Continuous Renal Replacement TherapyCRRTNCT02034448
CRRTNet Registry- A Prospective Observational Registry
An observational study of Continuous Renal Replacement Therapy, run by AKI Critical Care Research Foundation at 1 site in United States.
Trial summary
An observational registry to monitor the outcome of CRRT in adults with acute kidney injury. Read more about this study
- Who is it for?
- Ages 18 to 89 years
- Conditions the study is for
- Continuous Renal Replacement Therapy
- What is being tested?
- Continuous Renal Replacement Therapy
- Type of treatment
- Surgery or procedure
- How many people
- 2,000 participants
- Where
- 1 siteUnited States
- Study dates
- Nov 2013to Dec 2018
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 89 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: This is a prospective observational registry. A minimum sample size of 2000 patients with the detailed information being obtained would embody the largest and most detailed repository of adult CRRT patient information available.
Who may be able to join
None listed.
Who cannot join
- -
Trial locations and contacts
1 site in 1 country.
United States1 site, 1 recruiting
- Recruiting
Mike Heung
Ann Arbor, Michigan, 48109
Mike Heung, MD, 734-936-4890, mheung@umich.edu
Mike Heung, MD
About this study
Official title: CRRTNet Outcome Registry
An observational registry to monitor the outcome of CRRT in adults with acute kidney injury.
Read the detailed description
Continuous Renal Replacement Therapy (CRRT) is a form of dialysis provided to critically ill patients with acute renal failure, now known as acute kidney injury (AKI). While we have extensive experience with this therapy in critically ill patients, there is no consensus on when to start CRRT or a clinical standard as to the best possible way to deliver the therapy. Previous studies have examined one aspect of CRRT in detail (for instance the dose of delivered therapy, or anticoagulation strategies) or have been small single center studies, or large multinational studies examining very basic practice patterns. This is a prospective observational cohort study. All patients who receive CRRT as part of their standard of local care will be eligible for the study.
- Conditions
- Continuous Renal Replacement Therapy
- Being tested
- Continuous Renal Replacement Therapy
- Keywords
- CRRT, Renal, Kidney, adults, registry, AKI
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Continuous Renal Replacement TherapyProcedure or surgery
| Study group | Role | What they receive |
|---|---|---|
| Acute Kidney Injury | CRRT intervention with adult patients with Acute Kidney Injury Receives: Procedure: Continuous Renal Replacement Therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mortality
Measured: 30 days
Secondary outcomes (1)
Length of Stay
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Jan 2014 (estimated)
- Study startNov 2013
- Primary completionDec 2018 (estimated)
- Study completionDec 2018 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Continuous Renal Replacement TherapyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 2,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- AKI Critical Care Research Foundation
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Mike Heung, MD, Principal investigator, University of Michigan Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02034448
- Sponsor's protocol ID
- CRRTNet
- Acronym
- CRRT
- Status last verified
- Jan 2015
- First submitted
- 10 Jan 2014
- Last updated
- 14 Jan 2015
- Results posted
- No
- Data monitoring committee
- No
Publications
Kusirisin P, Lambert JW, Rewa OG, Neyra JA, Bagshaw SM; CRRTnet Investigator. Association between obesity and kidney outcomes in critically ill patients with acute kidney injury receiving continuous renal replacement therapy: a secondary analysis of the multicenter CRRTnet study. Crit Care. 2026 Mar 28;30(1):143. doi: 10.1186/s13054-026-05950-w.
PubMed 41904566Heung M, Bagshaw SM, House AA, Juncos LA, Piazza R, Goldstein SL. CRRTnet: a prospective, multi-national, observational study of continuous renal replacement therapy practices. BMC Nephrol. 2017 Jul 6;18(1):222. doi: 10.1186/s12882-017-0650-2.
PubMed 28683729
Study at a glance
From the registry record, last updated by the sponsor on 14 Jan 2015. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- CRRTNet Outcome Registry
- ClinicalTrials.gov ID
- NCT02034448
- Acronym / sponsor ID
- CRRT / CRRTNet
- Conditions
- Continuous Renal Replacement Therapy
- Keywords
- CRRT, Renal, Kidney, adults, registry, AKI
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 2,000 participants (estimated)
- Lead sponsor
- AKI Critical Care Research FoundationUniversity, hospital or other
- Study start
- Nov 2013
- Primary completion
- Dec 2018 (estimated)
- Study completion
- Dec 2018 (estimated)
- First posted
- 13 Jan 2014 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
An observational registry to monitor the outcome of CRRT in adults with acute kidney injury.
Detailed description
Continuous Renal Replacement Therapy (CRRT) is a form of dialysis provided to critically ill patients with acute renal failure, now known as acute kidney injury (AKI). While we have extensive experience with this therapy in critically ill patients, there is no consensus on when to start CRRT or a clinical standard as to the best possible way to deliver the therapy. Previous studies have examined one aspect of CRRT in detail (for instance the dose of delivered therapy, or anticoagulation strategies) or have been small single center studies, or large multinational studies examining very basic practice patterns. This is a prospective observational cohort study. All patients who receive CRRT as part of their standard of local care will be eligible for the study.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Acute Kidney Injury | – | Procedure: Continuous Renal Replacement TherapyCRRT intervention with adult patients with Acute Kidney Injury |
Who may qualify
- Ages
- 18 to 89 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- This is a prospective observational registry. A minimum sample size of 2000 patients with the detailed information being obtained would embody the largest and most detailed repository of adult CRRT patient information available.
Key inclusion criteria (0 listed)
Key exclusion criteria (1 listed)
- -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Continuous Renal Replacement Therapy | Procedure or surgery | Acute Kidney Injury |
Primary outcome
Mortality
Time frame: 30 days
1 secondary outcome
Length of Stay
Time frame: 6 months
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Jan 2015.
- Derived from this study: PubMed 41904566Kusirisin P, Lambert JW, Rewa OG, Neyra JA, Bagshaw SM; CRRTnet Investigator. Association between obesity and kidney outcomes in critically ill patients with acute kidney injury receiving continuous renal replacement therapy: a secondary analysis of the multicenter CRRTnet study. Crit Care. 2026 Mar 28;30(1):143. doi: 10.1186/s13054-026-05950-w.
- Derived from this study: PubMed 28683729Heung M, Bagshaw SM, House AA, Juncos LA, Piazza R, Goldstein SL. CRRTnet: a prospective, multi-national, observational study of continuous renal replacement therapy practices. BMC Nephrol. 2017 Jul 6;18(1):222. doi: 10.1186/s12882-017-0650-2.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Mike Heung, MD principal investigator
University of Michigan Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Continuous Renal Replacement Therapy, run by AKI Critical Care Research Foundation at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 0 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 14 Jan 2015. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mortality (time frame: 30 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02034448, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Jan 2015.