Spinal Cord InjuryNCTTNCT02769416
The National Center for Testing Treatments in Chronic Spinal Cord and Traumatic Brain Injury
An observational study of Spinal Cord Injury and Traumatic Brain Injury, run by The University of Texas Health Science Center, Houston at 1 site in United States.
Trial summary
The NCTT is a prospective, multicenter, observational research network for subjects with chronic spinal cord and/or chronic traumatic brain injury. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Spinal Cord Injury, Traumatic Brain Injury
- What is being tested?
- Data and sample repository
- How many people
- 5,000 participants
- Where
- 1 siteUnited States
- Study dates
- Dec 2015to Dec 2035
- How long will I take part?
- 5 Years
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Chronic spinal cord and traumatic brain injury patients, family members, and healthy vounteers
Who may be able to join
- History of spinal cord injury and/or brain injury
- Able to provide HIPAA authorization to share prior medical records/imaging
- Age 18 and older.
Who cannot join
- Life expectancy less than 6 months, vegetative state or co-existing disease or other characteristic that precludes appropriate diagnosis of spinal cord or brain injury.
- Other condition that, in the opinion of the site investigator, would interfere with adherence to study requirements.
- Inability or unwillingness of subject or legal guardian/representative to give informed consent (e.g., ward of the state).
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site
The University of Texas Health Science Center at Houston
Houston, Texas, 77030
About this study
The NCTT is a prospective, multicenter, observational research network for subjects with chronic spinal cord and/or chronic traumatic brain injury.
Read the detailed description
Current treatment for Spinal Cord Injury and Traumatic Brain Injury focuses on stabilizing the patient and preventing secondary injury with the aim of maximizing the best chance of recovery. Most patients will show varying amounts of recovery, but, when the injury is severe, that recovery is only partial. Enrollment in the NCTT will allow for classification and characterization of injury, function, co-morbidities, secondary issues/problems, research interests and will serve as a conduit for enrollment into interventional studies.
- Conditions
- Spinal Cord Injury, Traumatic Brain Injury
- Being tested
- Data and sample repository
- Keywords
- spinal cord injury, traumatic brain injury
- Medical subject headings
- Spinal Cord Injuries, Brain Injuries, Traumatic
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Data and sample repositoryOther
Subjects with spinal cord and/or traumatic brain injury, family members and healthy volunteers will provide data and samples.
| Study group | Role | What they receive |
|---|---|---|
| Spinal Cord and Traumatic Brain Injury Subjects | Patients with a history of spinal cord and/or traumatic brain injury will provide data and samples so that they may be queried for interventional studies. Receives: Other: Data and sample repository | |
| Family Members and Healthy Volunteers | Healthy volunteer controls or family members may be enrolled for identification of genetic mutations. Receives: Other: Data and sample repository |
What is being measured
The primary outcome is the main question the study is designed to answer.
International Standard Neurological Classification of Spinal Cord Injury
functional ability (sensory and motor) for spinal cord injury subjects
Measured: greater than 6 months post-injury
Disability Rating Scale
functional outcome scale for brain injury subjects
Measured: greater than 6 months post-injury
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 May 2016 (estimated)
- Study startDec 2015
- Primary completionDec 2035 (estimated)
- Study completionDec 2035 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Spinal Cord InjuryStudies of the same condition, open and under way.
- More trials run by The University of Texas Health Science Center, HoustonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 5,000 participants (estimated)
- Target duration
- 5 Years
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Georgene Hergenroeder, The University of Texas Health Science Center, Houston
- Investigators
- Georgene Hergenroeder, PhD, Principal investigator, UTHealth
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02769416
- Sponsor's protocol ID
- HSC-MS-15-0705
- Acronym
- NCTT
- Status last verified
- Jun 2026
- First submitted
- 19 Nov 2015
- Last updated
- 16 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: IPD data will not be freely available. Participating centers will share data.
Study at a glance
From the registry record, last updated by the sponsor on 16 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The National Center for Testing Treatments in Chronic Spinal Cord and Traumatic Brain Injury
- ClinicalTrials.gov ID
- NCT02769416
- Acronym / sponsor ID
- NCTT / HSC-MS-15-0705
- Conditions
- Spinal Cord Injury, Traumatic Brain Injury
- Keywords
- spinal cord injury, traumatic brain injury
- Study type
- Observational
- Recruitment status
- Enrolling by invitation
- Enrolment
- 5,000 participants (estimated)
- Lead sponsor
- The University of Texas Health Science Center, HoustonUniversity, hospital or other
- Study start
- Dec 2015 (actual)
- Primary completion
- Dec 2035 (estimated)
- Study completion
- Dec 2035 (estimated)
- First posted
- 11 May 2016 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The NCTT is a prospective, multicenter, observational research network for subjects with chronic spinal cord and/or chronic traumatic brain injury.
Detailed description
Current treatment for Spinal Cord Injury and Traumatic Brain Injury focuses on stabilizing the patient and preventing secondary injury with the aim of maximizing the best chance of recovery. Most patients will show varying amounts of recovery, but, when the injury is severe, that recovery is only partial. Enrollment in the NCTT will allow for classification and characterization of injury, function, co-morbidities, secondary issues/problems, research interests and will serve as a conduit for enrollment into interventional studies.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 5 Years
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Spinal Cord and Traumatic Brain Injury Subjects | – | Other: Data and sample repositoryPatients with a history of spinal cord and/or traumatic brain injury will provide data and samples so that they may be queried for interventional studies. |
| Family Members and Healthy Volunteers | – | Other: Data and sample repositoryHealthy volunteer controls or family members may be enrolled for identification of genetic mutations. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Chronic spinal cord and traumatic brain injury patients, family members, and healthy vounteers
Key inclusion criteria (3 listed)
- History of spinal cord injury and/or brain injury
- Able to provide HIPAA authorization to share prior medical records/imaging
- Age 18 and older.
Key exclusion criteria (3 listed)
- Life expectancy less than 6 months, vegetative state or co-existing disease or other characteristic that precludes appropriate diagnosis of spinal cord or brain injury.
- Other condition that, in the opinion of the site investigator, would interfere with adherence to study requirements.
- Inability or unwillingness of subject or legal guardian/representative to give informed consent (e.g., ward of the state).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Data and sample repositorySubjects with spinal cord and/or traumatic brain injury, family members and healthy volunteers will provide data and samples. | Other | Family Members and Healthy Volunteers, Spinal Cord and Traumatic Brain Injury Subjects |
Primary outcome
International Standard Neurological Classification of Spinal Cord Injury
Time frame: greater than 6 months post-injury
functional ability (sensory and motor) for spinal cord injury subjects
Disability Rating Scale
Time frame: greater than 6 months post-injury
functional outcome scale for brain injury subjects
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jun 2026.
- Individual participant dataSharing planned: No. IPD data will not be freely available. Participating centers will share data.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Georgene Hergenroeder, PhD principal investigator
UTHealth
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Spinal Cord Injury and Traumatic Brain Injury, run by The University of Texas Health Science Center, Houston at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 16 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
International Standard Neurological Classification of Spinal Cord Injury (time frame: greater than 6 months post-injury). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jun 2026.