Healthy SubjectsTrainMeUpMNNCT02150889
Training Effects on Fuel Metabolism
A study testing Running Program and Yoga Program in people with Healthy Subjects and Lean Trained Subjects, run by University of Minnesota at 1 site in United States.
Trial summary
The investigators are interested in how skeletal muscle processes fat and how this may affect insulin resistance. This is an important question since insulin resistance predates and predicts type 2 diabetes. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy Subjects, Lean Trained Subjects, Overweight and Obesity
- What is being tested?
- Running Program and Yoga Program
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 64 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Jul 2014to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- All subjects
- Subjects 18 to 40 years of age.
- Subjects are capable of giving informed consent
- Overweight or obese
- Insulin resistant based on screening oral glucose tolerance testing.
- BMI 25 to 40 kg/m2 inclusive
Show all 12Show fewer
- Stable weight for at least 3 months (± 5 lbs.)
- Sedentary status (self-report < 30 minutes/week regular exercise).
- Lean, physically active
- physically active subjects defined as 3-5 aerobic exercise sessions/week
- matched to age and gender
- generally healthy with normal fasting glucose levels (glucose ≤100 mg/dL).
Who cannot join
- All subjects
- Subjects 18 to 40 years of age.
- Subjects are capable of giving informed consent
- Overweight or obese
- Insulin resistant based on screening oral glucose tolerance testing.
- BMI 25 to 40 kg/m2 inclusive
Show all 12Show fewer
- Stable weight for at least 3 months (± 5 lbs.)
- Sedentary status (self-report < 30 minutes/week regular exercise).
- Lean, physically active
- physically active subjects defined as 3-5 aerobic exercise sessions/week
- matched to age and gender
- generally healthy with normal fasting glucose levels (glucose ≤100 mg/dL).
Trial locations and contacts
1 site in 1 country.
United States1 site
University of Minnesota
Minneapolis, Minnesota, 55455
About this study
The investigators are interested in how skeletal muscle processes fat and how this may affect insulin resistance. This is an important question since insulin resistance predates and predicts type 2 diabetes. The investigators are especially interested in learning about the effects of weight and training on insulin resistance. The investigators will study people before and after supervised aerobic or yoga training to identify differences in resting fat and sugar metabolism which may lead to differences in insulin resistance. The investigators will test these differences using stable isotopes, and the use of these stable isotopes is experimental.
Overweight/Obese Group: Eight visits will be required at the University of Minnesota Clinical Research Unit. Four visits will be done before training (screen and 3 pre-training visits), 1 visit during the training, and 3 post-training visits will be done. In between, the training will take about 16 weeks and will be a supervised treadmill program.
Lean/Trained Group: Four visits will be required at the University of Minnesota Clinical Research Unit (screen and 3 study visits).
Read the detailed description
Insulin resistance plays a critical role in the development of type 2 diabetes (T2DM), with skeletal muscle the largest site of insulin resistance in the human body. In sedentary humans, insulin resistance correlates with levels of intramyocellular lipid (IMCL) and lipid metabolites that adversely affect skeletal muscle glucose metabolism. However, even modest endurance training has been shown to reduce insulin resistance while increasing skeletal muscle IMCL. Moreover, lean endurance trained participants have IMCL levels comparable to those of patients with T2DM, yet have significantly lower insulin resistance. These findings suggest that the physiological changes caused by training protect against lipid induced insulin resistance and that this protection is present even at rest, however our preliminary data suggest that training facilitates utilization of readily available fuel, with lipid preferentially used over glucose when available. We will test the overarching hypothesis that training increases resting skeletal muscle lipid metabolism, as measured by markers of IMCL lipolysis, accumulation of fatty acid metabolites and mitochondrial utilization of fatty acids.
Research reported in this publication was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1-TR002494. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
- Being tested
- Running Program, Yoga Program
- Keywords
- insulin resistance, lipid metabolism, diabetes
- Medical subject headings
- Overweight, Obesity, Insulin Resistance, Diabetes Mellitus
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Running ProgramBehavioural
16 week supervised running program
Yoga ProgramBehavioural
once weekly supervised yoga
| Study group | Role | What they receive |
|---|---|---|
| Lean Trained | No intervention | Metabolic control |
| Obese or Overweight | Experimental | Running Program Yoga Program Receives: Behavioral: Running Program; Behavioral: Yoga Program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Differences in insulin sensitivity between groups
Will use HOMA-IR and hyperinsulinemia-euglycemic clamp
Measured: Before and after exercise program (exercise program will take 16 weeks, expected average for evaluation will be 20 weeks)
Secondary outcomes (1)
Differences in fitness level between groups
we will measure fitness level by treadmill based VO2 max testing.
Measured: before and after exercise program (exercise program will take 16 weeks, expected average for evaluation will be 20 weeks)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 May 2014 (estimated)
- Study start1 Jul 2014
- Primary completion30 Dec 2018
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Healthy SubjectsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 64 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Minnesota
- Sponsor type
- University, hospital or other
- Collaborators
- National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Responsible party
- Sponsor
- Investigators
- Lisa S. Chow, MD, Principal investigator, University of Minnesota
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02150889
- Sponsor's protocol ID
- 1209M20741
- Other IDs
- 5R01DK098203-02
- Acronym
- TrainMeUpMN
- Status last verified
- Jan 2026
- First submitted
- 22 May 2014
- Last updated
- 8 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
Publications
Nelson AB, Chow LS, Stagg DB, Gillingham JR, Evans MD, Pan M, Hughey CC, Myers CL, Han X, Crawford PA, Puchalska P. Acute aerobic exercise reveals that FAHFAs distinguish the metabolomes of overweight and normal-weight runners. JCI Insight. 2022 Apr 8;7(7):e158037. doi: 10.1172/jci.insight.158037.
PubMed 35192550Bantle AE, Bosch TA, Dengel DR, Wang Q, Mashek DG, Chow LS. DXA-Determined Regional Adiposity Relates to Insulin Resistance in a Young Adult Population with Overweight andObesity. J Clin Densitom. 2019 Apr-Jun;22(2):287-292. doi: 10.1016/j.jocd.2018.06.001. Epub 2018 Jun 7.
PubMed 30064815
Study at a glance
From the registry record, last updated by the sponsor on 8 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Training Effects on Fuel Metabolism
- ClinicalTrials.gov ID
- NCT02150889
- Acronym / sponsor ID
- TrainMeUpMN / 1209M20741
- Keywords
- insulin resistance, lipid metabolism, diabetes
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 64 participants (actual)
- Lead sponsor
- University of MinnesotaUniversity, hospital or other
- Collaborators
- National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Study start
- 1 Jul 2014 (actual)
- Primary completion
- 30 Dec 2018 (actual)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 30 May 2014 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The investigators are interested in how skeletal muscle processes fat and how this may affect insulin resistance. This is an important question since insulin resistance predates and predicts type 2 diabetes. The investigators are especially interested in learning about the effects of weight and training on insulin resistance. The investigators will study people before and after supervised aerobic or yoga training to identify differences in resting fat and sugar metabolism which may lead to differences in insulin resistance. The investigators will test these differences using stable isotopes, and the use of these stable isotopes is experimental.
Overweight/Obese Group: Eight visits will be required at the University of Minnesota Clinical Research Unit. Four visits will be done before training (screen and 3 pre-training visits), 1 visit during the training, and 3 post-training visits will be done. In between, the training will take about 16 weeks and will be a supervised treadmill program.
Lean/Trained Group: Four visits will be required at the University of Minnesota Clinical Research Unit (screen and 3 study visits).
Detailed description
Insulin resistance plays a critical role in the development of type 2 diabetes (T2DM), with skeletal muscle the largest site of insulin resistance in the human body. In sedentary humans, insulin resistance correlates with levels of intramyocellular lipid (IMCL) and lipid metabolites that adversely affect skeletal muscle glucose metabolism. However, even modest endurance training has been shown to reduce insulin resistance while increasing skeletal muscle IMCL. Moreover, lean endurance trained participants have IMCL levels comparable to those of patients with T2DM, yet have significantly lower insulin resistance. These findings suggest that the physiological changes caused by training protect against lipid induced insulin resistance and that this protection is present even at rest, however our preliminary data suggest that training facilitates utilization of readily available fuel, with lipid preferentially used over glucose when available. We will test the overarching hypothesis that training increases resting skeletal muscle lipid metabolism, as measured by markers of IMCL lipolysis, accumulation of fatty acid metabolites and mitochondrial utilization of fatty acids.
Research reported in this publication was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1-TR002494. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Lean Trained | No intervention | –Metabolic control |
| Obese or Overweight | Experimental | Behavioral: Running Program, Behavioral: Yoga ProgramRunning Program Yoga Program |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (12 listed)
- All subjects
- Subjects 18 to 40 years of age.
- Subjects are capable of giving informed consent
- Overweight or obese
- Insulin resistant based on screening oral glucose tolerance testing.
Key exclusion criteria (12 listed)
- All subjects
- Subjects 18 to 40 years of age.
- Subjects are capable of giving informed consent
- Overweight or obese
- Insulin resistant based on screening oral glucose tolerance testing.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Running Program16 week supervised running program | Behavioural | Obese or Overweight |
| Yoga Programonce weekly supervised yoga | Behavioural | Obese or Overweight |
Primary outcome
Differences in insulin sensitivity between groups
Time frame: Before and after exercise program (exercise program will take 16 weeks, expected average for evaluation will be 20 weeks)
Will use HOMA-IR and hyperinsulinemia-euglycemic clamp
1 secondary outcome
Differences in fitness level between groups
Time frame: before and after exercise program (exercise program will take 16 weeks, expected average for evaluation will be 20 weeks)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Jan 2026.
- Derived from this study: PubMed 35192550Nelson AB, Chow LS, Stagg DB, Gillingham JR, Evans MD, Pan M, Hughey CC, Myers CL, Han X, Crawford PA, Puchalska P. Acute aerobic exercise reveals that FAHFAs distinguish the metabolomes of overweight and normal-weight runners. JCI Insight. 2022 Apr 8;7(7):e158037. doi: 10.1172/jci.insight.158037.
- Derived from this study: PubMed 30064815Bantle AE, Bosch TA, Dengel DR, Wang Q, Mashek DG, Chow LS. DXA-Determined Regional Adiposity Relates to Insulin Resistance in a Young Adult Population with Overweight andObesity. J Clin Densitom. 2019 Apr-Jun;22(2):287-292. doi: 10.1016/j.jocd.2018.06.001. Epub 2018 Jun 7.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Lisa S. Chow, MD principal investigator
University of Minnesota
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Running Program and Yoga Program in people with Healthy Subjects and Lean Trained Subjects, run by University of Minnesota at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 12 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 8 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Differences in insulin sensitivity between groups (time frame: Before and after exercise program (exercise program will take 16 weeks, expected average for evaluation will be 20 weeks)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02150889, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Jan 2026.