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Community Acquired PneumoniaCAPNETZNCT02139163

Epidemiological Study on Community Acquired Pneumonia

An observational study of Community Acquired Pneumonia, run by Capnetz Stiftung at 1 site in Germany.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

The main objective of this study is to investigate prevalence and risk factors for community-acquired pneumonia (CAP) and its interaction with comorbidities in an unselected group of adult patients receiving outpatient and inpatient care. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Community Acquired Pneumonia
How many people
20,000 participants
Where
1 siteGermany
Study dates
Oct 2002to Jun 2028
How long will I take part?
6 Months
Phase
Observational
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: patients with pneumonia

Who may be able to join

  • age ≥ 18
  • infiltrate on chest X-ray
  • further Inclusion criteria (at least one must apply): cough or purulent sputum or pathologic lung auscultation (crackles) or fever

Who cannot join

  • Hospitalization lasting longer than 48 hours prior to the diagnosis of the current pneumonia
  • Newly diagnosed, active pulmonary tuberculosis within the last 2 months

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Frank Eberhardt contact

+49-511-532-5927

office@capnetz.de

Waldemar Kröner contact

+49-511-532-4447

office@capnetz.de

Germany1 site, 1 recruiting
  • Medical School Hannover

    Hanover, 30625

    Marius M Hoeper, Prof. D, +49 511 532 3531, pneumologie@mh-hannover.de

    Recruiting

Other trials in Germany

About this study

The main objective of this study is to investigate prevalence and risk factors for community-acquired pneumonia (CAP) and its interaction with comorbidities in an unselected group of adult patients receiving outpatient and inpatient care. In addition, information on HIV as a risk factor for CAP and on CAP in immunocompromised patients is collected.

Read the detailed description

The CAPNETZ study is a prospective, multicenter observational study investigating community-acquired pneumonia (CAP). Patients are recruited from outpatient and inpatient settings at hospitals and from primary care physicians (primarily specialists) and are followed for a period of six months. All CAP patients who meet the inclusion and exclusion criteria, consent to participate, and in whom the presence of a newly developed, community-acquired pneumonia can be verified are invited to participate. The baseline examination includes a detailed medical history, medication history, and a physical examination to record clinical and vital signs. In addition, the results of routine clinical imaging are documented, and biosamples (blood, urine, and respiratory specimens) are collected for clinical chemistry and microbiological analysis. Further in-person visits to document the course of the disease and treatment, including the collection of additional blood samples, take place 3 and 7 days after study enrollment. Twenty-eight days after enrollment, the patient's health status, treatment course, and complications are assessed by telephone. Finally, after 180 days, a telephone survey is conducted to determine the patient's whereabouts and survival status. Apart from the collection of biomaterials, no interventions are required or planned; physicians treat their patients as they normally would.

Keywords
Community acquired pneumonia, CAP, CAPNETZ, age ≥18, infiltrate on chest X-ray, cough or production of purulent sputum, pathologic lung auscultation, fever, adults
Medical subject headings
Community-Acquired Pneumonia, Cough, Fever

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Study groups in NCT02139163
Study groupRoleWhat they receive
patients with pneumoniaNot described
patients with CAP and HIVNot described
immunosuppressed patients with CAPNot described

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. diagnosis

    Assessment of diagnosis:

    Patients will be asked for example, about their diagnosis, comorbidities, specific risk factors and pneumonia symptoms.

    Measured: 2 weeks

  2. therapy

    Assessment of therapy:

    Patients will be asked about their therapy due to pneumonia symptoms, previous therapy, medication History etc.

    Measured: 2 weeks

  3. hospitalization

    Assessment of hospitalization:

    Patients will be asked about hospitalization, date, time and duration of hospitalization due to pneumonia symptoms.

    Measured: 2 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted15 May 2014 (estimated)
  2. Study startOct 2002
  3. Primary completionDec 2027 (estimated)
  4. Study completionJun 2028 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
20,000 participants (estimated)
Target duration
6 Months
IDs, dates and publications
ClinicalTrials.gov ID
NCT02139163
Sponsor's protocol ID
U1111-1147-8393
Acronym
CAPNETZ
Status last verified
Apr 2026
First submitted
24 Jan 2014
Last updated
5 May 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Yes: All individual non-personal data and biomaterials collected as part of the study are available for use. This requires a formal request that describes a specific research project and specifies the data needed. Applications have to be submitted on https://capnetz.de/en/project-application/ . Upon approval by the Executive Board, the relevant data and biomaterials will be provided.

Publications

  • Welte T, Suttorp N, Marre R. CAPNETZ-community-acquired pneumonia competence network. Infection. 2004 Aug;32(4):234-8. doi: 10.1007/s15010-004-3107-z. No abstract available.

    PubMed 15293080
  • Welte T, Marre R, Suttorp N. [CAPNet--network of competence for community acquired pneumonia: structures and aims]. Pneumologie. 2003 Jan;57(1):34-41. doi: 10.1055/s-2003-36635. German.

    PubMed 12528066
  • Weckler BC, Wu Q, Bertrams W, Kutzinski M, Reiter R, Khan SA, Ahnert P, Suttorp N, Witzenrath M, Wildberg C, Pletz MW, Rupp J, Zissler UM, Greulich T, Brenner T, Alter P, Rohde G, Vogelmeier CF, Mayr A, Schmeck B. Association Between Admission Eosinophil Count and Hospital Resource Use in Community-Acquired Pneumonia: A Prospective Multicenter Study. Chest. 2026 Aug;170(2):353-364. doi: 10.1016/j.chest.2026.03.018. Epub 2026 Mar 31.

    PubMed 41933608
  • Mendez R, Gonzalez-Jimenez P, Latorre A, Piqueras M, Mengot N, Hervas D, Knox D, Carr J, Barten-Neiner G, Rohde G, Pletz MW, Rupp J, Witzenrath M, Dean NC, Menendez R. The Long-term Pneumonia Mortality Index: an international multicenter derivation and validation study for patients with community-acquired pneumonia. Am J Respir Crit Care Med. 2026 Jun 1;212(6):1305-1314. doi: 10.1093/ajrccm/aamag060.

    PubMed 41738235
  • Millet Pascual-Leone B, Fiocca Vernengo F, Hillus D, Wernicke C, Krishnamoorthy G, Rupp J, Rohde G, Pletz MW, Witzenrath M; CAPNETZ-study group; Suttorp N, Sander LE, Vestergaard Jensen A, Opitz B, Thibeault C. Community-acquired pneumonia in diabetic patients is characterised by a distinct pathogen spectrum and enhanced inflammation: results from CAPNETZ, a prospective observational cohort study. Infection. 2026 Feb;54(1):275-285. doi: 10.1007/s15010-025-02659-w. Epub 2025 Oct 12.

    PubMed 41077620
  • Pott H, Gaffron S, Martin R, Maier D, Kutzinski M, Weckler B, Bertrams W, Jung AL, Laakmann K, Heider D, Vogelmeier CF, Rohde G; CAPNETZ Study Group; Schmeck B. Self-organising map clustering identifies high-risk clusters of post-acute mortality in a prospective multicentre study of community-acquired pneumonia. ERJ Open Res. 2026 Jan 19;12(1):00374-2025. doi: 10.1183/23120541.00374-2025. eCollection 2026 Jan.

    PubMed 41561102
  • Waldeck F, Lemmel S, Panning M, Kading N, Essig A, Rohde G, Pletz MW, Witzenrath M, Boutin S, Rupp J; Members of the CAPNETZ study group. Comparing viral, bacterial, and coinfections in community-acquired pneumonia, a retrospective cohort study. Int J Infect Dis. 2025 May;154:107841. doi: 10.1016/j.ijid.2025.107841. Epub 2025 Feb 21.

    PubMed 39988242
  • Rischke S, Gurke R, Zielbauer AS, Ziegler N, Hahnefeld L, Kohm M, Kannt A, Vehreschild MJ, Geisslinger G, Rohde G, Bellinghausen C, Behrens F, Study Group C. Proteomic, metabolomic and lipidomic profiles in community acquired pneumonia for differentiating viral and bacterial infections. Sci Rep. 2025 Jan 14;15(1):1922. doi: 10.1038/s41598-025-85229-2.

    PubMed 39809876
  • Dahne T, Bauer W, Essig A, Schaaf B, Barten-Neiner G, Spinner CD, Pletz MW, Rohde G, Rupp J, Witzenrath M, Panning M; Members of the CAPNETZ study group. Resurgence of common respiratory viruses in patients with community-acquired pneumonia (CAP)-A prospective multicenter study. J Clin Virol. 2024 Aug;173:105694. doi: 10.1016/j.jcv.2024.105694. Epub 2024 May 22.

    PubMed 38781632
  • Schleenvoigt BT, Ankert J, Barten-Neiner G, Voit F, Suttorp N, Boesecke C, Hoffmann C, Stolz D, Pletz MW, Rohde G, Witzenrath M, Panning M, Essig A, Rupp J, Degen O, Stephan C; CAPNETZ Study Group. Pathogen spectrum of community acquired pneumonia in people living with HIV (PLWH) in the German CAPNETZ-Cohort. Infection. 2024 Feb;52(1):129-137. doi: 10.1007/s15010-023-02070-3. Epub 2023 Jul 9.

    PubMed 37423969
  • Bahrs C, Kesselmeier M, Kolditz M, Ewig S, Rohde G, Barten-Neiner G, Rupp J, Witzenrath M, Welte T, Pletz MW; CAPNETZ Study Group. A longitudinal analysis of pneumococcal vaccine serotypes in pneumonia patients in Germany. Eur Respir J. 2022 Feb 3;59(2):2102432. doi: 10.1183/13993003.02432-2021. Print 2022 Feb.

    PubMed 34824055
  • Ewig S, Kolditz M, Pletz M, Altiner A, Albrich W, Dromann D, Flick H, Gatermann S, Kruger S, Nehls W, Panning M, Rademacher J, Rohde G, Rupp J, Schaaf B, Heppner HJ, Krause R, Ott S, Welte T, Witzenrath M. [Management of Adult Community-Acquired Pneumonia and Prevention - Update 2021 - Guideline of the German Respiratory Society (DGP), the Paul-Ehrlich-Society for Chemotherapy (PEG), the German Society for Infectious Diseases (DGI), the German Society of Medical Intensive Care and Emergency Medicine (DGIIN), the German Viological Society (DGV), the Competence Network CAPNETZ, the German College of General Practitioneers and Family Physicians (DEGAM), the German Society for Geriatric Medicine (DGG), the German Palliative Society (DGP), the Austrian Society of Pneumology Society (OGP), the Austrian Society for Infectious and Tropical Diseases (OGIT), the Swiss Respiratory Society (SGP) and the Swiss Society for Infectious Diseases Society (SSI)]. Pneumologie. 2021 Sep;75(9):665-729. doi: 10.1055/a-1497-0693. Epub 2021 Jul 1. German.

    PubMed 34198346
  • Jensen AV, Baunbaek Egelund G, Bang Andersen S, Petersen PT, Benfield T, Witzenrath M, Rohde G, Ravn P, Faurholt-Jepsen D; Members of the CAPNETZ study group except the authors:. The Glycemic Gap and 90-Day Mortality in Community-acquired Pneumonia. A Prospective Cohort Study. Ann Am Thorac Soc. 2019 Dec;16(12):1518-1526. doi: 10.1513/AnnalsATS.201901-007OC.

    PubMed 31437014
  • Kolditz M, Scherag A, Rohde G, Ewig S, Welte T, Pletz M; CAPNETZ Study Group. Comparison of the qSOFA and CRB-65 for risk prediction in patients with community-acquired pneumonia. Intensive Care Med. 2016 Dec;42(12):2108-2110. doi: 10.1007/s00134-016-4517-y. Epub 2016 Sep 19. No abstract available.

    PubMed 27647332
  • Kolditz M, Ewig S, Schutte H, Suttorp N, Welte T, Rohde G; CAPNETZ study group. Assessment of oxygenation and comorbidities improves outcome prediction in patients with community-acquired pneumonia with a low CRB-65 score. J Intern Med. 2015 Aug;278(2):193-202. doi: 10.1111/joim.12349. Epub 2015 Feb 13.

    PubMed 25597400

Questions about this trial

What is this clinical trial studying?

An observational study of Community Acquired Pneumonia, run by Capnetz Stiftung at 1 site in Germany.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 5 May 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Germany. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Frank Eberhardt (+49-511-532-5927, office@capnetz.de), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

diagnosis (time frame: 2 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT02139163, which also lists 16 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 May 2026.

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