AgingNCT02831335
Technical Development of Multi-Parametric Renocerebral MRI
An observational study of Aging, run by University of Minnesota at 1 site in United States.
Trial summary
The purpose of the study is to investigate the associations of the age-related changes in the brain, kidneys and cognitive performance in healthy adults by utilizing multiple anatomic and functional MRI methods along with a battery of cognitive tests. Read more about this study
- Who is it for?
- Ages 21 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Aging
- What is being tested?
- MRI and Group 4
- How many people
- 120 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Dec 2027to 31 Dec 2032
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Normal participants will be recruited for four age groups with the following age ranges: 21 - 35, 36 -50, 51 - 65 and 66 - 80 years. For each subject group, equal number of male and female subjects will be recruited.
Who may be able to join
- English-speaking as primary language
- No hearing loss or uncorrected vision
Who cannot join
- Lacking capacity to consent
- Having known history of cardiovascular diseases (e.g., clinical stroke)
- Having acute and chronic obstructive pulmonary disease
- Having known history of renal diseases (e.g., acute kidney injury)
- Having known history of cognitive disorder or psychiatric illness
- Having known history of chemical dependence (e.g., alcohol and narcotics)
- Being treated with stimulant medications, anticonvulsants, antihypertensives or ß-adrenergic blockers
Trial locations and contacts
1 site in 1 country.
United States1 site
Center for Magnetic Resonance Research
Minneapolis, Minnesota, 55455
About this study
The purpose of the study is to investigate the associations of the age-related changes in the brain, kidneys and cognitive performance in healthy adults by utilizing multiple anatomic and functional MRI methods along with a battery of cognitive tests.
- Conditions
- Aging
- Being tested
- MRI, Group 4
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MRIOther
Perform MRI studies
MRIOther
Perform MRI studies
MRIOther
Perform MRI studies
Group 4Other
Perform MRI studies
| Study group | Role | What they receive |
|---|---|---|
| Group 1 | normal 21-35 years old participants Receives: Other: MRI | |
| Group 2 | normal 36-50 years old participants Receives: Other: MRI | |
| Group 3 | normal 51-65 years old participants Receives: Other: MRI | |
| Group 4 | normal 66- 80 years old participants Receives: Other: Group 4 |
What is being measured
The primary outcome is the main question the study is designed to answer.
MRI measured perfusion for each group
MRI measurements will be summarized for each group by using mean and standard deviation or standard error.
Measured: Baseline
MRI measured vascular reactivity for each group
MRI measurements will be summarized for each group by using mean and standard deviation or standard error.
Measured: Baseline
Cognitive performance for each group
The total cognitive performance scores will be summarized for each group by using mean and standard deviation or standard error.
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Jul 2016 (estimated)
- Study start1 Dec 2027 (estimated)
- Primary completion31 Dec 2030 (estimated)
- Study completion31 Dec 2032 (estimated)
Why it stopped: Due to funding issus
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AgingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 120 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Minnesota
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Xiufeng Li, Ph.D., Principal investigator, University of Minnesota
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02831335
- Sponsor's protocol ID
- 1603M85492
- Status last verified
- Oct 2026
- First submitted
- 15 Jun 2016
- Last updated
- 14 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Technical Development of Multi-Parametric Renocerebral MRI
- ClinicalTrials.gov ID
- NCT02831335
- Acronym / sponsor ID
- 1603M85492
- Conditions
- Aging
- Study type
- Observational
- Recruitment status
- SuspendedReason stopped: Due to funding issus
- Enrolment
- 120 participants (estimated)
- Lead sponsor
- University of MinnesotaUniversity, hospital or other
- Study start
- 1 Dec 2027 (estimated)
- Primary completion
- 31 Dec 2030 (estimated)
- Study completion
- 31 Dec 2032 (estimated)
- First posted
- 13 Jul 2016 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of the study is to investigate the associations of the age-related changes in the brain, kidneys and cognitive performance in healthy adults by utilizing multiple anatomic and functional MRI methods along with a battery of cognitive tests.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Group 1 | – | Other: MRInormal 21-35 years old participants |
| Group 2 | – | Other: MRInormal 36-50 years old participants |
| Group 3 | – | Other: MRInormal 51-65 years old participants |
| Group 4 | – | Other: Group 4normal 66- 80 years old participants |
Who may qualify
- Ages
- 21 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Normal participants will be recruited for four age groups with the following age ranges: 21 - 35, 36 -50, 51 - 65 and 66 - 80 years. For each subject group, equal number of male and female subjects will be recruited.
Key inclusion criteria (2 listed)
- English-speaking as primary language
- No hearing loss or uncorrected vision
Key exclusion criteria (7 listed)
- Lacking capacity to consent
- Having known history of cardiovascular diseases (e.g., clinical stroke)
- Having acute and chronic obstructive pulmonary disease
- Having known history of renal diseases (e.g., acute kidney injury)
- Having known history of cognitive disorder or psychiatric illness
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MRIPerform MRI studies | Other | Group 1 |
| MRIPerform MRI studies | Other | Group 2 |
| MRIPerform MRI studies | Other | Group 3 |
| Group 4Perform MRI studies | Other | Group 4 |
Primary outcome
MRI measured perfusion for each group
Time frame: Baseline
MRI measurements will be summarized for each group by using mean and standard deviation or standard error.
MRI measured vascular reactivity for each group
Time frame: Baseline
MRI measurements will be summarized for each group by using mean and standard deviation or standard error.
Cognitive performance for each group
Time frame: Baseline
The total cognitive performance scores will be summarized for each group by using mean and standard deviation or standard error.
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Xiufeng Li, Ph.D. principal investigator
University of Minnesota
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Aging, run by University of Minnesota at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: paused, as of the sponsor's last update on 14 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
MRI measured perfusion for each group (time frame: Baseline). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Oct 2026.