Out-of-Hospital Cardiac ArrestDISCONCT02309151
Direct or Subacute Coronary Angiography in Out-of-hospital Cardiac Arrest
A study testing Immediate coronary angiography in people with Out-of-Hospital Cardiac Arrest, run by Uppsala University at 21 sites in 3 countries.
Trial summary
The overall aim of this prospective, randomized study is to investigate whether acute coronary angiography (within 120 minutes) with a predefined strategy for revascularization, will improve 30-day survival in patients with out of hospital cardiac arrest with no signs of ST-elevation on ECG after Restoration of… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Out-of-Hospital Cardiac Arrest
- What is being tested?
- Immediate coronary angiography
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 1,003 participants
- Where
- 21 sitesin 3 countries
- Study dates
- Dec 2014to Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Witnessed out of hospital cardiac arrest
- Restoration of Spontaneous Circulation (ROSC) >20 minutes
- Coronary angiography is expected to be performed within 120 minutes from inclusion and randomization at hospital
Who cannot join
- Patient age <18 years
- Obvious extracardiac genesis of cardiac arrest such as trauma, hemorrhagic shock, and / or asphyxia (eg drowning, suffocation, hanging, exposure to fire smoke)
- Terminally ill patients with a life expectancy of less than 1 year
- Patients with ST-elevation
- Known pregnancy
- Patient awake GCS >8 (Glasgow Coma Scale)
Trial locations and contacts
21 sites in 3 countries.
21 sites in 3 countries
Sweden10 sites
Sahlgrenska Universitetssjukhuset
Gothenburg
Karolinska Universitetssjukhuset
Huddinge
Skånes Universitetssjukhus
Lund
Skåne Universitetssjukhus
Malmö
Örebro Universitetssjukhus
Örebro
Karolinska Universitetssjukhuset
Solna
Danderyd Sjukhus
Stockholm
Södersjukhuset AB
Stockholm
Umeå Universitetssjukhus
Umeå
Uppsala University hospital
Uppsala, 75185
Netherlands8 sites
Amsterdam UMC
Amsterdam
Albert Schweitzer Hospital
Dordrecht
Catharina Ziekenhuis
Eindhoven
Treant Hospital
Emmen
Zuyderland Hospital
Heerlen
Antonius Hospital
Nieuwegein
Radboud University Medical Center
Nijmegen
Haaglanden Medisch Centrum
The Hague
Denmark3 sites
Aalborg University hospital
Aalborg
Aarhus University Hospital
Aarhus
Odense University hospital
Odense
About this study
Official title: Direct or Subacute Coronary Angiography in Out-of-hospital Cardiac Arrest - a Prospective, Randomized Study
The overall aim of this prospective, randomized study is to investigate whether acute coronary angiography (within 120 minutes) with a predefined strategy for revascularization, will improve 30-day survival in patients with out of hospital cardiac arrest with no signs of ST-elevation on ECG after Restoration of Spontaneous Circulation (ROSC). The patients will be randomized to a strategy of immediate coronary angiography within 120 minutes or to a strategy of delayed angiography that may be performed three days after the cardiac arrest.
Read the detailed description
The study is a prospective randomized open label multicenter study with a registry follow up in which patients with out of hospital cardiac arrest without ST-elevation on their first ECG will be randomized to either a strategy of immediate coronary angiography (treatment group) with possible coronary intervention or a strategy of delayed coronary angiography (control group). The study will include in total 1006 patients with Restoration of Spontaneous Circulation (ROSC). Randomization will be done via a web-based module after ECG is taken at the first medical contact but no later than after arrival at the emergency room. Coronary angiography should be performed within 120 minutes from randomization in the immediate angiography group. In the delayed angiography group, angiography with possible coronary intervention will be performed at the discretion of the interventional cardiologist and should preferably not be performed until three days after the cardiac arrest. This strategy is in accordance with standard practice. In case of recurrent chest pain, ST elevation, circulatory instability or cardiogenic shock, cross over to early angiography may occur. The quality of life and health economics will be evaluated at 6 months. The patients will undergo extensive neurocognitive tests and health instruments, these will be analyzed and presented.
- Conditions
- Out-of-Hospital Cardiac Arrest
- Being tested
- Immediate coronary angiography
- Medical subject headings
- Out-of-Hospital Cardiac Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Immediate coronary angiographyProcedure or surgery
Immediate coronary angiography for out of hospital cardiac arrest patients with no signs of ST elevation on their first ECG after ROSC
| Study group | Role | What they receive |
|---|---|---|
| Immediate coronary angiography | Experimental | Immediate coronary angiography for out of hospital cardiac arrest patients with no signs of ST elevation on their first ECG after ROSC Receives: Procedure: Immediate coronary angiography |
| Not immediate coronary angiography | No intervention | Coronary angiography with possible coronary intervention may be performed at the discretion of the interventional cardiologist and should preferably not be performed until three days after the cardiac arrest. This strategy is in accordance with standard practice. |
What is being measured
The primary outcome is the main question the study is designed to answer.
30 day survival
Follow up will be performed at 30 days, telephone call or visit.
Measured: 30 days
Secondary outcomes (7)
Survival with good neurological function
30-day survival and a follow up of health status, functional outcome associated to cerebral performance and general functional outcome/activities of daily living
Measured: 30 days
Survival at discharge from ICU (individual for each subject) and at 6-months
Recorded in the e-CRF (electronic Case Report Form)
Measured: At discharge from ICU, an expected average of 3-30 days and at 6-months
Survival with good neurological function at discharge from ICU and 6-months
Survival with good neurological function at discharge and at 6-months. Assessing functional outcome associated to cerebral performance and general functional outcome/activities of daily living and also global functional outcome, independent living and social reintegration at 6-months
Measured: At discharge from ICU, an expected average of 3-30 days and at 6-months
Cardiac function
Measured with echocardiography
Measured: 72 hours and at 6 months
Follow up of neurological function at 6-months
A 6 month follow up of neurological function will be assessed by validated screening battery in OHCA (Out of Hospital Cardiac Arrest) patients in general functional outcome, activities of daily living, cognitive functioning, attention, anxiety and depression, fatigue, cardiac disease specific health and care giver burden.
Measured: Measured at 6 months
Hemodynamic parameters (urine output, highest lactate and vasopressor/inotropic support)
Parameters measured daily during ICU care
Measured: During ICU care (maximum of 7 days)
ECG findings compared to findings at coronary angiography
Primary ECG, performed in the pre-hospital setting or at the emergency department, will be compared with findings at coronary angiography intervention (performed immediately or later during hospital stay depending on randomisation)
Measured: During hospital stay up to a maximum of 6-months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Dec 2014 (estimated)
- Study startDec 2014
- Primary completionApr 2026
- Study completionApr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Out-of-Hospital Cardiac ArrestStudies of the same condition, open and under way.
- More trials run by Uppsala UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 1,003 participants (actual)
Sponsor and investigators
- Lead sponsor
- Uppsala University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Sten Rubertsson, Md,PhD, Principal investigator, Uppsala Universtiy hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02309151
- Sponsor's protocol ID
- DSC001
- Acronym
- DISCO
- Status last verified
- Apr 2026
- First submitted
- 17 Nov 2014
- Last updated
- 8 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Elfwen L, Lagedal R, Rubertsson S, James S, Oldgren J, Olsson J, Hollenberg J, Jensen U, Ringh M, Svensson L, Nordberg P. Post-resuscitation myocardial dysfunction in out-of-hospital cardiac arrest patients randomized to immediate coronary angiography versus standard of care. Int J Cardiol Heart Vasc. 2020 Mar 2;27:100483. doi: 10.1016/j.ijcha.2020.100483. eCollection 2020 Apr.
PubMed 32154359Elfwen L, Lagedal R, Nordberg P, James S, Oldgren J, Bohm F, Lundgren P, Rylander C, van der Linden J, Hollenberg J, Erlinge D, Cronberg T, Jensen U, Friberg H, Lilja G, Larsson IM, Wallin E, Rubertsson S, Svensson L. Direct or subacute coronary angiography in out-of-hospital cardiac arrest (DISCO)-An initial pilot-study of a randomized clinical trial. Resuscitation. 2019 Jun;139:253-261. doi: 10.1016/j.resuscitation.2019.04.027. Epub 2019 Apr 24.
PubMed 31028826Lagedal R, Elfwen L, James S, Oldgren J, Erlinge D, Ostlund O, Wallin E, Larsson IM, Lilja G, Cronberg T, Rubertsson S, Nordberg P. Design of DISCO-Direct or Subacute Coronary Angiography in Out-of-Hospital Cardiac Arrest study. Am Heart J. 2018 Mar;197:53-61. doi: 10.1016/j.ahj.2017.11.009. Epub 2017 Dec 5.
PubMed 29447784
Study at a glance
From the registry record, last updated by the sponsor on 8 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Direct or Subacute Coronary Angiography in Out-of-hospital Cardiac Arrest - a Prospective, Randomized Study
- ClinicalTrials.gov ID
- NCT02309151
- Acronym / sponsor ID
- DISCO / DSC001
- Conditions
- Out-of-Hospital Cardiac Arrest
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 1,003 participants (actual)
- Lead sponsor
- Uppsala UniversityUniversity, hospital or other
- Study start
- Dec 2014 (actual)
- Primary completion
- Apr 2026 (actual)
- Study completion
- Apr 2026 (actual)
- First posted
- 5 Dec 2014 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The overall aim of this prospective, randomized study is to investigate whether acute coronary angiography (within 120 minutes) with a predefined strategy for revascularization, will improve 30-day survival in patients with out of hospital cardiac arrest with no signs of ST-elevation on ECG after Restoration of Spontaneous Circulation (ROSC). The patients will be randomized to a strategy of immediate coronary angiography within 120 minutes or to a strategy of delayed angiography that may be performed three days after the cardiac arrest.
Detailed description
The study is a prospective randomized open label multicenter study with a registry follow up in which patients with out of hospital cardiac arrest without ST-elevation on their first ECG will be randomized to either a strategy of immediate coronary angiography (treatment group) with possible coronary intervention or a strategy of delayed coronary angiography (control group). The study will include in total 1006 patients with Restoration of Spontaneous Circulation (ROSC). Randomization will be done via a web-based module after ECG is taken at the first medical contact but no later than after arrival at the emergency room. Coronary angiography should be performed within 120 minutes from randomization in the immediate angiography group. In the delayed angiography group, angiography with possible coronary intervention will be performed at the discretion of the interventional cardiologist and should preferably not be performed until three days after the cardiac arrest. This strategy is in accordance with standard practice. In case of recurrent chest pain, ST elevation, circulatory instability or cardiogenic shock, cross over to early angiography may occur. The quality of life and health economics will be evaluated at 6 months. The patients will undergo extensive neurocognitive tests and health instruments, these will be analyzed and presented.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Immediate coronary angiography | Experimental | Procedure: Immediate coronary angiographyImmediate coronary angiography for out of hospital cardiac arrest patients with no signs of ST elevation on their first ECG after ROSC |
| Not immediate coronary angiography | No intervention | –Coronary angiography with possible coronary intervention may be performed at the discretion of the interventional cardiologist and should preferably not be performed until three days after the cardiac arrest. This strategy is in accordance with standard practice. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Witnessed out of hospital cardiac arrest
- Restoration of Spontaneous Circulation (ROSC) >20 minutes
- Coronary angiography is expected to be performed within 120 minutes from inclusion and randomization at hospital
Key exclusion criteria (6 listed)
- Patient age <18 years
- Obvious extracardiac genesis of cardiac arrest such as trauma, hemorrhagic shock, and / or asphyxia (eg drowning, suffocation, hanging, exposure to fire smoke)
- Terminally ill patients with a life expectancy of less than 1 year
- Patients with ST-elevation
- Known pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Immediate coronary angiographyImmediate coronary angiography for out of hospital cardiac arrest patients with no signs of ST elevation on their first ECG after ROSC | Procedure or surgery | Immediate coronary angiography |
Primary outcome
30 day survival
Time frame: 30 days
Follow up will be performed at 30 days, telephone call or visit.
7 secondary outcomes
Survival with good neurological function
Time frame: 30 days
Survival at discharge from ICU (individual for each subject) and at 6-months
Time frame: At discharge from ICU, an expected average of 3-30 days and at 6-months
Survival with good neurological function at discharge from ICU and 6-months
Time frame: At discharge from ICU, an expected average of 3-30 days and at 6-months
Cardiac function
Time frame: 72 hours and at 6 months
Follow up of neurological function at 6-months
Time frame: Measured at 6 months
Hemodynamic parameters (urine output, highest lactate and vasopressor/inotropic support)
Time frame: During ICU care (maximum of 7 days)
ECG findings compared to findings at coronary angiography
Time frame: During hospital stay up to a maximum of 6-months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Apr 2026.
- Derived from this study: PubMed 32154359Elfwen L, Lagedal R, Rubertsson S, James S, Oldgren J, Olsson J, Hollenberg J, Jensen U, Ringh M, Svensson L, Nordberg P. Post-resuscitation myocardial dysfunction in out-of-hospital cardiac arrest patients randomized to immediate coronary angiography versus standard of care. Int J Cardiol Heart Vasc. 2020 Mar 2;27:100483. doi: 10.1016/j.ijcha.2020.100483. eCollection 2020 Apr.
- Derived from this study: PubMed 31028826Elfwen L, Lagedal R, Nordberg P, James S, Oldgren J, Bohm F, Lundgren P, Rylander C, van der Linden J, Hollenberg J, Erlinge D, Cronberg T, Jensen U, Friberg H, Lilja G, Larsson IM, Wallin E, Rubertsson S, Svensson L. Direct or subacute coronary angiography in out-of-hospital cardiac arrest (DISCO)-An initial pilot-study of a randomized clinical trial. Resuscitation. 2019 Jun;139:253-261. doi: 10.1016/j.resuscitation.2019.04.027. Epub 2019 Apr 24.
- Derived from this study: PubMed 29447784Lagedal R, Elfwen L, James S, Oldgren J, Erlinge D, Ostlund O, Wallin E, Larsson IM, Lilja G, Cronberg T, Rubertsson S, Nordberg P. Design of DISCO-Direct or Subacute Coronary Angiography in Out-of-Hospital Cardiac Arrest study. Am Heart J. 2018 Mar;197:53-61. doi: 10.1016/j.ahj.2017.11.009. Epub 2017 Dec 5.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Sten Rubertsson, Md,PhD principal investigator
Uppsala Universtiy hospital
21 sites in 3 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Immediate coronary angiography in people with Out-of-Hospital Cardiac Arrest, run by Uppsala University at 21 sites in 3 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 21 sites in Sweden, Netherlands, Denmark. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
30 day survival (time frame: 30 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02309151, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Apr 2026.