Physical Conditioning, HumanNCT02075944
Effects of Aerobic Exercise on Cognitive Function and Brain-derived Neurotrophic Factor in Young Adults
A study testing High intensity aerobic exercise and Low intensity aerobic exercise in people with Physical Conditioning, Human and Cognition, run by University of Southern Denmark at 1 site in Denmark.
Trial summary
The present study will investigate the effects of aerobic exercise on cognition and growth factors including brain-derived neurotrophic factor (BDNF) in young adults aged 15-21 years. The included subjects will be randomized to three different groups including one control group and two exercise groups. Read more about this study
- Who is it for?
- Ages 15 to 21 yearsHealthy volunteers can take part
- Conditions the study is for
- Physical Conditioning, Human, Cognition
- What is being tested?
- High intensity aerobic exercise and Low intensity aerobic exercise
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 130 participants
- Where
- 1 siteDenmark
- Study dates
- Feb 2014to Jun 2014
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 15 to 21 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- age 15-21
Who cannot join
- injury preventing one from being physically active
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Aerobic Exercise on Cognitive Function and Brain-derived Neurotrophic Factor in Young Adults Aged 15-21 Years
The present study will investigate the effects of aerobic exercise on cognition and growth factors including brain-derived neurotrophic factor (BDNF) in young adults aged 15-21 years. The included subjects will be randomized to three different groups including one control group and two exercise groups. Subjects randomized to the exercise groups will complete 30 minutes of aerobic exercise 3 times a week for 9 weeks incorporating low (group I) or high (group II) intensity aerobic exercise. The exercise will be conducted as running or indoor cycling (supervised). At baseline and 9-weeks follow-up all subjects will complete two cognitive tests (measures of concentration and sustained attention), a maximal cycling test (direct measures of VO2max), an intelligence quotient test, anthropometric measures, fasting blood samples and blood samples immediately following the cycling test. The blood samples will be analyzed for growth factors including BDNF and metabolic factors.
- Conditions
- Physical Conditioning, Human, Cognition
- Being tested
- High intensity aerobic exercise, Low intensity aerobic exercise
- Keywords
- Aerobic exercise, Cognitive function, Executive function, Brain-derived neurotrophic factor
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High intensity aerobic exerciseBehavioural
Low intensity aerobic exerciseBehavioural
| Study group | Role | What they receive |
|---|---|---|
| High intensity aerobic exercise | Experimental | 30 minutes of high intensity aerobic exercise 3 times a weeks for 9 weeks - incorporation interval training Receives: Behavioral: High intensity aerobic exercise |
| Low intensity aerobic exercise | Experimental | 30 minutes of low intensity aerobic exercise 3 times a weeks for 9 weeks Receives: Behavioral: Low intensity aerobic exercise |
| Control | No intervention | No intervention. Participants are told not to make any changes in their everyday life |
What is being measured
The primary outcome is the main question the study is designed to answer.
The Flanker Task
Measured: 9 weeks
The AX-Continuous Performance test
Measured: 9 weeks
Brain-derived neurotrophic factor
Measured: 9 weeks
Secondary outcomes (1)
Intelligence quotient
Measured: 9 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Mar 2014 (estimated)
- Study startFeb 2014
- Primary completionJun 2014
- Study completionJun 2014
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Physical Conditioning, HumanStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 130 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Southern Denmark
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Anna Bugge, Post Doc, University of Southern Denmark
- Investigators
- Anne K Thorsen, Cand. Scient, Principal investigator, University of Southern Denmark
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02075944
- Sponsor's protocol ID
- S-20130171
- Status last verified
- Jun 2014
- First submitted
- 27 Feb 2014
- Last updated
- 26 Jun 2014
- Results posted
- No
- Data monitoring committee
- Yes
Publications
Gejl AK, Bugge A, Ernst MT, Mortensen EL, Gejl KD, Andersen LB. Effects of 9 Weeks of High- or Moderate-Intensity Training on Cardiorespiratory Fitness, Inhibitory Control, and Plasma Brain-Derived Neurotrophic Factor in Danish Adolescents-A Randomized Controlled Trial. Scand J Med Sci Sports. 2024 Aug;34(8):e14703. doi: 10.1111/sms.14703.
PubMed 39054765
Study at a glance
From the registry record, last updated by the sponsor on 26 Jun 2014. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Aerobic Exercise on Cognitive Function and Brain-derived Neurotrophic Factor in Young Adults Aged 15-21 Years
- ClinicalTrials.gov ID
- NCT02075944
- Acronym / sponsor ID
- S-20130171
- Conditions
- Physical Conditioning, Human, Cognition
- Keywords
- Aerobic exercise, Cognitive function, Executive function, Brain-derived neurotrophic factor
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 130 participants (actual)
- Lead sponsor
- University of Southern DenmarkUniversity, hospital or other
- Study start
- Feb 2014
- Primary completion
- Jun 2014 (actual)
- Study completion
- Jun 2014 (actual)
- First posted
- 3 Mar 2014 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The present study will investigate the effects of aerobic exercise on cognition and growth factors including brain-derived neurotrophic factor (BDNF) in young adults aged 15-21 years. The included subjects will be randomized to three different groups including one control group and two exercise groups. Subjects randomized to the exercise groups will complete 30 minutes of aerobic exercise 3 times a week for 9 weeks incorporating low (group I) or high (group II) intensity aerobic exercise. The exercise will be conducted as running or indoor cycling (supervised). At baseline and 9-weeks follow-up all subjects will complete two cognitive tests (measures of concentration and sustained attention), a maximal cycling test (direct measures of VO2max), an intelligence quotient test, anthropometric measures, fasting blood samples and blood samples immediately following the cycling test. The blood samples will be analyzed for growth factors including BDNF and metabolic factors.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- Single blind (investigator)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| High intensity aerobic exercise | Experimental | Behavioral: High intensity aerobic exercise30 minutes of high intensity aerobic exercise 3 times a weeks for 9 weeks - incorporation interval training |
| Low intensity aerobic exercise | Experimental | Behavioral: Low intensity aerobic exercise30 minutes of low intensity aerobic exercise 3 times a weeks for 9 weeks |
| Control | No intervention | –No intervention. Participants are told not to make any changes in their everyday life |
Who may qualify
- Ages
- 15 to 21 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (1 listed)
- age 15-21
Key exclusion criteria (1 listed)
- injury preventing one from being physically active
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High intensity aerobic exercise | Behavioural | High intensity aerobic exercise |
| Low intensity aerobic exercise | Behavioural | Low intensity aerobic exercise |
Primary outcome
The Flanker Task
Time frame: 9 weeks
The AX-Continuous Performance test
Time frame: 9 weeks
Brain-derived neurotrophic factor
Time frame: 9 weeks
1 secondary outcome
Intelligence quotient
Time frame: 9 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Jun 2014.
- Derived from this study: PubMed 39054765Gejl AK, Bugge A, Ernst MT, Mortensen EL, Gejl KD, Andersen LB. Effects of 9 Weeks of High- or Moderate-Intensity Training on Cardiorespiratory Fitness, Inhibitory Control, and Plasma Brain-Derived Neurotrophic Factor in Danish Adolescents-A Randomized Controlled Trial. Scand J Med Sci Sports. 2024 Aug;34(8):e14703. doi: 10.1111/sms.14703.
Related trials for Physical Conditioning, Human
RecruitingPhase 1
Prophylactic DLI-X for Leukemia Relapse After HCT
Acute Lymphoid Leukemia, Acute Myeloid Leukemia
Not yet recruiting
Effects of Different Amounts of Plyometric Exercise Without Jumping in Physically Inactive Older Adults
Sedentary Behavior / Physical Inactivity, Aging
Not yet recruitingPhase 4
The INTERvening for LUNG Health Trial
Spirometry
Recruiting
GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study
Cardiovascular Diseases, Natriuretic Peptides
Not yet recruiting
Feasibility of a Robot-Guided Active Play Intervention for Children With Cerebral Palsy
Cerebral Palsy
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Anne K Thorsen, Cand. Scient principal investigator
University of Southern Denmark
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High intensity aerobic exercise and Low intensity aerobic exercise in people with Physical Conditioning, Human and Cognition, run by University of Southern Denmark at 1 site in Denmark.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 26 Jun 2014. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Denmark. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The Flanker Task (time frame: 9 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02075944, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Jun 2014.