AgingNCT02513680
Effects of Application LED Therapy and Laser Therapy in Facial Rejuvenation
A study testing Infrared Laser + Amber LED and Amber LED in people with Aging and Wrinkles, run by Federal University of Health Science of Porto Alegre.
Trial summary
In today's society, the search for keeping up with the appearance with no visible signs of aging has become common. Therefore, many therapies to try to mitigate these senility markers are present in specialized clinics. Read more about this study
- Who is it for?
- Ages 30 to 50 years, women onlyHealthy volunteers can take part
- What is being tested?
- Infrared Laser + Amber LED and Amber LED
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 32 participants
- Where
- No sites listed yet
- Study dates
- Jan 2015to Jun 2015
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 50 years
- Women only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Female patients study present ages 30 and 50;
- Wrinkles compatible with the G2 and G3 stages measured according Glogau scale;
- Phototypes consistent with those described and between FZ1 to FZ4 according to Fitzpatrick scale;
- Patients without previous hypersensitivity reaction
- Patients must agree and sign the consent form and clarified.
Who cannot join
- Patients who present wrinkles compatible with the G1 and G4 stages of Glogau scale;
- Patients who present FZ5 and FZ6 phototypes according to Fitzpatrick scale to increase the risk of burns from the treatment.
- Patients who have experienced any hypersensitivity reaction in some prior treatment has been paid;
- Volunteers who are being subjected to treatments with acids synthesized from vitamin A ( acid retinoic , Retinol A, Vitanol A, Retin , Isotretinoin , tretinoin ) and Vitamin C (creams , serums , capsules ) and / or tetracycline and / or which have made facial aesthetic treatments
About this study
Official title: Effects of Application LED Therapy and Laser Therapy in Facial Rejuvenation: Pilot Study
In today's society, the search for keeping up with the appearance with no visible signs of aging has become common. Therefore, many therapies to try to mitigate these senility markers are present in specialized clinics. Such therapies seek grounding in the theories of how the skin and its appendages respond to the aging process, causing this way, they can be created ways to slow or minimize wrinkles and other consequences of this natural biological process. However, this process can be accelerated by exposure to ultraviolet light such as to toxic substances as well as tobacco, among others. The low-power laser and light emitted diode (LED) characterized by being non-ablative light source, which means phototherapy which does not cause physical damage to the epidermis, as the case of CO2 laser ablative and other methods. This study has the purpose of comparing the effects of combined application of low level laser with LED and LED action alone in facial rejuvenation. For this, the analysis of these effects will be conducted through digital photography, blinded assessment and customer satisfaction questionnaire.
Read the detailed description
This is a pilot study seen the lack of studies on the subject chosen for a sample calculation accurately be defined. This will be done by 32 volunteers, respecting the criteria for inclusion and exclusion previously cited by reading and signing the Informed Consent and Clarified. The sample comprises a total of 30 subjects, divided randomly into two groups with 16 subjects in each. The first group will make use of both techniques in combined study: Infrared Laser and Led Amber. The second group, in turn, will use only the Led Amber.These will be allocated randomly and intervention will be simple blind.They will be held 10 sessions in individual applications, both group 1 (Laser and LED) and group 2 (LED) and applications for two groups will occur once per week. Group 1 will make the application of the two techniques on the same day session. Both will be applied in the following areas of the face: chin / perioral, nasolabial folds, periorbital, frontal and glabellar region. Both groups act as their own controls before starting the sessions, to ensure that the changes observed in the skin is caused by the treatment of fact and not the environment. For this, the volunteers will be accompanied during the first month, with completion of a photograph at the beginning of the month to another month-end, as well as a questionnaire at the end of 30 days.
To monitor the results, will be held 4 shoots of the subjects in the study. The first session will take place at the first meeting with the patients, who will undergo a 4-week follow-up without using any methodology. After these four weeks, a new shoot will be held to determine whether the environment was able to promote changes in the skin of patients or not. After this, it will start to bare-sessions. After five sessions of treatment, a new picture for monitoring will be held, and repeated this procedure at the end of treatment for so yes, compare the images and get search results.
To carry out the photos, there will be a standard procedure in order to maintain quality, the angle and the light always the same, so that the results observed can be truthful fact. Initially, the face of the patient will be cleaned, particularly aiming at the removal of cosmetic and excess oil on the surface to be photographed. This will precede the photographic record in at least 5 minutes so that friction marks and flushing fall apart.
Afterwards, the patients with the prisoners hair (or using burrows), will be photographed standing in front and lateral planes (both sides), parallel to the plane of the camera sensor. To better guide them, will be applied on the floor marks with the positions of the feet, to be followed.A camera mounted on the tripod, level and horizontal position, with the 105mm lens will be placed in proper height for framing the mouth, forehead and brows. The framework of each area will follow the alignment of facial landmarks to the camera's viewfinder grid in live view mode.
To photograph the brow area both iris will be aligned with the intersections between the line dividing the room and the lower horizontal lines that divide the extreme vertical side rooms of the grid. To shoot the mouth area "Cheilion" the two points will be aligned respectively with the intersections between the line that bisects the grid and the lines that divide the extreme horizontal side rooms. To photograph the area of the forehead (both sides) and the "Exocanthion" and "Otobasion Superious" points will be aligned with the intersections between the line that bisects the grid and the lines that divide the extreme horizontal side rooms. The flash is mounted on the hot shoe of the camera, set in TTL mode with the driven diffuser and will have its head directed forward. The camera will be displayed in manual mode, with f5.6 aperture, shutter speed to 1/60 second and 200 ISO.
At the end of the collection and collation, registration and randomization of the obtained photographs, there will be the evaluation of research students, who will receive the photos in random order and will have to put them in expected development order for a rejuvenation treatment. After learning the correct order, there will quantify the improvements in fine lines of the four areas chosen for analysis. In addition, two blind evaluators will be invited to participate in the project by analyzing the same way that researchers students. The external evaluators will be the ones who will have knowledge of what method the person was exposed. The evaluator will not know whether or not a placebo group in the study. Still, it is important to consider that the designated evaluator will be a person with extensive knowledge about the skin and possible treatments the same, so you can see exactly if there were no improvements or the skin of the participants. The analysis of the photos will take place in three steps:
STEP 1:
Slides with 3 or 4 photographs of each subject in random order (black and white photographs to color hair, earrings, not to interfere in the result).
The evaluator should classify the images in the order of 1-4, with 1 being the worst picture, and 4 the best (relative expression lines, skin texture and brightness) (it is expected that the treatment has left the skin better, so this sort order).
They will be received 4 slides pertaining to each subject, each containing the pictures of the respective regions assessed: frontal, nasolabial, periorbital, glabellar. Along with this, evaluators will be delivered to a table so that they can put the sort order of 1-4 each presented slide.
STEP 2:
Slide with a picture before starting treatment and the final photograph arranged chronologically (photographs in black and white).
The assessor should note the first and last picture of each region of each treated patient (4 regions per patient) and classify the changes in one of the degrees of the scale below:
0% = no change regarding the improvement of fine lines / wrinkles.
1% - 25% = little change regarding the improvement of fine lines / wrinkles, difficult to observe 25-50% = there has been a change regarding the improvement of fine lines / wrinkles, but nothing extremely significant 50% or more = a change in relation to improvement of fine lines / wrinkles is visible, the skin really improved considerably
STEP 3:
Slides containing two images of each patient in a more central area of the face (Vintage Photography).
The evaluator will receive the slides containing a photograph before the start of treatment and the last shot of each volunteer performed relating to a face of the central region. It is the evaluator understand the following items:
- Voluntary skin had spots? Yes or no?
- If stains showed there was a difference in the amount (uniformity) of the skin before and after treatment? Yes or no?
In addition, throughout this study of customer satisfaction questionnaires will be carried out in order to monitor whether the patient is enjoying the treatment, it is believed that is actually running (sorting qualitivamente the improvement of fine lines) and recommend this to other people.Thus, the treatment becomes, in general, valuable, since it is known that on the market, the transmission from one person to another feature of procedures that results is an efficient form of this disclosure. Such tests will be done in the middle of treatment (5 sessions) and at the end of it (10 sessions) to compare whether there was a change of the view in the meantime.
- Being tested
- Infrared Laser + Amber LED, Amber LED
- Keywords
- Skin Aging, laser phototherapy, Rejuvenation, Infrared Rays/therapeutic use, Female, Humans, Esthetics, Phototherapy, facial rejuvenation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Infrared Laser + Amber LEDDevice
This group will make the application on the machine program that uses laser and led together to photorejuvenation . Laser is applied for 30 seconds and soon after begins the LED by 2:30 minutes in each region to apply.
Amber LEDDevice
This group will make the application on the machine program that uses LED photorejuvenation only 3 minutes of time for each area to be applied.
| Study group | Role | What they receive |
|---|---|---|
| LASER and LED therapy application | Active comparator | The first group will use the two techniques under study combined: Infrared Laser + Amber LED (830 nm - 150mW + 590 nm - 1.500 mW) Receives: Device: Infrared Laser + Amber LED |
| LED Therapy application | Active comparator | The second group will use only Amber LED (590 nm - 1.500 mW) Receives: Device: Amber LED |
What is being measured
The primary outcome is the main question the study is designed to answer.
Therapeutic efficacy of LED and Laser therapy in facial photorejuvenation
Measured: Ten weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Aug 2015 (estimated)
- Study startJan 2015
- Primary completionJun 2015
- Study completionJun 2015
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AgingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 32 participants (actual)
Sponsor and investigators
- Lead sponsor
- Federal University of Health Science of Porto Alegre
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Patricia Viana da Rosa, Federal University of Health Science of Porto Alegre
- Investigators
- Lívia S Born, Principal investigator, Federal University of Health Science of Porto AlegreAna Claudia Fedi, Principal investigator, Federal University of Health Science of Porto Alegre
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02513680
- Sponsor's protocol ID
- 36980514.0.0000.5345
- Status last verified
- Jul 2015
- First submitted
- 30 Jun 2015
- Last updated
- 3 Aug 2015
- Results posted
- No
- Data monitoring committee
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Aug 2015. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Application LED Therapy and Laser Therapy in Facial Rejuvenation: Pilot Study
- ClinicalTrials.gov ID
- NCT02513680
- Acronym / sponsor ID
- 36980514.0.0000.5345
- Keywords
- Skin Aging, laser phototherapy, Rejuvenation, Infrared Rays/therapeutic use, Female, Humans, Esthetics, Phototherapy
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 32 participants (actual)
- Lead sponsor
- Federal University of Health Science of Porto AlegreUniversity, hospital or other
- Study start
- Jan 2015
- Primary completion
- Jun 2015 (actual)
- Study completion
- Jun 2015 (actual)
- First posted
- 3 Aug 2015 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In today's society, the search for keeping up with the appearance with no visible signs of aging has become common. Therefore, many therapies to try to mitigate these senility markers are present in specialized clinics. Such therapies seek grounding in the theories of how the skin and its appendages respond to the aging process, causing this way, they can be created ways to slow or minimize wrinkles and other consequences of this natural biological process. However, this process can be accelerated by exposure to ultraviolet light such as to toxic substances as well as tobacco, among others. The low-power laser and light emitted diode (LED) characterized by being non-ablative light source, which means phototherapy which does not cause physical damage to the epidermis, as the case of CO2 laser ablative and other methods. This study has the purpose of comparing the effects of combined application of low level laser with LED and LED action alone in facial rejuvenation. For this, the analysis of these effects will be conducted through digital photography, blinded assessment and customer satisfaction questionnaire.
Detailed description
This is a pilot study seen the lack of studies on the subject chosen for a sample calculation accurately be defined. This will be done by 32 volunteers, respecting the criteria for inclusion and exclusion previously cited by reading and signing the Informed Consent and Clarified. The sample comprises a total of 30 subjects, divided randomly into two groups with 16 subjects in each. The first group will make use of both techniques in combined study: Infrared Laser and Led Amber. The second group, in turn, will use only the Led Amber.These will be allocated randomly and intervention will be simple blind.They will be held 10 sessions in individual applications, both group 1 (Laser and LED) and group 2 (LED) and applications for two groups will occur once per week. Group 1 will make the application of the two techniques on the same day session. Both will be applied in the following areas of the face: chin / perioral, nasolabial folds, periorbital, frontal and glabellar region. Both groups act as their own controls before starting the sessions, to ensure that the changes observed in the skin is caused by the treatment of fact and not the environment. For this, the volunteers will be accompanied during the first month, with completion of a photograph at the beginning of the month to another month-end, as well as a questionnaire at the end of 30 days.
To monitor the results, will be held 4 shoots of the subjects in the study. The first session will take place at the first meeting with the patients, who will undergo a 4-week follow-up without using any methodology. After these four weeks, a new shoot will be held to determine whether the environment was able to promote changes in the skin of patients or not. After this, it will start to bare-sessions. After five sessions of treatment, a new picture for monitoring will be held, and repeated this procedure at the end of treatment for so yes, compare the images and get search results.
To carry out the photos, there will be a standard procedure in order to maintain quality, the angle and the light always the same, so that the results observed can be truthful fact. Initially, the face of the patient will be cleaned, particularly aiming at the removal of cosmetic and excess oil on the surface to be photographed. This will precede the photographic record in at least 5 minutes so that friction marks and flushing fall apart.
Afterwards, the patients with the prisoners hair (or using burrows), will be photographed standing in front and lateral planes (both sides), parallel to the plane of the camera sensor. To better guide them, will be applied on the floor marks with the positions of the feet, to be followed.A camera mounted on the tripod, level and horizontal position, with the 105mm lens will be placed in proper height for framing the mouth, forehead and brows. The framework of each area will follow the alignment of facial landmarks to the camera's viewfinder grid in live view mode.
To photograph the brow area both iris will be aligned with the intersections between the line dividing the room and the lower horizontal lines that divide the extreme vertical side rooms of the grid. To shoot the mouth area "Cheilion" the two points will be aligned respectively with the intersections between the line that bisects the grid and the lines that divide the extreme horizontal side rooms. To photograph the area of the forehead (both sides) and the "Exocanthion" and "Otobasion Superious" points will be aligned with the intersections between the line that bisects the grid and the lines that divide the extreme horizontal side rooms. The flash is mounted on the hot shoe of the camera, set in TTL mode with the driven diffuser and will have its head directed forward. The camera will be displayed in manual mode, with f5.6 aperture, shutter speed to 1/60 second and 200 ISO.
At the end of the collection and collation, registration and randomization of the obtained photographs, there will be the evaluation of research students, who will receive the photos in random order and will have to put them in expected development order for a rejuvenation treatment. After learning the correct order, there will quantify the improvements in fine lines of the four areas chosen for analysis. In addition, two blind evaluators will be invited to participate in the project by analyzing the same way that researchers students. The external evaluators will be the ones who will have knowledge of what method the person was exposed. The evaluator will not know whether or not a placebo group in the study. Still, it is important to consider that the designated evaluator will be a person with extensive knowledge about the skin and possible treatments the same, so you can see exactly if there were no improvements or the skin of the participants. The analysis of the photos will take place in three steps:
STEP 1:
Slides with 3 or 4 photographs of each subject in random order (black and white photographs to color hair, earrings, not to interfere in the result).
The evaluator should classify the images in the order of 1-4, with 1 being the worst picture, and 4 the best (relative expression lines, skin texture and brightness) (it is expected that the treatment has left the skin better, so this sort order).
They will be received 4 slides pertaining to each subject, each containing the pictures of the respective regions assessed: frontal, nasolabial, periorbital, glabellar. Along with this, evaluators will be delivered to a table so that they can put the sort order of 1-4 each presented slide.
STEP 2:
Slide with a picture before starting treatment and the final photograph arranged chronologically (photographs in black and white).
The assessor should note the first and last picture of each region of each treated patient (4 regions per patient) and classify the changes in one of the degrees of the scale below:
0% = no change regarding the improvement of fine lines / wrinkles.
1% - 25% = little change regarding the improvement of fine lines / wrinkles, difficult to observe 25-50% = there has been a change regarding the improvement of fine lines / wrinkles, but nothing extremely significant 50% or more = a change in relation to improvement of fine lines / wrinkles is visible, the skin really improved considerably
STEP 3:
Slides containing two images of each patient in a more central area of the face (Vintage Photography).
The evaluator will receive the slides containing a photograph before the start of treatment and the last shot of each volunteer performed relating to a face of the central region. It is the evaluator understand the following items:
- Voluntary skin had spots? Yes or no?
- If stains showed there was a difference in the amount (uniformity) of the skin before and after treatment? Yes or no?
In addition, throughout this study of customer satisfaction questionnaires will be carried out in order to monitor whether the patient is enjoying the treatment, it is believed that is actually running (sorting qualitivamente the improvement of fine lines) and recommend this to other people.Thus, the treatment becomes, in general, valuable, since it is known that on the market, the transmission from one person to another feature of procedures that results is an efficient form of this disclosure. Such tests will be done in the middle of treatment (5 sessions) and at the end of it (10 sessions) to compare whether there was a change of the view in the meantime.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| LASER and LED therapy application | Active comparator | Device: Infrared Laser + Amber LEDThe first group will use the two techniques under study combined: Infrared Laser + Amber LED (830 nm - 150mW + 590 nm - 1.500 mW) |
| LED Therapy application | Active comparator | Device: Amber LEDThe second group will use only Amber LED (590 nm - 1.500 mW) |
Who may qualify
- Ages
- 30 to 50 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Female patients study present ages 30 and 50;
- Wrinkles compatible with the G2 and G3 stages measured according Glogau scale;
- Phototypes consistent with those described and between FZ1 to FZ4 according to Fitzpatrick scale;
- Patients without previous hypersensitivity reaction
- Patients must agree and sign the consent form and clarified.
Key exclusion criteria (4 listed)
- Patients who present wrinkles compatible with the G1 and G4 stages of Glogau scale;
- Patients who present FZ5 and FZ6 phototypes according to Fitzpatrick scale to increase the risk of burns from the treatment.
- Patients who have experienced any hypersensitivity reaction in some prior treatment has been paid;
- Volunteers who are being subjected to treatments with acids synthesized from vitamin A ( acid retinoic , Retinol A, Vitanol A, Retin , Isotretinoin , tretinoin ) and Vitamin C (creams , serums , capsules ) and / or tetracycline and / or which have made facial aesthetic treatments
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Infrared Laser + Amber LEDThis group will make the application on the machine program that uses laser and led together to photorejuvenation . Laser is applied for 30 seconds and soon after begins the LED by 2:30 minutes in each region to apply. | Device | LASER and LED therapy application |
| Amber LEDThis group will make the application on the machine program that uses LED photorejuvenation only 3 minutes of time for each area to be applied. | Device | LED Therapy application |
Primary outcome
Therapeutic efficacy of LED and Laser therapy in facial photorejuvenation
Time frame: Ten weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Aug 2015.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Lívia S Born principal investigator
Federal University of Health Science of Porto Alegre
Ana Claudia Fedi principal investigator
Federal University of Health Science of Porto Alegre
Questions about this trial
What is this clinical trial studying?
A study testing Infrared Laser + Amber LED and Amber LED in people with Aging and Wrinkles, run by Federal University of Health Science of Porto Alegre.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Aug 2015. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Therapeutic efficacy of LED and Laser therapy in facial photorejuvenation (time frame: Ten weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Aug 2015.