SmokingNCT01812278
Randomized Trial of Web-Delivered Acceptance Therapy for Smoking Cessation (WebQuit)
A study testing ACT and CBT in people with Smoking, run by Fred Hutchinson Cancer Center at 1 site in United States.
Trial summary
The goal of this study is to determine whether the ACT website provides higher quit rates than a current standard smoking cessation website. Read more about this study
- Who is it for?
- Ages 18 to 99 yearsHealthy volunteers can take part
- Conditions the study is for
- Smoking
- What is being tested?
- ACT and CBT
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 2,637 participants
- Where
- 1 siteUnited States
- Study dates
- 24 Mar 2014to 31 Dec 2019
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 99 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- age 18 or older
- smokes at least five cigarettes daily for at least past 12 months
- wants to quit in next 30 days
- willing to be randomly assigned to either group
- resides in US
- has at least weekly access to a high speed Internet connection and email
Show all 13Show fewer
- willing and able to read in English
- not participating in other smoking cessation interventions (including our other intervention studies
- has never used the Smokefree.gov website
- willing to complete all three follow-up surveys
- provide email, phone, and mailing address
- provide contact information for two collaterals (e.g., relatives).
- does not have family, friends, or other household members participating
Who cannot join
- The exclusion criteria are the opposite of the inclusion criteria above.
Trial locations and contacts
1 site in 1 country.
United States1 site
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109
About this study
Official title: Randomized Trial of Web-Delivered Acceptance Therapy for Smoking Cessation
The goal of this study is to determine whether the ACT website provides higher quit rates than a current standard smoking cessation website.
- Conditions
- Smoking
- Being tested
- ACT, CBT
- Medical subject headings
- Smoking
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ACTBehavioural
Also called Acceptance & Commitment Therapy
CBTBehavioural
Also called Cognitive Behavioral Therapy
| Study group | Role | What they receive |
|---|---|---|
| ACT | Experimental | Acceptance \& Commitment Therapy Receives: Behavioral: ACT |
| CBT | Active comparator | Cognitive Behavioral Therapy Receives: Behavioral: CBT |
What is being measured
The primary outcome is the main question the study is designed to answer.
30-day point prevalence abstinence
No smoking in the past 30 days, as reported 12 month post treatment.
Measured: 12 month post randomization
Secondary outcomes (1)
7-day, 24-hour, and 30-day point prevalence quit rates
12 months: 24-hour and 7-day point prevalence quit rates. 3 and 6 months: 24-hour, 7-day, and 30-day point prevalence quit rates. Across 3, 6, and 12 month timepoints, the repeated 30-day point prevalence abstinence.
Measured: 3 months, 6 months, and 12 months post treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Mar 2013 (estimated)
- Study start24 Mar 2014
- Primary completion26 Oct 2016
- Study completion31 Dec 2019
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for SmokingStudies of the same condition, open and under way.
- More trials run by Fred Hutchinson Cancer CenterThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 2,637 participants (actual)
Sponsor and investigators
- Lead sponsor
- Fred Hutchinson Cancer Center
- Sponsor type
- University, hospital or other
- Collaborators
- Kaiser Permanente, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Responsible party
- Sponsor
- Investigators
- Jonathan Bricker, Principal investigator, Fred Hutch/University of Washington Cancer Consortium
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01812278
- Sponsor's protocol ID
- 7859
- Other IDs
- NCI-2019-06975, R01CA166646
- Status last verified
- Dec 2019
- First submitted
- 14 Mar 2013
- Last updated
- 31 Jul 2020
- Results posted
- No
- Data monitoring committee
- No
Publications
Theodoulou A, Fanshawe TR, Leavens E, Theodoulou E, Wu AD, Heath L, Stewart C, Nollen N, Ahluwalia JS, Butler AR, Hajizadeh A, Thomas J, Lindson N, Hartmann-Boyce J. Differences in the effectiveness of individual-level smoking cessation interventions by socioeconomic status. Cochrane Database Syst Rev. 2025 Jan 27;1(1):CD015120. doi: 10.1002/14651858.CD015120.pub2.
PubMed 39868569Santiago-Torres M, Kwon DM, Mull KE, Sullivan BM, Ahluwalia JS, Alexander AC, Nollen NL, Bricker JB. Efficacy of Web-Delivered Acceptance and Commitment Therapy (ACT) for Helping Black Adults Quit Smoking. J Racial Ethn Health Disparities. 2023 Dec;10(6):2816-2825. doi: 10.1007/s40615-022-01458-5. Epub 2022 Nov 21.
PubMed 36414931Jackson S, Brown J, Norris E, Livingstone-Banks J, Hayes E, Lindson N. Mindfulness for smoking cessation. Cochrane Database Syst Rev. 2022 Apr 14;4(4):CD013696. doi: 10.1002/14651858.CD013696.pub2.
PubMed 35420700Watson NL, Heffner JL, Mull KE, McClure JB, Bricker JB. Comparing Treatment Acceptability and 12-Month Cessation Rates in Response to Web-Based Smoking Interventions Among Smokers Who Do and Do Not Screen Positive for Affective Disorders: Secondary Analysis. J Med Internet Res. 2019 Jun 19;21(6):e13500. doi: 10.2196/13500.
PubMed 31219052Watson NL, Mull KE, Heffner JL, McClure JB, Bricker JB. Participant Recruitment and Retention in Remote eHealth Intervention Trials: Methods and Lessons Learned From a Large Randomized Controlled Trial of Two Web-Based Smoking Interventions. J Med Internet Res. 2018 Aug 24;20(8):e10351. doi: 10.2196/10351.
PubMed 30143479Bricker JB, Sridharan V, Zhu Y, Mull KE, Heffner JL, Watson NL, McClure JB, Di C. Trajectories of 12-Month Usage Patterns for Two Smoking Cessation Websites: Exploring How Users Engage Over Time. J Med Internet Res. 2018 Apr 20;20(4):e10143. doi: 10.2196/10143.
PubMed 29678799
Study at a glance
From the registry record, last updated by the sponsor on 31 Jul 2020. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Randomized Trial of Web-Delivered Acceptance Therapy for Smoking Cessation
- ClinicalTrials.gov ID
- NCT01812278
- Acronym / sponsor ID
- 7859
- Conditions
- Smoking
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 2,637 participants (actual)
- Lead sponsor
- Fred Hutchinson Cancer CenterUniversity, hospital or other
- Collaborators
- Kaiser Permanente, National Cancer Institute (NCI), National Institutes of Health (NIH)
- Study start
- 24 Mar 2014 (actual)
- Primary completion
- 26 Oct 2016 (actual)
- Study completion
- 31 Dec 2019 (actual)
- First posted
- 18 Mar 2013 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this study is to determine whether the ACT website provides higher quit rates than a current standard smoking cessation website.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| ACT | Experimental | Behavioral: ACTAcceptance \& Commitment Therapy |
| CBT | Active comparator | Behavioral: CBTCognitive Behavioral Therapy |
Who may qualify
- Ages
- 18 to 99 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (13 listed)
- age 18 or older
- smokes at least five cigarettes daily for at least past 12 months
- wants to quit in next 30 days
- willing to be randomly assigned to either group
- resides in US
Key exclusion criteria (1 listed)
- The exclusion criteria are the opposite of the inclusion criteria above.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ACTAlso: Acceptance & Commitment Therapy | Behavioural | ACT |
| CBTAlso: Cognitive Behavioral Therapy | Behavioural | CBT |
Primary outcome
30-day point prevalence abstinence
Time frame: 12 month post randomization
No smoking in the past 30 days, as reported 12 month post treatment.
1 secondary outcome
7-day, 24-hour, and 30-day point prevalence quit rates
Time frame: 3 months, 6 months, and 12 months post treatment
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Jul 2020.
- Derived from this study: PubMed 39868569Theodoulou A, Fanshawe TR, Leavens E, Theodoulou E, Wu AD, Heath L, Stewart C, Nollen N, Ahluwalia JS, Butler AR, Hajizadeh A, Thomas J, Lindson N, Hartmann-Boyce J. Differences in the effectiveness of individual-level smoking cessation interventions by socioeconomic status. Cochrane Database Syst Rev. 2025 Jan 27;1(1):CD015120. doi: 10.1002/14651858.CD015120.pub2.
- Derived from this study: PubMed 36414931Santiago-Torres M, Kwon DM, Mull KE, Sullivan BM, Ahluwalia JS, Alexander AC, Nollen NL, Bricker JB. Efficacy of Web-Delivered Acceptance and Commitment Therapy (ACT) for Helping Black Adults Quit Smoking. J Racial Ethn Health Disparities. 2023 Dec;10(6):2816-2825. doi: 10.1007/s40615-022-01458-5. Epub 2022 Nov 21.
- Derived from this study: PubMed 35420700Jackson S, Brown J, Norris E, Livingstone-Banks J, Hayes E, Lindson N. Mindfulness for smoking cessation. Cochrane Database Syst Rev. 2022 Apr 14;4(4):CD013696. doi: 10.1002/14651858.CD013696.pub2.
- Derived from this study: PubMed 31219052Watson NL, Heffner JL, Mull KE, McClure JB, Bricker JB. Comparing Treatment Acceptability and 12-Month Cessation Rates in Response to Web-Based Smoking Interventions Among Smokers Who Do and Do Not Screen Positive for Affective Disorders: Secondary Analysis. J Med Internet Res. 2019 Jun 19;21(6):e13500. doi: 10.2196/13500.
- Derived from this study: PubMed 30143479Watson NL, Mull KE, Heffner JL, McClure JB, Bricker JB. Participant Recruitment and Retention in Remote eHealth Intervention Trials: Methods and Lessons Learned From a Large Randomized Controlled Trial of Two Web-Based Smoking Interventions. J Med Internet Res. 2018 Aug 24;20(8):e10351. doi: 10.2196/10351.
- Derived from this study: PubMed 29678799Bricker JB, Sridharan V, Zhu Y, Mull KE, Heffner JL, Watson NL, McClure JB, Di C. Trajectories of 12-Month Usage Patterns for Two Smoking Cessation Websites: Exploring How Users Engage Over Time. J Med Internet Res. 2018 Apr 20;20(4):e10143. doi: 10.2196/10143.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jonathan Bricker principal investigator
Fred Hutch/University of Washington Cancer Consortium
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing ACT and CBT in people with Smoking, run by Fred Hutchinson Cancer Center at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 13 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 31 Jul 2020. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
30-day point prevalence abstinence (time frame: 12 month post randomization). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT01812278, which also lists 6 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Jul 2020.