ObesityPhase 4NCT02542449
Effects of Greenselect Phytosome® on Weight Maintenance After Weight Loss in Obese Women
A Phase 4 study testing Globes® in people with Obesity, run by Istituto Auxologico Italiano at 1 site in Italy.
Trial summary
This study evaluates whether supplementations with a highly bioavailable green tea extract may help obese women to counteract weight regain after a 3-month weight loss intervention. Read more about this study
- Who is it for?
- Ages 18 years and older, women only
- Conditions the study is for
- Obesity
- What is being tested?
- Globes®
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 40 participants
- Where
- 1 siteItaly
- Study dates
- Apr 2013to Nov 2014
- Phase
- Phase 4
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- Women only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- outpatient
- ≥18 years of age
- body mass index (BMI) ≥ 30 kg/m2
- a sufficient level of education to understand study procedures and be able to communicate with site personnel
Who cannot join
- breast feeding or pregnancy
- history of cardiovascular or cerebrovascular events
- uncontrolled hypertension
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Placebo Controlled, Randomized, Single Blinded Trial on the Effects of Greenselect Phytosome® on Weight Maintenance in Obese Women After a 3-month Weight Loss Intervention
This study evaluates whether supplementations with a highly bioavailable green tea extract may help obese women to counteract weight regain after a 3-month weight loss intervention.
Read the detailed description
Most obese subjects regain weight after weight loss due to compensatory adaptations finalized to maintain stable body energy stores. In lean or obese individuals, maintenance of a 10% or greater reduction in body weight is associated with a decline in 24-hour energy expenditure of approximately 20%-25%. The restraint of the energy expenditure decline during dieting by green tea (GT) preparations should be a useful strategy to facilitate weight maintenance. To increase absorption of GT, the investigators used a formulation with phospholipids (Greenselect Phytosome® ) added with piperine, a thermogenic agent and a booster of absorption for various phenolics.
At the end of a 3-month lifestyle intervention, all patients giving written informed consent were randomly assigned to two groups for the weight-maintenance phase: 20 of them were supplemented twice a day for 3 months with a dietary supplement (Globes®, Pharmextracta, Pontenure, Piacenza, Italy) and 20 with placebo.Women were blind to the supplementation throughout the whole trial. All women attended a monthly clinical visit during the supplementation period and 3 months after the end of supplementation.
- Conditions
- Obesity
- Being tested
- Globes®, Placebo
- Keywords
- Green tea, weight maintenance, obesity, fat mass
- Medical subject headings
- Obesity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Globes®Dietary supplement
At the end of a 3-month lifestyle intervention, all participants received twice a day for 3 months Globes® and attended a monthly clinical visit during the supplementation period and 3 months after the end of supplementation.
PlaceboDietary supplement
At the end of a 3-month lifestyle intervention, all participants received twice a day for 3 months placebo and attended a monthly clinical visit during the supplementation period and 3 months after the end of supplementation.
| Study group | Role | What they receive |
|---|---|---|
| Globes® | Active comparator | Partecipants received twice a day for 3 months Globes® (Pharmextracta, Pontenure, Piacenza, Italy) formulated to be enteric-coated and containing 150 mg/dose of Greenselect Phytosome® and pure piperine (15 mg/dose) from Piper nigrum L. Receives: Dietary Supplement: Globes® |
| Placebo | Placebo comparator | Partecipants received twice a day for 3 months placebo (undistinguishable from Globes in terms of size, shape, taste, odor, primary and secondary packaging). Receives: Dietary Supplement: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
change in body weight from baseline to 12 weeks of supplementation
Measured: baseline and 12 weeks of supplementation
Secondary outcomes (28)
change in body weight from baseline to 4 weeks of supplementation
Measured: baseline and 4 weeks of supplementation
change in body weight from 4 weeks to 8 weeks of supplementation
Measured: 4 weeks and 8 weeks of supplementation
change in body weight from 8 weeks to 12 weeks of supplementation
Measured: 8 weeks and 12 weeks of supplementation
change in body weight from 12 weeks of supplementation to 3 months after discontinuation of supplementation
Measured: 12 weeks of supplementation and 3 months after discontinuation of supplementation
change in waist circumference from baseline to 12 weeks of supplementation
Measured: baseline and 12 weeks of supplementation
change in waist circumference from baseline to 4 weeks of supplementation
Measured: baseline and 4 weeks of supplementation
change in waist circumference from 4 weeks to 8 weeks of supplementation
Measured: 4 weeks and 8 weeks of supplementation
change in waist circumference from 8 weeks to 12 weeks of supplementation
Measured: 8 weeks and 12 weeks of supplementation
change in waist circumference from 12 weeks of supplementation to 3 months after discontinuation of supplementation
Measured: 12 weeks of supplementation and 3 months after discontinuation of supplementation
change in body composition from baselineto 12 weeks of supplementation
Body composition was measured using a body composition analyzer with joined function of body fat analysis (Biki 300, Jawon Medical, Korea)
Measured: baseline and 12 weeks of supplementation
change in blood pressure from baseline to 12 weeks of supplementation
Measured: baseline and 12 weeks of supplementation
change in heart rate from baseline to 12 weeks of supplementation
Measured: baseline and 12 weeks of supplementation
change in body composition from baseline to 4 weeks of supplementation
Body composition was measured using a body composition analyzer with joined function of body fat analysis (Biki 300, Jawon Medical, Korea)
Measured: baseline and 4 weeks of supplementation
change in blood pressure from baseline to 4 weeks of supplementation
Measured: baseline and 4 weeks of supplementation
change in heart rate from baseline to 4 weeks of supplementation
Measured: baseline and 4 weeks of supplementation
change in body composition from 4 weeks to 8 weeks of supplementation
Body composition was measured using a body composition analyzer with joined function of body fat analysis (Biki 300, Jawon Medical, Korea)
Measured: 4 weeks and 8 weeks of supplementation
change in blood pressure from 4 weeks to 8 weeks of supplementation
Measured: 4 weeks and 8 weeks of supplementation
change in heart rate from 4 weeks to 8 weeks of supplementation
Measured: 4 weeks and 8 weeks of supplementation
change in body composition from 8 weeks to 12 weeks of supplementation
Body composition was measured using a body composition analyzer with joined function of body fat analysis (Biki 300, Jawon Medical, Korea)
Measured: 8 weeks and 12 weeks of supplementation
change in blood pressure from 8 weeks to 12 weeks of supplementation
Measured: 8 weeks and 12 weeks of supplementation
change in heart rate from 8 weeks to 12 weeks of supplementation
Measured: 8 weeks and 12 weeks of supplementation
change in body composition from 12 weeks of supplementation to 3 months after discontinuation of supplementation
Body composition was measured using a body composition analyzer with joined function of body fat analysis (Biki 300, Jawon Medical, Korea)
Measured: 12 weeks of supplementation and 3 months after discontinuation of supplementation
change in blood pressure from 12 weeks of supplementation to 3 months after discontinuation of supplementation
Measured: 12 weeks of supplementation and 3 months after discontinuation of supplementation
change in heart rate from 12 weeks of supplementation to 3 months after discontinuation of supplementation
Measured: 12 weeks of supplementation and 3 months after discontinuation of supplementation
the proportion of women with ≥ 5% weight loss
Measured: at 4 weeks of supplementation
the proportion of women with ≥ 5% weight loss
Measured: at 8 weeks of supplementation
the proportion of women with ≥ 5% weight loss
Measured: at 12 weeks of supplementation
the proportion of women with ≥ 5% weight loss
Measured: 3 months after discontinuation of supplementation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Sep 2015 (estimated)
- Study startApr 2013
- Primary completionNov 2014
- Study completionNov 2014
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (9)Papers the sponsor has linked to this study.
- Other trials for ObesityStudies of the same condition, open and under way.
- More trials run by Istituto Auxologico ItalianoThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 4
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- Istituto Auxologico Italiano
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Cecilia Invitti, MD, Principal investigator, Istituto Auxologico Italiano
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02542449
- Sponsor's protocol ID
- 19A301_2013
- Status last verified
- Aug 2015
- First submitted
- 1 Sep 2015
- Last updated
- 7 Sep 2015
- Results posted
- No
- Data monitoring committee
- No
Publications
Sumithran P, Prendergast LA, Delbridge E, Purcell K, Shulkes A, Kriketos A, Proietto J. Long-term persistence of hormonal adaptations to weight loss. N Engl J Med. 2011 Oct 27;365(17):1597-604. doi: 10.1056/NEJMoa1105816.
PubMed 22029981Hursel R, Westerterp-Plantenga MS. Catechin- and caffeine-rich teas for control of body weight in humans. Am J Clin Nutr. 2013 Dec;98(6 Suppl):1682S-1693S. doi: 10.3945/ajcn.113.058396. Epub 2013 Oct 30.
PubMed 24172301Jurgens TM, Whelan AM, Killian L, Doucette S, Kirk S, Foy E. Green tea for weight loss and weight maintenance in overweight or obese adults. Cochrane Database Syst Rev. 2012 Dec 12;12(12):CD008650. doi: 10.1002/14651858.CD008650.pub2.
PubMed 23235664Di Pierro F, Menghi AB, Barreca A, Lucarelli M, Calandrelli A. Greenselect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial. Altern Med Rev. 2009 Jun;14(2):154-60.
PubMed 19594224Lambert JD, Hong J, Kim DH, Mishin VM, Yang CS. Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice. J Nutr. 2004 Aug;134(8):1948-52. doi: 10.1093/jn/134.8.1948.
PubMed 15284381Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr. 1999 Dec;70(6):1040-5. doi: 10.1093/ajcn/70.6.1040.
PubMed 10584049Kovacs EM, Lejeune MP, Nijs I, Westerterp-Plantenga MS. Effects of green tea on weight maintenance after body-weight loss. Br J Nutr. 2004 Mar;91(3):431-7. doi: 10.1079/BJN20041061.
PubMed 15005829Westerterp-Plantenga MS, Lejeune MP, Kovacs EM. Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation. Obes Res. 2005 Jul;13(7):1195-204. doi: 10.1038/oby.2005.142.
PubMed 16076989Gilardini L, Pasqualinotto L, Di Pierro F, Risso P, Invitti C. Effects of Greenselect Phytosome(R) on weight maintenance after weight loss in obese women: a randomized placebo-controlled study. BMC Complement Altern Med. 2016 Jul 22;16:233. doi: 10.1186/s12906-016-1214-x.
PubMed 27450231
Study at a glance
From the registry record, last updated by the sponsor on 7 Sep 2015. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Placebo Controlled, Randomized, Single Blinded Trial on the Effects of Greenselect Phytosome® on Weight Maintenance in Obese Women After a 3-month Weight Loss Intervention
- ClinicalTrials.gov ID
- NCT02542449
- Acronym / sponsor ID
- 19A301_2013
- Conditions
- Obesity
- Keywords
- Green tea, weight maintenance, obesity, fat mass
- Phase
- Phase 4
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- Istituto Auxologico ItalianoUniversity, hospital or other
- Study start
- Apr 2013
- Primary completion
- Nov 2014 (actual)
- Study completion
- Nov 2014 (actual)
- First posted
- 7 Sep 2015 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study evaluates whether supplementations with a highly bioavailable green tea extract may help obese women to counteract weight regain after a 3-month weight loss intervention.
Detailed description
Most obese subjects regain weight after weight loss due to compensatory adaptations finalized to maintain stable body energy stores. In lean or obese individuals, maintenance of a 10% or greater reduction in body weight is associated with a decline in 24-hour energy expenditure of approximately 20%-25%. The restraint of the energy expenditure decline during dieting by green tea (GT) preparations should be a useful strategy to facilitate weight maintenance. To increase absorption of GT, the investigators used a formulation with phospholipids (Greenselect Phytosome® ) added with piperine, a thermogenic agent and a booster of absorption for various phenolics.
At the end of a 3-month lifestyle intervention, all patients giving written informed consent were randomly assigned to two groups for the weight-maintenance phase: 20 of them were supplemented twice a day for 3 months with a dietary supplement (Globes®, Pharmextracta, Pontenure, Piacenza, Italy) and 20 with placebo.Women were blind to the supplementation throughout the whole trial. All women attended a monthly clinical visit during the supplementation period and 3 months after the end of supplementation.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Globes® | Active comparator | Dietary Supplement: Globes®Partecipants received twice a day for 3 months Globes® (Pharmextracta, Pontenure, Piacenza, Italy) formulated to be enteric-coated and containing 150 mg/dose of Greenselect Phytosome® and pure piperine (15 mg/dose) from Piper nigrum L. |
| Placebo | Placebo comparator | Dietary Supplement: PlaceboPartecipants received twice a day for 3 months placebo (undistinguishable from Globes in terms of size, shape, taste, odor, primary and secondary packaging). |
Who may qualify
- Ages
- 18 years and older
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- outpatient
- ≥18 years of age
- body mass index (BMI) ≥ 30 kg/m2
- a sufficient level of education to understand study procedures and be able to communicate with site personnel
Key exclusion criteria (3 listed)
- breast feeding or pregnancy
- history of cardiovascular or cerebrovascular events
- uncontrolled hypertension
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Globes®At the end of a 3-month lifestyle intervention, all participants received twice a day for 3 months Globes® and attended a monthly clinical visit during the supplementation period and 3 months after the end of supplementation. | Dietary supplement | Globes® |
| PlaceboAt the end of a 3-month lifestyle intervention, all participants received twice a day for 3 months placebo and attended a monthly clinical visit during the supplementation period and 3 months after the end of supplementation. | Dietary supplement | Placebo |
Primary outcome
change in body weight from baseline to 12 weeks of supplementation
Time frame: baseline and 12 weeks of supplementation
28 secondary outcomes
change in body weight from baseline to 4 weeks of supplementation
Time frame: baseline and 4 weeks of supplementation
change in body weight from 4 weeks to 8 weeks of supplementation
Time frame: 4 weeks and 8 weeks of supplementation
change in body weight from 8 weeks to 12 weeks of supplementation
Time frame: 8 weeks and 12 weeks of supplementation
change in body weight from 12 weeks of supplementation to 3 months after discontinuation of supplementation
Time frame: 12 weeks of supplementation and 3 months after discontinuation of supplementation
change in waist circumference from baseline to 12 weeks of supplementation
Time frame: baseline and 12 weeks of supplementation
change in waist circumference from baseline to 4 weeks of supplementation
Time frame: baseline and 4 weeks of supplementation
change in waist circumference from 4 weeks to 8 weeks of supplementation
Time frame: 4 weeks and 8 weeks of supplementation
change in waist circumference from 8 weeks to 12 weeks of supplementation
Time frame: 8 weeks and 12 weeks of supplementation
change in waist circumference from 12 weeks of supplementation to 3 months after discontinuation of supplementation
Time frame: 12 weeks of supplementation and 3 months after discontinuation of supplementation
change in body composition from baselineto 12 weeks of supplementation
Time frame: baseline and 12 weeks of supplementation
change in blood pressure from baseline to 12 weeks of supplementation
Time frame: baseline and 12 weeks of supplementation
change in heart rate from baseline to 12 weeks of supplementation
Time frame: baseline and 12 weeks of supplementation
change in body composition from baseline to 4 weeks of supplementation
Time frame: baseline and 4 weeks of supplementation
change in blood pressure from baseline to 4 weeks of supplementation
Time frame: baseline and 4 weeks of supplementation
change in heart rate from baseline to 4 weeks of supplementation
Time frame: baseline and 4 weeks of supplementation
change in body composition from 4 weeks to 8 weeks of supplementation
Time frame: 4 weeks and 8 weeks of supplementation
change in blood pressure from 4 weeks to 8 weeks of supplementation
Time frame: 4 weeks and 8 weeks of supplementation
change in heart rate from 4 weeks to 8 weeks of supplementation
Time frame: 4 weeks and 8 weeks of supplementation
change in body composition from 8 weeks to 12 weeks of supplementation
Time frame: 8 weeks and 12 weeks of supplementation
change in blood pressure from 8 weeks to 12 weeks of supplementation
Time frame: 8 weeks and 12 weeks of supplementation
change in heart rate from 8 weeks to 12 weeks of supplementation
Time frame: 8 weeks and 12 weeks of supplementation
change in body composition from 12 weeks of supplementation to 3 months after discontinuation of supplementation
Time frame: 12 weeks of supplementation and 3 months after discontinuation of supplementation
change in blood pressure from 12 weeks of supplementation to 3 months after discontinuation of supplementation
Time frame: 12 weeks of supplementation and 3 months after discontinuation of supplementation
change in heart rate from 12 weeks of supplementation to 3 months after discontinuation of supplementation
Time frame: 12 weeks of supplementation and 3 months after discontinuation of supplementation
the proportion of women with ≥ 5% weight loss
Time frame: at 4 weeks of supplementation
the proportion of women with ≥ 5% weight loss
Time frame: at 8 weeks of supplementation
the proportion of women with ≥ 5% weight loss
Time frame: at 12 weeks of supplementation
the proportion of women with ≥ 5% weight loss
Time frame: 3 months after discontinuation of supplementation
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Sep 2015.
- Background: PubMed 22029981Sumithran P, Prendergast LA, Delbridge E, Purcell K, Shulkes A, Kriketos A, Proietto J. Long-term persistence of hormonal adaptations to weight loss. N Engl J Med. 2011 Oct 27;365(17):1597-604. doi: 10.1056/NEJMoa1105816.
- Background: PubMed 24172301Hursel R, Westerterp-Plantenga MS. Catechin- and caffeine-rich teas for control of body weight in humans. Am J Clin Nutr. 2013 Dec;98(6 Suppl):1682S-1693S. doi: 10.3945/ajcn.113.058396. Epub 2013 Oct 30.
- Background: PubMed 23235664Jurgens TM, Whelan AM, Killian L, Doucette S, Kirk S, Foy E. Green tea for weight loss and weight maintenance in overweight or obese adults. Cochrane Database Syst Rev. 2012 Dec 12;12(12):CD008650. doi: 10.1002/14651858.CD008650.pub2.
- Background: PubMed 19594224Di Pierro F, Menghi AB, Barreca A, Lucarelli M, Calandrelli A. Greenselect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial. Altern Med Rev. 2009 Jun;14(2):154-60.
- Background: PubMed 15284381Lambert JD, Hong J, Kim DH, Mishin VM, Yang CS. Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice. J Nutr. 2004 Aug;134(8):1948-52. doi: 10.1093/jn/134.8.1948.
- Background: PubMed 10584049Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr. 1999 Dec;70(6):1040-5. doi: 10.1093/ajcn/70.6.1040.
- Background: PubMed 15005829Kovacs EM, Lejeune MP, Nijs I, Westerterp-Plantenga MS. Effects of green tea on weight maintenance after body-weight loss. Br J Nutr. 2004 Mar;91(3):431-7. doi: 10.1079/BJN20041061.
- Background: PubMed 16076989Westerterp-Plantenga MS, Lejeune MP, Kovacs EM. Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation. Obes Res. 2005 Jul;13(7):1195-204. doi: 10.1038/oby.2005.142.
- Derived from this study: PubMed 27450231Gilardini L, Pasqualinotto L, Di Pierro F, Risso P, Invitti C. Effects of Greenselect Phytosome(R) on weight maintenance after weight loss in obese women: a randomized placebo-controlled study. BMC Complement Altern Med. 2016 Jul 22;16:233. doi: 10.1186/s12906-016-1214-x.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Cecilia Invitti, MD principal investigator
Istituto Auxologico Italiano
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 4 study testing Globes® in people with Obesity, run by Istituto Auxologico Italiano at 1 site in Italy.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 7 Sep 2015. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Italy. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 4 studies take place after a treatment is approved, to learn more about its long-term benefits and risks in everyday use.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
change in body weight from baseline to 12 weeks of supplementation (time frame: baseline and 12 weeks of supplementation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02542449, which also lists 9 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Sep 2015.