ObesityNCT02689154
W8Loss2Go: mHealth Weight Management Strategy
A study testing W8Loss2Go in people with Obesity, run by Children's Hospital Los Angeles at 1 site in United States.
Trial summary
The investigators will test a recent mobile technology based (mHealth) behavioral weight loss intervention (W8Loss2Go), which is designed for children and adolescents, and uses an addiction model to promote withdrawal from problem foods, snacking, and excessive amounts at meals. Read more about this study
- Who is it for?
- Ages 12 to 18 years
- Conditions the study is for
- Obesity
- What is being tested?
- W8Loss2Go
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 18 participants
- Where
- 1 siteUnited States
- Study dates
- Apr 2016to Sep 2017
- Phase
- Interventional
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 12 to 18 years
- All sexes
- No healthy volunteers
- Child, Adult
Who may be able to join
- Age 12-18 years
- Patients referred to EMPOWER
- Positive screen on the Yale Food Addiction Scale for Children
- Participant will not be leaving the country during the study duration.
Who cannot join
- Obesity comorbidities including impaired glucose tolerance, impaired fasting glucose, diabetes, fatty liver with ALT>40, BP > 99th percentile for age, gender, and height
- Psychiatric illness including depression and anxiety disorder
- Known developmental delay
Trial locations and contacts
1 site in 1 country.
United States1 site
Children's Hospital of Los Angeles
Los Angeles, California, 90027
About this study
Official title: W8Loss2Go: Behavioral Weight Loss Intervention Utilizing Mobile Health Technology in Pediatric Patients Referred to a Tertiary Care Center Weight Management Clinic
The investigators will test a recent mobile technology based (mHealth) behavioral weight loss intervention (W8Loss2Go), which is designed for children and adolescents, and uses an addiction model to promote withdrawal from problem foods, snacking, and excessive amounts at meals. The investigators will test whether this intervention will reduce body mass index (BMI), help subjects identify and withdraw from "problem foods", eliminate snacking, and reduce the amounts of foods consumed at home meals.
Read the detailed description
Background and Rationale: About one in five 12-18 year-olds in the U.S. are obese. It has been theorized that overeating in some individuals may have addictive qualities, and that specific foods may have addictive potential for these people. But few weight management interventions have tested therapeutic techniques founded in addiction medicine principles to date. Since mHealth interventions have been successful in the treatment of other addictions, the investigators hypothesize that mHealth technologies which are rooted in behavioral theory could be effective to promote weight loss in some individuals.
Dr. Robert Pretlow, together with E-Health International, created a weight loss intervention via an iPhone application (W8Loss2Go), based on the addiction treatment approach of staged, incremental withdrawal from problem foods, snacking/grazing, and excessive amounts of foods at meals. The W8Loss2Go application helps participants address their dependence on specific problem foods prior to addressing the amount of food consumed. A secondary focus of the application is to increase the amount of health provider-patient interaction outside of clinic based face-to-face-sessions in a cost-effective manner. Initial pilot studies in obese adolescents in a community setting showed success in improving these problem behaviors and improving BMI.
Intervention: The investigators will test a recent mobile technology based (mHealth) behavioral weight loss intervention, W8Loss2Go, which is designed for children and adolescents, and uses an addiction model to promote a staged withdrawal from problem foods, snacking, and excessive amounts at meals.
Hypothesis: The investigators hypothesize that participants who display addictive behaviors will respond well the mHealth intervention and will be able to withdraw from problem foods and eliminate snacking and excessive amounts eaten at meals, and will therefore show significant decrease in BMI z score from first to last visit.
Specific Aim 1: Determine if participants utilizing the app can stop eating certain self-identified problem foods.
Specific Aim 2: Determine if participants utilizing the app can reduce the amounts (portion-size and frequency) of foods that they consume in large quantities.
Study Design: New EMPOWER patients complete the Yale Food Addiction Study for Children (YFAS-c), a validated 25 item instrument designed to identify addictive behaviors related to food. Patients with more than two positive criteria on the YFAS-C will be recruited for participation in the W8Loss2Go study. Enrolled subjects and their parents will complete the Eating Behaviors Questionnaire (EBQ-Merlo 2009), and then receive the app, an iPhone 5S (if needed), a wireless body weight scale, and a wireless food scale. Over the next 6 months, subjects will proceed through all parts of the app program (problem food withdrawal, snacking control and withdrawal from excessive portions) and receive weekly phone calls from the study coordinator, who will be monitoring app usage and providing motivation. During the six months study period, subjects will return to the EMPOWER clinic for a three month weight check and face-to face meeting with their mentor. After the study period, participants will again complete the EBQ, and be offered continued enrollment in the EMPOWER clinic or continued home use of the mHealth technology Study Population: Twenty obese 12-18 year old adolescents will be recruited from new patients referred to the CHLA EMPOWER Clinic.
Control Population: The investigators will utilize historical controls using newly referred patients to the EMPOWER clinic who score negative on the YFAS-c.
Methods of Data Analysis: All outcome variables will be compared before and after the intervention using paired t-tests. Further analysis will compare the results of the W8Loss2Go program to the contemporary anthropomorphic changes in patients undergoing standard care in our EMPOWER program, using two sample t-tests.
Significance: This study will evaluate the feasibility of implementing a mHealth intervention in a large clinic setting and further explore the role of food addiction specific weight loss therapies as an effective and sustainable weight management strategy for children and adolescents.
- Conditions
- Obesity
- Being tested
- W8Loss2Go
- Keywords
- Pediatric Obesity, Food Addiction, Mobile Health (mHealth), Weight Management
- Medical subject headings
- Obesity, Pediatric Obesity, Food Addiction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
W8Loss2GoDevice
The participants will proceed through all parts of the app program (problem food withdrawal, snacking control and withdrawal from excessive portions) and receive weekly phone calls from the study coordinator, who will be monitoring app usage and providing motivation. Subjects will return to the EMPOWER clinic for a three month weight check and face-to-face meeting with their mentor. After the study period, participants will again complete the EBQ, and be offered continued enrollment in the EMPOWER clinic or continued home use of the mHealth technology.
| Study group | Role | What they receive |
|---|---|---|
| W8Loss2Go App | Experimental | Subjects will complete all stages of W8Loss2Go mHealth intervention. Receives: Device: W8Loss2Go |
What is being measured
The primary outcome is the main question the study is designed to answer.
Body Mass Index (BMI) z -Score
The Z-score indicates the number of standard deviations away from the mean. A Z-score of 0 is equal to the mean. Negative numbers indicate values lower than the mean and positive numbers indicate values higher than the mean. A negative change value reflects a decrease in BMI or a better outcome and a positive change value reflects an increase in BMI or a worsening in the outcome.
Measured: Baseline and 6 months
Secondary outcomes (3)
Number of Participants With Success in Withdrawing From Problem Foods
The number of participants who were able to withdraw from 5 or more problem foods was evaluated.
Measured: 6 months
Number of Participants Able to Eliminated Day Time Snacking
Success in these areas will be determined by data collected from within the application's database.
Measured: 3 months
Number of Participants Able to Reduce Daily Meal Portion Size Utilizing Wireless Food Scale.
Success in these areas will be determined by data collected from within the application's database. Participants will weight meals daily and the app will assist the participant in decrease the quantity of food consumed each day until they achieve age appropriate portion size.
Measured: 1 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Feb 2016 (estimated)
- Study startApr 2016
- Primary completionSep 2017
- Study completionSep 2017
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Publications (8)Papers the sponsor has linked to this study.
- Other trials for ObesityStudies of the same condition, open and under way.
- More trials run by Children's Hospital Los AngelesThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 18 participants (actual)
Sponsor and investigators
- Lead sponsor
- Children's Hospital Los Angeles
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Alaina Vidmar, MD, Children's Hospital Los Angeles
- Investigators
- Steve D Mittelman, MD, PhD, Study director, Children's Hospital Los Angeles
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02689154
- Sponsor's protocol ID
- CHLA-16-00007
- Status last verified
- Apr 2019
- First submitted
- 15 Feb 2016
- Last updated
- 12 Apr 2019
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- No
- Individual data sharing
- No: The individual participant data will be de-identified and coded. The sponsor of the study will have access to this data through the application download. The data will not be available to the public.
Publications
Chaplais E, Naughton G, Thivel D, Courteix D, Greene D. Smartphone Interventions for Weight Treatment and Behavioral Change in Pediatric Obesity: A Systematic Review. Telemed J E Health. 2015 Oct;21(10):822-30. doi: 10.1089/tmj.2014.0197. Epub 2015 Aug 20.
PubMed 26290954Dimitrijevic I, Popovic N, Sabljak V, Skodric-Trifunovic V, Dimitrijevic N. Food addiction-diagnosis and treatment. Psychiatr Danub. 2015 Mar;27(1):101-6.
PubMed 25751444Lin PH, Intille S, Bennett G, Bosworth HB, Corsino L, Voils C, Grambow S, Lazenka T, Batch BC, Tyson C, Svetkey LP. Adaptive intervention design in mobile health: Intervention design and development in the Cell Phone Intervention for You trial. Clin Trials. 2015 Dec;12(6):634-45. doi: 10.1177/1740774515597222. Epub 2015 Jul 30.
PubMed 26229119Delisle C, Sandin S, Forsum E, Henriksson H, Trolle-Lagerros Y, Larsson C, Maddison R, Ortega FB, Ruiz JR, Silfvernagel K, Timpka T, Lof M. A web- and mobile phone-based intervention to prevent obesity in 4-year-olds (MINISTOP): a population-based randomized controlled trial. BMC Public Health. 2015 Feb 7;15:95. doi: 10.1186/s12889-015-1444-8.
PubMed 25886009Gearhardt AN, Corbin WR. The role of food addiction in clinical research. Curr Pharm Des. 2011;17(12):1140-2. doi: 10.2174/138161211795656800.
PubMed 21492090Jeon E, Park HA. Development of a smartphone application for clinical-guideline-based obesity management. Healthc Inform Res. 2015 Jan;21(1):10-20. doi: 10.4258/hir.2015.21.1.10. Epub 2015 Jan 31.
PubMed 25705553Pretlow RA, Stock CM, Allison S, Roeger L. Treatment of child/adolescent obesity using the addiction model: a smartphone app pilot study. Child Obes. 2015 Jun;11(3):248-59. doi: 10.1089/chi.2014.0124. Epub 2015 Mar 11.
PubMed 25760813Vidmar AP, Pretlow R, Borzutzky C, Wee CP, Fox DS, Fink C, Mittelman SD. An addiction model-based mobile health weight loss intervention in adolescents with obesity. Pediatr Obes. 2019 Feb;14(2):e12464. doi: 10.1111/ijpo.12464. Epub 2018 Aug 16.
PubMed 30117309
Study at a glance
From the registry record, last updated by the sponsor on 12 Apr 2019. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- W8Loss2Go: Behavioral Weight Loss Intervention Utilizing Mobile Health Technology in Pediatric Patients Referred to a Tertiary Care Center Weight Management Clinic
- ClinicalTrials.gov ID
- NCT02689154
- Acronym / sponsor ID
- CHLA-16-00007
- Conditions
- Obesity
- Keywords
- Pediatric Obesity, Food Addiction, Mobile Health (mHealth), Weight Management
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 18 participants (actual)
- Lead sponsor
- Children's Hospital Los AngelesUniversity, hospital or other
- Study start
- Apr 2016
- Primary completion
- Sep 2017 (actual)
- Study completion
- Sep 2017 (actual)
- First posted
- 23 Feb 2016 (estimated)
- Results
- Posted 12 Apr 2019
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The investigators will test a recent mobile technology based (mHealth) behavioral weight loss intervention (W8Loss2Go), which is designed for children and adolescents, and uses an addiction model to promote withdrawal from problem foods, snacking, and excessive amounts at meals. The investigators will test whether this intervention will reduce body mass index (BMI), help subjects identify and withdraw from "problem foods", eliminate snacking, and reduce the amounts of foods consumed at home meals.
Detailed description
Background and Rationale: About one in five 12-18 year-olds in the U.S. are obese. It has been theorized that overeating in some individuals may have addictive qualities, and that specific foods may have addictive potential for these people. But few weight management interventions have tested therapeutic techniques founded in addiction medicine principles to date. Since mHealth interventions have been successful in the treatment of other addictions, the investigators hypothesize that mHealth technologies which are rooted in behavioral theory could be effective to promote weight loss in some individuals.
Dr. Robert Pretlow, together with E-Health International, created a weight loss intervention via an iPhone application (W8Loss2Go), based on the addiction treatment approach of staged, incremental withdrawal from problem foods, snacking/grazing, and excessive amounts of foods at meals. The W8Loss2Go application helps participants address their dependence on specific problem foods prior to addressing the amount of food consumed. A secondary focus of the application is to increase the amount of health provider-patient interaction outside of clinic based face-to-face-sessions in a cost-effective manner. Initial pilot studies in obese adolescents in a community setting showed success in improving these problem behaviors and improving BMI.
Intervention: The investigators will test a recent mobile technology based (mHealth) behavioral weight loss intervention, W8Loss2Go, which is designed for children and adolescents, and uses an addiction model to promote a staged withdrawal from problem foods, snacking, and excessive amounts at meals.
Hypothesis: The investigators hypothesize that participants who display addictive behaviors will respond well the mHealth intervention and will be able to withdraw from problem foods and eliminate snacking and excessive amounts eaten at meals, and will therefore show significant decrease in BMI z score from first to last visit.
Specific Aim 1: Determine if participants utilizing the app can stop eating certain self-identified problem foods.
Specific Aim 2: Determine if participants utilizing the app can reduce the amounts (portion-size and frequency) of foods that they consume in large quantities.
Study Design: New EMPOWER patients complete the Yale Food Addiction Study for Children (YFAS-c), a validated 25 item instrument designed to identify addictive behaviors related to food. Patients with more than two positive criteria on the YFAS-C will be recruited for participation in the W8Loss2Go study. Enrolled subjects and their parents will complete the Eating Behaviors Questionnaire (EBQ-Merlo 2009), and then receive the app, an iPhone 5S (if needed), a wireless body weight scale, and a wireless food scale. Over the next 6 months, subjects will proceed through all parts of the app program (problem food withdrawal, snacking control and withdrawal from excessive portions) and receive weekly phone calls from the study coordinator, who will be monitoring app usage and providing motivation. During the six months study period, subjects will return to the EMPOWER clinic for a three month weight check and face-to face meeting with their mentor. After the study period, participants will again complete the EBQ, and be offered continued enrollment in the EMPOWER clinic or continued home use of the mHealth technology Study Population: Twenty obese 12-18 year old adolescents will be recruited from new patients referred to the CHLA EMPOWER Clinic.
Control Population: The investigators will utilize historical controls using newly referred patients to the EMPOWER clinic who score negative on the YFAS-c.
Methods of Data Analysis: All outcome variables will be compared before and after the intervention using paired t-tests. Further analysis will compare the results of the W8Loss2Go program to the contemporary anthropomorphic changes in patients undergoing standard care in our EMPOWER program, using two sample t-tests.
Significance: This study will evaluate the feasibility of implementing a mHealth intervention in a large clinic setting and further explore the role of food addiction specific weight loss therapies as an effective and sustainable weight management strategy for children and adolescents.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| W8Loss2Go App | Experimental | Device: W8Loss2GoSubjects will complete all stages of W8Loss2Go mHealth intervention. |
Who may qualify
- Ages
- 12 to 18 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (4 listed)
- Age 12-18 years
- Patients referred to EMPOWER
- Positive screen on the Yale Food Addiction Scale for Children
- Participant will not be leaving the country during the study duration.
Key exclusion criteria (3 listed)
- Obesity comorbidities including impaired glucose tolerance, impaired fasting glucose, diabetes, fatty liver with ALT>40, BP > 99th percentile for age, gender, and height
- Psychiatric illness including depression and anxiety disorder
- Known developmental delay
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| W8Loss2GoThe participants will proceed through all parts of the app program (problem food withdrawal, snacking control and withdrawal from excessive portions) and receive weekly phone calls from the study coordinator, who will be monitoring app usage and providing motivation. Subjects will return to the EMPOWER clinic for a three month weight check and face-to-face meeting with their mentor. After the study period, participants will again complete the EBQ, and be offered continued enrollment in the EMPOWER clinic or continued home use of the mHealth technology. | Device | W8Loss2Go App |
Primary outcome
Body Mass Index (BMI) z -Score
Time frame: Baseline and 6 months
The Z-score indicates the number of standard deviations away from the mean. A Z-score of 0 is equal to the mean. Negative numbers indicate values lower than the mean and positive numbers indicate values higher than the mean. A negative change value reflects a decrease in BMI or a better outcome and a positive change value reflects an increase in BMI or a worsening in the outcome.
3 secondary outcomes
Number of Participants With Success in Withdrawing From Problem Foods
Time frame: 6 months
Number of Participants Able to Eliminated Day Time Snacking
Time frame: 3 months
Number of Participants Able to Reduce Daily Meal Portion Size Utilizing Wireless Food Scale.
Time frame: 1 month
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Apr 2019.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Background: PubMed 26290954Chaplais E, Naughton G, Thivel D, Courteix D, Greene D. Smartphone Interventions for Weight Treatment and Behavioral Change in Pediatric Obesity: A Systematic Review. Telemed J E Health. 2015 Oct;21(10):822-30. doi: 10.1089/tmj.2014.0197. Epub 2015 Aug 20.
- Background: PubMed 25751444Dimitrijevic I, Popovic N, Sabljak V, Skodric-Trifunovic V, Dimitrijevic N. Food addiction-diagnosis and treatment. Psychiatr Danub. 2015 Mar;27(1):101-6.
- Background: PubMed 26229119Lin PH, Intille S, Bennett G, Bosworth HB, Corsino L, Voils C, Grambow S, Lazenka T, Batch BC, Tyson C, Svetkey LP. Adaptive intervention design in mobile health: Intervention design and development in the Cell Phone Intervention for You trial. Clin Trials. 2015 Dec;12(6):634-45. doi: 10.1177/1740774515597222. Epub 2015 Jul 30.
- Background: PubMed 25886009Delisle C, Sandin S, Forsum E, Henriksson H, Trolle-Lagerros Y, Larsson C, Maddison R, Ortega FB, Ruiz JR, Silfvernagel K, Timpka T, Lof M. A web- and mobile phone-based intervention to prevent obesity in 4-year-olds (MINISTOP): a population-based randomized controlled trial. BMC Public Health. 2015 Feb 7;15:95. doi: 10.1186/s12889-015-1444-8.
- Background: PubMed 21492090Gearhardt AN, Corbin WR. The role of food addiction in clinical research. Curr Pharm Des. 2011;17(12):1140-2. doi: 10.2174/138161211795656800.
- Background: PubMed 25705553Jeon E, Park HA. Development of a smartphone application for clinical-guideline-based obesity management. Healthc Inform Res. 2015 Jan;21(1):10-20. doi: 10.4258/hir.2015.21.1.10. Epub 2015 Jan 31.
- Background: PubMed 25760813Pretlow RA, Stock CM, Allison S, Roeger L. Treatment of child/adolescent obesity using the addiction model: a smartphone app pilot study. Child Obes. 2015 Jun;11(3):248-59. doi: 10.1089/chi.2014.0124. Epub 2015 Mar 11.
- Derived from this study: PubMed 30117309Vidmar AP, Pretlow R, Borzutzky C, Wee CP, Fox DS, Fink C, Mittelman SD. An addiction model-based mobile health weight loss intervention in adolescents with obesity. Pediatr Obes. 2019 Feb;14(2):e12464. doi: 10.1111/ijpo.12464. Epub 2018 Aug 16.
- Individual participant dataSharing planned: No. The individual participant data will be de-identified and coded. The sponsor of the study will have access to this data through the application download. The data will not be available to the public.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Steve D Mittelman, MD, PhD study director
Children's Hospital Los Angeles
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing W8Loss2Go in people with Obesity, run by Children's Hospital Los Angeles at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Apr 2019. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Yes. Results are posted in the registry (first posted 12 Apr 2019). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Body Mass Index (BMI) z -Score (time frame: Baseline and 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02689154, which also lists 8 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Apr 2019.