Effects of Strength Training in Older AdultsNCT01707017
The Effects of Low- and High-intensity Resistance Exercise on Force-velocity Characteristics in Older Adults
A study testing Strength training in people with Effects of Strength Training in Older Adults, run by Universitaire Ziekenhuizen KU Leuven at 1 site in Belgium.
Trial summary
The purpose of this study is to compare the impact of high- and low-intensity resistance exercise on force-velocity characteristics, muscle mass and inflammatory processes in older adults. As all training protocols are designed to end with maximal effort, effects are expected to be similar between groups. Read more about this study
- Who is it for?
- Ages 60 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Effects of Strength Training in Older Adults
- What is being tested?
- Strength training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 56 participants
- Where
- 1 siteBelgium
- Study dates
- Jan 2012to Dec 2012
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- age 60 to 80 years
Who cannot join
- Knee or hip prothesis
- Systematic training
- Cardiovascular disease
- Acute lower back pain
- Dementia
Trial locations and contacts
1 site in 1 country.
Belgium1 site
Faculty of Kinesiology and Rehabilitation Sciences
Leuven, Leuven, 3001
About this study
The purpose of this study is to compare the impact of high- and low-intensity resistance exercise on force-velocity characteristics, muscle mass and inflammatory processes in older adults. As all training protocols are designed to end with maximal effort, effects are expected to be similar between groups.
- Being tested
- Strength training
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Strength trainingOther
| Study group | Role | What they receive |
|---|---|---|
| High-load strength training | Active comparator | Not described Receives: Other: Strength training |
| Low-load strength training | Active comparator | Not described Receives: Other: Strength training |
| Low-load + moderate-load strength training | Active comparator | Not described Receives: Other: Strength training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in force-velocity characteristics of knee extensors
Measured: Baseline, 12weeks, 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Oct 2012 (estimated)
- Study startJan 2012
- Primary completionDec 2012
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Effects of Strength Training in Older AdultsStudies of the same condition, open and under way.
- More trials run by Universitaire Ziekenhuizen KU LeuvenThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 56 participants (actual)
Sponsor and investigators
- Lead sponsor
- Universitaire Ziekenhuizen KU Leuven
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01707017
- Sponsor's protocol ID
- S53709
- Status last verified
- Nov 2011
- First submitted
- 2 Oct 2012
- Last updated
- 20 Feb 2013
- Results posted
- No
Publications
Van Roie E, Walker S, Van Driessche S, Baggen R, Coudyzer W, Bautmans I, Delecluse C. Training load does not affect detraining's effect on muscle volume, muscle strength and functional capacity among older adults. Exp Gerontol. 2017 Nov;98:30-37. doi: 10.1016/j.exger.2017.07.017. Epub 2017 Aug 1.
PubMed 28778747Nuvagah Forti L, Van Roie E, Njemini R, Coudyzer W, Beyer I, Delecluse C, Bautmans I. High Versus Low Load Resistance Training: The Effect of 24 Weeks Detraining on Serum Brain Derived-Neurotrophic Factor (BDNF) in Older Adults. J Frailty Aging. 2017;6(1):53-58. doi: 10.14283/jfa.2017.2.
PubMed 28244559
Study at a glance
From the registry record, last updated by the sponsor on 20 Feb 2013. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effects of Low- and High-intensity Resistance Exercise on Force-velocity Characteristics in Older Adults
- ClinicalTrials.gov ID
- NCT01707017
- Acronym / sponsor ID
- S53709
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 56 participants (actual)
- Lead sponsor
- Universitaire Ziekenhuizen KU LeuvenUniversity, hospital or other
- Study start
- Jan 2012
- Primary completion
- Dec 2012 (actual)
- First posted
- 15 Oct 2012 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to compare the impact of high- and low-intensity resistance exercise on force-velocity characteristics, muscle mass and inflammatory processes in older adults. As all training protocols are designed to end with maximal effort, effects are expected to be similar between groups.
Study design
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| High-load strength training | Active comparator | Other: Strength training |
| Low-load strength training | Active comparator | Other: Strength training |
| Low-load + moderate-load strength training | Active comparator | Other: Strength training |
Who may qualify
- Ages
- 60 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- age 60 to 80 years
Key exclusion criteria (5 listed)
- Knee or hip prothesis
- Systematic training
- Cardiovascular disease
- Acute lower back pain
- Dementia
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Strength training | Other | High-load strength training, Low-load + moderate-load strength training, Low-load strength training |
Primary outcome
Change in force-velocity characteristics of knee extensors
Time frame: Baseline, 12weeks, 6 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Feb 2013.
- Derived from this study: PubMed 28778747Van Roie E, Walker S, Van Driessche S, Baggen R, Coudyzer W, Bautmans I, Delecluse C. Training load does not affect detraining's effect on muscle volume, muscle strength and functional capacity among older adults. Exp Gerontol. 2017 Nov;98:30-37. doi: 10.1016/j.exger.2017.07.017. Epub 2017 Aug 1.
- Derived from this study: PubMed 28244559Nuvagah Forti L, Van Roie E, Njemini R, Coudyzer W, Beyer I, Delecluse C, Bautmans I. High Versus Low Load Resistance Training: The Effect of 24 Weeks Detraining on Serum Brain Derived-Neurotrophic Factor (BDNF) in Older Adults. J Frailty Aging. 2017;6(1):53-58. doi: 10.14283/jfa.2017.2.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Strength training in people with Effects of Strength Training in Older Adults, run by Universitaire Ziekenhuizen KU Leuven at 1 site in Belgium.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Feb 2013. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Belgium. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in force-velocity characteristics of knee extensors (time frame: Baseline, 12weeks, 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT01707017, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Feb 2013.