Post-Traumatic Stress DisorderREMEMBERNCT02810197
Resilience and Modification of Brain Control Network Following November 13
A study testing Psychopathological assessment, Neuropsychological assessment and Functional magnetic resonance imaging (fMRI) in people with Post-Traumatic Stress Disorder, run by Institut National de la Santé Et de la Recherche Médicale, France at 1 site in France.
Trial summary
This is a multiwave longitudinal neuroimaging study in a cohort of direct survivors of 11/13 Paris terrorist attacks. Both structural and functional brain imaging data will be collected at 8-12 months, 3 years, and 6 years after trauma in exposed participants as well as in control non-exposed participants. Read more about this study
- Who is it for?
- Ages 18 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Post-Traumatic Stress Disorder
- What is being tested?
- Psychopathological assessment, Neuropsychological assessment and Functional magnetic resonance imaging (fMRI)
- Type of treatment
- Medical device, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 216 participants
- Where
- 1 siteFrance
- Study dates
- 13 Jun 2016to 16 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Participants between 18 and 55 years old.
- Present at the scene of the attacks the evening of 13 November 2015 or inhabitant of one of the neighbourhood affected by the attacks (exposed group), or persons were not in Paris on the evening of the attacks and not residing in Paris and its region (unexposed group).
- Affiliated to the French national health care system
- Have a good knowledge of the French language
- Right-handed
- Body mass less than or equal to 35kg/m2
- Signed written consent form
Who cannot join
- Pregnancy or intent to get pregnant
- Person deprived of their liberty
- Person admitted to a health or social institution for purposes other than research
- Minor
- Person subjected to an exclusion period related to another protocol
- History of severe psychiatric disorders before the attacks : psychotic disorders, bipolar disorder, obsessive compulsive disorder and / or substance use disorders (excluding tobacco addiction)
Show all 9Show fewer
- Use of medication that may interfere with cognitive or cerebral functioning
- Presence of visual or hearing troubles that may compromise participant's ability to participate in the study
- MRI Contraindications
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Etude Longitudinale en Imagerie cérébrale, en Neuropsychologie, et en Psychopathologie, Des conséquences d'un événement Traumatique
This is a multiwave longitudinal neuroimaging study in a cohort of direct survivors of 11/13 Paris terrorist attacks. Both structural and functional brain imaging data will be collected at 8-12 months, 3 years, and 6 years after trauma in exposed participants as well as in control non-exposed participants. This project will capitalize on recent evidence showing that healthy participants can prevent unwanted images from entering consciousness using inhibitory control and memory suppression techniques, disrupting traces of the memories in sensory areas of the brain, and weakening their vividness and later reentrance. This process is believed to be affected in Post-traumatic stress disorder (PTSD) which is characterized by anxiety and persistent intrusive memory of the traumatic event with highly distressing contents. This project will thus provide a unique opportunity to observe the online and structural dysfunctions of intrusion control network following a severe psychological trauma and how such process may contribute to recovery and psychopathological dynamics. In addition, the disruption of social cognition and emotional processing following PTSD will also be investigated in relation to disrupted inhibitory control functioning.
- Conditions
- Post-Traumatic Stress Disorder
- Being tested
- Psychopathological assessment, Neuropsychological assessment, Functional magnetic resonance imaging (fMRI)
- Medical subject headings
- Stress Disorders, Post-Traumatic
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Psychopathological assessmentBehavioural
Neuropsychological assessmentBehavioural
Functional magnetic resonance imaging (fMRI)Device
| Study group | Role | What they receive |
|---|---|---|
| Exposed group | Experimental | Psychopathological assessment Neuropsychological assessment Functional magnetic resonance imaging (fMRI) Receives: Behavioral: Psychopathological assessment; Behavioral: Neuropsychological assessment; Device: Functional magnetic resonance imaging (fMRI) |
| unexposed group | Experimental | Psychopathological assessment Neuropsychological assessment Functional magnetic resonance imaging (fMRI) Receives: Behavioral: Psychopathological assessment; Behavioral: Neuropsychological assessment; Device: Functional magnetic resonance imaging (fMRI) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Blood Oxygen Level Dependent (BOLD) response as measured with fMRI
Measured: 1 hour
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jun 2016 (estimated)
- Study start13 Jun 2016
- Primary completion12 Jun 2017
- Study completion16 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Post-Traumatic Stress DisorderStudies of the same condition, open and under way.
- More trials run by Institut National de la Santé Et de la Recherche Médicale, FranceThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Enrolment
- 216 participants (actual)
Sponsor and investigators
- Sponsor type
- Other government
- Responsible party
- Sponsor
- Investigators
- Vincent de La Sayette, MD, Principal investigator, University Hospital, Caen
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02810197
- Sponsor's protocol ID
- C16-13
- Acronym
- REMEMBER
- Status last verified
- Feb 2026
- First submitted
- 20 Jun 2016
- Last updated
- 8 Oct 2026
- Results posted
- No
Publications
Leone G, Postel C, Mary A, Fraisse F, Vallee T, Viader F, de La Sayette V, Peschanski D, Dayan J, Eustache F, Gagnepain P. Altered predictive control during memory suppression in PTSD. Nat Commun. 2022 Jun 8;13(1):3300. doi: 10.1038/s41467-022-30855-x.
PubMed 35676268Coll SY, Eustache F, Doidy F, Fraisse F, Peschanski D, Dayan J, Gagnepain P, Laisney M. Avoidance behaviour generalizes to eye processing in posttraumatic stress disorder. Eur J Psychotraumatol. 2022 Apr 20;13(1):2044661. doi: 10.1080/20008198.2022.2044661. eCollection 2022.
PubMed 35479300Mary A, Dayan J, Leone G, Postel C, Fraisse F, Malle C, Vallee T, Klein-Peschanski C, Viader F, de la Sayette V, Peschanski D, Eustache F, Gagnepain P. Resilience after trauma: The role of memory suppression. Science. 2020 Feb 14;367(6479):eaay8477. doi: 10.1126/science.aay8477.
PubMed 32054733
Study at a glance
From the registry record, last updated by the sponsor on 8 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Etude Longitudinale en Imagerie cérébrale, en Neuropsychologie, et en Psychopathologie, Des conséquences d'un événement Traumatique
- ClinicalTrials.gov ID
- NCT02810197
- Acronym / sponsor ID
- REMEMBER / C16-13
- Conditions
- Post-Traumatic Stress Disorder
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 216 participants (actual)
- Lead sponsor
- Institut National de la Santé Et de la Recherche Médicale, FranceOther government
- Study start
- 13 Jun 2016 (actual)
- Primary completion
- 12 Jun 2017 (actual)
- Study completion
- 16 Dec 2025 (actual)
- First posted
- 22 Jun 2016 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a multiwave longitudinal neuroimaging study in a cohort of direct survivors of 11/13 Paris terrorist attacks. Both structural and functional brain imaging data will be collected at 8-12 months, 3 years, and 6 years after trauma in exposed participants as well as in control non-exposed participants. This project will capitalize on recent evidence showing that healthy participants can prevent unwanted images from entering consciousness using inhibitory control and memory suppression techniques, disrupting traces of the memories in sensory areas of the brain, and weakening their vividness and later reentrance. This process is believed to be affected in Post-traumatic stress disorder (PTSD) which is characterized by anxiety and persistent intrusive memory of the traumatic event with highly distressing contents. This project will thus provide a unique opportunity to observe the online and structural dysfunctions of intrusion control network following a severe psychological trauma and how such process may contribute to recovery and psychopathological dynamics. In addition, the disruption of social cognition and emotional processing following PTSD will also be investigated in relation to disrupted inhibitory control functioning.
Study design
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Exposed group | Experimental | Behavioral: Psychopathological assessment, Behavioral: Neuropsychological assessment, Device: Functional magnetic resonance imaging (fMRI)Psychopathological assessment Neuropsychological assessment Functional magnetic resonance imaging (fMRI) |
| unexposed group | Experimental | Behavioral: Psychopathological assessment, Behavioral: Neuropsychological assessment, Device: Functional magnetic resonance imaging (fMRI)Psychopathological assessment Neuropsychological assessment Functional magnetic resonance imaging (fMRI) |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (7 listed)
- Participants between 18 and 55 years old.
- Present at the scene of the attacks the evening of 13 November 2015 or inhabitant of one of the neighbourhood affected by the attacks (exposed group), or persons were not in Paris on the evening of the attacks and not residing in Paris and its region (unexposed group).
- Affiliated to the French national health care system
- Have a good knowledge of the French language
- Right-handed
Key exclusion criteria (9 listed)
- Pregnancy or intent to get pregnant
- Person deprived of their liberty
- Person admitted to a health or social institution for purposes other than research
- Minor
- Person subjected to an exclusion period related to another protocol
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Psychopathological assessment | Behavioural | Exposed group, unexposed group |
| Neuropsychological assessment | Behavioural | Exposed group, unexposed group |
| Functional magnetic resonance imaging (fMRI) | Device | Exposed group, unexposed group |
Primary outcome
Blood Oxygen Level Dependent (BOLD) response as measured with fMRI
Time frame: 1 hour
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Oct 2026.
- Results publication: PubMed 35676268Leone G, Postel C, Mary A, Fraisse F, Vallee T, Viader F, de La Sayette V, Peschanski D, Dayan J, Eustache F, Gagnepain P. Altered predictive control during memory suppression in PTSD. Nat Commun. 2022 Jun 8;13(1):3300. doi: 10.1038/s41467-022-30855-x.
- Results publication: PubMed 35479300Coll SY, Eustache F, Doidy F, Fraisse F, Peschanski D, Dayan J, Gagnepain P, Laisney M. Avoidance behaviour generalizes to eye processing in posttraumatic stress disorder. Eur J Psychotraumatol. 2022 Apr 20;13(1):2044661. doi: 10.1080/20008198.2022.2044661. eCollection 2022.
- Results publication: PubMed 32054733Mary A, Dayan J, Leone G, Postel C, Fraisse F, Malle C, Vallee T, Klein-Peschanski C, Viader F, de la Sayette V, Peschanski D, Eustache F, Gagnepain P. Resilience after trauma: The role of memory suppression. Science. 2020 Feb 14;367(6479):eaay8477. doi: 10.1126/science.aay8477.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Vincent de La Sayette, MD principal investigator
University Hospital, Caen
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Psychopathological assessment, Neuropsychological assessment and Functional magnetic resonance imaging (fMRI) in people with Post-Traumatic Stress Disorder, run by Institut National de la Santé Et de la Recherche Médicale, France at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Blood Oxygen Level Dependent (BOLD) response as measured with fMRI (time frame: 1 hour). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02810197, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Oct 2026.