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AzTrials

Coronary Artery DiseasePROGRESS-CTONCT02061436

Prospective Global Registry for the Study of Chronic Total Occlusion Intervention

An observational study of Coronary Artery Disease, run by Minneapolis Heart Institute Foundation at 48 sites in 6 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
Search all trials

Trial summary

Percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) is increasingly being performed in patients with advanced coronary artery disease, but there is limited information on the techniques utilized and the procedural outcomes. Read more about this study

Who is it for?
Any age
Conditions the study is for
Coronary Artery Disease
How many people
2,000 participants
Where
48 sitesin 6 countries
Study dates
Jan 2012to Jan 2030
How long will I take part?
1 Year
Phase
Observational
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages Any age
  • All sexes
  • No healthy volunteers
  • Child, Adult, Older adult

Study population: Patients undergoing CTO PCI at each of the participating centers.

Who may be able to join

  • Patients undergoing CTO PCI at each of the participating centers.

Who cannot join

  • None

Trial locations and contacts

48 sites in 6 countries. Contact the study team or a site near you to ask about taking part.

Emmanouil S Brilakis, MD, PhD contact

(214) 857-1547 ext. 71547

esbrilakis@gmail.com

48 sites in 6 countries

United States42 sites, 33 recruiting

  • Appleton Cardiology

    Appleton, Wisconsin, 54911

    Completed

  • Piedmont Heart Institute

    Atlanta, Georgia, 30309

    Active, not recruiting

  • Emory University Hospital- Emory Heart and Vascular Center

    Atlanta, Georgia, 30322

    Wissam Jaber, MD

    Recruiting

  • Peacehealth Cardiology

    Bellingham, Washington, 98225

    Active, not recruiting

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114

    Bobby Yeh, MD, MBA, RYEH@mgh.harvard.edu

    Farouc Jaffer, MD, PhD

    Recruiting

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215

    Linda Valsdottir, 6176327653, lvalsdot@bidmc.harvard.edu

    Robert W Yeh, MD, MBA

    Recruiting

  • Maimonides Medical Center

    Brooklyn, New York, 11219

    Bilal Malik, MD

    Recruiting

  • Trinity Medical WNY

    Buffalo, New York, 14221

    Henry Meltser, MD

    Recruiting

  • Northwestern Bluhm Cardiovascular Institute

    Chicago, Illinois, 60611

    Active, not recruiting

  • The Christ Hospital Ohio Heart & Vascular

    Cincinnati, Ohio, 45219

    Robert Riley, MD

    Recruiting

  • University Hospitals (UH) Case Western Reserve University

    Cleveland, Ohio, 44106

    Farshad Forouzandeh, MD, PhD

    Recruiting

  • Cleveland Clinic

    Cleveland, Ohio, 44195

    Jaikirshan Khatri, MD

    Recruiting

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75216

    Emmanouil S Brilakis, MD, PhD, esbrilakis@gmail.com

    Emmanouil S Brilakis, MD, PhD

    Recruiting

  • VA Dallas Medical Center

    Dallas, Texas, 75216

    Emmanouil S Brilakis, MD, PhD, (214) 857-1547 ext. 71547, esbrilakis@gmail.com

    Shuaib Abdullah, MD, Shuaib.Abdullah@va.gov

    Recruiting

  • Baylor Heart and Vascular Hospital

    Dallas, Texas, 75226

    James Choi, MD, James.Choi@baylorhealth.edu

    James Choi, MD

    Recruiting

  • Henry Ford Medical Center

    Detroit, Michigan, 48202

    Khaldoon Alaswad, MD, kalaswa1@hfhs.org

    Khaldoon Alaswad, MD

    Recruiting

  • Houston Methodist Hospital

    Houston, Texas, 77030

    Active, not recruiting

  • St. Vincent Heart Center

    Indianapolis, Indiana, 46260

    Charles Orr, MD

    Recruiting

  • Memorial Hospital

    Jacksonville, Florida, 32216

    Larry Van-Tomas Crisco

    Recruiting

  • Mid America Heart Institute

    Kansas City, Missouri, 64131

    Active, not recruiting

  • Kettering Health Network

    Kettering, Ohio, 45429

    Niranjan Reddy, MD

    Recruiting

  • Little Rock VA Medical Center

    Little Rock, Arkansas, 72205

    Barry Uretsky, MD, Barry.Uretsky@va.gov

    Barry Uretsky, MD

    Recruiting

  • Medical Center of the Rockies

    Loveland, Colorado, 80538

    Anthony Doing, MD, anthony.doing@uchealth.org

    Anthony Doing, MD

    Recruiting

  • Wellstar Health System

    Marietta, Georgia, 30060

    Abdul Sheikh

    Recruiting

  • Minneapolis Heart Institute

    Minneapolis, Minnesota, 55407

    Emmanouil S Brilakis, MD, PhD, 612-863-3900, esbrilakis@gmail.com

    Emmanouil S Brilakis, MD, PhD

    Recruiting

  • Minneapolis VA Healthcare System and University of Minnesota

    Minneapolis, Minnesota, 55417

    Santiago Garcia, MD, garci205@umn.edu

    Santiago Garcia, MD

    Recruiting

  • Tristar Centennial Medical Center

    Nashville, Tennessee, 37203

    Brian Jefferson, MD

    Taral Patel, MD

    Recruiting

  • Carolina East Medical Center

    New Bern, North Carolina, 28560

    David Jessup, MD, djessup@carolinaeasthealth.com

    David Jessup, MD

    Recruiting

  • Tulane University Heart and Vascular Institute

    New Orleans, Louisiana, 70112

    Suzanne Bowers, RN, 5049882030, sbowers@tulane.edu

    Nana Asafu-Adjaye, 5049886508, nasafuad@tulane.edu

    Recruiting

  • Columbia University

    New York, New York, 10032

    Dimitri Karmpaliotis, MD, dk2787@columbia.edu

    Dimitri Karmpaliotis, MD

    Recruiting

  • Oklahoma City VA Medical Center

    Oklahoma City, Oklahoma, 73117

    Faisal Latif, MD

    Recruiting

  • Banner Samaritan Health Center

    Phoenix, Arizona, 85006

    Completed

  • University of Pittsburgh Medical Center Presbyterian

    Pittsburgh, Pennsylvania, 15213

    Catalin Toma, MD, (412) 647-6000, tomac@upmc.edu

    Catalin Toma, MD

    Recruiting

  • Baylor Scott & White Research Institute-The Heart Hospital Baylor Plano

    Plano, Texas, 75093

    Srinivasa Potluri, MD

    Recruiting

  • Baylor Scott and White Research Institute/ The Heart Hospital Baylor Plano

    Plano, Texas, 75093

    Julie McCracken, 469-814-4717, Julie.McCracken@bswhealth.org

    Rachelle Winkle, 469-814-4183, Rachelle.Winkle@bswhealth.org

    Recruiting

  • The Heart Hospital Baylor Plano

    Plano, Texas, 75093

    Elizabeth Holper, MD, Elizabeth.Holper@bswhealth.org

    Elizabeth Holper, MD

    Recruiting

  • Providence Heart & Vascular Institute

    Portland, Oregon, 97225

    Jason Wollmuth, MD

    Recruiting

  • San Diego VAMC and University of California

    San Diego, California, 92161

    Mitul Patel, MD, mpatel@ucsd.edu

    Mitul Patel, MD

    Recruiting

  • Torrance Memorial Medical Center

    Torrance, California, 90505

    Active, not recruiting

  • Oklahoma Heart Institute at Hillcrest Medical Center

    Tulsa, Oklahoma, 74104

    Raj Chandwaney, MD

    Recruiting

  • Providence Health Center

    Waco, Texas, 76712

    Active, not recruiting

  • WellSpan Heart & Vascular

    York, Pennsylvania, 17405

    William Nicholson, MD

    Recruiting

Other trials in United States

Greece2 sites, 2 recruiting

  • Korgialeneio-Benakeio Hellenic Red Cross General Hospital of Athens

    Athens, Attica, 11526

    Michalis Koutouzis, MD, mkoutouzis@0310.syzefxis.gov.gr

    Michalis Koutouzis, MD

    Recruiting

  • Henry Hunant Hospital Center

    Athens

    Vaios Tzifos, MD

    Recruiting

Other trials in Greece

Canada1 site, 1 recruiting

  • St. Boniface General Hospital

    Winnipeg, Manitoba, R3E 0W3

    Basem Elbarouni, MD

    Recruiting

Other trials in Canada

Egypt1 site, 1 recruiting

  • Aswan Heart Centre

    Aswān

    Ahmed M ElGuindy, MD

    Recruiting

Other trials in Egypt

Lebanon1 site, 1 recruiting

  • St. George Hospital University Medical Center

    Beirut

    Nidal Abi Rafah, MD

    Recruiting

Other trials in Lebanon

Russia1 site, 1 recruiting

  • Meshalkin Novosibirsk Research Institute

    Novosibirsk, Novosibirsk Oblast, 630055

    Oleg Krestyaninov, MD, o_krestyaninov@meshalkin.ru

    Oleg Krestyaninov, MD

    Recruiting

Other trials in Russia

About this study

Official title: Multicenter Registry of Chronic Total Occlusion Interventions

Percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) is increasingly being performed in patients with advanced coronary artery disease, but there is limited information on the techniques utilized and the procedural outcomes. The goal of this multicenter, investigator initiated registry is to collect information on treatment strategies and outcomes of consecutive patients undergoing CTO PCI among various participating centers. The information collected will be used to determine the frequency of CTO PCI performed at the participating sites and examine the procedural strategies utilized, and the procedural (both immediate and during follow-up) outcomes.

Keywords
chronic total occlusion, percutaneous coronary intervention
Medical subject headings
Coronary Artery Disease

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. procedural success of chronic total occlusion PCI

    Procedural success is defined as achievement of technical success with no in-hospital major adverse cardiac events (MACE). In-hospital MACE includes any of the following adverse events prior to hospital discharge: death from any cause, Q-wave myocardial infarction, urgent repeat target vessel revascularization with PCI or coronary bypass surgery, tamponade requiring pericardiocentesis or surgery, or stroke.

    Measured: discharge from the hospital after PCI, which usually happens the day after the procedure

Secondary outcomes (2)

  1. technical success of chronic total occlusion PCI

    Technical success of CTO PCI was defined as successful CTO revascularization with achievement of <30% residual diameter stenosis within the treated segment and restoration of TIMI grade 3 antegrade flow.

    Measured: discharge from the hospital after PCI, which usually happens the day after the procedure

  2. major adverse cardiovascular events

    In-hospital major adverse cardiovascular events (MACE) include any of the following adverse events prior to hospital discharge: death from any cause, Q-wave myocardial infarction, urgent repeat target vessel revascularization with PCI or coronary bypass surgery, tamponade requiring pericardiocentesis or surgery, or stroke.

    MACE during clinical follow-up include death, myocardial infarction, target lesion and target vessel revascularization.

    Measured: discharge from the hospital after PCI (which usually happens the day after the procedure) and during clinically-indicated follow-up. There are no pre-specified follow-up time periods - patients are assessed if and when they come to receive clinical care.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted12 Feb 2014 (estimated)
  2. Study startJan 2012
  3. Primary completionJan 2030 (estimated)
  4. Study completionJan 2030 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
2,000 participants (estimated)
Target duration
1 Year
IDs, dates and publications
ClinicalTrials.gov ID
NCT02061436
Sponsor's protocol ID
#11-099
Acronym
PROGRESS-CTO
Status last verified
Aug 2026
First submitted
28 Jan 2014
Last updated
19 Aug 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No

Publications

  • Christopoulos G, Menon RV, Karmpaliotis D, Alaswad K, Lombardi W, Grantham JA, Michael TT, Patel VG, Rangan BV, Kotsia AP, Lembo N, Kandzari DE, Lee J, Kalynych A, Carlson H, Garcia S, Banerjee S, Thompson CA, Brilakis ES. Application of the "hybrid approach" to chronic total occlusions in patients with previous coronary artery bypass graft surgery (from a Contemporary Multicenter US registry). Am J Cardiol. 2014 Jun 15;113(12):1990-4. doi: 10.1016/j.amjcard.2014.03.039. Epub 2014 Mar 31.

    PubMed 24793678

  • Christopoulos G, Karmpaliotis D, Alaswad K, Lombardi WL, Grantham JA, Rangan BV, Kotsia AP, Lembo N, Kandzari DE, Lee J, Kalynych A, Carlson H, Garcia S, Banerjee S, Thompson CA, Brilakis ES. The efficacy of "hybrid" percutaneous coronary intervention in chronic total occlusions caused by in-stent restenosis: insights from a US multicenter registry. Catheter Cardiovasc Interv. 2014 Oct 1;84(4):646-51. doi: 10.1002/ccd.25465. Epub 2014 Jul 4.

    PubMed 24585508

  • Christopoulos G, Karmpaliotis D, Wyman MR, Alaswad K, McCabe J, Lombardi WL, Grantham JA, Marso SP, Kotsia AP, Rangan BV, Garcia SA, Lembo N, Kandzari D, Lee J, Kalynych A, Carlson H, Thompson CA, Banerjee S, Brilakis ES. Percutaneous intervention of circumflex chronic total occlusions is associated with worse procedural outcomes: insights from a Multicentre US Registry. Can J Cardiol. 2014 Dec;30(12):1588-94. doi: 10.1016/j.cjca.2014.07.007. Epub 2014 Jul 16.

    PubMed 25442459

  • Christopoulos G, Menon RV, Karmpaliotis D, Alaswad K, Lombardi W, Grantham A, Patel VG, Rangan BV, Kotsia AP, Lembo N, Kandzari D, Carlson H, Garcia S, Banerjee S, Thompson CA, Brilakis ES. The efficacy and safety of the "hybrid" approach to coronary chronic total occlusions: insights from a contemporary multicenter US registry and comparison with prior studies. J Invasive Cardiol. 2014 Sep;26(9):427-32.

    PubMed 25198485

  • Sapontis J, Christopoulos G, Grantham JA, Wyman RM, Alaswad K, Karmpaliotis D, Lombardi WL, McCabe JM, Marso SP, Kotsia AP, Rangan BV, Christakopoulos GE, Garcia S, Thompson CA, Banerjee S, Brilakis ES. Procedural failure of chronic total occlusion percutaneous coronary intervention: Insights from a multicenter US registry. Catheter Cardiovasc Interv. 2015 Jun;85(7):1115-22. doi: 10.1002/ccd.25807. Epub 2015 Feb 3.

    PubMed 25557905

  • Christopoulos G, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Wyman RM, Lombardi WL, Menon RV, Grantham JA, Kandzari DE, Lembo N, Moses JW, Kirtane AJ, Parikh M, Green P, Finn M, Garcia S, Doing A, Patel M, Bahadorani J, Tarar MN, Christakopoulos GE, Thompson CA, Banerjee S, Brilakis ES. Application and outcomes of a hybrid approach to chronic total occlusion percutaneous coronary intervention in a contemporary multicenter US registry. Int J Cardiol. 2015 Nov 1;198:222-8. doi: 10.1016/j.ijcard.2015.06.093. Epub 2015 Jun 27.

    PubMed 26189193

  • Christopoulos G, Wyman RM, Alaswad K, Karmpaliotis D, Lombardi W, Grantham JA, Yeh RW, Jaffer FA, Cipher DJ, Rangan BV, Christakopoulos GE, Kypreos MA, Lembo N, Kandzari D, Garcia S, Thompson CA, Banerjee S, Brilakis ES. Clinical Utility of the Japan-Chronic Total Occlusion Score in Coronary Chronic Total Occlusion Interventions: Results from a Multicenter Registry. Circ Cardiovasc Interv. 2015 Jul;8(7):e002171. doi: 10.1161/CIRCINTERVENTIONS.114.002171.

    PubMed 26162857

  • Alaswad K, Menon RV, Christopoulos G, Lombardi WL, Karmpaliotis D, Grantham JA, Marso SP, Wyman MR, Pokala NR, Patel SM, Kotsia AP, Rangan BV, Lembo N, Kandzari D, Lee J, Kalynych A, Carlson H, Garcia SA, Thompson CA, Banerjee S, Brilakis ES. Transradial approach for coronary chronic total occlusion interventions: Insights from a contemporary multicenter registry. Catheter Cardiovasc Interv. 2015 Jun;85(7):1123-9. doi: 10.1002/ccd.25827. Epub 2015 Feb 3.

    PubMed 25640902

  • Danek BA, Karatasakis A, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Patel M, Bahadorani J, Lombardi WL, Wyman MR, Grantham JA, Doing A, Moses JW, Kirtane A, Parikh M, Ali ZA, Kalra S, Kandzari DE, Lembo N, Garcia S, Rangan BV, Thompson CA, Banerjee S, Brilakis ES. Use of antegrade dissection re-entry in coronary chronic total occlusion percutaneous coronary intervention in a contemporary multicenter registry. Int J Cardiol. 2016 Jul 1;214:428-37. doi: 10.1016/j.ijcard.2016.03.215. Epub 2016 Apr 6.

    PubMed 27088405

  • Karacsonyi J, Karatasakis A, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Wyman MR, Lombardi WL, Grantham JA, Kandzari DE, Lembo N, Moses JW, Kirtane AJ, Parikh MA, Green P, Finn M, Garcia S, Doing A, Patel M, Bahadorani J, Martinez Parachini JR, Resendes E, Rangan BV, Ungi I, Thompson CA, Banerjee S, Brilakis ES. Effect of Previous Failure on Subsequent Procedural Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention (from a Contemporary Multicenter Registry). Am J Cardiol. 2016 Apr 15;117(8):1267-71. doi: 10.1016/j.amjcard.2016.01.021. Epub 2016 Jan 28.

    PubMed 26899493

  • Nguyen-Trong PK, Rangan BV, Karatasakis A, Danek BA, Christakopoulos GE, Martinez-Parachini JR, Resendes E, Ayers CR, Luna M, Abdullah S, Kumbhani DJ, Addo T, Grodin J, Banerjee S, Brilakis ES. Predictors and Outcomes of Side-Branch Occlusion in Coronary Chronic Total Occlusion Interventions. J Invasive Cardiol. 2016 Apr;28(4):168-73. Epub 2016 Jan 15.

    PubMed 26773239

  • Christopoulos G, Kandzari DE, Yeh RW, Jaffer FA, Karmpaliotis D, Wyman MR, Alaswad K, Lombardi W, Grantham JA, Moses J, Christakopoulos G, Tarar MNJ, Rangan BV, Lembo N, Garcia S, Cipher D, Thompson CA, Banerjee S, Brilakis ES. Development and Validation of a Novel Scoring System for Predicting Technical Success of Chronic Total Occlusion Percutaneous Coronary Interventions: The PROGRESS CTO (Prospective Global Registry for the Study of Chronic Total Occlusion Intervention) Score. JACC Cardiovasc Interv. 2016 Jan 11;9(1):1-9. doi: 10.1016/j.jcin.2015.09.022.

    PubMed 26762904

  • Karatasakis A, Tarar MN, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Wyman RM, Lombardi WL, Grantham JA, Kandzari DE, Lembo NJ, Moses JW, Kirtane AJ, Parikh M, Garcia S, Doing A, Pershad A, Shah A, Patel M, Bahadorani J, Shoultz CA Jr, Danek BA, Thompson CA, Banerjee S, Brilakis ES. Guidewire and microcatheter utilization patterns during antegrade wire escalation in chronic total occlusion percutaneous coronary intervention: Insights from a contemporary multicenter registry. Catheter Cardiovasc Interv. 2017 Mar 1;89(4):E90-E98. doi: 10.1002/ccd.26568. Epub 2016 May 17.

    PubMed 27184465

  • Christakopoulos GE, Karmpaliotis D, Alaswad K, Yeh RW, Jaffer FA, Wyman RM, Lombardi W, Grantham JA, Kandzari DA, Lembo N, Moses JW, Kirtane A, Parikh M, Green P, Finn M, Garcia S, Doing A, Patel M, Bahadorani J, Christopoulos G, Karatasakis A, Thompson CA, Banerjee S, Brilakis ES. Contrast Utilization During Chronic Total Occlusion Percutaneous Coronary Intervention: Insights From a Contemporary Multicenter Registry. J Invasive Cardiol. 2016 Jul;28(7):288-94.

    PubMed 27342206

  • Nguyen-Trong PK, Alaswad K, Karmpaliotis D, Lombardi W, Grantham JA, Lembo N, Kandzari D, Karatasakis A, Karacsonyi J, Danek BA, Rangan BV, Roesle M, Ayers CR, Thompson CA, Banerjee S, Brilakis ES. Use of Saphenous Vein Bypass Grafts for Retrograde Recanalization of Coronary Chronic Total Occlusions: Insights From a Multicenter Registry. J Invasive Cardiol. 2016 Jun;28(6):218-24.

    PubMed 27236005

Questions about this trial

What is this clinical trial studying?

An observational study of Coronary Artery Disease, run by Minneapolis Heart Institute Foundation at 48 sites in 6 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 19 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 48 sites in United States, Greece, Canada, Egypt, Lebanon and 1 more country. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Emmanouil S Brilakis, MD, PhD ((214) 857-1547 ext. 71547, esbrilakis@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

procedural success of chronic total occlusion PCI (time frame: discharge from the hospital after PCI, which usually happens the day after the procedure). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT02061436, which also lists 52 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Aug 2026.

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