Epilepsy, Unspecified, Pharmacologically ResistantMemO-EpiNCT01919957
Episodic Memory Before and After Surgery in Drug-resistant Partial Epilepsies
An observational study of Epilepsy, Unspecified, Pharmacologically Resistant and Memory Impairment, run by Institut National de la Santé Et de la Recherche Médicale, France at 1 site in France.
Trial summary
This study has two purposes: firstly, a better understanding of the neurobiological processes underlying episodic memory and, secondly, the development of useful clinical applications for epileptic patients, in particular the prediction of postoperative memory deficits and the development of cognitive remediation… Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Epilepsy, Unspecified, Pharmacologically Resistant, Memory Impairment
- How many people
- 29 participants
- Where
- 1 siteFrance
- Study dates
- 10 Oct 2013to 9 Oct 2022
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: The research requires the inclusion of healthy volunteers (controls) and epileptic patients
Who may be able to join
- Patients with drug-resistant epilepsy
- Age of 18 years or more
- Follow-up in the epilepsy unit at Pitié-Salpêtrière Hospital
- Before or after the presurgical evaluation unit including a video-EEG monitoring, a structural brain imaging and a full neuropsychological assessment
- Covered by a social security system
- Signing of consent form
Who cannot join
- Persons under guardianship, curatorship or any other administrative or judicial deprivation of rights and freedom
- Refusal to consent form
- Contraindications to MRI
- Pregnancy
- Refusal to be informed in the case of detection of an abnormality during the experiment
Trial locations and contacts
1 site in 1 country.
France1 site
INSERM - Plateau IRM du CENIR, CR-ICM Hôpital Pitié-Salpêtrière, 47/83 Boulevard de l'Hôpital
Paris, 75651 Cedex 13
About this study
Official title: Etude de la mémoire Avant et après Chirurgie d'Une épilepsie Partielle pharmacorésistante : Bases Neurobiologiques, Applications Cliniques
This study has two purposes: firstly, a better understanding of the neurobiological processes underlying episodic memory and, secondly, the development of useful clinical applications for epileptic patients, in particular the prediction of postoperative memory deficits and the development of cognitive remediation therapies.
Memory performances during a fMRI experiment will be assessed in controls and epileptic patients before and after the surgery.
- Keywords
- epilepsy, surgery, functional MRI, memory outcome
- Medical subject headings
- Epilepsy, Memory Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| memory outcome | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
Measure of successfull encoding
Our goal is to define correlation between the measure of successfull object encoding trials (especially for binding) and the beta value activation in fMRI
Measured: 8 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Aug 2013 (estimated)
- Study start10 Oct 2013
- Primary completion9 Oct 2021
- Study completion9 Oct 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Epilepsy, Unspecified, Pharmacologically ResistantStudies of the same condition, open and under way.
- More trials run by Institut National de la Santé Et de la Recherche Médicale, FranceThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 29 participants (actual)
Sponsor and investigators
- Sponsor type
- Other government
- Responsible party
- Sponsor
- Investigators
- Sophie Dupont, MD, PhD, Principal investigator, Service de Soins de Suites et Réadaptation Neurologique, Hôpital de la Pitié-Salpêtrière, 47/83 Bd de l'Hôpital, 75651 Paris Cedex 13
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01919957
- Sponsor's protocol ID
- C12-11
- Other IDs
- 2013-A00343-42
- Acronym
- MemO-Epi
- Status last verified
- Apr 2025
- First submitted
- 1 Jul 2013
- Last updated
- 24 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
Study at a glance
From the registry record, last updated by the sponsor on 24 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Etude de la mémoire Avant et après Chirurgie d'Une épilepsie Partielle pharmacorésistante : Bases Neurobiologiques, Applications Cliniques
- ClinicalTrials.gov ID
- NCT01919957
- Acronym / sponsor ID
- MemO-Epi / C12-11
- Keywords
- epilepsy, surgery, functional MRI, memory outcome
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 29 participants (actual)
- Lead sponsor
- Institut National de la Santé Et de la Recherche Médicale, FranceOther government
- Study start
- 10 Oct 2013 (actual)
- Primary completion
- 9 Oct 2021 (actual)
- Study completion
- 9 Oct 2022 (actual)
- First posted
- 9 Aug 2013 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study has two purposes: firstly, a better understanding of the neurobiological processes underlying episodic memory and, secondly, the development of useful clinical applications for epileptic patients, in particular the prediction of postoperative memory deficits and the development of cognitive remediation therapies.
Memory performances during a fMRI experiment will be assessed in controls and epileptic patients before and after the surgery.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| memory outcome | – | – |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- The research requires the inclusion of healthy volunteers (controls) and epileptic patients
Key inclusion criteria (6 listed)
- Patients with drug-resistant epilepsy
- Age of 18 years or more
- Follow-up in the epilepsy unit at Pitié-Salpêtrière Hospital
- Before or after the presurgical evaluation unit including a video-EEG monitoring, a structural brain imaging and a full neuropsychological assessment
- Covered by a social security system
Key exclusion criteria (5 listed)
- Persons under guardianship, curatorship or any other administrative or judicial deprivation of rights and freedom
- Refusal to consent form
- Contraindications to MRI
- Pregnancy
- Refusal to be informed in the case of detection of an abnormality during the experiment
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Measure of successfull encoding
Time frame: 8 years
Our goal is to define correlation between the measure of successfull object encoding trials (especially for binding) and the beta value activation in fMRI
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Sep 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Sophie Dupont, MD, PhD principal investigator
Service de Soins de Suites et Réadaptation Neurologique, Hôpital de la Pitié-Salpêtrière, 47/83 Bd de l'Hôpital, 75651 Paris Cedex 13
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Epilepsy, Unspecified, Pharmacologically Resistant and Memory Impairment, run by Institut National de la Santé Et de la Recherche Médicale, France at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Measure of successfull encoding (time frame: 8 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Sep 2026; AzTrials last refreshed its copy on 30 Oct 2026.