Substance Use DisordersNCT02356718
Cognitive Training in Inpatient Treatment for Substance Use Disorders
A study testing Cognitive training activities and Inpatient psychosocial therapy in people with Substance Use Disorders, run by Centre for Addiction and Mental Health at 1 site in Canada.
Trial summary
This study examines whether computer tasks can improve memory and other cognitive functions among patients receiving inpatient treatment for substance use disorders. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Substance Use Disorders
- What is being tested?
- Cognitive training activities and Inpatient psychosocial therapy
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 111 participants
- Where
- 1 siteCanada
- Study dates
- Jan 2015to Jul 2016
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Participants must be patients registered for inpatient treatment at the Centre for Addiction and Mental Health
- Age 18-60
- Fluency in English
- Able to attend scheduled training sessions
- Comfortable using a computer and mouse
Who cannot join
- Severe cognitive impairment
- Current or past psychosis or diagnosis of schizophrenia
- Photosensitive epilepsy or history of seizures triggered by light
- Legal mandate to attend treatment
Trial locations and contacts
1 site in 1 country.
About this study
This study examines whether computer tasks can improve memory and other cognitive functions among patients receiving inpatient treatment for substance use disorders.
Read the detailed description
Participants will complete cognitive training sessions on a regular basis during inpatient treatment. Alternate versions of the computer tasks will be compared in a randomized design. Primary and secondary outcomes will consist of changes in cognitive performance before and after the training period.
- Conditions
- Substance Use Disorders
- Being tested
- Cognitive training activities, Inpatient psychosocial therapy
- Medical subject headings
- Substance-Related Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Cognitive training activitiesBehavioural
Training activities consist of computer tasks designed to improve memory and cognition. The intervention consists of 45-minute training sessions delivered regularly during inpatient treatment.
Inpatient psychosocial therapyBehavioural
Group psychosocial therapy delivered in an inpatient setting.
| Study group | Role | What they receive |
|---|---|---|
| Experimental | Experimental | Computerized cognitive training activities Receives: Behavioral: Cognitive training activities; Behavioral: Inpatient psychosocial therapy |
| Control | Active comparator | Non-adaptive computerized cognitive training activities Receives: Behavioral: Cognitive training activities; Behavioral: Inpatient psychosocial therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Auditory memory capacity - WAIS Digit Span score
WAIS Digit Span score
Measured: Baseline, 3 weeks
Secondary outcomes (4)
Auditory memory capacity - WAIS Letter-number sequencing score
WAIS Letter-number sequencing score
Measured: Baseline to 3 weeks
Visual memory capacity - WMS Spatial span score
WMS Spatial span score
Measured: Baseline to 3 weeks
Visual memory capacity - WMS Symbol span score
WMS Symbol span score
Measured: Baseline to 3 weeks
Training progress score - Cognitive progress indicator score
Cognitive progress indicator score
Measured: Baseline to 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Feb 2015 (estimated)
- Study startJan 2015
- Primary completionJul 2016
- Study completionJul 2016
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Substance Use DisordersStudies of the same condition, open and under way.
- More trials run by Centre for Addiction and Mental HealthThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 111 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre for Addiction and Mental Health
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Christian Hendershot, Centre for Addiction and Mental Health
- Investigators
- Christian Hendershot, PhD, Principal investigator, Centre for Addiction and Mental Health
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02356718
- Sponsor's protocol ID
- 0422014
- Status last verified
- Jul 2016
- First submitted
- 2 Feb 2015
- Last updated
- 27 Jul 2016
- Results posted
- No
- Data monitoring committee
- No
Publications
Hendershot CS, Wardell JD, Vandervoort J, McPhee MD, Keough MT, Quilty LC. Randomized trial of working memory training as an adjunct to inpatient substance use disorder treatment. Psychol Addict Behav. 2018 Dec;32(8):861-872. doi: 10.1037/adb0000415. Epub 2018 Nov 26.
PubMed 30475014
Study at a glance
From the registry record, last updated by the sponsor on 27 Jul 2016. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Cognitive Training in Inpatient Treatment for Substance Use Disorders
- ClinicalTrials.gov ID
- NCT02356718
- Acronym / sponsor ID
- 0422014
- Conditions
- Substance Use Disorders
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 111 participants (actual)
- Lead sponsor
- Centre for Addiction and Mental HealthUniversity, hospital or other
- Study start
- Jan 2015
- Primary completion
- Jul 2016 (actual)
- Study completion
- Jul 2016 (actual)
- First posted
- 5 Feb 2015 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study examines whether computer tasks can improve memory and other cognitive functions among patients receiving inpatient treatment for substance use disorders.
Detailed description
Participants will complete cognitive training sessions on a regular basis during inpatient treatment. Alternate versions of the computer tasks will be compared in a randomized design. Primary and secondary outcomes will consist of changes in cognitive performance before and after the training period.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Experimental | Experimental | Behavioral: Cognitive training activities, Behavioral: Inpatient psychosocial therapyComputerized cognitive training activities |
| Control | Active comparator | Behavioral: Cognitive training activities, Behavioral: Inpatient psychosocial therapyNon-adaptive computerized cognitive training activities |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Participants must be patients registered for inpatient treatment at the Centre for Addiction and Mental Health
- Age 18-60
- Fluency in English
- Able to attend scheduled training sessions
- Comfortable using a computer and mouse
Key exclusion criteria (4 listed)
- Severe cognitive impairment
- Current or past psychosis or diagnosis of schizophrenia
- Photosensitive epilepsy or history of seizures triggered by light
- Legal mandate to attend treatment
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Cognitive training activitiesTraining activities consist of computer tasks designed to improve memory and cognition. The intervention consists of 45-minute training sessions delivered regularly during inpatient treatment. | Behavioural | Control, Experimental |
| Inpatient psychosocial therapyGroup psychosocial therapy delivered in an inpatient setting. | Behavioural | Control, Experimental |
Primary outcome
Auditory memory capacity - WAIS Digit Span score
Time frame: Baseline, 3 weeks
WAIS Digit Span score
4 secondary outcomes
Auditory memory capacity - WAIS Letter-number sequencing score
Time frame: Baseline to 3 weeks
Visual memory capacity - WMS Spatial span score
Time frame: Baseline to 3 weeks
Visual memory capacity - WMS Symbol span score
Time frame: Baseline to 3 weeks
Training progress score - Cognitive progress indicator score
Time frame: Baseline to 4 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Jul 2016.
- Derived from this study: PubMed 30475014Hendershot CS, Wardell JD, Vandervoort J, McPhee MD, Keough MT, Quilty LC. Randomized trial of working memory training as an adjunct to inpatient substance use disorder treatment. Psychol Addict Behav. 2018 Dec;32(8):861-872. doi: 10.1037/adb0000415. Epub 2018 Nov 26.
- The Centre for Addiction and Mental Health (CAMH) is the leading mental health and addictions research facility in Canada, and one of the largest in the world.Link provided by the sponsor.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Christian Hendershot, PhD principal investigator
Centre for Addiction and Mental Health
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Cognitive training activities and Inpatient psychosocial therapy in people with Substance Use Disorders, run by Centre for Addiction and Mental Health at 1 site in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Jul 2016. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Auditory memory capacity - WAIS Digit Span score (time frame: Baseline, 3 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02356718, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Jul 2016.