, 721 51

  • Investigational Site Number 752004

    Kristianstad, 29185

  • Investigational Site Number 752015

    Malmö, S-20502

  • Investigational Site Number 752012

    Mölndal, 43180

  • Investigational Site Number 752009

    Stockholm, 11883

  • Investigational Site Number 752002

    Stockholm, 14186

  • Investigational Site Number 752014

    Sundsvall, 85186

  • Investigational Site Number 752007

    Uppsala, 75237

Other trials in Sweden

Taiwan13 sites
  • Investigational Site Number 158003

    Changhua, 500

  • Investigational Site Number 158008

    Division of Cardiology, 833

  • Investigational Site Number 158014

    Hsinchu, 30071

  • Investigational Site Number 158013

    Kaohsiung City, 807

  • Investigational Site Number 158004

    Taichung, 402

  • Investigational Site Number 158009

    Tainan, 704

  • Investigational Site Number 158011

    Tainan, 710

  • Investigational Site Number 158005

    Taipei, 104

  • Investigational Site Number 158001

    Taipei, 112

  • Investigational Site Number 158010

    Taipei, 114

  • Investigational Site Number 158007

    Taipei

  • Investigational Site Number 158012

    Taoyuan Hsien

  • Investigational Site Number 158002

    Yunlin

Other trials in Taiwan

Greece12 sites
  • Investigational Site Number 300001

    Athens, 11521

  • Investigational Site Number 300002

    Athens, 11527

  • Investigational Site Number 300007

    Athens, 16673

  • Investigational Site Number 300008

    Chios

  • Investigational Site Number 300013

    Haidari, 12462

  • Investigational Site Number 300010

    Heraklion, 70013

  • Investigational Site Number 300005

    Ioannina, 45500

  • Investigational Site Number 300003

    Marousi, 151 26

  • Investigational Site Number 300006

    N. Ionia, 14233

  • Investigational Site Number 300004

    Pátrai, 26500

  • Investigational Site Number 300011

    Thessaloniki, 546 36

  • Investigational Site Number 300009

    Thessaloniki, 54642

Other trials in Greece

New Zealand12 sites
  • Investigational Site Number 554010

    Auckland, 1023

  • Investigational Site Number 554001

    Christchurch

  • Investigational Site Number 554006

    Dunedin

  • Investigational Site Number 554004

    Hamilton, 3200

  • Investigational Site Number 554011

    Lower Hutt, 5010

  • Investigational Site Number 554005

    Nelson, 7010

  • Investigational Site Number 554007

    New Plymouth

  • Investigational Site Number 554002

    Otahuhu, 2025

  • Investigational Site Number 554008

    Palmerston North, 4414

  • Investigational Site Number 554012

    Rotorua, 3010

  • Investigational Site Number 554009

    Takapuna, 1309

  • Investigational Site Number 554003

    Wellington

Other trials in New Zealand

Turkey (Türkiye)12 sites
  • Investigational Site Number 792007

    Adana, 01339

  • Investigational Site Number 792009

    Ankara, 06018

  • Investigational Site Number 792006

    Bursa, 16509

  • Investigational Site Number 792016

    Eskişehir, 26480

  • Investigational Site Number 792014

    Istanbul, 34034

  • Investigational Site Number 792005

    Istanbul, 34098

  • Investigational Site Number 792011

    Istanbul, 34846

  • Investigational Site Number 792013

    Istanbul, 34896

  • Investigational Site Number 792004

    Izmir, 35100

  • Investigational Site Number 792003

    Izmir, 35340

  • Investigational Site Number 792015

    Kocaeli, 41300

  • Investigational Site Number 792010

    Mersin, 33169

Other trials in Turkey (Türkiye)

Bosnia and Herzegovina11 sites
  • Investigational Site Number 070001

    Banja Luka, 78000

  • Investigational Site Number 070002

    Banja Luka, 78000

  • Investigational Site Number 070011

    Bihać, 77000

  • Investigational Site Number 070003

    Mostar, 8000

  • Investigational Site Number 070004

    Mostar, 8000

  • Investigational Site Number 070005

    Sarajevo, 71000

  • Investigational Site Number 070007

    Sarajevo, 71000

  • Investigational Site Number 070010

    Sarajevo, 71000

  • Investigational Site Number 070008

    Tuzla, 75000

  • Investigational Site Number 070009

    Tuzla, 75000

  • Investigational Site Number 070006

    Zenica, 72000

Other trials in Bosnia and Herzegovina

Thailand11 sites
  • Investigational Site Number 764001

    Bangkok, 10220

  • Investigational Site Number 764011

    Bangkok, 10300

  • Investigational Site Number 764007

    Bangkok, 10400

  • Investigational Site Number 764012

    Bangkok, 10400

  • Investigational Site Number 764009

    Bangkok Noi, 10700

  • Investigational Site Number 764005

    Hat Yai, 90110

  • Investigational Site Number 764008

    Klong Luang, 12120

  • Investigational Site Number 764002

    Moung, 30000

  • Investigational Site Number 764003

    Muang, 50200

  • Investigational Site Number 764010

    Nonthaburi, 11000

  • Investigational Site Number 764006

    Pratumwan, 10400

Other trials in Thailand

Sri Lanka10 sites
  • Investigational Site Number 144002

    Colombo, 1000

  • Investigational Site Number 144003

    Colombo, 1000

  • Investigational Site Number 144004

    Colombo, 1000

  • Investigational Site Number 144010

    Colombo, 1000

  • Investigational Site Number 144005

    Colombo, 10250

  • Investigational Site Number 144006

    Colombo, 10250

  • Investigational Site Number 144001

    Colombo, 7000

  • Investigational Site Number 144008

    Kandy, 20000

  • Investigational Site Number 144009

    Kurunegala, 60000

  • Investigational Site Number 144007

    Ragama, 11010

Other trials in Sri Lanka

Lithuania9 sites
  • Investigational Site Number 440004

    Kaunas, 50009

  • Investigational Site Number 440005

    Kaunas, 50009

  • Investigational Site Number 440009

    Kaunas, 50128

  • Investigational Site Number 440008

    Kaunas, 50177

  • Investigational Site Number 440001

    Klaipėda, LT-91131

  • Investigational Site Number 440006

    Klaipėda, LT-92288

  • Investigational Site Number 440002

    Vilnius, 07157

  • Investigational Site Number 440007

    Vilnius, 10309

  • Investigational Site Number 440003

    Vilnius, LT-08661

Other trials in Lithuania

Norway9 sites
  • Investigational Site Number 578004

    Arendal, 4809

  • Investigational Site Number 578013

    Bergen, 5021

  • Investigational Site Number 578009

    Hamar

  • Investigational Site Number 578006

    Kongsvinger, 2226

  • Investigational Site Number 578003

    Oslo

  • Investigational Site Number 578005

    Oslo

  • Investigational Site Number 578012

    Stavanger, 4068

  • Investigational Site Number 578002

    Svelvik, 3060

  • Investigational Site Number 578011

    Tynset, 2500

Other trials in Norway

Portugal9 sites
  • Investigational Site Number 620004

    Almada, 2801-951

  • Investigational Site Number 620005

    Aveiro, 3814-501

  • Investigational Site Number 620011

    Coimbra, 3000-075

  • Investigational Site Number 620008

    Coimbra, 3041-801

  • Investigational Site Number 620001

    Leiria, 2410-197

  • Investigational Site Number 620003

    Ponta Delgada, 9500-370

  • Investigational Site Number 620002

    Setúbal, 2910-446

  • Investigational Site Number 620010

    Vila Franca de Xira, 2600-009

  • Investigational Site Number 620006

    Vila Nova Gaia, 4434-502

Other trials in Portugal

Estonia7 sites
  • Investigational Site Number 233007

    Pärnu, 80010

  • Investigational Site Number 233004

    Tallinn, 10138

  • Investigational Site Number 233002

    Tallinn, 11913

  • Investigational Site Number 233001

    Tallinn, 13415

  • Investigational Site Number 233005

    Tallinn, 13419

  • Investigational Site Number 233003

    Tartu, 50406

  • Investigational Site Number 233006

    Viljandimaa, 71024

Other trials in Estonia

Georgia7 sites
  • Investigational Site Number 268004

    Batumi, 6010

  • Investigational Site Number 268001

    Kutaisi, 4600

  • Investigational Site Number 268005

    Tbilisi, 102

  • Investigational Site Number 268002

    Tbilisi, 159

  • Investigational Site Number 268003

    Tbilisi, 159

  • Investigational Site Number 268008

    Tbilisi, 159

  • Investigational Site Number 268009

    Tbilisi, 159

Other trials in Georgia

Malaysia7 sites
  • Investigational Site Number 458004

    Batu Caves, 68100

  • Investigational Site Number 458007

    Kota Bharu, 16150

  • Investigational Site Number 458006

    Kota Kinabalu, 88300

  • Investigational Site Number 458002

    Kuala Lumpur, 50400

  • Investigational Site Number 458005

    Kuala Lumpur, 56000

  • Investigational Site Number 458003

    Kuching, 94300

  • Investigational Site Number 458001

    Sungai Buloh, 47000

Other trials in Malaysia

Austria6 sites
  • Investigational Site Number 040004

    Feldkirch, 6800

  • Investigational Site Number 040007

    Graz, 8036

  • Investigational Site Number 040001

    Salzburg, 5020

  • Investigational Site Number 040006

    Vienna, 1030

  • Investigational Site Number 040003

    Vienna, 1090

  • Investigational Site Number 040002

    Vienna, 1160

Other trials in Austria

Latvia6 sites
  • Investigational Site Number 428004

    Daugavpils, LV-5417

  • Investigational Site Number 428002

    Liepāja, LV-3414

  • Investigational Site Number 428006

    Riga, LV-1002

  • Investigational Site Number 428001

    Riga, LV-1011

  • Investigational Site Number 428005

    Riga, LV-1038

  • Investigational Site Number 428003

    Ventspils, LV-3601

Other trials in Latvia

North Macedonia5 sites
  • Investigational Site Number 807005

    Bitola, 7000

  • Investigational Site Number 807004

    Shtip, 2000

  • Investigational Site Number 807002

    Skopje, 1000

  • Investigational Site Number 807001

    Skopje, 1109

  • Investigational Site Number 807003

    Tetovo, 1200

Other trials in North Macedonia

Slovenia5 sites
  • Investigational Site Number 705001

    Celje, 3000

  • Investigational Site Number 705004

    Izola, 6310

  • Investigational Site Number 705002

    Jesenice, 4270

  • Investigational Site Number 705005

    Ljubljana, 1525

  • Investigational Site Number 705006

    Ljubljana, SI-1525

Other trials in Slovenia

Finland4 sites
  • Investigational Site Number 246004

    Helsinki, 00029 HUS

  • Investigational Site Number 246001

    Oulu, 90220

  • Investigational Site Number 246003

    Tampere, 33520

  • Investigational Site Number 246002

    Turku, 20520

Other trials in Finland

Guatemala4 sites
  • Investigational Site Number 320003

    Guatemala City, 01001

  • Investigational Site Number 320001

    Guatemala City, 01014

  • Investigational Site Number 320002

    Guatemala City

  • Investigational Site Number 320004

    Guatemala City

Other trials in Guatemala

Switzerland4 sites
  • Investigational Site Number 756005

    Basel, 4031

  • Investigational Site Number 756003

    Geneva, 1205

  • Investigational Site Number 756004

    Lugano, 6900

  • Investigational Site Number 756002

    Zurich, 8091

Other trials in Switzerland

Singapore3 sites
  • Investigational Site Number 702002

    Singapore, 119228

  • Investigational Site Number 702003

    Singapore, 159964

  • Investigational Site Number 702001

    Singapore, 168752

Other trials in Singapore

Hong Kong2 sites
  • Investigational Site Number 344003

    Hong Kong

  • Investigational Site Number 344001

    Shatin, Nt

Other trials in Hong Kong

About this study

Official title: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Effect of Alirocumab (SAR236553/REGN727) on the Occurrence of Cardiovascular Events in Patients Who Have Recently Experienced an Acute Coronary Syndrome

Primary Objective:

To compare the effect of alirocumab with placebo on the occurrence of cardiovascular (CV) events (composite endpoint of coronary heart disease (CHD) death, non-fatal myocardial infarction (MI), fatal and non-fatal ischemic stroke, unstable angina (UA) requiring hospitalization) in participants who experienced an acute coronary syndrome (ACS) event 4 to 52 weeks prior to randomization and were treated with evidence-based medical and dietary management of dyslipidemia.

Read more

Secondary Objectives:

  • To evaluate the effect of alirocumab on secondary endpoints (any CHD event , major CHD event, any CV event, composite of all cause mortality/non-fatal MI/non-fatal ischemic stroke, CHD deaths, CV deaths, all cause mortality).
  • To evaluate the safety and tolerability of alirocumab.
  • To evaluate the effect of alirocumab on lipid parameters.
Read the detailed description

18924 number of participants aged >= 40 years old were randomized in the study.

Being tested
Alirocumab, Placebo, LMT
Medical subject headings
Atherosclerosis

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • AlirocumabDrug

    Also called SAR236553, REGN727, Praluent®

    Alirocumab administered as SC injection of 1 mL in the abdomen or thigh with a disposable auto-injector.

  • PlaceboDrug

    Placebo matched to alirocumab administered as a SC injection of 1 mL in the abdomen or thigh with a disposable auto-injector.

  • LMTDrug

    Statins (atorvastatin or rosuvastatin) at stable maximal tolerated dose of statin with or without other LMT as clinically indicated.

Study groups in NCT01663402
Study groupRoleWhat they receive
PlaceboPlacebo comparatorPlacebo (for alirocumab) subcutaneous (SC) injection every 2 weeks (Q2W) added to stable Lipid-Modifying Therapy (LMT) for up to 64 months.
Receives: Drug: Placebo; Drug: LMT
Alirocumab 75 mg Q2W/Up to 150 mg Q2WExperimentalAlirocumab 75 mg SC injection Q2W added to stable LMT for up to 64 months. Alirocumab dose up-titrated to 150 mg Q2W from Month 2 when Low-Density Lipoprotein Cholesterol (LDL-C) levels >=50 mg/dL (1.29 mmol/L) at Month 1; or if up-titration was missed due to unavailability of LDL-C value, it was up-titrated at month 4 based on LDL-C value at Month 2. For participants receiving 150 mg Q2W, alirocumab dose was down-titrated in a blinded manner to 75 mg Q2W if two consecutive values of LDL-C were <25 mg/dL (0.65 mmol/L). For participants receiving 75 mg Q2W, alirocumab dose was switched to placebo in a blinded manner if two consecutive values of LDL-C were <15 mg/dL (0.39 mmol/L).
Receives: Drug: Alirocumab; Drug: LMT

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Time to First Occurrence of Major Adverse Cardiovascular Event (MACE); Percentage of Observed Participants With Outcome Measure Events During the Study

    All MACE positively adjudicated by Clinical Events Committee (CEC) in a blinded fashion, were used in the analysis of the composite cardiovascular (CV) outcome measure comprised of Coronary Heart Disease (CHD) death, non-fatal Myocardial Infarction (MI), fatal and non-fatal ischemic stroke (IS), or unstable angina (UA) requiring hospitalization. Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of MACE over time. Percentage of observed participants with outcome measure events during the study were reported.

    Measured: From randomization up to 64 months

Secondary outcomes (12)
  1. Time to First Occurrence of Any Coronary Heart Disease Event; Percentage of Observed Participants With Outcome Measure Events During the Study

    All CHD events positively adjudicated by CEC in a blinded fashion, were used in the analysis of the composite CHD endpoint comprised of any CHD death, non-fatal non-fatal MI, UA requiring hospitalization, or ischemia-driven coronary revascularization procedure. Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of any CHD event over time. Percentage of observed participants with outcome measure events during the study were reported.

    Measured: From randomization up to 64 months

  2. Time to First Occurrence of Any Major Coronary Heart Disease Event; Percentage of Observed Participants With Outcome Measure Events During the Study

    All Major CHD events positively adjudicated by CEC in a blinded fashion, were used in the analysis of the composite CHD endpoint comprised of any CHD death and non-fatal MI. Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of any major CHD event over time. Percentage of observed participants with outcome measure events during the study were reported.

    Measured: From randomization up to 64 months

  3. Time to First Occurrence of Any Cardiovascular Event; Percentage of Observed Participants With Outcome Measure Events During the Study

    All CV events positively adjudicated by CEC in a blinded fashion, were used in the analysis of the composite CV endpoint comprised of any non-fatal CHD event, any CV death and non-fatal IS. Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of any CV event over time. Percentage of observed participants with outcome measure events during the study were reported.

    Measured: From randomization up to 64 months

  4. Time to First Occurrence of All-Cause Mortality, Non-Fatal Myocardial Infarction, Non-Fatal Ischemic Stroke; Percentage of Observed Participants With Outcome Measure Events During the Study

    All-cause mortality, non-fatal MI and non-fatal IS positively adjudicated by CEC in a blinded fashion, were used in the analysis of this endpoint. Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of all-cause mortality, non-fatal MI and non-fatal IS over time. Percentage of observed participants with outcome measure events during the study were reported.

    Measured: From randomization up to 64 months

  5. Time to Coronary Heart Disease Death; Percentage of Observed Participants With Outcome Measure Events During the Study

    Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the CHD death over time. Percentage of observed participants with CHD death (positively adjudicated by CEC in a blinded fashion) were reported.

    Measured: From randomization up to 64 months

  6. Time to Cardiovascular Death; Percentage of Observed Participants With Outcome Measure Events During the Study

    Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the CV death over time. Percentage of observed participants with CV death (positively adjudicated by CEC in a blinded fashion) were reported.

    Measured: From randomization up to 64 months

  7. Time to All-Cause Death; Percentage of Observed Participants With Outcome Measure Events During the Study

    Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the all-cause death over time. Percentage of observed participants with all-cause death (positively adjudicated by CEC in a blinded fashion) were reported.

    Measured: From randomization up to 64 months

  8. Time to First Occurrence of Any Non-Fatal Myocardial Infarction; Percentage of Observed Participants With Outcome Measure Events During the Study

    Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of any non-fatal MI over time. Percentage of observed participants with any non-fatal MI (positively adjudicated by CEC in a blinded fashion) were reported.

    Measured: From randomization up to 64 months

  9. Time to First Occurrence of Fatal or Any Non-Fatal Ischemic Stroke; Percentage of Observed Participants With Outcome Measure Events During the Study

    Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of fatal or any non-fatal IS over time. Percentage of observed participants with fatal or any non-fatal IS (positively adjudicated by CEC in a blinded fashion) were reported.

    Measured: From randomization up to 64 months

  10. Time to First Occurrence of Any Unstable Angina Requiring Hospitalization; Percentage of Observed Participants With Outcome Measure Events During the Study

    Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of any UA requiring hospitalization over time. Percentage of observed participants with any UA requiring hospitalization (positively adjudicated by CEC in a blinded fashion) were reported.

    Measured: From randomization up to 64 months

  11. Time to First Occurrence of Any Ischemia-Driven Coronary Revascularization Procedure; Percentage of Observed Participants With Outcome Measure Events During the Study

    Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of any ischemia-driven coronary revascularization procedure over time. Percentage of observed participants with any ischemia-driven coronary revascularization procedure (positively adjudicated by CEC in a blinded fashion) were reported.

    Measured: From randomization up to 64 months

  12. Time to First Occurrence of Any Congestive Heart Failure (CHF) Requiring Hospitalization; Percentage of Observed Participants With Outcome Measure Events During the Study

    Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of any CHF requiring hospitalization over time. Percentage of observed participants with any CHF requiring hospitalization (positively adjudicated by CEC in a blinded fashion) were reported.

    Measured: From randomization up to 64 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted13 Aug 2012 (estimated)
  2. Study startOct 2012
  3. Primary completion23 Jan 2018
  4. Study completion23 Jan 2018

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Prevention
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
18,924 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT01663402
Sponsor's protocol ID
EFC11570
Other IDs
2011-005698-21, U1111-1127-4323
Status last verified
Mar 2019
First submitted
8 Aug 2012
Last updated
18 Mar 2019
Data monitoring committee
Yes

Publications

  • Tsimikas S, Szarek M, Cobbaert CM, Romijn F, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Yuan C, Gong XM, Goodman SG, White HD, Witztum JL, Steg PG, Schwartz GG; ODYSSEY OUTCOMES Investigators. Oxidized Phospholipids, Lipoprotein(a), and Cardiovascular Outcomes After Acute Coronary Syndrome. Circulation. 2025 Dec 16;152(24):1666-1678. doi: 10.1161/CIRCULATIONAHA.125.073855. Epub 2025 Dec 1.

    PubMed 41321238
  • Reijnders E, Bossuyt PM, Jukema JW, Ruhaak LR, Romijn FPHTM, Szarek M, Trompet S, Bhatt DL, Bittner VA, Diaz R, Fazio S, Stevanovic I, Goodman SG, Harrington RA, White HD, Steg PG, Schwartz GG, Cobbaert CM. Multiplex Apolipoprotein Panel Improves Cardiovascular Event Prediction and Cardiovascular Outcome by Identifying Patients Who Benefit From Targeted PCSK9 Inhibitor Therapy. Arterioscler Thromb Vasc Biol. 2025 Nov;45(11):2111-2123. doi: 10.1161/ATVBAHA.124.322336. Epub 2025 Sep 25.

    PubMed 40995631
  • Geba GP, Mohammadi KA, Damask A, Paulding C, Lotta LA, Hindy G, Pordy R, Manvelian G, Shapiro MD, Bittner VA, Bhatt DL, Szarek M, Schwartz GG, Steg PG, Fazio S. Effect of PCSK9 Inhibition With Alirocumab in Patients With Probable Familial Hypercholesterolemia or Type III Hyperlipoproteinemia: Results From the ODYSSEY OUTCOMES Trial. J Am Heart Assoc. 2025 Sep 2;14(17):e041190. doi: 10.1161/JAHA.124.041190. Epub 2025 Aug 22.

    PubMed 40847481
  • Steg PG, Szarek M, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, White HD, Zeiher AM, Schwartz GG; ODYSSEY OUTCOMES Investigators. Relation of Low-Density Lipoprotein Cholesterol, High-Sensitivity C-Reactive Protein, and Lipoprotein(a) Each to Future Cardiovascular Events and Death After Acute Coronary Syndrome on High-Intensity Statin Therapy: An Analysis of the Placebo Arm of ODYSSEY OUTCOMES. Circulation. 2025 Apr 8;151(14):1047-1050. doi: 10.1161/CIRCULATIONAHA.124.071269. Epub 2025 Apr 7. No abstract available.

    PubMed 40193536
  • Geba GP, Chen R, Talapatra K, Brackin T, Mohammadi KA, Pordy R, Manvelian G, Maron DJ, Schwartz GG, Szarek M, Steg PG, Fazio S. Alirocumab and chest pain after acute coronary syndrome: An analysis of ODYSSEY OUTCOMES. Am J Prev Cardiol. 2024 Nov 26;20:100900. doi: 10.1016/j.ajpc.2024.100900. eCollection 2024 Dec.

    PubMed 39687787
  • Reijnders E, Romijn FPHTM, Arslan F, Georges JJJ, Pieterse MM, Schipper ER, Didden-Buitendijk S, Martherus-Bultman MC, Smit NPM, Diederiks NM, Treep MM, Jukema JW, Cobbaert CM, Ruhaak LR. Quality Assurance for Multiplex Quantitative Clinical Chemistry Proteomics in Large Clinical Trials. J Appl Lab Med. 2024 Nov 4;9(6):949-963. doi: 10.1093/jalm/jfae092.

    PubMed 39239905
  • Zahger D, Schwartz GG, Du W, Szarek M, Bhatt DL, Bittner VA, Budaj AJ, Diaz R, Goodman SG, Jukema JW, Kiss RG, Harrington RA, Moriarty PM, Scemama M, Manvelian G, Pordy R, White HD, Zeiher AM, Fazio S, Geba GP, Steg PG; ODYSSEY OUTCOMES Investigators. Triglyceride Levels, Alirocumab Treatment, and Cardiovascular Outcomes After an Acute Coronary Syndrome. J Am Coll Cardiol. 2024 Sep 10;84(11):994-1006. doi: 10.1016/j.jacc.2024.06.035.

    PubMed 39232634
  • Bittner VA, Schwartz GG, Bhatt DL, Chua T, De Silva HA, Diaz R, Goodman SG, Harrington RA, Jukema JW, McGinniss J, Pordy R, Garon G, Scemama M, White HD, Steg PG, Szarek M; ODYSSEY OUTCOMES Investigators. Alirocumab and cardiovascular outcomes according to sex and lipoprotein(a) after acute coronary syndrome: a report from the ODYSSEY OUTCOMES study. J Clin Lipidol. 2024 Jul-Aug;18(4):e548-e561. doi: 10.1016/j.jacl.2024.04.122. Epub 2024 Apr 10.

    PubMed 38960812
  • Lawler PR, Manvelian G, Coppi A, Damask A, Cantor MN, Ferreira MAR, Paulding C, Banerjee N, Li D, Jorgensen S, Attre R, Carey DJ, Krebs K, Milani L, Hveem K, Damas JK, Solligard E, Stender S, Tybjaerg-Hansen A, Nordestgaard BG, Hernandez-Beeftink T, Rogne T, Flores C, Villar J, Walley KR, Liu VX, Fohner AE, Lotta LA, Kyratsous CA, Sleeman MW, Scemama M, DelGizzi R, Pordy R, Horowitz JE, Baras A, Martin GS, Steg PG, Schwartz GG, Szarek M, Goodman SG. Pharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival From Sepsis. Crit Care Explor. 2023 Nov 8;5(11):e0997. doi: 10.1097/CCE.0000000000000997. eCollection 2023 Nov.

    PubMed 37954898
  • Goodman SG, Steg PG, Poulouin Y, Bhatt DL, Bittner VA, Diaz R, Garon G, Harrington RA, Jukema JW, Manvelian G, Stipek W, Szarek M, White HD, Schwartz GG; ODYSSEY OUTCOMES Investigators. Long-Term Efficacy, Safety, and Tolerability of Alirocumab in 8242 Patients Eligible for 3 to 5 Years of Placebo-Controlled Observation in the ODYSSEY OUTCOMES Trial. J Am Heart Assoc. 2023 Sep 19;12(18):e029216. doi: 10.1161/JAHA.122.029216. Epub 2023 Sep 13. No abstract available.

    PubMed 37702079
  • Szarek M, Reijnders E, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, Ruhaak LR, Schwertfeger M, Tsimikas S, White HD, Steg PG, Cobbaert C, Schwartz GG; ODYSSEY OUTCOMES Investigators. Relating Lipoprotein(a) Concentrations to Cardiovascular Event Risk After Acute Coronary Syndrome: A Comparison of 3 Tests. Circulation. 2024 Jan 16;149(3):192-203. doi: 10.1161/CIRCULATIONAHA.123.066398. Epub 2023 Aug 26.

    PubMed 37632469
  • Suc G, Schwartz GG, Goodman SG, Jukema JW, Manvelian G, Poulouin Y, Pordy R, Scemama M, Szarek M, Steg PG; ODYSSEY OUTCOMES Investigators. Effect of alirocumab on cataracts in patients with acute coronary syndromes. BMC Ophthalmol. 2023 Jun 16;23(1):279. doi: 10.1186/s12886-023-03012-1.

    PubMed 37328736
  • Schwartz GG, Szarek M, Bhatt DL, Bittner VA, Bujas-Bobanovic M, Diaz R, Fazio S, Fras Z, Goodman SG, Harrington RA, Jukema JW, Manvelian G, Pordy R, Ray KK, Scemama M, White HD, Steg PG; ODYSSEY OUTCOMES Investigators. Transiently achieved very low LDL-cholesterol levels by statin and alirocumab after acute coronary syndrome are associated with cardiovascular risk reduction: the ODYSSEY OUTCOMES trial. Eur Heart J. 2023 Mar 5;44(16):1408-17. doi: 10.1093/eurheartj/ehad144. Online ahead of print.

    PubMed 36879424
  • Hagstrom E, Steg PG, Szarek M, Bhatt DL, Bittner VA, Danchin N, Diaz R, Goodman SG, Harrington RA, Jukema JW, Liberopoulos E, Marx N, McGinniss J, Manvelian G, Pordy R, Scemama M, White HD, Zeiher AM, Schwartz GG; ODYSSEY OUTCOMES Investigators. Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab. Circulation. 2022 Aug 30;146(9):657-672. doi: 10.1161/CIRCULATIONAHA.121.057807. Epub 2022 Jun 30.

    PubMed 35770629
  • Landmesser U, McGinniss J, Steg PG, Bhatt DL, Bittner VA, Diaz R, Dilic M, Goodman SG, Jukema JW, Loy M, Pecin I, Pordy R, Poulsen SH, Szarek M, White HD, Schwartz GG; ODYSSEY OUTCOMES Investigators. Achievement of ESC/EAS LDL-C treatment goals after an acute coronary syndrome with statin and alirocumab. Eur J Prev Cardiol. 2022 Oct 20;29(14):1842-1851. doi: 10.1093/eurjpc/zwac107.

    PubMed 35708715

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Alirocumab and LMT in people with Atherosclerotic Cardiovascular Disease, run by Sanofi at 1,388 sites in 57 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 18 Mar 2019. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1,388 sites in United States, China, India, Argentina, Russia and 52 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

Yes. Results are posted in the registry (first posted 18 Mar 2019). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Time to First Occurrence of Major Adverse Cardiovascular Event (MACE); Percentage of Observed Participants With Outcome Measure Events During the Study (time frame: From randomization up to 64 months). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT01663402, which also lists 36 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Mar 2019.

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