Kidney Transplant RecipientsKNOW-KTNCT02042963
KoreaN Cohort Study for Outcome in Patients With Kidney Transplantation (KNOW-KT)
An observational study of Kidney Transplant Recipients and Complications After Kidney Transplant, run by Seoul National University Hospital at 1 site in South Korea.
Trial summary
KNOW-KT (KoreaN cohort study for Outcome in patients With KT: A 9-year Longitudinal cohort study of the Korean adult KT patients), funded by Korea Center for Disease Control and Prevention (KCDC) was established in 2012 by a group of transplant physicians, transplant surgeons, nephrologists, epidemiologists, and… Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Kidney Transplant Recipients, Complications After Kidney Transplant
- How many people
- 1,000 participants
- Where
- 1 siteSouth Korea
- Study dates
- Mar 2012to Feb 2021
- How long will I take part?
- 9 Years
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: Kidney transplant recipients and their donors (donors for baseline data)
Who may be able to join
- Recipients and Donors of kidney transplant
Who cannot join
- Multi-organ transplant recipients
Trial locations and contacts
1 site in 1 country.
About this study
Official title: KoreaN Cohort Study for Outcome in Patients With Kidney Transplantation : A 9-year Longitudinal Cohort Study of the Kidney Transplantation (KNOW-KT)
KNOW-KT (KoreaN cohort study for Outcome in patients With KT: A 9-year Longitudinal cohort study of the Korean adult KT patients), funded by Korea Center for Disease Control and Prevention (KCDC) was established in 2012 by a group of transplant physicians, transplant surgeons, nephrologists, epidemiologists, and biostatisticians in Korea.
We aimed to establish an adult KT cohort, to investigate the renal allograft outcomes, mortality, complications, and to explore traditional or nontraditional risk factors for morbidity and mortality. We established a bio-bank to integrate clinical and biological information. Here, we report design and method of the KNOW-KT.
- Keywords
- The cohort of Asian kidney transplant recipients, The cohort of metabolic complication after kidney transplant, The biorepository of Asian kidney transplant recipients
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| KNOW-KT | 1000 Kidney transplant recipients in Korea |
What is being measured
The primary outcome is the main question the study is designed to answer.
overall mortality
Measured: 9 years
Allograft survival
defined as re-transplant or initiation of maintenance dialysis
Measured: 9 years
Secondary outcomes (5)
cardiovascular event
Acute Myocardial Infarction Revascularization : PCI or CABG Stroke Admission from Congestive heart failure
Measured: 9 years
Albuminuria
Measured: 9 years
Acute Rejection
Measured: 9 years
New onset of diabetes after transplant
Measured: 9 years
Quality of Life
Measured: 2 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Jan 2014 (estimated)
- Study startMar 2012
- Primary completionFeb 2021 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Kidney Transplant RecipientsStudies of the same condition, open and under way.
- More trials run by Seoul National University HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 1,000 participants (estimated)
- Target duration
- 9 Years
Sponsor and investigators
- Lead sponsor
- Seoul National University Hospital
- Sponsor type
- University, hospital or other
- Collaborators
- Asan Medical Center, Chonbuk National University Medical School, Gachon University Gil Medical Center, Keimyung University Dongsan Medical Center, Korea University, Kyungpook National University Hospital, Samsung Medical Center, Medical Research Collaborating Center, Seoul, Korea, Yonsei University, Seoul National University College of Medicine
- Responsible party
- Principal investigator, Curie Ahn, Seoul National University Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02042963
- Sponsor's protocol ID
- KNOW-KT
- Acronym
- KNOW-KT
- Status last verified
- Jan 2014
- First submitted
- 20 Jan 2014
- Last updated
- 23 Jan 2014
- Results posted
- No
- Data monitoring committee
- Yes
Publications
Jung HY, Seo YJ, Huh KH, Park JB, Kim MG, Kang KP, Han S, Cho JH, Park SH, Kim CD, Kim YL, Ryu JH, Yang J. Self-Reported Sleep Duration, Death-Censored Graft Failure and Health-Related Quality of Life Among Kidney Transplant Recipients: Results From the KNOW-KT Study. Nephrology (Carlton). 2026 Jun;31(6):e70229. doi: 10.1111/nep.70229.
PubMed 42209439Jung HY, Jeon Y, Huh KH, Park JB, Kim MG, Lee S, Han S, Ro H, Yang J, Ahn C, Cho JH, Park SH, Kim YL, Kim CD. Pretransplant and Posttransplant Alcohol Consumption and Outcomes in Kidney Transplantation: A Prospective Multicenter Cohort Study. Transpl Int. 2022 May 30;35:10243. doi: 10.3389/ti.2022.10243. eCollection 2022.
PubMed 35707634Hong N, Lee J, Kim HW, Jeong JJ, Huh KH, Rhee Y. Machine Learning-Derived Integer-Based Score and Prediction of Tertiary Hyperparathyroidism among Kidney Transplant Recipients: An Integer-Based Score to Predict Tertiary Hyperparathyroidism. Clin J Am Soc Nephrol. 2022 Jul;17(7):1026-1035. doi: 10.2215/CJN.15921221. Epub 2022 Jun 10.
PubMed 35688469Yang J, Lee J, Huh KH, Park JB, Cho JH, Lee S, Ro H, Han SY, Kim YH, Jeong JC, Park BJ, Han DJ, Park SB, Chung W, Park SK, Kim CD, Kim SJ, Kim YS, Ahn C; KNOW-KT Study Group. KNOW-KT (KoreaN cohort study for outcome in patients with kidney transplantation: a 9-year longitudinal cohort study): study rationale and methodology. BMC Nephrol. 2014 May 9;15:77. doi: 10.1186/1471-2369-15-77.
PubMed 24884405
Study at a glance
From the registry record, last updated by the sponsor on 23 Jan 2014. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- KoreaN Cohort Study for Outcome in Patients With Kidney Transplantation : A 9-year Longitudinal Cohort Study of the Kidney Transplantation (KNOW-KT)
- ClinicalTrials.gov ID
- NCT02042963
- Acronym / sponsor ID
- KNOW-KT / KNOW-KT
- Keywords
- The cohort of Asian kidney transplant recipients, The cohort of metabolic complication after kidney transplant, The biorepository of Asian kidney transplant recipients
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 1,000 participants (estimated)
- Lead sponsor
- Seoul National University HospitalUniversity, hospital or other
- Collaborators
- Asan Medical Center, Chonbuk National University Medical School, Gachon University Gil Medical Center, Keimyung University Dongsan Medical Center, Korea University, Kyungpook National University Hospital, Samsung Medical Center, Medical Research Collaborating Center, Seoul, Korea, Yonsei University, Seoul National University College of Medicine
- Study start
- Mar 2012
- Primary completion
- Feb 2021 (estimated)
- First posted
- 23 Jan 2014 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
KNOW-KT (KoreaN cohort study for Outcome in patients With KT: A 9-year Longitudinal cohort study of the Korean adult KT patients), funded by Korea Center for Disease Control and Prevention (KCDC) was established in 2012 by a group of transplant physicians, transplant surgeons, nephrologists, epidemiologists, and biostatisticians in Korea.
We aimed to establish an adult KT cohort, to investigate the renal allograft outcomes, mortality, complications, and to explore traditional or nontraditional risk factors for morbidity and mortality. We established a bio-bank to integrate clinical and biological information. Here, we report design and method of the KNOW-KT.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 9 Years
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| KNOW-KT | – | –1000 Kidney transplant recipients in Korea |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Kidney transplant recipients and their donors (donors for baseline data)
Key inclusion criteria (1 listed)
- Recipients and Donors of kidney transplant
Key exclusion criteria (1 listed)
- Multi-organ transplant recipients
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
overall mortality
Time frame: 9 years
Allograft survival
Time frame: 9 years
defined as re-transplant or initiation of maintenance dialysis
5 secondary outcomes
cardiovascular event
Time frame: 9 years
Albuminuria
Time frame: 9 years
Acute Rejection
Time frame: 9 years
New onset of diabetes after transplant
Time frame: 9 years
Quality of Life
Time frame: 2 years
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jan 2014.
- Derived from this study: PubMed 42209439Jung HY, Seo YJ, Huh KH, Park JB, Kim MG, Kang KP, Han S, Cho JH, Park SH, Kim CD, Kim YL, Ryu JH, Yang J. Self-Reported Sleep Duration, Death-Censored Graft Failure and Health-Related Quality of Life Among Kidney Transplant Recipients: Results From the KNOW-KT Study. Nephrology (Carlton). 2026 Jun;31(6):e70229. doi: 10.1111/nep.70229.
- Derived from this study: PubMed 35707634Jung HY, Jeon Y, Huh KH, Park JB, Kim MG, Lee S, Han S, Ro H, Yang J, Ahn C, Cho JH, Park SH, Kim YL, Kim CD. Pretransplant and Posttransplant Alcohol Consumption and Outcomes in Kidney Transplantation: A Prospective Multicenter Cohort Study. Transpl Int. 2022 May 30;35:10243. doi: 10.3389/ti.2022.10243. eCollection 2022.
- Derived from this study: PubMed 35688469Hong N, Lee J, Kim HW, Jeong JJ, Huh KH, Rhee Y. Machine Learning-Derived Integer-Based Score and Prediction of Tertiary Hyperparathyroidism among Kidney Transplant Recipients: An Integer-Based Score to Predict Tertiary Hyperparathyroidism. Clin J Am Soc Nephrol. 2022 Jul;17(7):1026-1035. doi: 10.2215/CJN.15921221. Epub 2022 Jun 10.
- Derived from this study: PubMed 24884405Yang J, Lee J, Huh KH, Park JB, Cho JH, Lee S, Ro H, Han SY, Kim YH, Jeong JC, Park BJ, Han DJ, Park SB, Chung W, Park SK, Kim CD, Kim SJ, Kim YS, Ahn C; KNOW-KT Study Group. KNOW-KT (KoreaN cohort study for outcome in patients with kidney transplantation: a 9-year longitudinal cohort study): study rationale and methodology. BMC Nephrol. 2014 May 9;15:77. doi: 10.1186/1471-2369-15-77.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Kidney Transplant Recipients and Complications After Kidney Transplant, run by Seoul National University Hospital at 1 site in South Korea.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 23 Jan 2014. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in South Korea. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
overall mortality (time frame: 9 years). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02042963, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jan 2014.