AzTrials
AzTrials

Borderline Personality DisorderMOTRNCT01896024

Effects of Motive-Oriented Therapeutic Relationship in the Early-Phase Treatment of Borderline Personality Disorder

A study testing Psychiatric Management and Motive-oriented therapeutic relationship/Plan Analysis in people with Borderline Personality Disorder, run by University of Lausanne Hospitals at 1 site in Switzerland.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
Search all trials

Trial summary

The present research aims at examining the effectiveness of a specific set of therapist relational interventions and attitudes, called the Motive-Oriented Therapeutic Relationship (MOTR), based on Plan Analysis (Caspar, 2007) in the early-phase treatment of patients diagnosed with Borderline Personality Disorder. Read more about this study

Who is it for?
Ages 18 to 65 years
Conditions the study is for
Borderline Personality Disorder
What is being tested?
Psychiatric Management and Motive-oriented therapeutic relationship/Plan Analysis
Could I receive a placebo?
No, everyone receives an active treatment
How many people
85 participants
Where
1 siteSwitzerland
Study dates
Jun 2010to Apr 2014
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 65 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • DSM-IV Borderline Personality Disorder;
  • between 18 and 65 yrs of age

Who cannot join

  • DSM-IV psychotic disorders,
  • mental retardation,
  • substance abuse in the forefront

Trial locations and contacts

1 site in 1 country.

Switzerland1 site

  • Department of Psychiatry-CHUV, University of Lausanne

    Lausanne, Canton of Vaud, 1004

Other trials in Switzerland

About this study

The present research aims at examining the effectiveness of a specific set of therapist relational interventions and attitudes, called the Motive-Oriented Therapeutic Relationship (MOTR), based on Plan Analysis (Caspar, 2007) in the early-phase treatment of patients diagnosed with Borderline Personality Disorder.

The investigators intend to include N = 80 outpatients diagnosed with Borderline Personality Disorder, consulting at the Outpatient Personality Disorder Program of the Karl Jaspers Clinical Unit, in collaboration with the Institute of Psychotherapy, at the Department of Psychiatry-CHUV, University of Lausanne and in collaboration with the University of Berne, Switzerland. Patients are assigned by chance to two treatment conditions 1) Control condition (General Psychiatric Management; Gunderson \& Links, 2008) and 2) MOTR-condition. The investigators hypothesize better results in the MOTR-condition, as compared to the control condition in terms of symptom reduction pre-post.

The conduct of the study represents a significant contribution to the understanding and enhancement of relationship aspects in the treatment of patients diagnosed with Borderline Personality Disorder which may be of potential benefit for these patients.

Being tested
Psychiatric Management, Motive-oriented therapeutic relationship/Plan Analysis
Medical subject headings
Borderline Personality Disorder

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Psychiatric ManagementBehavioural

  • Motive-oriented therapeutic relationship/Plan AnalysisBehavioural

Study groups in NCT01896024
Study groupRoleWhat they receive
General Psychiatric Management (GPM; Gunderson & Links, 2008)Active comparatorpsychodynamic-psychiatric treatment for borderline personality disorder
Receives: Behavioral: Psychiatric Management
GPM plus Motive-Oriented Therapeutic RelationshipExperimentaluse of Plan Analysis and Motive-oriented therapeutic relationship, as add-on variable to GPM
Receives: Behavioral: Psychiatric Management; Behavioral: Motive-oriented therapeutic relationship/Plan Analysis

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Outcome Questionnaire -45.2 (Lambert et al., 2004)

    pre- post- intervention in a randomized controlle trial; measure of symptom reduction over 3 months

    Measured: 3 months

Secondary outcomes (1)

  1. Inventory of Interpersonal Problems (Horowitz et al., 1988)

    Measure of interpersonal problems after 3 months of therapy

    Measured: 3 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted11 Jul 2013 (estimated)
  2. Study startJun 2010
  3. Primary completionMay 2013
  4. Study completionApr 2014

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Outcomes assessor
Enrolment
85 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT01896024
Sponsor's protocol ID
SNSF 100014-134562
Acronym
MOTR
Status last verified
Dec 2014
First submitted
5 Jul 2013
Last updated
2 Dec 2014
Results posted
No
Data monitoring committee
No

Publications

  • Kramer U, Berger T, Kolly S, Marquet P, Preisig M, de Roten Y, Despland JN, Caspar F. Effects of motive-oriented therapeutic relationship in early-phase treatment of borderline personality disorder: a pilot study of a randomized trial. J Nerv Ment Dis. 2011 Apr;199(4):244-50. doi: 10.1097/NMD.0b013e3182125d19.

    PubMed 21451348

  • Kramer U, Kolly S, Berthoud L, Keller S, Preisig M, Caspar F, Berger T, de Roten Y, Marquet P, Despland JN. Effects of motive-oriented therapeutic relationship in a ten-session general psychiatric treatment of borderline personality disorder: a randomized controlled trial. Psychother Psychosom. 2014;83(3):176-86. doi: 10.1159/000358528. Epub 2014 Apr 17.

    PubMed 24752034

  • Kramer U, Fluckiger C, Kolly S, Caspar F, Marquet P, Despland JN, de Roten Y. Unpacking the effects of therapist responsiveness in borderline personality disorder: motive-oriented therapeutic relationship, patient in-session experience, and the therapeutic alliance. Psychother Psychosom. 2014;83(6):386-7. doi: 10.1159/000365400. Epub 2014 Oct 16. No abstract available.

    PubMed 25324025

  • Sallin L, Geissbuehler I, Grandjean L, Beuchat H, Martin-Soelch C, Pascual-Leone A, Kramer U. Self-Contempt, the Working Alliance and Outcome in Treatments for Borderline Personality Disorder: An Exploratory Study. Psychother Res. 2021 Jul;31(6):765-777. doi: 10.1080/10503307.2020.1849848. Epub 2020 Nov 30.

    PubMed 33256540

  • Storebo OJ, Stoffers-Winterling JM, Vollm BA, Kongerslev MT, Mattivi JT, Jorgensen MS, Faltinsen E, Todorovac A, Sales CP, Callesen HE, Lieb K, Simonsen E. Psychological therapies for people with borderline personality disorder. Cochrane Database Syst Rev. 2020 May 4;5(5):CD012955. doi: 10.1002/14651858.CD012955.pub2.

    PubMed 32368793

  • Penzenstadler L, Kolly S, Rothen S, Khazaal Y, Kramer U. Effects of substance use disorder on treatment process and outcome in a ten-session psychiatric treatment for borderline personality disorder. Subst Abuse Treat Prev Policy. 2018 Feb 26;13(1):10. doi: 10.1186/s13011-018-0145-6.

    PubMed 29482597

Questions about this trial

What is this clinical trial studying?

A study testing Psychiatric Management and Motive-oriented therapeutic relationship/Plan Analysis in people with Borderline Personality Disorder, run by University of Lausanne Hospitals at 1 site in Switzerland.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 2 Dec 2014. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Outcome Questionnaire -45.2 (Lambert et al., 2004) (time frame: 3 months). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT01896024, which also lists 6 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Dec 2014.

AzTrials uses cookies for analytics and advertising. You can accept or reject them; the site works either way. Privacy Policy.

Free account

Log in to keep searching

You’ve used your 3 free searches. AzTrials is free: log in or create a free account to keep searching clinical trials and save the ones you want to follow.

Create a free accountLog in