Cardiovascular Risk FactorNSSNCT02368938
Prognosis in the Elderly Chinese: the Northern Shanghai Study
An observational study of Cardiovascular Risk Factor, run by Shanghai 10th People's Hospital.
Trial summary
The Northern Shanghai Study is a prospective community-based study, which is aimed to investigate the prognostic factors, including conventional cardiovascular risk factors and asymptomatic target organ damage, for mortality and cardiovascular diseases, in 5,000 elderly Chinese. Read more about this study
- Who is it for?
- Ages 65 years and olderHealthy volunteers can take part
- Conditions the study is for
- Cardiovascular Risk Factor
- How many people
- 5,000 participants
- Where
- No sites listed yet
- Study dates
- Aug 2014to Sep 2017
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 years and older
- All sexes
- Healthy volunteers accepted
- Older adult
Study population: 5000 subjects aged over 65 years old, living in communities located in the northern Shanghai, will be invited to participate in the present study, if they are willing to give their written informed consents.
Who may be able to join
- age≥65 years old(depending on identity card);
- informed consent should be signed voluntarily;
- the individuals are long-term residents in northern Shanghai.
Who cannot join
- is diagnosed serious heart disease (NYHA>IV) or end stage renal disease (CKD > 4);
- suffered with cancer and life expectancy was less than 5 years;
- has stroke within 3 months;
- is not willing to participate in the clinical study;
- suffered with other disease to quite the trial;
- violated the protocol;
- lost contact with laboratory staff.
About this study
Official title: Prognosis Factors of Mortality and Cardiovascular Diseases in the Elderly Chinese: the Northern Shanghai Study
The Northern Shanghai Study is a prospective community-based study, which is aimed to investigate the prognostic factors, including conventional cardiovascular risk factors and asymptomatic target organ damage, for mortality and cardiovascular diseases, in 5,000 elderly Chinese.
- Conditions
- Cardiovascular Risk Factor
- Keywords
- Cardiovascular risk factors, Prospective study, Mortality, Cardiovascular events, Asymptomatic target organ damage, elderly Chinese
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Several communities in the north of Shanghai | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
all-cause and cardiovascular mortality, cardiovascular events
Measured: one year
Cardiovascular diseases
Measured: one year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Feb 2015 (estimated)
- Study startAug 2014
- Primary completionSep 2017 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (16)Papers the sponsor has linked to this study.
- Other trials for Cardiovascular Risk FactorStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Ecologic or community
- Time perspective
- Prospective
- Enrolment
- 5,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Shanghai 10th People's Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ya-Wei Xu, Shanghai 10th People's Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02368938
- Sponsor's protocol ID
- NSS
- Acronym
- NSS
- Status last verified
- Feb 2015
- First submitted
- 15 Feb 2015
- Last updated
- 23 Feb 2015
- Results posted
- No
- Data monitoring committee
- No
Publications
Chi C, Li J, Yang H, Teliewubai J, Zhao S, Yu S, Xiong J, Zhang Y. Cf-PWV Versus ba-PWV in Predicting Cardiovascular Events: Insights From a Community-Based Cohort. Hypertension. 2026 Aug 24. doi: 10.1161/HYPERTENSIONAHA.125.25929. Online ahead of print.
PubMed 42634937Han J, Tang J, Zhao Y, Xiong J, Zhao S, Yue W, Xu Y, Yu S, Zhang Y; Northern Shanghai Study. Subendocardial Viability Ratio Is Associated With Target Organ Damage and Hints at a Potential Independent Predictor of Cardiovascular Mortality in Older Adults: A Prospective Cohort Study. J Am Heart Assoc. 2026 Jan 6;15(1):e043643. doi: 10.1161/JAHA.125.043643. Epub 2025 Dec 30.
PubMed 41467407Xu C, Zhao S, Tang J, Han J, Zhang H, Liu W, Zhao Y, Xu Y, Zhang Y. Associations between different anthropometric measures and major adverse cardiovascular events among the elderly in China. Obes Res Clin Pract. 2025 Nov-Dec;19(6):497-502. doi: 10.1016/j.orcp.2025.10.010. Epub 2025 Nov 9.
PubMed 41207843Shi J, Ye X, Yu S, Zhao Y, Xiong J, Ji H, Zhang Y. Vascular Aging, Cardiovascular-Kidney-Metabolic Syndrome, and Cardiovascular Risk: The Northern Shanghai Study. JACC Adv. 2025 Dec;4(12 Pt 1):102242. doi: 10.1016/j.jacadv.2025.102242. Epub 2025 Oct 29.
PubMed 41165644Ren Z, Yang H, Zhu W, Han J, Yu S, Zhao S, Meng W, Xu Y, Zhao Y, Zhang Y. Age and blood pressure stratified healthy vascular aging, organ damage and prognosis in the community-dwelling elderly: insights from the North Shanghai Study. Clin Hypertens. 2024 Nov 1;30(1):31. doi: 10.1186/s40885-024-00288-3.
PubMed 39482774Zhao S, Tang J, Yu S, Maimaitiaili R, Teliewubai J, Xu C, Li J, Chi C, Xu Y, Zhang Y. Monocyte to high-density lipoprotein ratio presents a linear association with atherosclerosis and nonlinear association with arteriosclerosis in elderly Chinese population: The Northern Shanghai Study. Nutr Metab Cardiovasc Dis. 2023 Mar;33(3):577-583. doi: 10.1016/j.numecd.2022.12.002. Epub 2022 Dec 10.
PubMed 36646605Lyu Y, Yu S, Chi C, Teliewubai J, Li J, Blacher J, Pu J, Zhang Y, Xu Y. Associations of Walking Activity With Hypertensive Mediated Organ Damage in Community-Dwelling Elderly Chinese: The Northern Shanghai Study. Front Cardiovasc Med. 2021 Oct 21;8:734766. doi: 10.3389/fcvm.2021.734766. eCollection 2021.
PubMed 34746252Ren Z, Zhang J, Yu S, Zhao S, Tang J, Zheng Y, Meng W, Xu C, Zhang Y, Xu Y. Hypertension-Mediated Organ Damage Correlates With Serum Homocysteine Level in Community-Dwelling Elderly Chinese: The North Shanghai Study. Front Cardiovasc Med. 2021 May 10;8:662741. doi: 10.3389/fcvm.2021.662741. eCollection 2021.
PubMed 34041284Xu C, Zhao S, Yu S, Chi C, Fan X, Ji H, Maimaitiaili R, Teliewubai J, Li X, Zhang Y, Xu Y. Association between organ damage and visceral adiposity index in community-dwelling elderly Chinese population: the Northern Shanghai Study. Aging Clin Exp Res. 2021 Aug;33(8):2291-2297. doi: 10.1007/s40520-020-01752-4. Epub 2020 Nov 21.
PubMed 33219935Teliewubai J, Fan X, Ji H, Maimaitiaili R, Tang J, Zhao S, Yu S, Chi C, Xu Y, Zhang Y. Does healthy obesity exist in the elderly? Findings from the Northern Shanghai Study. Nutr Metab Cardiovasc Dis. 2020 May 7;30(5):749-757. doi: 10.1016/j.numecd.2020.01.010. Epub 2020 Jan 25.
PubMed 32249139Fan X, Teliewubai J, Xiong J, Chi C, Lu Y, Zhu M, Zhang Y, Xu Y. Renal functional impairment in the elderly, the importance of fasting plasma glucose: the Northern Shanghai Study. Aging Clin Exp Res. 2021 Feb;33(2):353-360. doi: 10.1007/s40520-020-01527-x. Epub 2020 Mar 21.
PubMed 32200498Chi C, Teliewubai J, Lu YY, Fan XM, Yu SK, Xiong J, Zhou YW, Ji HW, Zhang Y, Xu YW. Comparison of various lipid parameters in association of target organ damage: a cohort study. Lipids Health Dis. 2018 Aug 25;17(1):199. doi: 10.1186/s12944-018-0800-y.
PubMed 30144803Teliewubai J, Bai B, Zhou Y, Lu Y, Yu S, Chi C, Li J, Blacher J, Xu Y, Zhang Y. Association of asymptomatic target organ damage with secreted frizzled related protein 5 in the elderly: the Northern Shanghai Study. Clin Interv Aging. 2018 Mar 6;13:389-395. doi: 10.2147/CIA.S155514. eCollection 2018.
PubMed 29551893Xiong J, Yu X, Yu S, Bai B, Xu H, Ji H, Teliewubai J, Wang K, Chi C, Lu Y, Zhou Y, Fan X, Li J, Zhang Y, Xu Y. Comparison of central and peripheral hemodynamics in association with left ventricular diastolic dysfunction in the community-based elderly Chinese. J Am Soc Hypertens. 2017 Jun;11(6):366-375. doi: 10.1016/j.jash.2017.04.009. Epub 2017 Apr 27.
PubMed 28528875Ji H, Xiong J, Yu S, Chi C, Fan X, Bai B, Zhou Y, Teliewubai J, Lu Y, Xu H, Zhang Y, Xu Y. Northern Shanghai Study: cardiovascular risk and its associated factors in the Chinese elderly-a study protocol of a prospective study design. BMJ Open. 2017 Mar 29;7(3):e013880. doi: 10.1136/bmjopen-2016-013880.
PubMed 28360242
Study at a glance
From the registry record, last updated by the sponsor on 23 Feb 2015. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Prognosis Factors of Mortality and Cardiovascular Diseases in the Elderly Chinese: the Northern Shanghai Study
- ClinicalTrials.gov ID
- NCT02368938
- Acronym / sponsor ID
- NSS / NSS
- Conditions
- Cardiovascular Risk Factor
- Keywords
- Cardiovascular risk factors, Prospective study, Mortality, Cardiovascular events, Asymptomatic target organ damage, elderly Chinese
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 5,000 participants (estimated)
- Lead sponsor
- Shanghai 10th People's HospitalUniversity, hospital or other
- Study start
- Aug 2014
- Primary completion
- Sep 2017 (estimated)
- First posted
- 23 Feb 2015 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The Northern Shanghai Study is a prospective community-based study, which is aimed to investigate the prognostic factors, including conventional cardiovascular risk factors and asymptomatic target organ damage, for mortality and cardiovascular diseases, in 5,000 elderly Chinese.
Study design
- Observational model
- Ecologic or community
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Several communities in the north of Shanghai | – | – |
Who may qualify
- Ages
- 65 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Older adult
- Study population
- 5000 subjects aged over 65 years old, living in communities located in the northern Shanghai, will be invited to participate in the present study, if they are willing to give their written informed consents.
Key inclusion criteria (3 listed)
- age≥65 years old(depending on identity card);
- informed consent should be signed voluntarily;
- the individuals are long-term residents in northern Shanghai.
Key exclusion criteria (7 listed)
- is diagnosed serious heart disease (NYHA>IV) or end stage renal disease (CKD > 4);
- suffered with cancer and life expectancy was less than 5 years;
- has stroke within 3 months;
- is not willing to participate in the clinical study;
- suffered with other disease to quite the trial;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
all-cause and cardiovascular mortality, cardiovascular events
Time frame: one year
Cardiovascular diseases
Time frame: one year
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Feb 2015.
- Derived from this study: PubMed 42634937Chi C, Li J, Yang H, Teliewubai J, Zhao S, Yu S, Xiong J, Zhang Y. Cf-PWV Versus ba-PWV in Predicting Cardiovascular Events: Insights From a Community-Based Cohort. Hypertension. 2026 Aug 24. doi: 10.1161/HYPERTENSIONAHA.125.25929. Online ahead of print.
- Derived from this study: PubMed 41467407Han J, Tang J, Zhao Y, Xiong J, Zhao S, Yue W, Xu Y, Yu S, Zhang Y; Northern Shanghai Study. Subendocardial Viability Ratio Is Associated With Target Organ Damage and Hints at a Potential Independent Predictor of Cardiovascular Mortality in Older Adults: A Prospective Cohort Study. J Am Heart Assoc. 2026 Jan 6;15(1):e043643. doi: 10.1161/JAHA.125.043643. Epub 2025 Dec 30.
- Derived from this study: PubMed 41207843Xu C, Zhao S, Tang J, Han J, Zhang H, Liu W, Zhao Y, Xu Y, Zhang Y. Associations between different anthropometric measures and major adverse cardiovascular events among the elderly in China. Obes Res Clin Pract. 2025 Nov-Dec;19(6):497-502. doi: 10.1016/j.orcp.2025.10.010. Epub 2025 Nov 9.
- Derived from this study: PubMed 41165644Shi J, Ye X, Yu S, Zhao Y, Xiong J, Ji H, Zhang Y. Vascular Aging, Cardiovascular-Kidney-Metabolic Syndrome, and Cardiovascular Risk: The Northern Shanghai Study. JACC Adv. 2025 Dec;4(12 Pt 1):102242. doi: 10.1016/j.jacadv.2025.102242. Epub 2025 Oct 29.
- Derived from this study: PubMed 39482774Ren Z, Yang H, Zhu W, Han J, Yu S, Zhao S, Meng W, Xu Y, Zhao Y, Zhang Y. Age and blood pressure stratified healthy vascular aging, organ damage and prognosis in the community-dwelling elderly: insights from the North Shanghai Study. Clin Hypertens. 2024 Nov 1;30(1):31. doi: 10.1186/s40885-024-00288-3.
- Derived from this study: PubMed 36646605Zhao S, Tang J, Yu S, Maimaitiaili R, Teliewubai J, Xu C, Li J, Chi C, Xu Y, Zhang Y. Monocyte to high-density lipoprotein ratio presents a linear association with atherosclerosis and nonlinear association with arteriosclerosis in elderly Chinese population: The Northern Shanghai Study. Nutr Metab Cardiovasc Dis. 2023 Mar;33(3):577-583. doi: 10.1016/j.numecd.2022.12.002. Epub 2022 Dec 10.
- Derived from this study: PubMed 34746252Lyu Y, Yu S, Chi C, Teliewubai J, Li J, Blacher J, Pu J, Zhang Y, Xu Y. Associations of Walking Activity With Hypertensive Mediated Organ Damage in Community-Dwelling Elderly Chinese: The Northern Shanghai Study. Front Cardiovasc Med. 2021 Oct 21;8:734766. doi: 10.3389/fcvm.2021.734766. eCollection 2021.
- Derived from this study: PubMed 34041284Ren Z, Zhang J, Yu S, Zhao S, Tang J, Zheng Y, Meng W, Xu C, Zhang Y, Xu Y. Hypertension-Mediated Organ Damage Correlates With Serum Homocysteine Level in Community-Dwelling Elderly Chinese: The North Shanghai Study. Front Cardiovasc Med. 2021 May 10;8:662741. doi: 10.3389/fcvm.2021.662741. eCollection 2021.
- Derived from this study: PubMed 33219935Xu C, Zhao S, Yu S, Chi C, Fan X, Ji H, Maimaitiaili R, Teliewubai J, Li X, Zhang Y, Xu Y. Association between organ damage and visceral adiposity index in community-dwelling elderly Chinese population: the Northern Shanghai Study. Aging Clin Exp Res. 2021 Aug;33(8):2291-2297. doi: 10.1007/s40520-020-01752-4. Epub 2020 Nov 21.
- Derived from this study: PubMed 32249139Teliewubai J, Fan X, Ji H, Maimaitiaili R, Tang J, Zhao S, Yu S, Chi C, Xu Y, Zhang Y. Does healthy obesity exist in the elderly? Findings from the Northern Shanghai Study. Nutr Metab Cardiovasc Dis. 2020 May 7;30(5):749-757. doi: 10.1016/j.numecd.2020.01.010. Epub 2020 Jan 25.
- Derived from this study: PubMed 32200498Fan X, Teliewubai J, Xiong J, Chi C, Lu Y, Zhu M, Zhang Y, Xu Y. Renal functional impairment in the elderly, the importance of fasting plasma glucose: the Northern Shanghai Study. Aging Clin Exp Res. 2021 Feb;33(2):353-360. doi: 10.1007/s40520-020-01527-x. Epub 2020 Mar 21.
- Derived from this study: PubMed 30144803Chi C, Teliewubai J, Lu YY, Fan XM, Yu SK, Xiong J, Zhou YW, Ji HW, Zhang Y, Xu YW. Comparison of various lipid parameters in association of target organ damage: a cohort study. Lipids Health Dis. 2018 Aug 25;17(1):199. doi: 10.1186/s12944-018-0800-y.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Cardiovascular Risk Factor, run by Shanghai 10th People's Hospital.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 23 Feb 2015. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
all-cause and cardiovascular mortality, cardiovascular events (time frame: one year). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02368938, which also lists 16 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Feb 2015.