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Acute Chest PainEMPACTNCT02536677

The Evaluation and Management of Patients With Acute ChesT Pain in China

An observational study of Acute Chest Pain and Acute Coronary Syndrome, run by Yuguo Chen at 1 site in China.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

EMPACT is the first attempt to comprehensively evaluate the current emergency care of acute chest pain from a regional representative sample in China.Findings will allow new opportunities to facilitate the clinical quality improvements and ultimately reduce the mortality and health care burden in patients with acute… Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Acute Chest Pain, Acute Coronary Syndrome
How many people
8,374 participants
Where
1 siteChina
Study dates
Jan 2016to Oct 2017
How long will I take part?
1 Month
Phase
Observational
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: We used a stratified random sampling design to generate a Shandong province representative sample of hospitals. Twenty two hospitals were randomly selected including 12 rural hospitals, 6 grade II and 4 grade III urban hospitals. One grade II-urban hospital refused to participate. As a coordinating center, Qilu Hospital of Shandong University participated in the study without being sampled. Finally, 22 hospitals were included. A total of more than 10000 patients were anticipated to be consecutively enrolled from the participating hospitals over the course of the 12-month program. The beginning dates of enrollment in 22 centers were distributed from January, 2016 to September 2016.

Who may be able to join

  • Eighteen years and older
  • Presenting to the ED
  • With acute chest pain or suspected ACS
  • Symptoms occurring within 24 hours
  • Informed consent from patient or next of kin

Who cannot join

  • Chest pain caused by trauma
  • Persisting or recurrent chest pain caused by rheumatic diseases or cancer
  • Transferred from another grade II or grade III hospital
  • Presenting to the ED again within 30 days after initial enrollment

Trial locations and contacts

1 site in 1 country.

China1 site

  • Qilu Hospital of Shandong University

    Jinan, Shandong, 250012

Other trials in China

About this study

EMPACT is the first attempt to comprehensively evaluate the current emergency care of acute chest pain from a regional representative sample in China.Findings will allow new opportunities to facilitate the clinical quality improvements and ultimately reduce the mortality and health care burden in patients with acute chest pain. It also will help to establish a regional network and database for further research and performance improvement.

Keywords
Acute Chest Pain, Acute Coronary Syndrome, Evaluation and Management, Decision Aid, Healthcare Utilization
Medical subject headings
Acute Coronary Syndrome

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Major adverse cardiac events (MACE)

    The primary outcome was a composite of adjudicated MACEs, including death from all causes, non-fatal acute myocardial infarction (AMI), urgent revascularization, stroke, cardiac arrest, and cardiogenic shock.

    Measured: 30 days after presenting to the emergency departments(ED)

Secondary outcomes (1)

  1. revisiting to ED and rehospitalization

    Measured: 30 days after presenting to the EDs

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted1 Sep 2015 (estimated)
  2. Study startJan 2016
  3. Primary completionOct 2017
  4. Study completionOct 2017

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
8,374 participants (actual)
Target duration
1 Month
IDs, dates and publications
ClinicalTrials.gov ID
NCT02536677
Sponsor's protocol ID
QLEmer201507
Acronym
EMPACT
Status last verified
Jan 2018
First submitted
27 Aug 2015
Last updated
9 Jan 2018
Results posted
No
Data monitoring committee
No

Publications

  • Cheng K, Zheng W, Wang J, Wu S, Zheng J, Sang W, Ma J, Pang J, Pan C, Wang G, Wu Y, Chen Y, Xu F. Incidence, management and outcomes of patients with acute chest pain presenting to the emergency departments in China: findings from a prospective multicentre registry. BMJ Open. 2025 Mar 27;15(3):e091085. doi: 10.1136/bmjopen-2024-091085.

    PubMed 40147987

  • Yin X, Pan X, Zhang J, Wu S, Cui W, Wang Y, Li C, Wang J, Chen Y. Impact of admission glucose and 30-day major adverse cardiovascular events on patients with chest pain in an emergency setting: insights from the China EMPACT registry. Front Cardiovasc Med. 2024 Oct 9;11:1367704. doi: 10.3389/fcvm.2024.1367704. eCollection 2024.

    PubMed 39444552

  • Zheng W, Wang J, Xu F, Zheng J, Zhang H, Ma J, Wang G, Wang H, Chew DP, Chen Y. Evaluation and management of patients with acute chest pain in China (EMPACT): protocol for a prospective, multicentre registry study. BMJ Open. 2018 Jan 23;8(1):e017872. doi: 10.1136/bmjopen-2017-017872.

    PubMed 29362251

Questions about this trial

What is this clinical trial studying?

An observational study of Acute Chest Pain and Acute Coronary Syndrome, run by Yuguo Chen at 1 site in China.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 9 Jan 2018. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Major adverse cardiac events (MACE) (time frame: 30 days after presenting to the emergency departments(ED)). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT02536677, which also lists 3 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Jan 2018.

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