AnorexicOLFANORNCT02297165
Efficacy Study of an Olfactory Stimulation Program for the Recuperation of Autobiographical Memories in Anorexia
A study testing olfactory stimulation program in people with Anorexic, run by Lille Catholic University at 1 site in France.
Trial summary
The purpose of this study is to estimate the impact of an olfactive stimulation, in relaxing environment, on the access at the autobiographical memories in anorexic patients. Read more about this study
- Who is it for?
- Ages 13 to 24 years, women only
- Conditions the study is for
- Anorexic
- What is being tested?
- olfactory stimulation program
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 1 siteFrance
- Study dates
- Jun 2014to Jul 2018
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 13 to 24 years
- Women only
- No healthy volunteers
- Child, Adult
Who may be able to join
- Eating disorders, anorexia (restrictive form or mixed) according to DSM IV-TR ( Diagnostic and Statistical Manual of Mental Disorders IV - Text Revision) criteria
- Patient hospitalized in a department of one of the inquiring centers for a minimal duration of 5 weeks
- French language ability
- Coverage by the social insurance
- Fully informed patient who consent to participate in the study
Who cannot join
- Major mental associated disorders (psychotic disorders, bipolar disorder, major depression), neurological disorders or addiction to substances
- Psychotropic treatment (with the exception of antidepressants, anxiolytics and sleeping drugs, if the treatment was started more than 30 days ago)
- Any disorder susceptible to alter the reasoning capacities, discernment or judgment
- Physically or psychologically unable to answer questionnaires
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Efficacy Study of an Olfactory Stimulation Program in Relaxing Environment for the Recuperation of Autobiographical Memories in Anorexic Patients
The purpose of this study is to estimate the impact of an olfactive stimulation, in relaxing environment, on the access at the autobiographical memories in anorexic patients.
- Conditions
- Anorexic
- Being tested
- olfactory stimulation program
- Keywords
- anorexic, olfactory stimulation, autobiographical memories recovery
- Medical subject headings
- Anorexia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
olfactory stimulation programBehavioural
8 individual sessions of olfactory stimulation at the rate of 2 sessions per week. 3 semi-directed interviews will be help (one at the beginning of the trial, the second 5 weeks later and the third at 6 month).
For each session, patients have to smell two different odors (previously selected from a panel presented to the patient during first visits) and then they are invited to evoke memories and feelings related to each odor.
| Study group | Role | What they receive |
|---|---|---|
| Program | Experimental | olfactory stimulation program Receives: Behavioral: olfactory stimulation program |
| Control | No intervention | normal follow-up |
What is being measured
The primary outcome is the main question the study is designed to answer.
Proportion of reminded specific autobiographical memories (Autobiographical Memory Test (AMT)
Autobiographical Memory Test (AMT) at inclusion and 5 weeks after
Measured: After 5 weeks
Secondary outcomes (7)
Body mass index
Evaluation of size and weight
Measured: first day of enrollment and 5 weeks after
Evaluation of the specific memories recovery stimulation on the emotional differentiation ability (Level of Emotional Awareness Scale (LEAS)
Level of Emotional Awareness Scale (LEAS)
Measured: first day of enrollment and 5 weeks after
Evaluation of mental rumination (Cambridge Exeter Rumination Thinking Scale)
Cambridge Exeter Rumination Thinking Scale
Measured: first day of enrollment and 5 weeks after
Evaluation of anxiety and depression (Hospital Anxiety and Depression Scale)
Hospital Anxiety and Depression Scale
Measured: first day of enrollment and 5 weeks after
Evaluation of eating behaviors (Eating Disorder Inventory)
Eating Disorder Inventory
Measured: first day of enrollment and 5 weeks after
Evaluation of history of abuse (Childhood Trauma Questionnaire)
Childhood Trauma Questionnaire
Measured: first day of enrollment and 5 weeks after
Evaluation of cognitive avoidance strategies (Questionnaire of cognitive avoidance)
Questionnaire of cognitive avoidance
Measured: first day of enrollment and 5 weeks after
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Nov 2014 (estimated)
- Study startJun 2014
- Primary completionSep 2017
- Study completionJul 2018
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for AnorexicStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 100 participants (actual)
Sponsor and investigators
- Lead sponsor
- Lille Catholic University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Vincent Dodin, Study director, Groupement des Hôpitaux de l'Institut Catholique de Lille
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02297165
- Sponsor's protocol ID
- RC-P0028
- Acronym
- OLFANOR
- Status last verified
- Apr 2026
- First submitted
- 4 Nov 2014
- Last updated
- 20 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- Individual data sharing
- No
Publications
Gandolphe MC, Nandrino JL, Hendrickx M, Willem C, Cottencin O, Gerardin P, Guardia D, Buttitta M, Zanini V, Dodin V. Specificity and wealth of autobiographical memories in restrictive and mixed anorexic patients. PLoS One. 2021 Sep 10;16(9):e0256959. doi: 10.1371/journal.pone.0256959. eCollection 2021.
PubMed 34506532
Study at a glance
From the registry record, last updated by the sponsor on 20 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Efficacy Study of an Olfactory Stimulation Program in Relaxing Environment for the Recuperation of Autobiographical Memories in Anorexic Patients
- ClinicalTrials.gov ID
- NCT02297165
- Acronym / sponsor ID
- OLFANOR / RC-P0028
- Conditions
- Anorexic
- Keywords
- anorexic, olfactory stimulation, autobiographical memories recovery
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 100 participants (actual)
- Lead sponsor
- Lille Catholic UniversityUniversity, hospital or other
- Study start
- Jun 2014
- Primary completion
- Sep 2017 (actual)
- Study completion
- Jul 2018 (actual)
- First posted
- 21 Nov 2014 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to estimate the impact of an olfactive stimulation, in relaxing environment, on the access at the autobiographical memories in anorexic patients.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Program | Experimental | Behavioral: olfactory stimulation programolfactory stimulation program |
| Control | No intervention | –normal follow-up |
Who may qualify
- Ages
- 13 to 24 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (5 listed)
- Eating disorders, anorexia (restrictive form or mixed) according to DSM IV-TR ( Diagnostic and Statistical Manual of Mental Disorders IV - Text Revision) criteria
- Patient hospitalized in a department of one of the inquiring centers for a minimal duration of 5 weeks
- French language ability
- Coverage by the social insurance
- Fully informed patient who consent to participate in the study
Key exclusion criteria (4 listed)
- Major mental associated disorders (psychotic disorders, bipolar disorder, major depression), neurological disorders or addiction to substances
- Psychotropic treatment (with the exception of antidepressants, anxiolytics and sleeping drugs, if the treatment was started more than 30 days ago)
- Any disorder susceptible to alter the reasoning capacities, discernment or judgment
- Physically or psychologically unable to answer questionnaires
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| olfactory stimulation program8 individual sessions of olfactory stimulation at the rate of 2 sessions per week. 3 semi-directed interviews will be help (one at the beginning of the trial, the second 5 weeks later and the third at 6 month). For each session, patients have to smell two different odors (previously selected from a panel presented to the patient during first visits) and then they are invited to evoke memories and feelings related to each odor. | Behavioural | Program |
Primary outcome
Proportion of reminded specific autobiographical memories (Autobiographical Memory Test (AMT)
Time frame: After 5 weeks
Autobiographical Memory Test (AMT) at inclusion and 5 weeks after
7 secondary outcomes
Body mass index
Time frame: first day of enrollment and 5 weeks after
Evaluation of the specific memories recovery stimulation on the emotional differentiation ability (Level of Emotional Awareness Scale (LEAS)
Time frame: first day of enrollment and 5 weeks after
Evaluation of mental rumination (Cambridge Exeter Rumination Thinking Scale)
Time frame: first day of enrollment and 5 weeks after
Evaluation of anxiety and depression (Hospital Anxiety and Depression Scale)
Time frame: first day of enrollment and 5 weeks after
Evaluation of eating behaviors (Eating Disorder Inventory)
Time frame: first day of enrollment and 5 weeks after
Evaluation of history of abuse (Childhood Trauma Questionnaire)
Time frame: first day of enrollment and 5 weeks after
Evaluation of cognitive avoidance strategies (Questionnaire of cognitive avoidance)
Time frame: first day of enrollment and 5 weeks after
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Apr 2026.
- Results publication: PubMed 34506532Gandolphe MC, Nandrino JL, Hendrickx M, Willem C, Cottencin O, Gerardin P, Guardia D, Buttitta M, Zanini V, Dodin V. Specificity and wealth of autobiographical memories in restrictive and mixed anorexic patients. PLoS One. 2021 Sep 10;16(9):e0256959. doi: 10.1371/journal.pone.0256959. eCollection 2021.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Vincent Dodin study director
Groupement des Hôpitaux de l'Institut Catholique de Lille
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing olfactory stimulation program in people with Anorexic, run by Lille Catholic University at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Proportion of reminded specific autobiographical memories (Autobiographical Memory Test (AMT) (time frame: After 5 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02297165, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Apr 2026.