Frontotemporal DementiaANALOGNCT02236832
Study of the Neural Basis of Analogical Reasoning
A study testing transcranial magnetic stimulation, MRI imaging and EEG recording in people with Frontotemporal Dementia and Progressive Supranuclear Palsy, run by Institut National de la Santé Et de la Recherche Médicale, France at 1 site in France.
Trial summary
Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. Read more about this study
- Who is it for?
- Ages 20 to 85 yearsHealthy volunteers can take part
- Conditions the study is for
- Frontotemporal Dementia, Progressive Supranuclear Palsy, Healthy Subjects
- What is being tested?
- transcranial magnetic stimulation, MRI imaging and EEG recording
- Type of treatment
- Medical device, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 130 participants
- Where
- 1 siteFrance
- Study dates
- Feb 2015to Feb 2021
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 85 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Healthy subjects:
- subject affiliated to national health insurance
- informed consent signed
- normal neurological examination
- subject aged at least 20
- Patients:
Show all 9Show fewer
- FTD or PSP diagnostic criteria filled
- patient affiliated to national health insurance
- informed consent signed
Who cannot join
- Severe psychiatric symptomatology and psychotropic drug use
- unability to understand or perform the cognitive tasks.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Organisation du Cortex préfrontal ventrolatéral Pour l'Analogie: Approche Bimodale Chez le Sujet Sain et Chez le Patient Ayant un Syndrome Frontal.
Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. The aim of this project is to test our hypotheses about the role of the prefrontal cortex in explicit and implicit categorisation and analogy tasks.
- Being tested
- transcranial magnetic stimulation, MRI imaging, EEG recording, Neuropsychological examination
- Medical subject headings
- Frontotemporal Dementia, Supranuclear Palsy, Progressive
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MRI imagingOther
EEG recordingOther
Neuropsychological examinationBehavioural
| Study group | Role | What they receive |
|---|---|---|
| FTD (frontotemporal dementia) patients | Experimental | fronto-temporal demential patients Receives: Other: MRI imaging; Other: EEG recording; Behavioral: Neuropsychological examination |
| PSP patients | Experimental | progressive supra nuclear palsy patients Receives: Other: MRI imaging; Other: EEG recording; Behavioral: Neuropsychological examination |
| healthy controls | Active comparator | healthy control education matched, age matched and sex matched with PSP and FTD patients Receives: Other: MRI imaging; Other: EEG recording; Behavioral: Neuropsychological examination |
| healthy participants | Experimental | healthy participants that will participate to the TMS study. Receives: Device: transcranial magnetic stimulation; Other: MRI imaging; Other: EEG recording; Behavioral: Neuropsychological examination |
| healthy young participants | Experimental | Healthy participants will be included for an EEG study Receives: Other: EEG recording; Behavioral: Neuropsychological examination |
What is being measured
The primary outcome is the main question the study is designed to answer.
Performance in the implicat task
Reaction time and accuracy will be registered for this categorization task. This task will be used in patients with FTD and in healthy controls (n=60).
Participants will come only once during one day ot the research centre.
Measured: day of inclusion (one day)
Performance in the Similitude task
Reaction time and accuracy will be recorded while healthy subjects perform this categorization task, after a session of rTMS or during on line TMS (n=40).
Participants will come 3 to 5 times at the research centre in a maximum period of 4 months.
Measured: from inclusion to 4 months after inclusion
Secondary outcomes (2)
recording of EEG
EEG will be recorded in patients with FTD and in healthy controls for an analysis of event related potentials.
Participants will come only once during one day a the research centre.
Measured: day of inclusion (one day)
Analysis of MRI
T1 MRI will be recorded for VBM analysis in patients with FTD and healthy controls.
Participants will come only once during one day at the research centre
Measured: day of inclusion (one day)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Sep 2014 (estimated)
- Study startFeb 2015
- Primary completionFeb 2021
- Study completionFeb 2021
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Frontotemporal DementiaStudies of the same condition, open and under way.
- More trials run by Institut National de la Santé Et de la Recherche Médicale, FranceThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 130 participants (actual)
Sponsor and investigators
- Sponsor type
- Other government
- Collaborators
- Fondation pour la Recherche Médicale
- Responsible party
- Sponsor
- Investigators
- Richard Levy, MD, PhD, Principal investigator, Institut du Cerveau et de la Moelle épinière, Paris
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02236832
- Sponsor's protocol ID
- C14-17'
- Other IDs
- 140662B-31, 2014-A00649-38
- Acronym
- ANALOG
- Status last verified
- Mar 2017
- First submitted
- 28 Aug 2014
- Last updated
- 4 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- Individual data sharing
- Undecided: IPD sharing will be only performed on individual request for a specified study.
Publications
Ovando-Tellez M, Rohaut B, George N, Bieth T, Hugueville L, Ibrahim Y, Courbet O, Naccache L, Levy R, Garcin B, Volle E. Does adding <i>beer</i> to <i>coffee</i> enhance the activation of <i>drinks</i>? An ERP study of semantic category priming. Cogn Neurosci. 2022 Jan-Jun;13(2):61-76. doi: 10.1080/17588928.2021.1940117. Epub 2021 Jul 7.
PubMed 34232829
Study at a glance
From the registry record, last updated by the sponsor on 4 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Organisation du Cortex préfrontal ventrolatéral Pour l'Analogie: Approche Bimodale Chez le Sujet Sain et Chez le Patient Ayant un Syndrome Frontal.
- ClinicalTrials.gov ID
- NCT02236832
- Acronym / sponsor ID
- ANALOG / C14-17'
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 130 participants (actual)
- Lead sponsor
- Institut National de la Santé Et de la Recherche Médicale, FranceOther government
- Collaborators
- Fondation pour la Recherche Médicale
- Study start
- Feb 2015 (actual)
- Primary completion
- Feb 2021 (actual)
- Study completion
- Feb 2021 (actual)
- First posted
- 11 Sep 2014 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. The aim of this project is to test our hypotheses about the role of the prefrontal cortex in explicit and implicit categorisation and analogy tasks.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 5
| Arm | Type | Receives |
|---|---|---|
| FTD (frontotemporal dementia) patients | Experimental | Other: MRI imaging, Other: EEG recording, Behavioral: Neuropsychological examinationfronto-temporal demential patients |
| PSP patients | Experimental | Other: MRI imaging, Other: EEG recording, Behavioral: Neuropsychological examinationprogressive supra nuclear palsy patients |
| healthy controls | Active comparator | Other: MRI imaging, Other: EEG recording, Behavioral: Neuropsychological examinationhealthy control education matched, age matched and sex matched with PSP and FTD patients |
| healthy participants | Experimental | Device: transcranial magnetic stimulation, Other: MRI imaging, Other: EEG recording, Behavioral: Neuropsychological examinationhealthy participants that will participate to the TMS study. |
| healthy young participants | Experimental | Other: EEG recording, Behavioral: Neuropsychological examinationHealthy participants will be included for an EEG study |
Who may qualify
- Ages
- 20 to 85 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (9 listed)
- subject affiliated to national health insurance
- informed consent signed
- normal neurological examination
- subject aged at least 20
- FTD or PSP diagnostic criteria filled
Key exclusion criteria (2 listed)
- Severe psychiatric symptomatology and psychotropic drug use
- unability to understand or perform the cognitive tasks.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| transcranial magnetic stimulation | Device | healthy participants |
| MRI imaging | Other | FTD (frontotemporal dementia) patients, PSP patients, healthy controls, healthy participants |
| EEG recording | Other | FTD (frontotemporal dementia) patients, PSP patients, healthy controls, healthy participants, healthy young participants |
| Neuropsychological examination | Behavioural | FTD (frontotemporal dementia) patients, PSP patients, healthy controls, healthy participants, healthy young participants |
Primary outcome
Performance in the implicat task
Time frame: day of inclusion (one day)
Reaction time and accuracy will be registered for this categorization task. This task will be used in patients with FTD and in healthy controls (n=60). Participants will come only once during one day ot the research centre.
Performance in the Similitude task
Time frame: from inclusion to 4 months after inclusion
Reaction time and accuracy will be recorded while healthy subjects perform this categorization task, after a session of rTMS or during on line TMS (n=40). Participants will come 3 to 5 times at the research centre in a maximum period of 4 months.
2 secondary outcomes
recording of EEG
Time frame: day of inclusion (one day)
Analysis of MRI
Time frame: day of inclusion (one day)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Sep 2025.
- Results publication: PubMed 34232829Ovando-Tellez M, Rohaut B, George N, Bieth T, Hugueville L, Ibrahim Y, Courbet O, Naccache L, Levy R, Garcin B, Volle E. Does adding <i>beer</i> to <i>coffee</i> enhance the activation of <i>drinks</i>? An ERP study of semantic category priming. Cogn Neurosci. 2022 Jan-Jun;13(2):61-76. doi: 10.1080/17588928.2021.1940117. Epub 2021 Jul 7.
- Individual participant dataSharing planned: Undecided. IPD sharing will be only performed on individual request for a specified study.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Richard Levy, MD, PhD principal investigator
Institut du Cerveau et de la Moelle épinière, Paris
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing transcranial magnetic stimulation, MRI imaging and EEG recording in people with Frontotemporal Dementia and Progressive Supranuclear Palsy, run by Institut National de la Santé Et de la Recherche Médicale, France at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Performance in the implicat task (time frame: day of inclusion (one day)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02236832, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Sep 2025.