SchizophreniaNCT01805128
Exploration of the Social Cognition in Adolescents With a Dissociative Disorder or Autism Spectrum
A study testing Facial recognition of emotions, understanding metaphors and Attribution of intentionality to others in social situations depending on the type of situation in people with Schizophrenia and Autistic Disorder, run by Centre Hospitalier Universitaire de Nice at 3 sites in France.
Trial summary
The schizophrenic disorders and pervasive developmental disorders are neurodevelopmental disorders distinct origin who share common challenges to engage and maintain social relationships and mutual disturbances of affective contact. Read more about this study
- Who is it for?
- Ages 12 to 18 yearsHealthy volunteers can take part
- Conditions the study is for
- Schizophrenia, Autistic Disorder
- What is being tested?
- Facial recognition of emotions, understanding metaphors and Attribution of intentionality to others in social situations depending on the type of situation
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 3 sitesFrance
- Study dates
- Jan 2013to May 2013
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 12 to 18 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- Child with a DSM-IV diagnosis of schizophrenia or autism spectrum disorder:
- Schizophrenic patients, positive to the award of psychosis section of the Kiddie SADS and having a negative ADI.
- or:
- Patients with autism spectrum disorder, diagnosed by the scale ADI (Autism Diagnostic Interview) or ADOS (Autism Diagnostic Observation Schedule): Autism Asperger and PDD nos. These patients do not respond to a diagnosis of psychosis Kiddie-SADS according.
- Total IQ greater than or equal to 70
Who cannot join
- Genetic disorders, neurological and neurosensory
- Child satisfy both the diagnosis of autism spectrum disorder and schizophrenia than (comorbidity).
- Will not be included patients who participate in a study on rehabilitation for social skills.
Trial locations and contacts
3 sites in 1 country.
France3 sites
Centre Hospitalier d'Antibes Juans les Pins
Antibes, 06600
Centre hospitalier de Cannes
Cannes, 06400
CHU de Nice
Nice, 06000
About this study
Official title: EXPLORATION OF THE SOCIAL COGNITION IN ADOLESCENTS WITH A Dissociative Disorder OR AUTISM SPECTRUM
The schizophrenic disorders and pervasive developmental disorders are neurodevelopmental disorders distinct origin who share common challenges to engage and maintain social relationships and mutual disturbances of affective contact. An important issue of research is to determine the cognitive and brain mechanisms underlying social disability in these two pathologies. Several lines of social cognition have been systematically explored: the perception of emotions, the ability to attribute intentionality and mental states to others (theory of mind), the understanding of social situations in different contexts. We made the observation today that research findings clearly in the field of autism and schizophrenic disorders that converge on common patterns neurocognitive abnormalities. Consequently, many programs support published today use the same therapeutic targets and the same tools in both pathologies. This raises two questions of science: (1) whether the disorders of social cognition reported in the field of autism and schizophrenia are "specific deficit" and not "specific condition", that is to say they are inherent social disadvantage whatever condition or (2) if these disorders of social cognition is a pattern common to autism and schizophrenia but are the result of specific neurocognitive mechanisms and different in each these pathologies. Systematic exploration of these issues is a current issue for understanding the pathophysiological borders between the two neurodevelopmental disorders but also to better define the potential targets of therapeutic strategies, psycho-educational and remediation of disorders of social cognition in autism and schizophrenia.
Main objective: To compare clinical cognitive profiles in adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition: perception of emotions, attribution of intentions to others (theory of mind) and style attribution. We shall constitute three population groups of patients, a group of patients meeting the diagnosis of schizophrenia, a group of patients with autism and a control group (healthy subjects).
Read the detailed description
The schizophrenic disorders and pervasive developmental disorders are neurodevelopmental disorders distinct origin who share common challenges to engage and maintain social relationships and mutual disturbances of affective contact. An important issue of research is to determine the cognitive and brain mechanisms underlying social disability in these two pathologies. Several lines of social cognition have been systematically explored: the perception of emotions, the ability to attribute intentionality and mental states to others (theory of mind), the understanding of social situations in different contexts. We made the observation today that research findings clearly in the field of autism and schizophrenic disorders that converge on common patterns neurocognitive abnormalities. Consequently, many programs support published today use the same therapeutic targets and the same tools in both pathologies. This raises two questions of science: (1) whether the disorders of social cognition reported in the field of autism and schizophrenia are "specific deficit" and not "specific condition", that is to say they are inherent social disadvantage whatever condition or (2) if these disorders of social cognition is a pattern common to autism and schizophrenia but are the result of specific neurocognitive mechanisms and different in each these pathologies. Systematic exploration of these issues is a current issue for understanding the pathophysiological borders between the two neurodevelopmental disorders but also to better define the potential targets of therapeutic strategies, psycho-educational and remediation of disorders of social cognition in autism and schizophrenia.
Main objective: To compare clinical cognitive profiles in adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition: perception of emotions, attribution of intentions to others (theory of mind) and style attribution. We shall constitute three population groups of patients, a group of patients meeting the diagnosis of schizophrenia, a group of patients with autism and a control group (healthy subjects).
Inclusion criteria: patients aged 12 to 18, with a verbal IQ greater than or equal to 70, a DSM-IV diagnosis of autism and / or schizophrenia.
Assessment instruments: (1) clinical assessment instruments using standardized structured interviews that have already shown good sensitivity in our preliminary studies (2) techniques neuro-social cognition scientifically validated by the expert group of the ANR we are partners.
The study of active files and preliminary results, we can estimate the population to 20 patients per group, a total of 60 patients.
The originality of this study focuses on the ability to compare two populations in the same field of social cognition in three dimensions, which hitherto have been explored separately in the literature. The expected results are a range of prevention and treatment of major psychiatric children and adolescents because they help define therapeutic targets specific to each population
- Conditions
- Schizophrenia, Autistic Disorder
- Being tested
- Facial recognition of emotions, understanding metaphors, Attribution of intentionality to others in social situations depending on the type of situation
- Keywords
- Schizophrenia, Autistic Disorder, social cognition
- Medical subject headings
- Schizophrenia, Autistic Disorder
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Facial recognition of emotionsOther
The purpose is to consider the recognition of emotions expressed on face in patients with a schizophrenic disorder, autism and in healthy subjects.
understanding metaphorsOther
Explore understanding of figurative language, including metaphor, in schizophrenic patients, autistic and healthy, and well understand how patients develop an interpretation from access to speaker's communicative intentionality (theory mind).
Attribution of intentionality to others in social situations depending on the type of situationOther
Compare the style of attribution of intentions in three populations of subjects: schizophrenic, autistic and healthy.
| Study group | Role | What they receive |
|---|---|---|
| schizophrenia | Experimental | child with a DSM-IV diagnosis of schizophrenia Receives: Other: Facial recognition of emotions; Other: understanding metaphors; Other: Attribution of intentionality to others in social situations depending on the type of situation |
| autism spectrum disorder | Experimental | child with a DSM-IV diagnosis of autism spectrum disorder Receives: Other: Facial recognition of emotions; Other: understanding metaphors; Other: Attribution of intentionality to others in social situations depending on the type of situation |
| Healthy | Experimental | child having no DSM-IV diagnosis of schizophrenia spectrum disorder or autism Receives: Other: Facial recognition of emotions; Other: understanding metaphors; Other: Attribution of intentionality to others in social situations depending on the type of situation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Compare cognitive profiles in clinical adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition
Compare cognitive profiles in clinical adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition: the perception of emotions, attribution of intentions to others (theory of mind) and style attribution.
We will study the brain evoked potentials during the execution of the task of facial emotion recognition.
Measured: First day
Secondary outcomes (2)
Compare the cognitive profiles within the clinical group of schizophrenic
Compare the cognitive profiles within the clinical group of schizophrenic patients, depending on the type of schizophrenia presented (as positive, negative or disorganized).
For the study of attribution of intentions to others: This is to test the understanding of metaphors patients. Three types of statements are presented: forward literals, metaphorical statements and statements incongruous; patients should judge the plausibility semantics of these sentences. We study the behavioral and electrophysiological data.
Measured: First day
Cognitive profiles compare clinical results between the different types of schizophrenia and autism patients.
Cognitive profiles compare clinical results between the different types of schizophrenia and autism patients.
Self-assessment in the form of a questionnaire with several social situations of everyday life. The subject must plan and assign intentionality to a character. We get scores dimensions studied.
Measured: First day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Mar 2013 (estimated)
- Study startJan 2013
- Primary completionApr 2013
- Study completionMay 2013
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for SchizophreniaStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire de NiceThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire de Nice
- Sponsor type
- University, hospital or other
- Collaborators
- Centre Hospitalier d'Antibes Juans les Pins, Centre Hospitalier de Cannes
- Responsible party
- Sponsor
- Investigators
- Emmanuelle DOR, Medical Doctor, Principal investigator, Centre Hospitalier Universitaire de Nice
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01805128
- Sponsor's protocol ID
- 12-AOI-04
- Status last verified
- Mar 2026
- First submitted
- 22 Feb 2013
- Last updated
- 31 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
Publications
Bonnard-Couton V, Lubrano S, Tosello AL, Serret S, Askenazy-Gittard F. [Autism spectrum disorders, a pilot parent-child unit]. Soins Pediatr Pueric. 2018 Nov-Dec;39(305):37-41. doi: 10.1016/j.spp.2018.09.010. French.
PubMed 30449399
Study at a glance
From the registry record, last updated by the sponsor on 31 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- EXPLORATION OF THE SOCIAL COGNITION IN ADOLESCENTS WITH A Dissociative Disorder OR AUTISM SPECTRUM
- ClinicalTrials.gov ID
- NCT01805128
- Acronym / sponsor ID
- 12-AOI-04
- Conditions
- Schizophrenia, Autistic Disorder
- Keywords
- Schizophrenia, Autistic Disorder, social cognition
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Centre Hospitalier Universitaire de NiceUniversity, hospital or other
- Collaborators
- Centre Hospitalier d'Antibes Juans les Pins, Centre Hospitalier de Cannes
- Study start
- Jan 2013
- Primary completion
- Apr 2013 (actual)
- Study completion
- May 2013 (actual)
- First posted
- 6 Mar 2013 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The schizophrenic disorders and pervasive developmental disorders are neurodevelopmental disorders distinct origin who share common challenges to engage and maintain social relationships and mutual disturbances of affective contact. An important issue of research is to determine the cognitive and brain mechanisms underlying social disability in these two pathologies. Several lines of social cognition have been systematically explored: the perception of emotions, the ability to attribute intentionality and mental states to others (theory of mind), the understanding of social situations in different contexts. We made the observation today that research findings clearly in the field of autism and schizophrenic disorders that converge on common patterns neurocognitive abnormalities. Consequently, many programs support published today use the same therapeutic targets and the same tools in both pathologies. This raises two questions of science: (1) whether the disorders of social cognition reported in the field of autism and schizophrenia are "specific deficit" and not "specific condition", that is to say they are inherent social disadvantage whatever condition or (2) if these disorders of social cognition is a pattern common to autism and schizophrenia but are the result of specific neurocognitive mechanisms and different in each these pathologies. Systematic exploration of these issues is a current issue for understanding the pathophysiological borders between the two neurodevelopmental disorders but also to better define the potential targets of therapeutic strategies, psycho-educational and remediation of disorders of social cognition in autism and schizophrenia.
Main objective: To compare clinical cognitive profiles in adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition: perception of emotions, attribution of intentions to others (theory of mind) and style attribution. We shall constitute three population groups of patients, a group of patients meeting the diagnosis of schizophrenia, a group of patients with autism and a control group (healthy subjects).
Detailed description
The schizophrenic disorders and pervasive developmental disorders are neurodevelopmental disorders distinct origin who share common challenges to engage and maintain social relationships and mutual disturbances of affective contact. An important issue of research is to determine the cognitive and brain mechanisms underlying social disability in these two pathologies. Several lines of social cognition have been systematically explored: the perception of emotions, the ability to attribute intentionality and mental states to others (theory of mind), the understanding of social situations in different contexts. We made the observation today that research findings clearly in the field of autism and schizophrenic disorders that converge on common patterns neurocognitive abnormalities. Consequently, many programs support published today use the same therapeutic targets and the same tools in both pathologies. This raises two questions of science: (1) whether the disorders of social cognition reported in the field of autism and schizophrenia are "specific deficit" and not "specific condition", that is to say they are inherent social disadvantage whatever condition or (2) if these disorders of social cognition is a pattern common to autism and schizophrenia but are the result of specific neurocognitive mechanisms and different in each these pathologies. Systematic exploration of these issues is a current issue for understanding the pathophysiological borders between the two neurodevelopmental disorders but also to better define the potential targets of therapeutic strategies, psycho-educational and remediation of disorders of social cognition in autism and schizophrenia.
Main objective: To compare clinical cognitive profiles in adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition: perception of emotions, attribution of intentions to others (theory of mind) and style attribution. We shall constitute three population groups of patients, a group of patients meeting the diagnosis of schizophrenia, a group of patients with autism and a control group (healthy subjects).
Inclusion criteria: patients aged 12 to 18, with a verbal IQ greater than or equal to 70, a DSM-IV diagnosis of autism and / or schizophrenia.
Assessment instruments: (1) clinical assessment instruments using standardized structured interviews that have already shown good sensitivity in our preliminary studies (2) techniques neuro-social cognition scientifically validated by the expert group of the ANR we are partners.
The study of active files and preliminary results, we can estimate the population to 20 patients per group, a total of 60 patients.
The originality of this study focuses on the ability to compare two populations in the same field of social cognition in three dimensions, which hitherto have been explored separately in the literature. The expected results are a range of prevention and treatment of major psychiatric children and adolescents because they help define therapeutic targets specific to each population
Study design
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| schizophrenia | Experimental | Other: Facial recognition of emotions, Other: understanding metaphors, Other: Attribution of intentionality to others in social situations depending on the type of situationchild with a DSM-IV diagnosis of schizophrenia |
| autism spectrum disorder | Experimental | Other: Facial recognition of emotions, Other: understanding metaphors, Other: Attribution of intentionality to others in social situations depending on the type of situationchild with a DSM-IV diagnosis of autism spectrum disorder |
| Healthy | Experimental | Other: Facial recognition of emotions, Other: understanding metaphors, Other: Attribution of intentionality to others in social situations depending on the type of situationchild having no DSM-IV diagnosis of schizophrenia spectrum disorder or autism |
Who may qualify
- Ages
- 12 to 18 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (5 listed)
- Child with a DSM-IV diagnosis of schizophrenia or autism spectrum disorder:
- Patients with autism spectrum disorder, diagnosed by the scale ADI (Autism Diagnostic Interview) or ADOS (Autism Diagnostic Observation Schedule): Autism Asperger and PDD nos. These patients do not respond to a diagnosis of psychosis Kiddie-SADS according.
Key exclusion criteria (3 listed)
- Genetic disorders, neurological and neurosensory
- Child satisfy both the diagnosis of autism spectrum disorder and schizophrenia than (comorbidity).
- Will not be included patients who participate in a study on rehabilitation for social skills.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Facial recognition of emotionsThe purpose is to consider the recognition of emotions expressed on face in patients with a schizophrenic disorder, autism and in healthy subjects. | Other | Healthy, autism spectrum disorder, schizophrenia |
| understanding metaphorsExplore understanding of figurative language, including metaphor, in schizophrenic patients, autistic and healthy, and well understand how patients develop an interpretation from access to speaker's communicative intentionality (theory mind). | Other | Healthy, autism spectrum disorder, schizophrenia |
| Attribution of intentionality to others in social situations depending on the type of situationCompare the style of attribution of intentions in three populations of subjects: schizophrenic, autistic and healthy. | Other | Healthy, autism spectrum disorder, schizophrenia |
Primary outcome
Compare cognitive profiles in clinical adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition
Time frame: First day
Compare cognitive profiles in clinical adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition: the perception of emotions, attribution of intentions to others (theory of mind) and style attribution. We will study the brain evoked potentials during the execution of the task of facial emotion recognition.
2 secondary outcomes
Compare the cognitive profiles within the clinical group of schizophrenic
Time frame: First day
Cognitive profiles compare clinical results between the different types of schizophrenia and autism patients.
Time frame: First day
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Mar 2026.
- Results publication: PubMed 30449399Bonnard-Couton V, Lubrano S, Tosello AL, Serret S, Askenazy-Gittard F. [Autism spectrum disorders, a pilot parent-child unit]. Soins Pediatr Pueric. 2018 Nov-Dec;39(305):37-41. doi: 10.1016/j.spp.2018.09.010. French.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Emmanuelle DOR, Medical Doctor principal investigator
Centre Hospitalier Universitaire de Nice
3 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Facial recognition of emotions, understanding metaphors and Attribution of intentionality to others in social situations depending on the type of situation in people with Schizophrenia and Autistic Disorder, run by Centre Hospitalier Universitaire de Nice at 3 sites in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 31 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 3 sites in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Compare cognitive profiles in clinical adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition (time frame: First day). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT01805128, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Mar 2026.