Late-effects of Childhood CancerSURfitNCT02730767
SURfit - A Physical Activity Intervention for Childhood Cancer Survivors
A study testing partially supervised exercise intervention in people with Late-effects of Childhood Cancer, run by University of Zurich at 1 site in Switzerland.
Trial summary
Exercise can play a major role to mitigate or even prevent late effects in cancer survivors, such as cardiovascular disease, obesity, osteoporosis, fatigue, depression, reduced quality of life, mental health and physical performance. Read more about this study
- Who is it for?
- Ages 16 years and older
- Conditions the study is for
- Late-effects of Childhood Cancer
- What is being tested?
- partially supervised exercise intervention
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 151 participants
- Where
- 1 siteSwitzerland
- Study dates
- Aug 2015to Mar 2019
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 years and older
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Registered in the Swiss Childhood Cancer Registry.
- Age at cancer diagnosis <16 years.
- Diagnosed with a cancer classifiable within the International Classification of Childhood Cancer (ICCC-3) or diagnosed with a Langerhans Cell Histiocytosis.
- Diagnosed and/or treated at the University Children's Hospital Basel, Cantonal Hospital of Aarau and/or Cantonal Hospital of Lucerne.
- Survived ≥5 years since primary cancer diagnosis or any subsequent cancer event (relapse or further cancer diagnoses)
- Age at the time of the study ≥16 years
- Informed Consent as documented by signature
Who cannot join
- Participation in another clinical trial <4 weeks prior to baseline assessment (eventually later re-enrolment)
- Contradiction to one of the inclusion criteria mentioned above
- Inability to exercise
- Exercise potentially harmful
- Women who are pregnant or breast feeding
- Women who intend to become pregnant during the course of the study
Show all 16Show fewer
- Instable clinical condition (eventually later re-enrolment)
- Under treatment for relapse or further cancer diagnoses
- Cardiac arrhythmias under exercise (during baseline assessment or by history)
- Diagnosis of diabetes <3 months ago (eventually re-enrolment after 3 months if diabetes is under good control)
- Detection of a clinical condition that needs immediate treatment during baseline assessments (eventually re-enrolment after 3 months if in stable clinical condition)
- Planned relevant surgeries for the next 12 months
- Major musculoskeletal injuries, fractures <2 months ago (eventually later re-enrolment)
- Recent change in medication that interfere with the parameters of the CVD risk score (primary outcome) <1 month ago (eventually later re-enrolment)
- >4 hours of reported vigorous activities per week
- Inability to follow the procedures and understand the intervention and assessments of the study e.g. due to cognitive impairment, language problems, psychological disorders etc.
Trial locations and contacts
1 site in 1 country.
Switzerland1 site
University Children's Hospital Basel (UKBB)
Basel, Basel, 4056
About this study
Official title: Effects of a 1-year Partially Supervised Exercise Program in Childhood Cancer Survivors - a Randomized Controlled Trial
Exercise can play a major role to mitigate or even prevent late effects in cancer survivors, such as cardiovascular disease, obesity, osteoporosis, fatigue, depression, reduced quality of life, mental health and physical performance.
The objective of this study is to assess the effect of an exercise program of 1 year on cardiovascular health, obesity and diabetes, osteoporosis, physical fitness, mental health and quality of life in childhood cancer survivors. The investigators will recruit childhood cancer survivors aged 16 years and above from three Swiss paediatric oncology clinics and randomize them into an intervention and a control group. The intervention group will be asked to increase physical activity for 1 year by at least 2.5 hours of intense physical activity weekly. Regular feedback will be given via a step counter, an online activity diary, and by the centre staff. The control group participants will keep their activity level constant. All participants will be seen after 3, 6 and 12 months to assess health and quality of life parameters over one year. After 1 year, the control group is offered to receive the same intervention to profit as well from an active lifestyle.
If the program shows to be effective, a complete package will become available to interested centres treating paediatric cancer patients in Switzerland to promote exercise in all survivors. The program will allow clinicians without previous experience in exercise counselling to improve the care of their patients.
- Conditions
- Late-effects of Childhood Cancer
- Being tested
- partially supervised exercise intervention
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
partially supervised exercise interventionBehavioural
Also called physical activity intervention
| Study group | Role | What they receive |
|---|---|---|
| Intervention Group | Experimental | Partially supervised exercise intervention: Survivors in the intervention group will be asked to add at least 2.5 hours of intense physical activities per week. These should include at least 30 min of strength building exercises and 2 hours of aerobic exercises per week. Exercise bouts lasting 20 min or longer will be counted with respect to total weekly training time. Receives: Behavioral: partially supervised exercise intervention |
| Control Group | No intervention | The control group will keep their physical activity level constant over the 1 year of the study. Thereafter, they will have the opportunity to receive the same intervention than the intervention group had received (off-trial) to benefit in the same way from an active lifestyle. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Composite cardiovascular risk score [z-score]
summarized mean z-score of waist circumference, blood pressure, HOMA-IR, inverted high density lipoprotein cholesterol, triglycerides and cardiorespiratory fitness
Measured: 12 months
Secondary outcomes (36)
Waist circumference [cm]
Measured: 3, 6, and 12 months
Systolic and diastolic blood pressure [mmHg]
Measured: 3, 6, and 12 months
Homeostasis Model Assessment Insulin Resistance (HOMA-IR)
calculated from insulin and glucose
Measured: 6 and 12 months
HbA1C [mmol/mol]
Measured: 6 and 12 months
Insulin resistance from response to oral glucose tolerance test (oGTT)
Assessment of fasting glucose [mmol/l] and insulin [mIU/l] and glucose 2 hours after drinking of a glucose solution
Measured: 12 months
Inverted high-density lipoprotein cholesterol (HDL) [mmol/l]
Measured: 6 and 12 months
Low-density lipoprotein cholesterol (LDL) [mmol/l]
Measured: 6 and 12 months
Total cholesterol [mmol/l]
Measured: 6 and 12 months
Triglycerides [mmol/l]
Measured: 6 and 12 months
Body Mass Index (BMI) [z-score]
Calculated from height and weight
Measured: 3, 6, and 12 months
Absolute [kg] and relative [%] body fat mass
Assessed with two methods: skinfold measurement (3, 6, and 12 months) and dual x-ray absorptiometry (DXA, 12 months only).
Measured: 3, 6, and 12 months
Areal bone mineral density [g/cm2 and z-scores]
Bone mineral density for total body, lumbar spine, and femoral neck assessed with dual x-ray absorptiometry (DXA)
Measured: 12 months
Bone mineral content [g/cm and z-scores]
Bone mineral content for total body, lumbar spine, and femoral neck assessed with dual x-ray absorptiometry (DXA)
Measured: 12 months
Total cross sectional bone area [mm2 and z-scores]
Cross sectional area of the distal and proximal sites of radius and tibia assessed with peripheral quantitative computer tomography (pQCT)
Measured: 12 months
Cortical cross sectional bone area [mm2 and z-scores]
Cross sectional area of the proximal site of radius and tibia assessed with peripheral quantitative computer tomography (pQCT)
Measured: 12 months
Total and trabecular bone mineral density [g/cm3 and z-scores]
Bone mineral density of the distal site of radius and tibia assessed with peripheral quantitative computer tomography (pQCT)
Measured: 12 months
Cortical bone mineral density [g/cm3 and z-scores]
Bone mineral density of the proximal site of radius and tibia assessed with peripheral quantitative computer tomography (pQCT)
Measured: 12 months
Muscle cross-sectional area [cm2 and z-scores]
Muscle cross-sectional area of the proximal site of radius and tibia assessed with peripheral quantitative computer tomography (pQCT)
Measured: 12 months
Peak oxygen uptake (VO2max) [ml/(kg*min) and % predicted]
Assessed with maximal spiroergometry test
Measured: 6 and 12 months
Peak performance [watt/kg and % predicted]
Assessed with maximal spiroergometry test
Measured: 6 and 12 months
Heart rate recovery [delta beats/min]
Assessed at the end of the maximal spiroergometry test: delta beats/min between peak heart rate and heart rate 1 minute post exercise.
Measured: 6 and 12 months
Hand grip strength in the left and right hand [kg]
Assessed with a hydrolic hand grip dynamometer.
Measured: 6 and 12 months
Leg strength and endurance [repetitions/min]
Assessed with the 1 minute sit-to-stand test
Measured: 6 and 12 months
Total physical activity [counts/min]
Assessed by accelerometer
Measured: 6 and 12 months
Moderate to vigorous physical activities [minutes/day]
Assessed by accelerometer
Measured: 6 and 12 months
High impact activities with ground forces >3.9 G [n/day]
Assessed by accelerometer
Measured: 6 and 12 month
Sedentary behaviour [minutes/day]
Assessed by accelerometer
Measured: 6 and 12 months
Number of steps per day [steps/day]
Assessed by accelerometer
Measured: 6 and 12 months
Health related quality of life [T-score with mean=50, standard deviation=10 and range=0-100]
Health related quality of life assessed by the self-reported questionnaire short form 36 (SF-36).
Measured: 6 and 12 months
Psychological distress [T-score with mean=50, standard deviation=10 and range=0-100]
Psychological distress assessed by the self-reported questionnaire Brief Symptom Inventory (BSI).
Measured: 6 and 12 months
Fatigue on a visual analogue scale (VAS) [mm]
Measured: 3, 6 and 12 months
Fatigue
Fatigue assessed with the self-reported questionnaire Checklist of Individual Strength (CIS).
Measured: 3, 6 and 12 months
Number of adverse events and serious adverse events [n]
Number of participants with adverse events and exercise related complications categorized into seriousness of the event (adverse event [AE] or severe adverse event [SAE]).
Measured: 3, 6 and 12 months
Proportion of aimed physical activity reached [%]
Only intervention participants: compliance with intervention
Measured: 12 months
Number of weeks where physical activity aim was reached [n/year]
Only intervention participants: compliance with intervention
Measured: 12 months
Number of missing days in the online diary [n/year]
Only intervention participants: compliance with intervention
Measured: 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Apr 2016 (estimated)
- Study startAug 2015
- Primary completionMar 2019
- Study completionMar 2019
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (8)Papers the sponsor has linked to this study.
- Other trials for Late-effects of Childhood CancerStudies of the same condition, open and under way.
- More trials run by University of ZurichThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 151 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Zurich
- Sponsor type
- University, hospital or other
- Collaborators
- University Children's Hospital Basel
- Responsible party
- Sponsor
- Investigators
- Nicolas X von der Weid, Prof, MD, Principal investigator, University Children's Hospital Basel
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02730767
- Sponsor's protocol ID
- SURfit
- Acronym
- SURfit
- Status last verified
- Apr 2025
- First submitted
- 10 Dec 2015
- Last updated
- 4 Apr 2025
- Results posted
- No
- Data monitoring committee
- No
- Individual data sharing
- No
Publications
Jung R, Zurcher SJ, Schindera C, Eser P, Meier C, Schai A, Braun J, Deng WH, Hebestreit H, Neuhaus C, Schaeff J, Rueegg CS, von der Weid NX, Kriemler S. Effect of a physical activity intervention on lower body bone health in childhood cancer survivors: A randomized controlled trial (SURfit). Int J Cancer. 2023 Jan 15;152(2):162-171. doi: 10.1002/ijc.34234. Epub 2022 Aug 26.
PubMed 35913755Zurcher SJ, Jung R, Monnerat S, Schindera C, Eser P, Meier C, Rueegg CS, von der Weid NX, Kriemler S. High impact physical activity and bone health of lower extremities in childhood cancer survivors: A cross-sectional study of SURfit. Int J Cancer. 2020 Oct 1;147(7):1845-1854. doi: 10.1002/ijc.32963. Epub 2020 Mar 25.
PubMed 32167159Rueegg CS, Kriemler S, Zuercher SJ, Schindera C, Renner A, Hebestreit H, Meier C, Eser P, von der Weid NX. A partially supervised physical activity program for adult and adolescent survivors of childhood cancer (SURfit): study design of a randomized controlled trial [NCT02730767]. BMC Cancer. 2017 Dec 5;17(1):822. doi: 10.1186/s12885-017-3801-8.
PubMed 29207962Rueegg CS, Zurcher SJ, Schindera C, Jung R, Deng WH, Banteli I, Schaeff J, Hebestreit H, von der Weid NX, Kriemler S. Effect of a 1-year physical activity intervention on cardiovascular health in long-term childhood cancer survivors-a randomised controlled trial (SURfit). Br J Cancer. 2023 Oct;129(8):1284-1297. doi: 10.1038/s41416-023-02410-y. Epub 2023 Aug 31.
PubMed 37653075Deng WH, Zurcher SJ, Schindera C, Jung R, Hebestreit H, Banteli I, Bologna K, von der Weid NX, Kriemler S, Rueegg CS. Effect of a 1-year physical activity intervention on quality of life, fatigue, and distress in adult childhood cancer survivors-A randomized controlled trial (SURfit). Cancer. 2024 May 15;130(10):1869-1883. doi: 10.1002/cncr.35207. Epub 2024 Feb 5.
PubMed 38315522Schindera C, Zurcher SJ, Jung R, Boehringer S, Balder JW, Rueegg CS, Kriemler S, von der Weid NX. Physical fitness and modifiable cardiovascular disease risk factors in survivors of childhood cancer: A report from the SURfit study. Cancer. 2021 May 15;127(10):1690-1698. doi: 10.1002/cncr.33351. Epub 2021 Jan 6.
PubMed 33405260Jung R, Zurcher SJ, Schindera C, Braun J, Deng WH, von der Weid NX, Rueegg CS, Kriemler S. Adherence and contamination in a 1-year physical activity program in childhood cancer survivors: A report from the SURfit study. Cancer Med. 2023 Jul;12(13):14731-14741. doi: 10.1002/cam4.6096. Epub 2023 May 18.
PubMed 37199378Schindera C, Usemann J, Zuercher SJ, Jung R, Kasteler R, Frauchiger B, Naumann G, Rueegg CS, Latzin P, Kuehni CE, von der Weid NX. Pulmonary Dysfunction after Treatment for Childhood Cancer. Comparing Multiple-Breath Washout with Spirometry. Ann Am Thorac Soc. 2021 Feb;18(2):281-289. doi: 10.1513/AnnalsATS.202003-211OC.
PubMed 32877212
Study at a glance
From the registry record, last updated by the sponsor on 4 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of a 1-year Partially Supervised Exercise Program in Childhood Cancer Survivors - a Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT02730767
- Acronym / sponsor ID
- SURfit / SURfit
- Conditions
- Late-effects of Childhood Cancer
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 151 participants (actual)
- Lead sponsor
- University of ZurichUniversity, hospital or other
- Collaborators
- University Children's Hospital Basel
- Study start
- Aug 2015 (actual)
- Primary completion
- Mar 2019 (actual)
- Study completion
- Mar 2019 (actual)
- First posted
- 6 Apr 2016 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Exercise can play a major role to mitigate or even prevent late effects in cancer survivors, such as cardiovascular disease, obesity, osteoporosis, fatigue, depression, reduced quality of life, mental health and physical performance.
The objective of this study is to assess the effect of an exercise program of 1 year on cardiovascular health, obesity and diabetes, osteoporosis, physical fitness, mental health and quality of life in childhood cancer survivors. The investigators will recruit childhood cancer survivors aged 16 years and above from three Swiss paediatric oncology clinics and randomize them into an intervention and a control group. The intervention group will be asked to increase physical activity for 1 year by at least 2.5 hours of intense physical activity weekly. Regular feedback will be given via a step counter, an online activity diary, and by the centre staff. The control group participants will keep their activity level constant. All participants will be seen after 3, 6 and 12 months to assess health and quality of life parameters over one year. After 1 year, the control group is offered to receive the same intervention to profit as well from an active lifestyle.
If the program shows to be effective, a complete package will become available to interested centres treating paediatric cancer patients in Switzerland to promote exercise in all survivors. The program will allow clinicians without previous experience in exercise counselling to improve the care of their patients.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Intervention Group | Experimental | Behavioral: partially supervised exercise interventionPartially supervised exercise intervention: Survivors in the intervention group will be asked to add at least 2.5 hours of intense physical activities per week. These should include at least 30 min of strength building exercises and 2 hours of aerobic exercises per week. Exercise bouts lasting 20 min or longer will be counted with respect to total weekly training time. |
| Control Group | No intervention | –The control group will keep their physical activity level constant over the 1 year of the study. Thereafter, they will have the opportunity to receive the same intervention than the intervention group had received (off-trial) to benefit in the same way from an active lifestyle. |
Who may qualify
- Ages
- 16 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (7 listed)
- Registered in the Swiss Childhood Cancer Registry.
- Age at cancer diagnosis <16 years.
- Diagnosed with a cancer classifiable within the International Classification of Childhood Cancer (ICCC-3) or diagnosed with a Langerhans Cell Histiocytosis.
- Diagnosed and/or treated at the University Children's Hospital Basel, Cantonal Hospital of Aarau and/or Cantonal Hospital of Lucerne.
- Survived ≥5 years since primary cancer diagnosis or any subsequent cancer event (relapse or further cancer diagnoses)
Key exclusion criteria (16 listed)
- Participation in another clinical trial <4 weeks prior to baseline assessment (eventually later re-enrolment)
- Contradiction to one of the inclusion criteria mentioned above
- Inability to exercise
- Exercise potentially harmful
- Women who are pregnant or breast feeding
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| partially supervised exercise interventionAlso: physical activity intervention | Behavioural | Intervention Group |
Primary outcome
Composite cardiovascular risk score [z-score]
Time frame: 12 months
summarized mean z-score of waist circumference, blood pressure, HOMA-IR, inverted high density lipoprotein cholesterol, triglycerides and cardiorespiratory fitness
36 secondary outcomes
Waist circumference [cm]
Time frame: 3, 6, and 12 months
Systolic and diastolic blood pressure [mmHg]
Time frame: 3, 6, and 12 months
Homeostasis Model Assessment Insulin Resistance (HOMA-IR)
Time frame: 6 and 12 months
HbA1C [mmol/mol]
Time frame: 6 and 12 months
Insulin resistance from response to oral glucose tolerance test (oGTT)
Time frame: 12 months
Inverted high-density lipoprotein cholesterol (HDL) [mmol/l]
Time frame: 6 and 12 months
Low-density lipoprotein cholesterol (LDL) [mmol/l]
Time frame: 6 and 12 months
Total cholesterol [mmol/l]
Time frame: 6 and 12 months
Triglycerides [mmol/l]
Time frame: 6 and 12 months
Body Mass Index (BMI) [z-score]
Time frame: 3, 6, and 12 months
Absolute [kg] and relative [%] body fat mass
Time frame: 3, 6, and 12 months
Areal bone mineral density [g/cm2 and z-scores]
Time frame: 12 months
Bone mineral content [g/cm and z-scores]
Time frame: 12 months
Total cross sectional bone area [mm2 and z-scores]
Time frame: 12 months
Cortical cross sectional bone area [mm2 and z-scores]
Time frame: 12 months
Total and trabecular bone mineral density [g/cm3 and z-scores]
Time frame: 12 months
Cortical bone mineral density [g/cm3 and z-scores]
Time frame: 12 months
Muscle cross-sectional area [cm2 and z-scores]
Time frame: 12 months
Peak oxygen uptake (VO2max) [ml/(kg*min) and % predicted]
Time frame: 6 and 12 months
Peak performance [watt/kg and % predicted]
Time frame: 6 and 12 months
Heart rate recovery [delta beats/min]
Time frame: 6 and 12 months
Hand grip strength in the left and right hand [kg]
Time frame: 6 and 12 months
Leg strength and endurance [repetitions/min]
Time frame: 6 and 12 months
Total physical activity [counts/min]
Time frame: 6 and 12 months
Moderate to vigorous physical activities [minutes/day]
Time frame: 6 and 12 months
High impact activities with ground forces >3.9 G [n/day]
Time frame: 6 and 12 month
Sedentary behaviour [minutes/day]
Time frame: 6 and 12 months
Number of steps per day [steps/day]
Time frame: 6 and 12 months
Health related quality of life [T-score with mean=50, standard deviation=10 and range=0-100]
Time frame: 6 and 12 months
Psychological distress [T-score with mean=50, standard deviation=10 and range=0-100]
Time frame: 6 and 12 months
Fatigue on a visual analogue scale (VAS) [mm]
Time frame: 3, 6 and 12 months
Fatigue
Time frame: 3, 6 and 12 months
Number of adverse events and serious adverse events [n]
Time frame: 3, 6 and 12 months
Proportion of aimed physical activity reached [%]
Time frame: 12 months
Number of weeks where physical activity aim was reached [n/year]
Time frame: 12 months
Number of missing days in the online diary [n/year]
Time frame: 12 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Apr 2025.
- Background: PubMed 35913755Jung R, Zurcher SJ, Schindera C, Eser P, Meier C, Schai A, Braun J, Deng WH, Hebestreit H, Neuhaus C, Schaeff J, Rueegg CS, von der Weid NX, Kriemler S. Effect of a physical activity intervention on lower body bone health in childhood cancer survivors: A randomized controlled trial (SURfit). Int J Cancer. 2023 Jan 15;152(2):162-171. doi: 10.1002/ijc.34234. Epub 2022 Aug 26.
- Background: PubMed 32167159Zurcher SJ, Jung R, Monnerat S, Schindera C, Eser P, Meier C, Rueegg CS, von der Weid NX, Kriemler S. High impact physical activity and bone health of lower extremities in childhood cancer survivors: A cross-sectional study of SURfit. Int J Cancer. 2020 Oct 1;147(7):1845-1854. doi: 10.1002/ijc.32963. Epub 2020 Mar 25.
- Background: PubMed 29207962Rueegg CS, Kriemler S, Zuercher SJ, Schindera C, Renner A, Hebestreit H, Meier C, Eser P, von der Weid NX. A partially supervised physical activity program for adult and adolescent survivors of childhood cancer (SURfit): study design of a randomized controlled trial [NCT02730767]. BMC Cancer. 2017 Dec 5;17(1):822. doi: 10.1186/s12885-017-3801-8.
- Results publication: PubMed 37653075Rueegg CS, Zurcher SJ, Schindera C, Jung R, Deng WH, Banteli I, Schaeff J, Hebestreit H, von der Weid NX, Kriemler S. Effect of a 1-year physical activity intervention on cardiovascular health in long-term childhood cancer survivors-a randomised controlled trial (SURfit). Br J Cancer. 2023 Oct;129(8):1284-1297. doi: 10.1038/s41416-023-02410-y. Epub 2023 Aug 31.
- Results publication: PubMed 38315522Deng WH, Zurcher SJ, Schindera C, Jung R, Hebestreit H, Banteli I, Bologna K, von der Weid NX, Kriemler S, Rueegg CS. Effect of a 1-year physical activity intervention on quality of life, fatigue, and distress in adult childhood cancer survivors-A randomized controlled trial (SURfit). Cancer. 2024 May 15;130(10):1869-1883. doi: 10.1002/cncr.35207. Epub 2024 Feb 5.
- Results publication: PubMed 33405260Schindera C, Zurcher SJ, Jung R, Boehringer S, Balder JW, Rueegg CS, Kriemler S, von der Weid NX. Physical fitness and modifiable cardiovascular disease risk factors in survivors of childhood cancer: A report from the SURfit study. Cancer. 2021 May 15;127(10):1690-1698. doi: 10.1002/cncr.33351. Epub 2021 Jan 6.
- Results publication: PubMed 37199378Jung R, Zurcher SJ, Schindera C, Braun J, Deng WH, von der Weid NX, Rueegg CS, Kriemler S. Adherence and contamination in a 1-year physical activity program in childhood cancer survivors: A report from the SURfit study. Cancer Med. 2023 Jul;12(13):14731-14741. doi: 10.1002/cam4.6096. Epub 2023 May 18.
- Derived from this study: PubMed 32877212Schindera C, Usemann J, Zuercher SJ, Jung R, Kasteler R, Frauchiger B, Naumann G, Rueegg CS, Latzin P, Kuehni CE, von der Weid NX. Pulmonary Dysfunction after Treatment for Childhood Cancer. Comparing Multiple-Breath Washout with Spirometry. Ann Am Thorac Soc. 2021 Feb;18(2):281-289. doi: 10.1513/AnnalsATS.202003-211OC.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Nicolas X von der Weid, Prof, MD principal investigator
University Children's Hospital Basel
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing partially supervised exercise intervention in people with Late-effects of Childhood Cancer, run by University of Zurich at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 16 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Composite cardiovascular risk score [z-score] (time frame: 12 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02730767, which also lists 8 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Apr 2025.