Health BehaviorNCT01875146
Effects of High-intensity Interval Training in Combination With Side-alternating Whole-body Vibration
A study testing 4x4 min HIT, 4x4 min HIT + WBV (18 Hz) and 4x4 min HIT + (30 Hz) in people with Health Behavior, run by University of Zurich at 1 site in Switzerland.
Trial summary
Investigation of the training effects following 8 weeks of high-intensity interval training (HIT)in combination with side-alternating whole-body vibration compared to conventional HIT or side-alternating whole-body vibration. The adaptations are investigated on a molecular (muscle biopsy of the M. Read more about this study
- Who is it for?
- Ages 18 to 35 years, men only
- Conditions the study is for
- Health Behavior
- What is being tested?
- 4x4 min HIT, 4x4 min HIT + WBV (18 Hz) and 4x4 min HIT + (30 Hz)
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 33 participants
- Where
- 1 siteSwitzerland
- Study dates
- Jan 2013to Dec 2013
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- Men only
- No healthy volunteers
- Adult
Who may be able to join
- no fever / no common cold at the beginning of the study
- between 18 and 35 years of age
- non-smoker
- no known cardiovascular or orthopedic problems
- no cardiac pacemaker
- fullfills healts questionnaire's requirements
Who cannot join
- fever / common cold at beginning of study
- age under 18 oder above 35y
- smoker
- cardiovascular or orthopedic problems
- cardiac pacemaker
- does not fullfill health questionnaire's requirements
Trial locations and contacts
1 site in 1 country.
Switzerland1 site
University Hospital Zurich, Division of Neurology
Zurich, Canton of Zurich, 8091
About this study
Investigation of the training effects following 8 weeks of high-intensity interval training (HIT)in combination with side-alternating whole-body vibration compared to conventional HIT or side-alternating whole-body vibration. The adaptations are investigated on a molecular (muscle biopsy of the M. vastus lateralis) and systemic (e.g. cycling, jumping mechanography, dynamometry) level. In addition, the acute effects of the first and last training session will be investigated on a molecular (e.g. satellite cell activation, mRNA abundance) and systemic (e.g. ventilatory ga exchange, heart rate, rating of perceived exertion) level.
- Conditions
- Health Behavior
- Being tested
- 4x4 min HIT, 4x4 min HIT + WBV (18 Hz), 4x4 min HIT + (30 Hz), whole-body vibration at 30 Hz
- Medical subject headings
- Health Behavior
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
4x4 min HITOther
Conventional 4x4 min high-intensity interval training
4x4 min HIT + WBV (18 Hz)Other
4x4 min high-intensity interval training in combination with whole-body vibration at 18 Hz during the active rest
4x4 min HIT + (30 Hz)Other
4x4 min high-intensity interval training in combination with whole-body vibration at 30 Hz during the active rest
whole-body vibration at 30 HzOther
4x3 min whole-body vibration at 30 Hz
| Study group | Role | What they receive |
|---|---|---|
| 4x4 min HIT | Active comparator | Conventional 4x4 min high-intensity interval training Receives: Other: 4x4 min HIT |
| 4x4 min HIT + WBV (18 Hz) | Experimental | 4x4 min high-intensity interval training in combination with whole-body vibration at 18 Hz during the active rest Receives: Other: 4x4 min HIT + WBV (18 Hz) |
| 4x4 min HIT + WBV (30 Hz) | Experimental | 4x4 min high-intensity interval training in combination with whole-body vibration at 30 Hz during the active rest Receives: Other: 4x4 min HIT + (30 Hz) |
| whole-body vibration at 30 Hz | Active comparator | 4x3 min whole-body vibration at 30 Hz Receives: Other: whole-body vibration at 30 Hz |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change from baseline in Critical Power
The differences in changes in Critical Power [Watts] are compared between the 4 training groups. For this purpose, participants complete before and after the training intervention an incremental cycling ramp test and 4 cycling constant-load tests.
Measured: 8 weeks intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Jun 2013 (estimated)
- Study startJan 2013
- Primary completionDec 2013
- Study completionDec 2013
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Health BehaviorStudies of the same condition, open and under way.
- More trials run by University of ZurichThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 33 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Zurich
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Hans H Jung, Prof MD, Principal investigator, University Hospital Zurich, Division of Neurology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01875146
- Sponsor's protocol ID
- vyc
- Status last verified
- Dec 2013
- First submitted
- 16 May 2013
- Last updated
- 7 Jan 2014
- Results posted
- No
Publications
Mueller SM, Aguayo D, Zuercher M, Fleischmann O, Boutellier U, Auer M, Jung HH, Toigo M. High-intensity interval training with vibration as rest intervals attenuates fiber atrophy and prevents decreases in anaerobic performance. PLoS One. 2015 Feb 13;10(2):e0116764. doi: 10.1371/journal.pone.0116764. eCollection 2015.
PubMed 25679998
Study at a glance
From the registry record, last updated by the sponsor on 7 Jan 2014. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of High-intensity Interval Training in Combination With Side-alternating Whole-body Vibration
- ClinicalTrials.gov ID
- NCT01875146
- Acronym / sponsor ID
- vyc
- Conditions
- Health Behavior
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 33 participants (actual)
- Lead sponsor
- University of ZurichUniversity, hospital or other
- Study start
- Jan 2013
- Primary completion
- Dec 2013 (actual)
- Study completion
- Dec 2013 (actual)
- First posted
- 11 Jun 2013 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Investigation of the training effects following 8 weeks of high-intensity interval training (HIT)in combination with side-alternating whole-body vibration compared to conventional HIT or side-alternating whole-body vibration. The adaptations are investigated on a molecular (muscle biopsy of the M. vastus lateralis) and systemic (e.g. cycling, jumping mechanography, dynamometry) level. In addition, the acute effects of the first and last training session will be investigated on a molecular (e.g. satellite cell activation, mRNA abundance) and systemic (e.g. ventilatory ga exchange, heart rate, rating of perceived exertion) level.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| 4x4 min HIT | Active comparator | Other: 4x4 min HITConventional 4x4 min high-intensity interval training |
| 4x4 min HIT + WBV (18 Hz) | Experimental | Other: 4x4 min HIT + WBV (18 Hz)4x4 min high-intensity interval training in combination with whole-body vibration at 18 Hz during the active rest |
| 4x4 min HIT + WBV (30 Hz) | Experimental | Other: 4x4 min HIT + (30 Hz)4x4 min high-intensity interval training in combination with whole-body vibration at 30 Hz during the active rest |
| whole-body vibration at 30 Hz | Active comparator | Other: whole-body vibration at 30 Hz4x3 min whole-body vibration at 30 Hz |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- no fever / no common cold at the beginning of the study
- between 18 and 35 years of age
- non-smoker
- no known cardiovascular or orthopedic problems
- no cardiac pacemaker
Key exclusion criteria (6 listed)
- fever / common cold at beginning of study
- age under 18 oder above 35y
- smoker
- cardiovascular or orthopedic problems
- cardiac pacemaker
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| 4x4 min HITConventional 4x4 min high-intensity interval training | Other | 4x4 min HIT |
| 4x4 min HIT + WBV (18 Hz)4x4 min high-intensity interval training in combination with whole-body vibration at 18 Hz during the active rest | Other | 4x4 min HIT + WBV (18 Hz) |
| 4x4 min HIT + (30 Hz)4x4 min high-intensity interval training in combination with whole-body vibration at 30 Hz during the active rest | Other | 4x4 min HIT + WBV (30 Hz) |
| whole-body vibration at 30 Hz4x3 min whole-body vibration at 30 Hz | Other | whole-body vibration at 30 Hz |
Primary outcome
Change from baseline in Critical Power
Time frame: 8 weeks intervention
The differences in changes in Critical Power [Watts] are compared between the 4 training groups. For this purpose, participants complete before and after the training intervention an incremental cycling ramp test and 4 cycling constant-load tests.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jan 2014.
- Derived from this study: PubMed 25679998Mueller SM, Aguayo D, Zuercher M, Fleischmann O, Boutellier U, Auer M, Jung HH, Toigo M. High-intensity interval training with vibration as rest intervals attenuates fiber atrophy and prevents decreases in anaerobic performance. PLoS One. 2015 Feb 13;10(2):e0116764. doi: 10.1371/journal.pone.0116764. eCollection 2015.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Hans H Jung, Prof MD principal investigator
University Hospital Zurich, Division of Neurology
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing 4x4 min HIT, 4x4 min HIT + WBV (18 Hz) and 4x4 min HIT + (30 Hz) in people with Health Behavior, run by University of Zurich at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 7 Jan 2014. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change from baseline in Critical Power (time frame: 8 weeks intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT01875146, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jan 2014.