AzTrials
AzTrials

StrokeNCT01671007

GLORIA-AF Registry Program (Phase II/III - EU/EEA Member States)

An observational study of Stroke and Atrial Fibrillation, run by Boehringer Ingelheim at 522 sites in 22 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
Search all trials

Trial summary

In this part of the Registry Program patients with non-valvular atrial fibrillation (AF) at risk for stroke are enrolled to characterize the target population and to collect real world data on important outcome events. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Stroke, Atrial Fibrillation
How many people
10,471 participants
Where
522 sitesin 22 countries
Study dates
22 Aug 2012to 13 Dec 2019
Phase
Observational
Are there results?
Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: patients with non-valvular AF

Who may be able to join

  • Age =>18 years at enrollment
  • Male or female patient (or legally acceptable representative) willing and able to provide written informed consent
  • Patient newly diagnosed (< 3 months prior to baseline visit) with non-valvular AF and at risk for stroke.
  • Other inclusion criteria apply.

Who cannot join

  • Presence of any mechanical heart valve, or valve disease that is expected to require valve replacement intervention;
  • Patients who have received more than 60 days of vitamin K antagonist (VKA) treatment in their lifetime;
  • AF with a generally reversible cause;
  • Patients with a medical condition other than atrial fibrillation for which chronic use of an oral anticoagulant (for example, a VKA) is indicated Other exclusion criteria apply

Trial locations and contacts

522 sites in 22 countries.

522 sites in 22 countries

France91 sites

  • HOP Général, Cardio, Abbeville

    Abbeville, 80142

  • HOP d'Agen, Cardio, Agen

    Agen, 47923

  • HOP d'Aix en Provence, cardio, Aix-en-Provence

    Aix-en-Provence, 13616

  • HOP Général, Cardio, Abbeville

    Aix-en-Provence, 13616

  • HOP Louis Pasteur, Cardio, Bagnols sur Ceze

    Bagnols-sur-Cèze, 30205

  • HOP Bar le Duc, Pneumo, Bar le Duc

    Bar-le-Duc, 55012

  • HOP de Bayonne

    Bayonne, 64109

  • HOP Jean Minjoz

    Besançon, 25030

  • CAB Berdagué P, Cardio, Beziers

    Béziers, 34500

  • CAB Breton Dr Nicolas

    Béziers, 34500

  • HOP de Béziers

    Béziers, 34525

  • CLI Tivoli

    Bordeaux, 33000

  • HOP Saint-André

    Bordeaux, 33075

  • HOP Ambroise Paré

    Boulogne-Billancourt, 92104

  • HOP Fleyriat, GERIA, Bourg-en-Bresse

    Bour-en-Bresse, 01012

  • HOP de la Cavale Blanche

    Brest, 29609

  • CLI les Cedres, Cardio, Brive La Gaillarde

    Brive-la-Gaillarde, 19100

  • CAB Cadinot Dr D, Broglie

    Broglie, 27270

  • CAB Frappé T, MG, BRUAY LA BUISSIERE

    Bruay-la-Buissière, 62700

  • HOP Saint Martin, cardio, Caen

    Caen, 14000

  • HOP Côte de Nacre

    Caen, 14033

  • CAB Brunschwig, Cardio, Cannes

    Cannes, 06400

  • HOP William Morey, Cardio, Chalon-Sur-Saône

    Chalon-sur-Saône, 71100

  • CAB Loiselet P

    Cherbourg, 50100

  • HOP Gabriel-Montpied

    Clermont-Ferrand, 63000

  • CAB Brunehaut M, Cardio, Clermont Ferrand

    Clermont-Ferrand, 63100

  • HOP Sud Francilien, Cardio, Corbeil-Essonnes

    Corbeil-Essonnes, 91106

  • HOP Sud Francilien

    Corbeil-Essonnes, 91106

  • HOP Henri Mondor

    Créteil, 94000

  • HOP Bocage

    Dijon, 21079

  • HOP Louis Pasteur, Cardio, Dole

    Dole, 39108

  • CTRE Evecquemont, Cardio, Evecquemont

    Évecquemont, 78740

  • HOP du Val d'Ariège, Cardio, Foix

    Foix, 09107

  • HOP Michallon

    La Tronche, 38700

  • CAB Benhalima B, Cardio, Le bourget

    Le Bourget, 93350

  • HOP André Mignot

    Le Chesnay, 78150

  • HOP Louis Pasteur, Cardio, Le Coudray

    Le Coudray, 28630

  • HOP Le Mans

    Le Mans, 72037

  • CAB Phan Cao Phai, Cardio, Levallois Perret

    Levallois-Perret, 92300

  • CLI Libournais, Cardio, Libourne

    Libourne, 33500

  • HOP Robert Boulin, cardio, Libourne

    Libourne, 33500

  • CLI de la Louviere

    Lille, 59000

  • CLI le Colombier, Cardio, Limoges

    Limoges, 87100

  • HOP St Joseph-St Luc, Cardio, Lyon

    Lyon, 69365

  • CAB Gartenlaub O, Cardio, Maison Alfort

    Maisons-Alfort, 94700

  • CAB, Salem A, Cardio, Marseille

    Marseille, 13001

  • HOP Européen

    Marseille, 13003

  • CAB Scala P-J

    Marseille, 13008

  • CAB Scemama J

    Marseille, 13008

  • CAB vial, Cardio, Marseille

    Marseille, 13009

  • HOP Timone

    Marseille, 13385

  • HOP des Rayettes

    Martigues, 13698

  • HOP de la région d'Annecy, Cardio, Metz-Tessy

    Metz-Tessy, 74370

  • CAB Dillinger J, MG, Mondelange

    Mondelange, 57300

  • CLI de Montargis, Cardio, Montargis

    Montargis, 45200

  • CLI du Pont de Chaume

    Montauban, 82000

  • HOP Raincy Montfermeil, Cardio, Montfermeil

    Montfermeil, 93370

  • HOP Arnaud de Villeneuve

    Montpellier, 34295

  • CAB Prunier L, Cardio, Montreuil

    Montreuil, 93100

  • HOP Central, Neuro, Nancy

    Nancy, 54035

  • HOP de Courbevoie, Spécialités Med, Neuilly sur Seine

    Neuilly-sur-Seine, 92200

  • CAB Jamon Y, Cardio, Nîmes

    Nîmes, 30000

  • HOP Carémeau

    Nîmes, 3000

  • CLI Les Franciscaines, cardio, Nïmes

    Nïmes, 30032

  • HOP Orléans, Cardio, Orléans

    Orléans, 45100

  • CAB Audouin P, Cardio, Paris

    Paris, 75007

  • CLI Turin, Cardio, Paris

    Paris, 75008

  • CAB Cohen S, Paris

    Paris, 75012

  • CAB Poulain F, Paris

    Paris, 75014

  • HOP Européen G. Pompidou

    Paris, 75015

  • HOP Pontchaillou

    Rennes, 35033

  • CAB Duvilla N, Cardio, Rouen

    Rouen, 76000

  • CAB Dascotte O, Cardio, St André lez Lille

    Saint-André-lez-Lille, 59350

  • CAB Lequeux B, Cardio, Saint Benoit

    Saint-Benoît, 86280

  • HOP Privé de la Loire, Cardio, Saint Etienne

    Saint-Etienne, 42000

  • CAB Tessier P, Cardio, St Raphael

    Saint-Raphaël, 83700

  • CAB Dary P, Cardio, St-Yrieix-la-Perche

    Saint-Yrieix-la-Perche, 87500

  • CAB Muller J-J, Cardio, Strasbourg

    Strasbourg, 67000

  • CLI de l'Ormeau, Cardio, Tarbes

    Tarbes, 65000

  • CAB Houppe Nousse MP, Cardio, Thionville

    Thionville, 57100

  • HOP du Léman

    Thonon-les-Bains, 74203

  • HOP Sainte Musse

    Toulon, 83100

  • HOP Rangueil

    Toulouse, 31059

  • HOP Cardio, Tourcoing

    Tourcoing, 59200

  • CAB Leprince P, MG, Tours

    Tours, 37000

  • HOP Trousseau

    Tours, 37044

  • CLI Village de Santé, Cardio, Trélaze

    Trélazé, 49804

  • HOP Valence, Cardio, Valence

    Valence, 26000

  • HOP Bretagne Atlantique, Cardio, Vannes

    Vannes, 56017

  • CAB Lejay D, MG, Vieux Condé

    Vieux-Condé, 59690

  • CAB Schaupp T, MG, Vihiers

    Vihiers, 49310

Other trials in France

United Kingdom81 sites

  • Gale Farm Surgery

    Acomb, YO24 3BU

  • William Harvey Hospital

    Ashford, TN24 0LZ

  • Axbridge and Wedmore Medical Practice

    Axbridge, BS26 2BJ

  • Basildon University Hospital

    Basildon, SS16 5NL

  • North Hampshire Hospital

    Basingstoke, RG24 9NA

  • Royal United Hospital

    Bath, BA1 3NG

  • Beehive Surgery

    Bath, BA2 1NH

  • Birmingham City Hospital

    Birmingham, B18 7QH

  • Royal Bournemouth and Christchurch Hospital

    Bournemouth, BH7 7DW

  • Bradford on Avon Health Centre

    Bradford on Avon, BA15 1DQ

  • Southmead Hospital

    Bristol, BS10 5NB

  • Bradgate Surgery

    Bristol, BS10 6SP

  • Bristol Royal Infirmary

    Bristol, BS2 8HW

  • Clevedon Riverside Group

    Bristol, BS21 6DG

  • Burbage Surgery

    Burbage, Hinkley, LE10 2SE

  • West Suffolk Hospital

    Bury St Edmunds, IP33 2QZ

  • Cumberland Infirmary

    Carlisle, CA2 7HY

  • Countess of Chester Hospital

    Chester, CH2 1UL

  • Castle Hill Hopsital

    Cottingham, HU16 5JQ

  • Pound Hill Medical Group

    Crawley, RH10 7DX

  • Dorset County Hospital

    Dorchester, DT1 2JY

  • Russells Hall Hospital

    Dudley, DY1 2HQ

  • Ninewells Hospital & Medical School

    Dundee, DD1 9SY

  • University Hospital of North Durham

    Durham, DH1 5TW

  • Royal Devon and Exeter Hospital

    Exeter, EX2 5DW

  • Gloucestershire Royal Hospital

    Gloucester, GL1 3NN

  • The County Hospital

    Hereford, HR1 2ER

  • Wycombe General Hospital

    High Wycombe, HP11 2TT

  • Honiton Surgery Group - Seamark

    Honiton, EX14 2NY

  • Hedon Group Practice

    Hull, HU12 8JD

  • Airedale General Hospital

    Keighley, BD20 6TD

  • Westmorland General Hospital

    Kendal, LA9 7RG

  • Leeds General Infirmary

    Leeds, LS1 3EX

  • Research Unit, Liverpool Heart and Chest Hospital

    Liverpool, L14 3PE

  • Aintree University Hospital

    Liverpool, L9 7AL

  • University Hospital Lewisham

    London, SE13 6LH

  • St George's Hospital

    London, SW17 0RE

  • Altnagelvin Area Hospital

    Londonderry, BT47 6SB

  • Luton and Dunstable University Hospital

    Luton, LU4 0DZ

  • Arrowe Park Hospital

    Metropolitan Borough of Wirral, CH49 5PE

  • St Chad's Surgery

    Midsomer Norton, BA3 2UH

  • Northampton General Hospital

    Northampton, NN1 5BD

  • Norfolk and Norwich University Hospital

    Norwich, NR4 7UY

  • George Eliot Hospital

    Nuneaton, CV10 7DJ

  • Royal Oldham Hospital

    Oldham, OL1 2JH

  • Perth Royal Infirmary

    Perth, PH1 1NX

  • Peterborough City Hospital

    Peterborough, PE3 9GZ

  • Derriford Hospital

    Plymouth, PL6 8DH

  • Poole Hospital

    Poole, BH15 2JB

  • Craigavon Area Hospital

    Portadown, County Atrim, BT63 5QQ

  • Royal Preston Hospital

    Preston, PR2 9HT

  • Royal Berkshire Hospital

    Reading, RG1 5AN

  • Alexandra Hospital

    Redditch, B98 7UB

  • Sherbourne Medical Centre

    Royal Leamington Spa, CV32 4RA

  • Cape Cornwall Surgery

    Saint Just, Penzance, TR19 7HX

  • The Conquest Hospital

    Saint Leonards-on-Sea, TN37 7RD

  • Salisbury District Hospital

    Salisbury, SP2 8BJ

  • Royal Shrewsbury Hospital

    Shrewsbury, SY3 8XQ

  • Wexham Park Hospital

    Slough, SL2 4HL

  • County Hospital

    Stafford, ST16 3SA

  • Branch End Surgery

    Stocksfield, NE43 7LL

  • Royal Stoke University Hospital

    Stoke-on-Trent, ST4 6QG

  • Sunderland Royal Hospital

    Sunderland, SR4 7TP

  • King's Mill Hospital

    Sutton in Ashfield, NG17 4JL

  • Singleton Hospital

    Swansea, SA2 8QA

  • Musgrove Park Hospital

    Taunton, TA1 5DA

  • Torbay Hospital

    Torquay, TQ2 7AA

  • South Tyneside District Hospital

    Tyne-and-Wear, NE34 0PL

  • Hillingdon Hospital

    Uxbridge, UB8 3NN

  • Wansford Surgery

    Wansford, Peterborough, PE8 6PL

  • The Avenue Surgery

    Warminster, BA12 9AA

  • Warwick Hospital

    Warwick, CV34 5BJ

  • Queen Elizabeth II Hospital

    Welwyn Garden City, AL7 4HQ

  • Westbury Group Practice

    Westbury, BA13 3FQ

  • Southend General Hospital

    Westcliffe-on-Sea, SS0 0RY

  • Whitby Group Practice

    Whitby, YO21 1SD

  • New Cross Hospital

    Wolverhampton, WV10 0QP

  • Jorvik Medical Practice

    York, YO1 7NP

  • York Medical Group

    York, YO24 4HD

  • The York Hospital

    York, YO31 8HE

  • MyHealth, Strensall Health Care Centre

    York, YO32 5UA

Other trials in United Kingdom

Germany80 sites

  • Bezirkskrankenhaus, Ansbach

    Ansbach, 91522

  • Kerckhoff-Klinik, Bad Nauheim

    Bad Nauheim, 61231

  • Neurologische Klinik GmbH, Bad Neustadt

    Bad Neustadt/Saale, 97616

  • Sozialstiftung Bamberg

    Bamberg, 96046

  • Evangelisches Elisabeth-Krankenhaus, Berlin Mitte

    Berlin, 10785

  • Praxis Dr. Rieker, Berlin

    Berlin, 10789

  • Vivantes Netzwerk für Gesundheit GmbH

    Berlin, 10967

  • Charité - Universitätsmedizin Berlin

    Berlin, 12203

  • Vivantes Netzwerk für Gesundheit GmbH

    Berlin, 12351

  • Praxis Dr. Altmann, Berlin

    Berlin, 12489

  • Praxisgemeinschaft Dres. Weinrich

    Berlin, 12555

  • Praxis Dr. Claus, 10969 Berlin

    Berlin, 12559

  • Kardiologische Praxis Dr. Jochen Bott

    Berlin, 13405

  • Vivantes Netzwerk für Gesundheit GmbH

    Berlin, 13505

  • Vivantes Netzwerk für Gesundheit GmbH

    Berlin, 13509

  • Vivantes Netzwerk für Gesundheit GmbH

    Berlin, 13585

  • Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil gGmbH

    Bochum, 44791

  • Gesundheit Nord gGmbH | Klinikverbund Bremen

    Bremen, 28177

  • Klinikum Bremerhaven

    Bremerhaven, 27574

  • Herz- und Gefaesszentrum am Neumarkt

    Celle, 29221

  • Gemeinschaftspraxis Dr. med. J. Sek, Chemnitz

    Chemnitz, 09116

  • Klinikum Coburg gGmbH

    Coburg, 96450

  • Praxis für Kardiologie, Köln

    Cologne, 51105

  • HELIOS Amper Kliniken, Dachau

    Dachau, 85221

  • Kardiologische Praxisgemeinschaft,Darmstadt

    Darmstadt, 64287

  • Praxis Dr. Rybak, Dessau

    Dessau, 06847

  • Klinikum Lippe-Detmold GmbH

    Detmold, 32756

  • Kardiologischen Gemeinschaftspraxis Dinslaken

    Dinslaken, 46535

  • Praxis Dr. med. Bernhard-Paul Lodde

    Dortmund, 44147

  • Praxisklinik Herz und Gefäße

    Dresden, 01099

  • Universitätsklinikum Carl Gustav Carus Dresden

    Dresden, 01307

  • Evangelisches Krankenhaus Düsseldorf

    Düsseldorf, 40217

  • Universitätsklinikum Erlangen

    Erlangen, 91054

  • Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH

    Essen, 45122

  • Klinikum Esslingen GmbH

    Esslingen am Neckar, 73730

  • Praxis für Herz-Kreislauf-Erkrankungen Zeulenroda-Greiz

    Greiz, 07973

  • Asklepios Klinik St. Geort

    Hamburg, 20099

  • Universitätsklinikum Hamburg-Eppendorf

    Hamburg, 20246

  • Asklepios Klinik Harburg

    Hamburg, 21075

  • Asklepios Klinik Barmbek

    Hamburg, 22291

  • Praxis Herz im Zentrum Laske

    Hanover, 30159

  • Universitätsklinikum Heidelberg

    Heidelberg, 69120

  • Klinikum Ingolstadt GmbH

    Ingolstadt, 85049

  • Praxis Dr. Mibach, Itzehoe

    Itzehoe, 25524

  • Universitätsklinikum Jena

    Jena, 07740

  • Kardiologische Gemeinschaftspraxis Kassel

    Kassel, 34117

  • Praxis Dr. med. Frickel Siegfried

    Kempen, 47906

  • Praxis Dr. med. Matthias Gabelmann

    Kirchzarten, 79199

  • St. Antonius-Hospital, Kleve

    Kleve, 47533

  • Universitätsklinikum Leipzig

    Leipzig, 04103

  • Herzzentrum Leipzig GmbH

    Leipzig, 04289

  • Klinikum Leverkusen gGmbH, Leverkusen

    Leverkusen, 51375

  • Cardio Centrum Ludwigsburg

    Ludwigsburg, 71634

  • Klinikum der Stadt Ludwigshafen am Rhein gGmbH

    Ludwigshafen, 67063

  • Universitätsklinikum Magdeburg A. ö. R.

    Magdeburg, 39120

  • Gemeinsachftspraxis Regner/Schmitt/Kros, Mainz

    Mainz, 55116

  • Praxis Dr.med. Jens Taggeselle, Markkleeberg

    Markkleeberg, 04416

  • Klinikum Memmingen

    Memmingen, 87700

  • Johannes Wesling Klinikum

    Minden, 32429

  • Kliniken Maria Hilf GmbH

    Mönchengladbach, 41063

  • Praxis Dr. med. Norbert Schön, Mühldorf

    Mühldorf, 84453

  • Herzzentrum ALTER HOF München

    München, 80331

  • Klinikum rechts der Isar der Technischen Universität München

    München, 81675

  • Universitätsklinikum Münster

    Münster, 45129

  • Praxis Dr. med. Joachim Gmehling

    Nuremberg, 90402

  • Klinikum Osnabrück GmbH

    Osnabrück, 49076

  • St. Vincenz-Krankenhaus GmbH

    Paderborn, 33098

  • Kardiologische Praxis Papenburg

    Papenburg, 26871

  • Kardiologisches Zentrum Peine

    Peine, 31224

  • Städt. Krankenhaus, Pforzheim

    Pforzheim, 75175

  • Kardiologische Gemeinschaftspraxis Potsdam

    Potsdam, 14471

  • Kardiologische Gemeinschaftspraxis Rostock

    Rostock, 18057

  • Kreisklinikum Siegen GmbH

    Siegen, 57076

  • Berufsausübungsgemeinschaft Klein /Kratochvil

    Stuttgart, 70178

  • Herzklinik Ulm Gemeinschaftspraxis

    Ulm, 89077

  • Schwarzwald-Baar Klinikum

    Villingen-Schwenningen, 78011

  • Kardiologische Praxis, Wermsdorf

    Wermsdorf, 04779

  • MedKonsil, Wiesbaden

    Wiesbaden, 65189

  • Kardiologische Gemeinschaftspraxis Wittenberg

    Wittenberg, 06886

  • Universitätsklinikum Würzburg

    Würzburg, 97080

Other trials in Germany

Italy73 sites

  • Ospedale Riuniti Albano Genzano

    Albano Laziale, 00041

  • Az. Osp. S.M. di Misericordia

    Albenga, 17031

  • Az. Ospedaliere Umberto I di Ancona

    Ancona, 60020

  • Ospedale Reg Umberto Parini

    Aosta, 11100

  • Ospedale C. G. Mazzoni

    Ascoli Piceno, 63100

  • AZ. Osp. Assisi U.O.

    Assisi, 06081

  • Osp. SS Filippo Nicola

    Avezzano, 67051

  • Policlinico di Bari

    Bari, 70124

  • Policlinico Universitario di Bari

    Bari, 70124

  • Policlinico S. Orsola Malpighi

    Bologna, 40138

  • A. O. G. Brotzu

    Cagliari, 09134

  • Presidio Ospedaliero di Castrovillari

    Castrovillari (CS), 87012

  • P. O. "Garibaldi" - Nesima

    Catania, 95122

  • A.O. Univ. Vittorio Ferrarotto S. Bambino

    Catania, 95124

  • Policlinico Universitario Mater Domini, Universita di Catanzaro

    Catanzaro, 88100

  • Osp. Clin. SS. Anunziata

    Chieti, 66013

  • Azienda Ospedaliera Universitaria Arcispedale Sant'Anna

    Cona (FE), 44124

  • Osp.S.Salvatore

    Coppitto (AQ), 67100

  • AZ. Osped. Ospedale Maggiore di Crema

    Crema (CR), 26013

  • A. Istituti Osp. di Cremona

    Cremona, 26100

  • Ospedale S. Biagio

    Domodossola (VB), 28845

  • P. O. S. Maria Nuova

    Florence, 50122

  • Azienda Ospedaliera Careggi

    Florence, 50134

  • Azienda Ospedaliera Careggi

    Florence, 50139

  • Az.Osp. Universitaria "Ospedali Riuniti"

    Foggia, 71100

  • Ospedale S. Cuore di Gesù

    Gallipoli, 73014

  • Policlinico San Martino

    Genova, 16132

  • Ospedale della Misericordia

    Grosseto, 58100

  • Ospedale F. Veneziale

    Isernia, 86170

  • Azienda Ospedaliera C. Poma

    Mantua, 46100

  • Osp. Pediatrico Aprano Pasquinucci

    Massa, 54100

  • Az Osp. Amico " Gaetano Fucito"

    Mercato San Severino (SA), 84085

  • Centro Cardiologico Monzino-IRCCS

    Milan, 20138

  • Nuovo Ospedale Civile S. Agostino-Estense

    Modena, 46100

  • Osp.Riun.Valdichiana Senese

    Montepulciano Senese (SI), 53045

  • A.O. San Gerardo di Monza

    Monza (MB), 20900

  • Ospedale Nuovo Pellegrini

    Naples, 80134

  • Ospedale Cardarelli

    Naples, 80135

  • Osp.Sacro Cuore-Don Calabria

    Negrar (VR), 37024

  • Az. Osp. San Giacomo

    Novi Ligure, 15067

  • Az. Osp. San Francesco

    Nuoro, 08100

  • Azienda Sanitaria Ospedale S. Luigi Gonzaga

    Orbassano (TO), 10043

  • Azienda Ospedaliera Universitaria di Padova

    Padova, 35128

  • A.O. Univ. Policlinico Giaccone

    Palermo, 90129

  • Fondazione IRCCS Policlinico S. Matteo

    Pavia, 27100

  • Ospedale S.Maria della Misericordia, AO di Perugia

    Perugia, 06156

  • Ospedale San Salvatore

    Pesaro, 6121

  • Osp. Guglielmo da Saliceto AUSL di Piacenza

    Piacenza, 29121

  • Ospedale Santa Corona Azienda Sanitaria Locale n.2 Savonese

    Pietra Ligure, 17027

  • Ospedale di Cisanello

    Pisa, 56124

  • Ospedale S.Tommaso dei Battuti

    Portogruaro (VE), 30026

  • P.O.S. Maria Grazie

    Pozzuoli, 80078

  • Azienda Unità Sanitaria Locale di Reggio Emilia

    Reggio Emilia, 12100

  • Ospedale "Giambattista Grassi

    Roma, 00122

  • Pol. Universitario Tor Vergata

    Roma, 00133

  • Azienda Complessa Ospedaliera Ospedale San Fiippo Neri

    Roma, 00135

  • Ospedale "S. Eugenio"

    Roma, 00144

  • A.O. San Camillo Forlanini

    Roma, 00151

  • Umberto I Pol. di Roma-Università di Roma La Sapienza

    Roma, 00161

  • Policlinico Gemelli

    Roma, 00168

  • Policlinico Casilino U.O. Cardiologia

    Roma, 00169

  • Az. Osp.Madre Giuseppina Vannini-

    Roma, 00177

  • Az. Osp. S.Giovanni-Addolorata

    Roma, 00184

  • Ospedale S. Spirito

    Roma, 00193

  • Nuovo Ospedale Civile di Sassuolo

    Sassuolo, 41049

  • IRCCS Gruppo Multimedica

    Sesto S.Giovanni (MI), 20090

  • A.O.U. Senese Policlinico Santa Maria alle Scotte

    Siena, 53100

  • AO Città della Salute e della

    Torino, 10126

  • Ospedale Mauriziano di Torino

    Torino, 10128

  • Ospedale S. Maria di Ca' Foncello Azienda ULSS9 TREVISO

    Treviso, 31100

  • A. O. S. Maria della Misericordia

    Udine, 33100

  • A. O. Ospedale Circolo Fond. Macchi

    Varese, 21100

  • Ospedale San Bortolo

    Vicenza, 36100

Other trials in Italy

Spain43 sites

  • Hospital A Coruña

    A Coruña, 15006

  • Hospital del Mar

    Barcelona, 08003

  • Hospital Vall d'Hebron

    Barcelona, 08035

  • Hospital Clínic de Barcelona

    Barcelona, 08036

  • CAP Passeig de Maragall

    Barcelona, 08041

  • Hospital La Princesa

    Cáceres, 10820

  • Consultorio Cañaveral

    Cañaveral (Cáceres), 10820

  • Hospital Santa Lucía

    Cartagena (Murcia), 30202

  • Hospital Universitario Reina Sofía

    Córdoba, 14004

  • Hospital Universitario Virgen de la Arrixaca

    El Palmar - Murcia, 30120

  • Hospital Universitario San Cecilio

    Granada, 18012

  • Hospital Jerez de la Frontera

    Jerez de La Frontera - Cádiz, 11407

  • Hospital de Gran Canaria Dr. Negrín

    Las Palmas de Gran Canaria, 35010

  • Hospital Severo Ochoa

    Leganes - Madrid, 28911

  • Hospital de León

    León, 24071

  • Hospital Universitario Lucus Augusti

    Lugo, 27004

  • Hospital Ramón y Cajal

    Madrid, 28031

  • Centro de Salud Jazmin

    Madrid, 28033

  • Centro de Salud Isla de Oza

    Madrid, 28035

  • Fundación Jiménez Díaz

    Madrid, 28040

  • Hospital Regional Universitario de Málaga

    Madrid, 28040

  • Hospital Universitario 12 de Octubre

    Madrid, 28041

  • Hospital La Paz

    Madrid, 28046

  • Hospital Virgen de la Victoria

    Málaga, 29010

  • Hospital Costa del Sol

    Marbella . Málaga, 29603

  • Hospital de Son Llàtzer

    Palma de Mallorca, 07198

  • Complejo Hospitalario de Navarra

    Pamplona, 31009

  • Hospital General Universitario de Alicante

    Sant Joan d'Alacant, 03550

  • Hospital Moises Broggi

    Sant Joan Despí, 08970

  • Hospital Universitario Marqués de Valdecilla

    Santander, 39008

  • Hospital Clínico de Santiago

    Santiago de Compostela, 15706

  • Hospital San Juan de Dios

    Seville, 41005

  • Hospital Virgen del Rocío

    Seville, 41012

  • ABP Salud Sevilla

    Seville, 41013

  • Hospital Nuestra Señora de Valme

    Seville, 41014

  • CS Ingeniero Joaquin Benlloch

    Valencia, 46006

  • Hospital Univ La Fe

    Valencia, 46009

  • Hospital General Universitario de Valencia

    Valencia, 46014

  • Hospital Arnau de Vilanova

    Valencia, 46015

  • Hospital Dr. Peset

    Valencia, 46017

  • Hospital Comarcal Axarquía

    Vélez-Málaga, 29700

  • Hospital Meixoeiro

    Vigo, 36200

  • Hospital Povisa

    Vigo, 36211

Other trials in Spain

Netherlands21 sites

  • Jeroen Bosch Ziekenhuis-Hertogenbosch

    's-Hertogenbosch, 5223 GZ

  • Amsterdam UMC, Locatie AMC

    Amsterdam, 1105 AZ

  • Rijnstate Hospital

    Arnhem, 6815 AD

  • IJsselland Ziekenhuis

    Capelle aan den IJssel, 2906 ZC

  • Reinier de Graaf Groep

    Delft, 2625 AD

  • Noordwest Ziekenhuisgroep

    Den Helder, 1782 GZ

  • Deventer Ziekenhuis

    Deventer, 7416 SE

  • Van Weel-Bethesda Ziekenhuis

    Dirksland, 3247 BW

  • Catharina Ziekenhuis

    Eindhoven, 5623 EJ

  • Medisch Spectrum Twente

    Enschede, 7512KZ

  • Zuyderland Medisch Centrum

    Heerlen, 6419 PC

  • TREANT zorggroep

    Hoogeveen, 7909 AA

  • Westfries Gasthuis

    Hoorn, 1624 NP

  • METC Academisch Ziekenhuis Maastricht/Universiteit van Maastricht

    Maastricht, 6229 HX

  • St. Antonius ziekenhuis, locatie Nieuwegein

    Nieuwegein, 3435 CM

  • Havenziekenhuis

    Rotterdam, 3011 TD

  • Zuyderland Medisch Centrum

    Sittard - Geleen, 6162 BG

  • Antonius Ziekenhuis

    Sneek, 8601 ZK

  • Ziekenhuis Rivierenland

    Tiel, 4002 WP

  • VieCuri Medisch Centrum, locatie Venray

    Venray, 5801 CE

  • Isala Zwolle

    Zwolle, 8011 JW

Other trials in Netherlands

Greece18 sites

  • University Hospital of Alexandroupolis

    Alexandroupoli, 68100

  • Euroclinic of Athens

    Athens, 11521

  • "Korgialeneio-Benakeio" Hellenic Red Cross Hospital

    Athens, 11526

  • Sotiria Hosp.,Hypertension Unit,3rd Clinic of Internal Med.

    Athens, 11527

  • Asclepion Voulas Hospital, Cardiological Clinic

    Athens, 16673

  • General Hospital of Chalkida

    Chalcis, 34100

  • General Hospital of Chania

    Chania, 73100

  • General Hospital of Edessa, Cardiology Clinic

    Edessa, 58200

  • Gen. Hosp. of Elefsina "Thriassio"

    Elefsina, 19600

  • University General Hospital of Heraklion

    Herakleion, Crete, 71110

  • Univ. Gen. Hosp. of Ioannina

    Ioannina, 45500

  • General Hospital Komotinis

    Komotini, 69100

  • General University Hospital of Larissa

    Larissa, 41110

  • University of Patras Medical School

    Pátrai, 26504

  • General Hospital of Rhodes

    Rhodes, 85100

  • Gen. Hosp. of Thessaloniki "Hippokation", Cardiology Clinic

    Thessaloniki, 54642

  • "Papageorgiou" General Hospital of Thessaloniki, B' Cardiolo

    Thessaloniki, 56429

  • General Panarkadiko Hospital of Tripolis, Cardiology Clinic

    Tripoli, 22100

Other trials in Greece

Bulgaria14 sites

  • MHAT "Deva Maria", Dept. of Cardiology, Burgas

    Burgas, 5800

  • MHAT "Dr.Stambolski", Cardiology&Intensiv Care Dept,Kazanlak

    Kazanlak, 6100

  • UMHAT Sv.Georgi EAD

    Plovdiv, 4002

  • MHAT, Fourth Dept. of Internal Medicine, Rousse

    Rousse, 7002

  • MHAT Akta Medika OOD, Sevlievo

    Sevlievo, 5400

  • Multiprofile Hospital for Active Treatment, Sliven

    Sliven, 8800

  • Diagnostic & Consultancy Center "Ascendent", Sofia

    Sofia, 1202

  • MHAT "National Cardiology Hosp." Cardiology Dept., Sofia

    Sofia, 1309

  • University Multiprofile Hospital 'Alexandrovska', Sofia

    Sofia, 1431

  • MHAT, "Vita" Surgery Department, Sofia

    Sofia, 1505

  • MHAT "Tsaritsa Yoanna-ISUL" Clinic of Cardiology, Sofia

    Sofia, 1527

  • UMHAT, Clinic of Cardiology, Stara Zagora

    Stara Zagora, 6003

  • Medical Military Academy MHAT Varna

    Varna, 9010

  • Specialized Hosp.f.Active Treatment, Cardiology Dept, Yambol

    Yambol, 8600

Other trials in Bulgaria

Poland14 sites

  • Univ. Clinic Hosp, Bialystok

    Bialystok, 15276

  • Private Practice Jacek Kowalczyk, Bytom

    Bytom, 41902

  • Specialist Out-patient Clinics 'Na Gornej',Cieszyn

    Cieszyn, 43400

  • Specialistic Cardiology&Hypertension Out-patient Clin,Kielce

    Kielce, 25525

  • Private Practice of Heart Diseases Malgorzata Lelonek,Lodz

    Lodz, 90727

  • Allmedica Sp. z.o.o, prac. Nowy Targ

    Nowy Targ, 34400

  • Private Specialistic Practices, Nysa

    Nysa, 48300

  • Reg.Hosp, Intern.Med.Ward w/ Intensive Cardiol.Care, Opoczno

    Opoczno, 26300

  • Szpital Specjalistyczny w Pulawach

    Puławy, 24-100

  • Cardiology Out-patient Clinic "Cardio-Plus", Radlin

    Radlin, 44144

  • Internal Medicine,Cardiol.practiceWanda&Jerzy Sudnik,Sokolka

    Sokółka, 16100

  • Individual Specialist.Private Practice Dr.W.Krysiak,Szczecin

    Szczecin

  • Individual Specialistic Private Practice,Dr.A.Tomasik,Zabrze

    Zabrze, 41800

  • Slaskie Center Heart Disease SUM,Cardiol.&Electr.Clin.Zabrze

    Zabrze, 41800

Other trials in Poland

Romania12 sites

  • CMI Dr. Bogdan Minescu, Braila

    Brăila, 810262

  • Emergency University Hospital, Bucharest

    Bucharest, 050098

  • ILRO Medical SRL, Bucharest

    Bucharest, 10628

  • Med.Centre Diagnosis,Treatm&Prev Med.Cardiol.Dept, Bucharest

    Bucharest, 11792

  • SC Titan Medical SRL, Bucharest

    Bucharest, 21323

  • Humanitas Medical Center, Bucharest

    Bucharest, 62272

  • SC Cardiomed SRL, Cluj Napoca

    Cluj-Napoca, 400015

  • SC Cardiomed SRL, Constanta

    Constanța, 900704

  • S.C Cardiomed S.R.L

    Craiova, 200147

  • SC Cardiomed SRL, Iasi

    Iași, 700034

  • Galenus Medical Center, Targu Mures

    Târgu Mureş, 540099

  • Medicorclinics, Timisoara

    Timișoara, 300014

Other trials in Romania

Portugal11 sites

  • Hospital Garcia de Orta, EPE

    Almada, 2805-267

  • CHLO, EPE - Hospital de Santa Cruz

    Carnaxide, 2799-523

  • Centro Hospitalar da Cova da Beira Hospital Pêro da Covilhã

    Covilha, 6200-251

  • Hospital do Espírito Santo, EPE

    Evora, 7000-811

  • Centro Hospitalar Algarve, EPE

    Faro, 8000-386

  • CHULN, EPE - Hospital de Santa Maria

    Lisbon, 1064-035

  • CHLO, EPE - Hospital S. Francisco Xavier

    Lisbon, 1449-005

  • Hospital da Luz

    Lisbon, 1500-650

  • CHULN, EPE - Hospital de Santa Maria

    Lisbon, 1649-035

  • Centro Hospitalar Universitário São João,EPE

    Porto, 4202-451

  • Hospital de Santiago

    Setúbal, 2900-722

Other trials in Portugal

Croatia10 sites

  • Magdalena-Special Hosp.f.Cardiovas.Surgery,Krapinske Toplice

    Krapinske Toplice, 49217

  • Thalassoterapia,Rehab.of heart&lung,Cardiology Clin, Opatija

    Opatija, 51410

  • Clinical Hospital Split

    Split, 21000

  • General Hosp. Zadar, Clinic of Internal Med, Cardiology Dept

    Zadar, 23 000

  • Clinical Hosp.Merkur,Clin.Internal Med,Cardiology Dep,Zagreb

    Zagreb, 10 000

  • Polyclinic St. Luke, Cardiology Dept., Zagreb

    Zagreb, 10 000

  • Univ. Hosp. Sisters of Mercy, Cardiology Dept., Zagreb

    Zagreb, 10 000

  • University hospital center Zagreb

    Zagreb, 10 000

  • Univ. Hosp. Sisters of Mercy, Neurology Clinic, Zagreb

    Zagreb, 100 00

  • University hospital center Zagreb

    Zagreb, 10000

Other trials in Croatia

Belgium9 sites

  • Namur - HOSP St-Luc de Bouge

    Bouge/Namur, 5004

  • AZ Sint-Lucas

    Bruges, 8310

  • Brussels - HOSP St-Jan

    Brussels, 1000

  • ULB Hopital Erasme

    Brussels, 1070

  • Brussels - HOSP Europe (Ste-Elisabeth)

    Brussels, 1180

  • Ziekenhuis Oost-Limburg - Campus Sint-Jan

    Genk, 3600

  • Liège - HOSP CHR de la Citadelle

    Liège, 4000

  • Ottignies - HOSP St-Pierre

    Ottignies, 1340

  • Tienen - PRAC De Wolf, Luc

    Tienen, 3300

Other trials in Belgium

Norway8 sites

  • Legegruppen Arendal

    Arendal, N-4836

  • Vestre Viken HF, Bærum sykehus

    Drammen, N-3004

  • Medisinsk Senter Fornebu DA

    Fornebu, N-1364

  • Vestre Viken, Ringerike Sykehus HF

    Hønefoss, N-3511

  • Sykehuset Innlandet HF, Kongsvinger

    Kongsvinger, N-2212

  • Sykehuset Innlandet HF, Avd. Lillehammer

    Lillehammer, N-2629

  • Volvat Medisinske senter, Oslo

    Oslo, N-0370

  • Universitetssykehuset Nord-Norge, Tromsø

    Tromsø, N-9038

Other trials in Norway

Sweden7 sites

  • Falu lasarett

    Falun, 791 82

  • Sahlgrenska Universitetssjukhuset, Östra

    Gothenburg, 416 85

  • Skånes universitetssjukhus, Malmö

    Malmö, 205 02

  • Stockholm Heart Center AB

    Stockholm, 111 35

  • Danderyds Sjukhus

    Stockholm, 182 88

  • Norrlands Universitetssjukhus

    Umeå, 901 85

  • Centrallasarettet, Västerås

    Västerås, 721 89

Other trials in Sweden

Austria6 sites

  • Klinik Pirawarth, Therapie und Rehabilitation, Bad Pirawarth

    Bad Pirawarth, 2222

  • KH der Barmherzigen Schwestern Linz

    Linz, 4010

  • Kepler Univ. Klinikum Linz

    Linz, 4021

  • Ordination Dr. Martin Koschutnik, Oberwart

    Oberwart, 7400

  • KH d. Barmherzigen Brüder Wien, Neurologie

    Vienna, 1020

  • AKH - Medical University of Vienna

    Vienna, 1090

Other trials in Austria

Czechia6 sites

  • Cardiology Private Practice, Brno

    Brno, 61600

  • University Hospital Brno

    Brno, 625 00

  • Cardiocentrum, Private Practice, Kladno

    Kladno, 272 80

  • Cardiology Private Practice

    Litovel, 784 01

  • Cardiology Private Practice, Praha

    Prague, 15005

  • Cardiology Private Practice, Roznov pod Radhostem

    Rožnov pod Radhoštěm, 756 61

Other trials in Czechia

Denmark6 sites

  • Forskningens Hus

    Aalborg, 9000

  • Sydvestjysk Sygehus Esbjerg, Hjertemedicinsk afd.

    Esbjerg, 6700

  • Herlev and Gentofte Hospital

    Herlev, 2730

  • Nordsjællands Hospital - Hillerød

    Hillerød, 3400

  • Kolding Sygehus

    Kolding, 6000

  • Odense University Hospital

    Odense, 5000

Other trials in Denmark

Ireland5 sites

  • Portiuncula Hospital

    Ballinasloe, H53 T971

  • Adelaide & Meath Hospital

    Dublin, 24

  • St James's Hospital

    Dublin, Dublin 8

  • University Hospital Galway

    Galway, GALWAY

  • The Redhouse Family Practice

    Mallow

Other trials in Ireland

Latvia3 sites

  • Liepaja Regional Hospital, Therapy Department

    Liepāja, 3414

  • P.Stradins Clin.Univ.Hosp,Cardio.Diagnos&Outpatient Dep,Riga

    Riga, 1002

  • Riga East University Hospital

    Riga, 1038

Other trials in Latvia

Estonia2 sites

  • East Tallinn Central Hospital

    Tallinn, 10138

  • North Estonia Med.Centre,Internal Med.Clin/Cardiology,Tallin

    Tallinn, 134 19

Other trials in Estonia

Slovenia2 sites

  • General Hospital Celje

    Celje, 3000

  • Univ. Medical Centre Ljubljana, Dept. of Vascular Diseases

    Ljubljana, 1000

Other trials in Slovenia

About this study

Official title: GLORIA - AF: Global Registry on Long-Term Oral Anti-thrombotic TReatment In PAtients With Atrial Fibrillation (Phase II/III - EU/EEA Member States)

In this part of the Registry Program patients with non-valvular atrial fibrillation (AF) at risk for stroke are enrolled to characterize the target population and to collect real world data on important outcome events. For administrative purposes the study is divided into two protocol numbers: 1160.129 for non-EU (European Union) and non-EEA (European Economic Area) countries, and 1160.136 for EU and EEA countries. The total number of patients enrolled in both protocols is estimated to be 48,000 patients, and all these patients will be included in the data analysis for study 1160.129.

Medical subject headings
Stroke, Atrial Fibrillation

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Incidence Rate of Composite Outcome (Stroke, Systemic Embolism, Myocardial Infarction, Life-threatening Bleeding Events and Vascular Death)

    Incidence rate of composite outcome which includes events of Stroke, systemic embolism, myocardial infarction, life-threatening bleeding events and vascular death on restricted set that included Dabigatran etexilate (DE) and Vitamin K Antagonist (VKA) only. In case of multiple events for a patient, the first event was considered. Unknown death was imputed by multiple imputation. The average of the 20 incidence rates from the 20 imputed datasets were used to obtain the point estimate of the incidence rate that is reported here. The bootstrapping approach was used to obtain the 95% confidence interval of the incidence rate.

    Measured: From baseline visit until end of initial treatment regimen episode (minimum date of permanent stop of DE + 3 days/ VKA+ 6 days, start date of other treatments - 1 day, and date of study completion/discontinuation), up to 3 years.

  2. Incidence Rate of Vascular Composite Outcome (Stroke, Systemic Embolism, Myocardial Infarction and Vascular Death)

    Incidence rate of vascular composite outcome including events of stroke, systemic embolism, myocardial infarction and vascular death on restricted set that included Dabigatran etexilate (DE) and Vitamin K Antagonist (VKA) only. In case of multiple events for a patient, the first event was considered. Unknown death was imputed by multiple imputation. The average of the 20 incidence rates from the 20 imputed datasets were used to obtain the point estimate of the incidence rate that is reported here. The bootstrapping approach was used to obtain the 95% confidence interval of the incidence rate.

    Measured: From baseline visit until end of initial treatment regimen episode (minimum date of permanent stop of DE + 3 days/ VKA+ 6 days, start date of other treatments - 1 day, and date of study completion/discontinuation), up to 3 years.

  3. Incidence Rate of Stroke or Systemic Embolism

    Incidence rate of stroke or systemic embolism on restricted set that included Dabigatran etexilate (DE) and Vitamin K Antagonist (VKA) only.

    Measured: From baseline visit until end of initial treatment regimen episode (minimum date of permanent stop of DE + 3 days/ VKA+ 6 days, start date of other treatments - 1 day, and date of study completion/discontinuation), up to 3 years.

  4. Incidence Rate of Stroke

    Incidence rate of stroke on restricted set that included Dabigatran etexilate (DE) and Vitamin K Antagonist (VKA) only. Stroke is an acute onset of a focal neurological deficit of presumed vascular origin lasting for 24 hours or more or resulting in death. The stroke included ischemic or hemorrhagic or uncertain classification.

    Measured: From baseline visit until end of initial treatment regimen episode (minimum date of permanent stop of DE + 3 days/ VKA+ 6 days, start date of other treatments - 1 day, and date of study completion/discontinuation), up to 3 years.

  5. Incidence Rate of Transient Ischaemic Attack (TIA)

    Incidence rate of transient ischaemic attack (TIA) on restricted set that included Dabigatran etexilate (DE) and Vitamin K Antagonist (VKA) only.

    Measured: From baseline visit until end of initial treatment regimen episode (minimum date of permanent stop of DE + 3 days/ VKA+ 6 days, start date of other treatments - 1 day, and date of study completion/discontinuation), up to 3 years.

  6. Incidence Rate of Systemic Embolism (SEE)

    Incidence rate of systemic embolism (SEE) on restricted set that included Dabigatran etexilate (DE) and Vitamin K Antagonist (VKA) only.

    Measured: From baseline visit until end of initial treatment regimen episode (minimum date of permanent stop of DE + 3 days/ VKA+ 6 days, start date of other treatments - 1 day, and date of study completion/discontinuation), up to 3 years.

  7. Incidence Rate of Pulmonary Embolism (PE)

    Incidence rate of pulmonary embolism (PE) on restricted set that included Dabigatran etexilate (DE) and Vitamin K Antagonist (VKA) only.

    Measured: From baseline visit until end of initial treatment regimen episode (minimum date of permanent stop of DE + 3 days/ VKA+ 6 days, start date of other treatments - 1 day, and date of study completion/discontinuation), up to 3 years.

  8. Incidence Rate of Major Bleeding Events

    Incidence rate of major bleeding events on restricted set that included Dabigatran etexilate (DE) and Vitamin K Antagonist (VKA) only. Major bleeding was defined as meeting one or more of the following criteria: Overt bleeding associated with a reduction in haemoglobin of at least 20 grams per liter or leading to a transfusion of at least 2 units of blood or packed cells; Symptomatic bleeding in a critical area or organ: Intraocular, intracranial, intraspinal or intramuscular with compartment syndrome, retroperitoneal bleeding, intra-articular bleeding or pericardial bleeding; Life-threatening bleeding.

    Measured: From baseline visit until end of initial treatment regimen episode (minimum date of permanent stop of DE + 3 days/ VKA+ 6 days, start date of other treatments - 1 day, and date of study completion/discontinuation), up to 3 years.

  9. Incidence Rate of Life-threatening Bleeding Events

    Incidence rate of life-threatening bleeding events on restricted set that included Dabigatran etexilate (DE) and Vitamin K Antagonist (VKA) only. Life-threatening bleeding was defined as meeting one or more of the following criteria: Symptomatic intracranial bleed; Reduction in haemoglobin of at least 50 grams per liter; Transfusion of at least 4 units of blood or packed cells, associated with hypotension requiring the use of intravenous inotropic agents; Necessitated surgical intervention; Fatal bleeding.

    Measured: From baseline visit until end of initial treatment regimen episode (minimum date of permanent stop of DE + 3 days/ VKA+ 6 days, start date of other treatments - 1 day, and date of study completion/discontinuation), up to 3 years.

  10. Incidence Rate of Vascular Death

    Incidence rate of vascular death on restricted set that included Dabigatran etexilate (DE) and Vitamin K Antagonist (VKA) only.

    Measured: From baseline visit until end of initial treatment regimen episode (minimum date of permanent stop of DE + 3 days/ VKA+ 6 days, start date of other treatments - 1 day, and date of study completion/discontinuation), up to 3 years.

  11. Incidence Rate of Myocardial Infarction

    Incidence rate of myocardial infarction on restricted set that included Dabigatran etexilate (DE) and Vitamin K Antagonist (VKA) only.

    Measured: From baseline visit until end of initial treatment regimen episode (minimum date of permanent stop of DE + 3 days/ VKA+ 6 days, start date of other treatments - 1 day, and date of study completion/discontinuation), up to 3 years.

  12. Incidence Rate of All-cause Death

    Incidence rate of all-cause death on restricted set that included Dabigatran etexilate (DE) and Vitamin K Antagonist (VKA) only.

    Measured: From baseline visit until end of initial treatment regimen episode (minimum date of permanent stop of DE + 3 days/ VKA+ 6 days, start date of other treatments - 1 day, and date of study completion/discontinuation), up to 3 years.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted23 Aug 2012 (estimated)
  2. Study start22 Aug 2012
  3. Primary completion13 Dec 2019
  4. Study completion13 Dec 2019

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
10,471 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT01671007
Sponsor's protocol ID
1160.136
Status last verified
Dec 2020
First submitted
20 Aug 2012
Last updated
31 Dec 2020

Publications

  • Joddrell M, El-Bouri W, Harrison SL, Huisman MV, Lip GYH, Zheng Y; GLORIA-AFinvestigators. Machine learning for outcome prediction in patients with non-valvular atrial fibrillation from the GLORIA-AF registry. Sci Rep. 2024 Nov 7;14(1):27088. doi: 10.1038/s41598-024-78120-z.

    PubMed 39511367

  • Romiti GF, Corica B, Proietti M, Mei DA, Frydenlund J, Bisson A, Boriani G, Olshansky B, Chan YH, Huisman MV, Chao TF, Lip GYH; GLORIA-AF Investigators. Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry. EClinicalMedicine. 2023 Aug 25;63:102039. doi: 10.1016/j.eclinm.2023.102039. eCollection 2023 Sep.

    PubMed 37753446

  • Ding WY, Fawzy AM, Romiti GF, Proietti M, Pastori D, Huisman MV, Lip GYH; GLORIA-AF Investigators. Validating the predictive ability of the 2MACE score for major adverse cardiovascular events in patients with atrial fibrillation: results from phase II/III of the GLORIA-AF registry. J Thromb Thrombolysis. 2024 Jan;57(1):39-49. doi: 10.1007/s11239-023-02866-y. Epub 2023 Aug 11.

    PubMed 37566295

  • Ding WY, Lane DA, Gupta D, Huisman MV, Lip GYH; GLORIA-AF Investigators. Incidence and Risk Factors for Residual Adverse Events Despite Anticoagulation in Atrial Fibrillation: Results From Phase II/III of the GLORIA-AF Registry. J Am Heart Assoc. 2022 Aug 2;11(15):e026410. doi: 10.1161/JAHA.122.026410. Epub 2022 Jul 25.

    PubMed 35876418

  • Ding WY, Calvert P, Gupta D, Huisman MV, Lip GYH; GLORIA-AF Investigators. Impact of early ablation of atrial fibrillation on long-term outcomes: results from phase II/III of the GLORIA-AF registry. Clin Res Cardiol. 2022 Sep;111(9):1057-1068. doi: 10.1007/s00392-022-02022-1. Epub 2022 Apr 29.

    PubMed 35488127

  • Lip GYH, Kotalczyk A, Teutsch C, Diener HC, Dubner SJ, Halperin JL, Ma CS, Rothman KJ, Marler S, Gurusamy VK, Huisman MV; GLORIA-AF Investigators. Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry. Clin Res Cardiol. 2022 May;111(5):560-573. doi: 10.1007/s00392-022-01996-2. Epub 2022 Mar 16.

    PubMed 35294625

  • Huisman MV, Teutsch C, Lu S, Diener HC, Dubner SJ, Halperin JL, Ma CS, Rothman KJ, Lohmann R, Gurusamy VK, Bartels DB, Lip GYH; GLORIA-AF Investigators. Dabigatran versus vitamin K antagonists for atrial fibrillation in clinical practice: final outcomes from Phase III of the GLORIA-AF registry. Clin Res Cardiol. 2022 May;111(5):548-559. doi: 10.1007/s00392-021-01957-1. Epub 2022 Mar 16.

    PubMed 35294623

  • Bayer V, Kotalczyk A, Kea B, Teutsch C, Larsen P, Button D, Huisman MV, Lip GYH, Olshansky B. Global Oral Anticoagulation Use Varies by Region in Patients With Recent Diagnosis of Atrial Fibrillation: The GLORIA-AF Phase III Registry. J Am Heart Assoc. 2022 Mar 15;11(6):e023907. doi: 10.1161/JAHA.121.023907. Epub 2022 Mar 4.

    PubMed 35243870

  • Ntaios G, Huisman MV, Diener HC, Halperin JL, Teutsch C, Marler S, Gurusamy VK, Thompson M, Lip GYH, Olshansky B; GLORIA-AF Investigators. Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation: The GLORIA-AF registry. Hellenic J Cardiol. 2021 Mar-Apr;62(2):152-157. doi: 10.1016/j.hjc.2020.11.009. Epub 2020 Dec 15.

    PubMed 33338644

  • Huisman MV, Rothman KJ, Paquette M, Teutsch C, Diener HC, Dubner SJ, Halperin JL, Ma CS, Zint K, Elsaesser A, Lu S, Bartels DB, Lip GYH; GLORIA-AF Investigators. Two-year follow-up of patients treated with dabigatran for stroke prevention in atrial fibrillation: Global Registry on Long-Term Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF) registry. Am Heart J. 2018 Apr;198:55-63. doi: 10.1016/j.ahj.2017.08.018. Epub 2017 Aug 31.

    PubMed 29653649

  • Huisman MV, Lip GY, Diener HC, Dubner SJ, Halperin JL, Ma CS, Rothman KJ, Teutsch C, Zint K, Ackermann D, Clemens A, Bartels DB. Design and rationale of Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation: a global registry program on long-term oral antithrombotic treatment in patients with atrial fibrillation. Am Heart J. 2014 Mar;167(3):329-34. doi: 10.1016/j.ahj.2013.12.006. Epub 2013 Dec 19.

    PubMed 24576516

Questions about this trial

What is this clinical trial studying?

An observational study of Stroke and Atrial Fibrillation, run by Boehringer Ingelheim at 522 sites in 22 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 31 Dec 2020. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 522 sites in France, United Kingdom, Germany, Italy, Spain and 17 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

Yes. Results are posted in the registry (first posted 31 Dec 2020). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Incidence Rate of Composite Outcome (Stroke, Systemic Embolism, Myocardial Infarction, Life-threatening Bleeding Events and Vascular Death) (time frame: From baseline visit until end of initial treatment regimen episode (minimum date of permanent stop of DE + 3 days/ VKA+ 6 days, start date of other treatments - 1 day, and date of study completion/discontinuation), up to 3 years.). The study lists 12 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT01671007, which also lists 11 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Dec 2020.

AzTrials uses cookies for analytics and advertising. You can accept or reject them; the site works either way. Privacy Policy.

Free account

Keep searching with a free account

You’ve used your 3 free searches for this session. Log in or create a free AzTrials account to keep searching clinical trials and save the ones you want to follow.

Create a free accountLog in
Clinical Trial NCT01671007 | AzTrials