Gait Analysis in Neurological DisordersNCT02165787
Investigation of Gait Parameters in Health and Neurological Disease Under Varying Locomotor Conditions
An observational study of Gait Analysis in Neurological Disorders, run by University of Zurich at 1 site in Switzerland.
Trial summary
In the cross-sectional component of this study, our overall objective is to gather a large pool of data from which we can generate gait "profiles". These profiles will consist of a constellation of gait (+/- electrophysiological) parameters associated with a particular neurological diagnosis or specific lesion(s) in… Read more about this study
- Who is it for?
- Ages 18 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Gait Analysis in Neurological Disorders
- How many people
- 208 participants
- Where
- 1 siteSwitzerland
- Study dates
- Apr 2014to 10 Dec 2019
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Adult patients aged 18-80 with spinal cord injury, hemispheric stroke, multiple sclerosis, Parkinson disease, vestibular disease, cerebellar disease. Healthy control subjects aged 18-80.
Who may be able to join
- Patients:
- age 18 - 80
- written, informed consent
- one of the following established diagnoses: unilateral stroke affecting motor system, Parkinson syndrome, cerebellar disease, vestibular dysfunction, spinal cord injury, multiple sclerosis
- Brain and whole spine T1, T2 \& FLAIR magnetic resonance imaging performed within the last four months and available for study purposes or no contraindications to performing these scans
- Healthy subjects:
- age 18 - 80
- written informed consent
Who cannot join
- Patients:
- Colour-blindness
- Known to be pregnant or breastfeeding
- Body mass index (weight in kg/height in metres squared) >40 Unable to walk 50m within 6 minutes (with or without walking aids) Inability to undertake any component of the trial protocol
- Terminal diagnosis with life expectancy less than six months
- Cognitive disturbance defined as MMSE < 25 Clinically significant comorbidities such as severe cardiovascular, pulmonary or malignant disease
Show all 12Show fewer
- Healthy subjects:
- Colour-blindness
- Known to be pregnant or breastfeeding
- Body mass index (weight in kg/height in metres squared) >40 Unable to walk 50m within 6 minutes
- Reliance on walking aids / prostheses for mobilisation
- Significant neurological or orthopaedic diagnosis with potential impact on gait // Previous operations on the lower limbs or spine with potential impact on gait Inability to undertake any component of the trial protocol Clinically significant conditions such as severe cardiovascular, pulmonary or malignant disease
Trial locations and contacts
1 site in 1 country.
About this study
In the cross-sectional component of this study, our overall objective is to gather a large pool of data from which we can generate gait "profiles". These profiles will consist of a constellation of gait (+/- electrophysiological) parameters associated with a particular neurological diagnosis or specific lesion(s) in neuroanatomical systems. Once developed, these profiles can be compared for differences and similarities; allowing insights into the specificity of the effect on gait of a given diagnosis or lesion in the case of the former and redundancy of neuroanatomical systems in that of the latter. A longitudinal component of the study will look at the evolution of gait parameters over time in a group of patients with spinal cord injury.
- Conditions
- Gait Analysis in Neurological Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| patients | Not described | |
| healthy control subjects | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change of gait parameter after injury to CNS
Measured: Timepoint 0 plus timepoint 6 months and 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Jun 2014 (estimated)
- Study startApr 2014
- Primary completionDec 2019
- Study completion10 Dec 2019
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Gait Analysis in Neurological DisordersStudies of the same condition, open and under way.
- More trials run by University of ZurichThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Other
- Enrolment
- 208 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Zurich
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02165787
- Sponsor's protocol ID
- KEK-ZH-2014-0004/PB_2016-00386
- Status last verified
- Sep 2025
- First submitted
- 23 May 2014
- Last updated
- 22 Sep 2025
- Results posted
- No
- Data monitoring committee
- Yes
Publications
Killeen T, Easthope CS, Filli L, Linnebank M, Curt A, Bolliger M, Zorner B. Modulating Arm Swing Symmetry with Cognitive Load: A Window on Rhythmic Spinal Locomotor Networks in Humans? J Neurotrauma. 2017 May 15;34(10):1897-1902. doi: 10.1089/neu.2016.4554. Epub 2016 Oct 12.
PubMed 27574966Killeen T, Easthope CS, Filli L, Lorincz L, Schrafl-Altermatt M, Brugger P, Linnebank M, Curt A, Zorner B, Bolliger M. Increasing cognitive load attenuates right arm swing in healthy human walking. R Soc Open Sci. 2017 Jan 25;4(1):160993. doi: 10.1098/rsos.160993. eCollection 2017 Jan.
PubMed 28280596Filli L, Meyer C, Killeen T, Lorincz L, Gopfert B, Linnebank M, von Tscharner V, Curt A, Bolliger M, Zorner B. Probing Corticospinal Control During Different Locomotor Tasks Using Detailed Time-Frequency Analysis of Electromyograms. Front Neurol. 2019 Jan 29;10:17. doi: 10.3389/fneur.2019.00017. eCollection 2019.
PubMed 30761064Killeen T, Easthope CS, Demko L, Filli L, Lorincz L, Linnebank M, Curt A, Zorner B, Bolliger M. Minimum toe clearance: probing the neural control of locomotion. Sci Rep. 2017 May 15;7(1):1922. doi: 10.1038/s41598-017-02189-y.
PubMed 28507300
Study at a glance
From the registry record, last updated by the sponsor on 22 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigation of Gait Parameters in Health and Neurological Disease Under Varying Locomotor Conditions
- ClinicalTrials.gov ID
- NCT02165787
- Acronym / sponsor ID
- KEK-ZH-2014-0004/PB_2016-00386
- Conditions
- Gait Analysis in Neurological Disorders
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 208 participants (actual)
- Lead sponsor
- University of ZurichUniversity, hospital or other
- Study start
- Apr 2014
- Primary completion
- Dec 2019 (actual)
- Study completion
- 10 Dec 2019 (actual)
- First posted
- 17 Jun 2014 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In the cross-sectional component of this study, our overall objective is to gather a large pool of data from which we can generate gait "profiles". These profiles will consist of a constellation of gait (+/- electrophysiological) parameters associated with a particular neurological diagnosis or specific lesion(s) in neuroanatomical systems. Once developed, these profiles can be compared for differences and similarities; allowing insights into the specificity of the effect on gait of a given diagnosis or lesion in the case of the former and redundancy of neuroanatomical systems in that of the latter. A longitudinal component of the study will look at the evolution of gait parameters over time in a group of patients with spinal cord injury.
Study design
- Observational model
- Other
- Time perspective
- Other
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| patients | – | – |
| healthy control subjects | – | – |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients aged 18-80 with spinal cord injury, hemispheric stroke, multiple sclerosis, Parkinson disease, vestibular disease, cerebellar disease. Healthy control subjects aged 18-80.
Key inclusion criteria (8 listed)
- age 18 - 80
- written, informed consent
- one of the following established diagnoses: unilateral stroke affecting motor system, Parkinson syndrome, cerebellar disease, vestibular dysfunction, spinal cord injury, multiple sclerosis
- Brain and whole spine T1, T2 \& FLAIR magnetic resonance imaging performed within the last four months and available for study purposes or no contraindications to performing these scans
- age 18 - 80
Key exclusion criteria (12 listed)
- Colour-blindness
- Known to be pregnant or breastfeeding
- Body mass index (weight in kg/height in metres squared) >40 Unable to walk 50m within 6 minutes (with or without walking aids) Inability to undertake any component of the trial protocol
- Terminal diagnosis with life expectancy less than six months
- Cognitive disturbance defined as MMSE < 25 Clinically significant comorbidities such as severe cardiovascular, pulmonary or malignant disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Change of gait parameter after injury to CNS
Time frame: Timepoint 0 plus timepoint 6 months and 12 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Sep 2025.
- Background: PubMed 27574966Killeen T, Easthope CS, Filli L, Linnebank M, Curt A, Bolliger M, Zorner B. Modulating Arm Swing Symmetry with Cognitive Load: A Window on Rhythmic Spinal Locomotor Networks in Humans? J Neurotrauma. 2017 May 15;34(10):1897-1902. doi: 10.1089/neu.2016.4554. Epub 2016 Oct 12.
- Background: PubMed 28280596Killeen T, Easthope CS, Filli L, Lorincz L, Schrafl-Altermatt M, Brugger P, Linnebank M, Curt A, Zorner B, Bolliger M. Increasing cognitive load attenuates right arm swing in healthy human walking. R Soc Open Sci. 2017 Jan 25;4(1):160993. doi: 10.1098/rsos.160993. eCollection 2017 Jan.
- Background: PubMed 30761064Filli L, Meyer C, Killeen T, Lorincz L, Gopfert B, Linnebank M, von Tscharner V, Curt A, Bolliger M, Zorner B. Probing Corticospinal Control During Different Locomotor Tasks Using Detailed Time-Frequency Analysis of Electromyograms. Front Neurol. 2019 Jan 29;10:17. doi: 10.3389/fneur.2019.00017. eCollection 2019.
- Background: PubMed 28507300Killeen T, Easthope CS, Demko L, Filli L, Lorincz L, Linnebank M, Curt A, Zorner B, Bolliger M. Minimum toe clearance: probing the neural control of locomotion. Sci Rep. 2017 May 15;7(1):1922. doi: 10.1038/s41598-017-02189-y.
Related trials for Gait Analysis in Neurological Disorders
Recruiting
Assessment of a Portable Digital Device for Quantified Analysis of Markerless Walking in Volunteers With Neuromuscular Diseases or Asymptomatic Volunteers
Spinal Muscular Atrophy (SMA), Charcot-Marie-Tooth
RecruitingObservational study
Usability of the Smart Hallway System in Clinical Setting
Amputation, Gait Disorders, Neurologic
Recruiting
Short-Term Effects of Manual Therapy Prior to Neuromotor Therapy in Children With Cerebral Palsy
Cerebral Palsy (CP), Unilateral Spastic Cerebral Palsy
Not yet recruiting
Dual-Task Balance Training in People With Multiple Sclerosis: a Randomized Feasibility Study
Multiple Sclerosis
RecruitingObservational study
Quadriceps Muscle Activity and Gait Kinematics in Patients With Post-Stroke Stiff-Knee Gait Compared With Healthy Controls
Stroke, Hemiparesis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Gait Analysis in Neurological Disorders, run by University of Zurich at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change of gait parameter after injury to CNS (time frame: Timepoint 0 plus timepoint 6 months and 12 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02165787, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Sep 2025.