All Tumor TypesSPECTANCT02834884
SPECTA: Screening Cancer Patients for Efficient Clinical Trial Access
An observational study of All Tumor Types, run by European Organisation for Research and Treatment of Cancer - EORTC at 136 sites in 20 countries.
Trial summary
SPECTA is a quality assured platform for collecting clinicopathologically annotated biological material, imaging data, operative images, environmental assessment, questionnaires as well as patient-reported outcomes from cancer patients to support biospecimen-based translational research and clinical cancer research… Read more about this study
- Who is it for?
- Ages 12 years and older
- Conditions the study is for
- All Tumor Types
- What is being tested?
- RP-1828 IMMUcan, RP-1759 AYA/TYA and RP-1843 Arcagen
- How many people
- 4,975 participants
- Where
- 136 sitesin 20 countries
- Study dates
- 3 May 2017to Oct 2031
- How long will I take part?
- 5 Years
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 12 years and older
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: Patients with pathologically confirmed selected tumor types.
- Patients with pathologically confirmed selected tumor types (at site or centrally);
- Mandatory availability of adequate human biological material (HBM);
- Centrally performed confirmation of HBM adequacy in terms of quality and quantity for SPECTA downstream project requirements;
- Age ≥ 12 years;
- Absence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule;
- Written informed consent according to applicable legal and ethical requirements;
Trial locations and contacts
136 sites in 20 countries. Contact the study team or a site near you to ask about taking part.
136 sites in 20 countries
France37 sites, 37 recruiting
- Recruiting
Centre Hospitalier Avignon
Avignon, 84902
- Recruiting
CHRU de Besancon - Hopital Jean Minjoz
Besançon, 25030
- Recruiting
Centre de Radiotherapie Pierre Curie
Beuvry, 62660
- Recruiting
CHU de Bordeaux - Groupe Hospitalier Saint-Andre - Hopital Saint-Andre
Bordeaux, 33075
- Recruiting
Institut Bergonie
Bordeaux, 33076
- Recruiting
Centre Hospitalier - Boulogne Sur Mer
Boulogne-sur-Mer, 62321
- Recruiting
CHU de Lyon - Hopital Louis Pradel
Bron, 69500
- Recruiting
CHU Lyon - Hopital neurologique Pierre Wertheimer
Bron, 69677 Cedex
- Recruiting
Centre Francois Baclesse
Caen, 14076
- Recruiting
Centre Hopitalier Intercommunal De Creteil
Créteil, 94010
- Recruiting
Centre Georges-Francois-Leclerc
Dijon, 21079
- Recruiting
CHU de Grenoble - La Tronche - Hôpital A. Michallon
Grenoble, 38043
- Recruiting
Centre Hospitalier Departemental Vendee
La Roche-sur-Yon, 85925
- Recruiting
Centre Oscar Lambret
Lille, 59000
- Recruiting
CHRU de Lille
Lille, 59037 Cedex
- Recruiting
CHU de Lyon - Hopital Edouard Herriot
Lyon, 69003
- Recruiting
Centre Léon Berard
Lyon, 69008
- Recruiting
CHU de Lyon - Hopital Lyon Sud
Lyon, 69495
- Recruiting
Assistance Publique - Hopitaux de Marseille - Hopital Nord
Marseille, 13015
- Recruiting
Centre Hospitalier D'Annecy Genevois
Metz-Tessy, 74370
- Recruiting
CHU Montpellier-Hopital Arnaud De Villeneuve
Montpellier, 34295 CEDEX 5
- Recruiting
Institut du Cancer de Montpellier
Montpellier, 34298
- Recruiting
Centre Hospitalier Des Pays De Morlaix
Morlaix, 29600
- Recruiting
Centre d'Oncologie de Gentilly
Nancy, 54100
- Recruiting
CHU de Nice - Hopital De L'Archet
Nice, 06200
- Recruiting
Assitance Publique - Hopitaux de Paris - Hopital Saint-Louis
Paris, 75010
- Recruiting
Assistance Publique - Hopitaux de Paris - Hopital Saint Antoine
Paris, 75012
- Recruiting
Assistance Publique - Hopitaux de Paris - La Pitie Salpetriere
Paris, 75013
- Recruiting
Institut Curie- Hopital de Paris
Paris, 75248 CEDEX 05
- Recruiting
Groupe Hospitalier Paris Saint-Joseph - Hopital Saint Joseph
Paris, 75674
- Recruiting
Centre Eugene Marquis
Rennes, 35042
- Recruiting
Institut de Cancerologie de l'Ouest (ICO) - Centre Rene Gauducheau
Saint-Herblain, 44805
- Recruiting
Clinique Mutualiste de l'Estuaire - Centre d'oncologie
Saint-Nazaire, 44600
- Recruiting
Institut de Cancerologie de la Loire Lucien Neuwirth
Saint-Priest-en-Jarez, 42270
- Recruiting
Institut de Cancerologie Strasbourg Europe (formar Paul Strauss)
Strasbourg, 67200
- Recruiting
CHU Toulouse - Hopital Larrey
Toulouse, 31059
- Recruiting
Gustave Roussy
Villejuif, 94805
Spain17 sites, 16 recruiting
- Recruiting
Vall d'Hebron Institut d'Oncologia
Barcelona, 08035
- Recruiting
Hospital Clinic Universitari de Barcelona
Barcelona, 08036
- Recruiting
Hospital De La Santa Creu I Sant Pau
Barcelona, 08041
- Active, not recruiting
Hospital General Universitario De Elche
Elche, 03203
- Recruiting
ICO Girona - Hospital Doctor Josep Trueta (Institut Catala D'Oncologia)
Girona, 17007
- Recruiting
ICO L'Hospitalet - Hospital Duran i Reynals (Institut Catala D'Oncologia)
L'Hospitalet de Llobregat, Barcelona, 08908
- Recruiting
ICO L'Hospitalet- Hospital Universitari de Bellvitge
L'Hospitalet de Llobregat, 08907
- Recruiting
Hospital Infantil Universitario Nino Jesus
Madrid, 28009
- Recruiting
Hospital Universitario Infanta Leonor
Madrid, 28031
- Recruiting
Hospital Universitario Ramon y Cajal
Madrid, 28034
- Recruiting
Hospital Universitario San Carlos
Madrid, 28040
- Recruiting
Hospital Universitario 12 de Octubre
Madrid, 28041
- Recruiting
Hospital Universitario QuironSalud
Madrid, 28223
- Recruiting
Hospital Universitario Virgen De La Victoria
Málaga, 29010
- Recruiting
Hospital Clinico Universitario De Valencia
Valencia, 46010
- Recruiting
Hospital Clinico Universitario De Valladolid
Valladolid, 47003
- Recruiting
Hospital Clinico Universitaro De Valladolid
Valladolid, 47011
Italy16 sites, 14 recruiting
- Recruiting
Ospedale Civile Santi Antonio e Biagio e Cesare Arrigo
Alessandria, 15100
- Recruiting
Alma Mater Studiorium Universita di Bologna - Loc. Ospedala Sant'Orsolo
Bologna, 40138
- Suspended
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
Brescia, 25123
- Recruiting
Azienda Istituti Ospitalieri di Cremona
Cremona, 26100
- Recruiting
IRCCS Azienda Ospedaliera Universitaria San Martino "IST" Istituto Nazionale per la Ricerca sul Cancro
Genova, 16132
- Recruiting
Azienda Unita Locale Socio-Sanitaria N. 9-Mater Salutis Hospital
Legnago, 37045
- Recruiting
IRCCS - Fondazione Istituto Nazionale dei Tumori
Milan, 20133
- Recruiting
IRCCS - Istituto Neurologico Carlo Besta
Milan, 20133
- Recruiting
Azienda Sanitaria Locale Napoli 1 Centro
Naples, 80147
- Recruiting
Universita Di Torino - Ospedale S. Luigi Gonzaga
Orbassano, 10043
- Recruiting
IRCCS - Istituto Oncologico Veneto
Padova, 35128
- Recruiting
Istituti Clinici Scientifici Maugeri
Pavia, 27100
- Recruiting
Regina Elena National Cancer Center
Roma, 00144
- Recruiting
Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale Molinette
Torino, 10126
- Recruiting
Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale San Giovanni - Dipartimento Neuroscienze
Torino, 10126
- Suspended
Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale Sant'Anna
Torino, 10126
Belgium13 sites, 13 recruiting
- Recruiting
Onze Lieve Vrouw Ziekenhuis
Aalst, 9300
- Recruiting
ZAS Middelheim
Antwerp, 2020
- Recruiting
Hopitaux Universitaires - Institut Jules Bordet
Brussels, 1000
- Recruiting
Universitair Ziekenhuis Brussel
Brussels, 1000
- Recruiting
Cliniques Universitaires Saint-Luc
Brussels, 1200
- Recruiting
Universitair Ziekenhuis Gent
Ghent, 9000
- Recruiting
Pole Hospitalier Jolimont - Hopital Jolimont
Haine-Saint-Paul, 7100
- Recruiting
U.Z. Leuven - Campus Gasthuisberg
Leuven, 3000
- Recruiting
C.H.U. Sart-Tilman
Liège, 4000
- Recruiting
Centre Hospitalier Regional De La Citadelle
Liège, 4000
- Recruiting
CHU Site Sainte-Elisabeth-UCL Namur
Namur, 5000
- Recruiting
AZ Turnhout - Campus Sint Elisabeth
Turnhout, 2300
- Recruiting
CHU Mont Godinne - UCL Namur
Yvoir, 5530
United Kingdom13 sites, 12 recruiting
- Recruiting
University Hospitals Birmingham NHS Foundation Trust (UHB) - UHB-Queen Elisabeth Medical Centre
Birmingham, B15 2TH
- Active, not recruiting
Royal Orthopaedics Hospital, NHS Trust
Birmingham, B312AP
- Recruiting
Betsi Cadwaladr University Health Board - Glan Clwyd District General Hospital
Bodelwyddan, Denbighshire, LL18 5UJ
- Recruiting
Cambridge University Hospital NHS - Addenbrookes Hospital
Cambridge, CB2 0QQ
- Recruiting
Velindre NHS Trust - Velindre Cancer Centre
Cardiff, CF14 2TL
- Recruiting
University Hospitals Coventry and Warwickshire NHS Trust - University Hospital
Coventry, CV2 2DX
- Recruiting
NHS Lothian - Western General Hospital
Edinburgh, EH4 2XU
- Recruiting
NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital
Glasgow, G12 OYN
- Recruiting
Hereford County Hospital
Hereford, HR1 2ER
- Recruiting
Leeds Teaching Hospitals NHS Trust - St. James's University Hospital
Leeds, LS9 7TF
- Recruiting
The Clatterbridge cancer Center NHS foundation Trust - Clatterbridge Cancer Center - Liverpool
Liverpool, L7
- Recruiting
Royal Free Hospital
London, NW3 2QG
- Recruiting
The Christie NHS Foundation Trust
Manchester, M20 4BX
Portugal8 sites, 8 recruiting
- Recruiting
Instituto Portugues De Oncologia - Centro De Coimbra
Coimbra, 3000-075
- Recruiting
Instituto Portugues de Oncologia de Lisboa Francisco Gentil - EPE
Lisbon, 1099-023 CODEX
- Recruiting
Hospital CUF Tejo
Lisbon, 1350-352
- Recruiting
Centro Hospitalar de Lisboa Ocidental- San Francisco Xavier Hospital
Lisbon, 1449-005
- Recruiting
Hospital CUF Descobertas
Lisbon, 1998-018
- Recruiting
Centro Hospitalar do Porto- Hospital de Santo Antonio
Porto, 4099-001
- Recruiting
Instituto Portugues de Oncologia do Porto
Porto, 4200-162
- Recruiting
Unidade Local de Saúde Gaia e Espinho
Vila Nova de Gaia, 4430
Germany5 sites, 5 recruiting
- Recruiting
Charite - Universitaetsmedizin Berlin - Campus Virchow-Klinikum
Berlin, 13353
- Recruiting
Universitaetsklinikum Carl Gustav Carus
Dresden, 01307
- Recruiting
Universitaetsklinikum Greifswald der Ernst Morizt Arndt Univ. Greifswald AoR
Greifswald, 17475
- Recruiting
Universitaetsklinikum Jena
Jena, 07447
- Recruiting
Onkologie UnterEms, Leer-Papenburg-Emden
Leer, 26789
Netherlands5 sites, 5 recruiting
- Recruiting
The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis
Amsterdam, 1066 CX
- Recruiting
Amsterdam UMC - Locatie AMC
Amsterdam, 1105 AZ
- Recruiting
University Medical Center Groningen
Groningen, 9713 GZ
- Recruiting
Academisch Ziekenhuis Maastricht
Maastricht, 6202 AZ
- Recruiting
Radboud University Medical Center Nijmegen
Nijmegen, 6525GA
Greece4 sites, 3 recruiting
- Recruiting
NIMTS - Veterans Administration Hospital
Athens, 11521
- Recruiting
Athens University - Attikon University General Hospital
Athens, 12462
- Recruiting
Hygeia Hospital
Athens, 151 23
- Active, not recruiting
Ioannina University Hospital
Ioannina, 45500
Poland4 sites, 3 recruiting
- Recruiting
Medical University Of Gdansk
Gdansk, 80 211
- Recruiting
Maria S. Curie Memorial Institute-Gliwice Branch
Gliwice, 44-101
- Recruiting
The Great Poland Cancer Centre
Poznan, 61 866
- Active, not recruiting
Maria Sklodowska-Curie Memorial Cancer Centre
Warsaw
Switzerland3 sites, 3 recruiting
- Recruiting
Hirslanden Klinik-Tumor Zentrum Aarau
Aarau, 5000
- Recruiting
Kantonsspital St Gallen
Sankt Gallen, 9007
- Recruiting
UniversitaetsSpital Zurich
Zurich, 8091
Serbia2 sites, 2 recruiting
- Recruiting
University Clinic Centre Serbia - Pulmonology clinic
Belgrade, 11000
- Recruiting
University Clinical Center of Serbia - Clinic for ENT and MFH
Belgrade, 11000
Slovenia2 sites, 2 recruiting
- Recruiting
University Clinic Golnik
Golnik, 4204
- Recruiting
University Medical Center Maribor
Maribor, 2000
Austria1 site, 1 recruiting
- Recruiting
Medical University Vienna - General Hospital AKH
Vienna, 1090
Croatia1 site
- Active, not recruiting
University Hospital Centre Zagreb
Zagreb, 10000
Cyprus1 site, 1 recruiting
- Recruiting
Bank Of Cyprus Oncology Centre
Stróvolos, 2006
Czechia1 site, 1 recruiting
- Recruiting
University Hospital Motol
Prague, 150 06
Estonia1 site, 1 recruiting
- Recruiting
North Estonia Medical Centre - Mustamäe unit
Tallinn, 13419
Lithuania1 site, 1 recruiting
- Recruiting
Lithuanian Oncology Center-Nat. Cancer Inst
Vilnius, 08660
Romania1 site, 1 recruiting
- Recruiting
Medisprof Cancer Center srl
Cluj-Napoca, Cluj Napoca, 400058
About this study
SPECTA is a quality assured platform for collecting clinicopathologically annotated biological material, imaging data, operative images, environmental assessment, questionnaires as well as patient-reported outcomes from cancer patients to support biospecimen-based translational research and clinical cancer research, including biomarker discovery to improve the understanding of tumor biology and cancer patients care.
Read the detailed description
Patients are recruited in the platform for the research purpose of 5 downstream projects. For more information, please have a look at the "Groups and cohorts" section.
- Conditions
- All Tumor Types
- Being tested
- RP-1828 IMMUcan, RP-1759 AYA/TYA, RP-1843 Arcagen, RP-1920 BioRadon, 2148 MRD
- Keywords
- rare cancer, biomarker, molecular screening, cancer, biobanking
- Medical subject headings
- Neoplasms
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
RP-1828 IMMUcanGenetic
WES, lcWGS and RNAseq, multiplex IF and IMC
RP-1759 AYA/TYAGenetic
WES, RNAseq and EPIC array
RP-1843 ArcagenGenetic
NGS panel
RP-1920 BioRadonGenetic
NGS panel
2148 MRDGenetic
ctDNA detection and WES
| Study group | Role | What they receive |
|---|---|---|
| RP-1828 IMMUcan (CLOSED for recruitment since August 2024) | The goal is to generate broad molecular and cellular profiling data of the tumour and its microenvironment from cancer patients integrated with clinical data, to understand how the immune system and tumours interact, and the impact of current therapeutic interventions.
Tumor types: Thorax, Head and Neck, Breast, Gastrointestinal, Genito Urinary Receives: Genetic: RP-1828 IMMUcan | |
| RP-1759 AYA/TYA (CLOSED for recruitment since December 2021) | The pilot study will be focusing on young adults (12 to 29 years old) with rare cancer to understand better the biology of the tumor in this specific population, and compare it to children and adults with similar disease, as well as to improve the inclusion of young adults into clinical trials.
Tumor type: CNS Receives: Genetic: RP-1759 AYA/TYA | |
| RP-1843 Arcagen (CLOSED for recruitment since November 2022) | This is a collaborative project between EORTC and EURACAN to perform molecular characterisation of rare cancers patients, using Foundation Medicine tests. The goal of this project is to get a better understanding of the genomic landscape of rare cancers and potentially help define possibilities for targeted treatments/clinical trials for this population.
Tumor types: all 10 EURACAN domains Receives: Genetic: RP-1843 Arcagen | |
| RP-1920 BioRadon | The primary objective is to assess the correlation between the molecular profiles of NSCLC patients and indoor radon concentration, measured with an alpha-particle detector (a standardized and validated way of measuring indoor radon).
Tumor type: Thorax Receives: Genetic: RP-1920 BioRadon | |
| 2148 MRD | The main objective of the 2148 Minimal Residual Disease Assessment project is to assess the potential of circulating tumor DNA (ctDNA) as a surrogate marker of recurrence by studying its positive predictive value (PPV). This will help determine how accurately ctDNA can predict cancer recurrence.
Tumour types: Head and Neck, Melanoma Receives: Genetic: 2148 MRD |
What is being measured
The primary outcome is the main question the study is designed to answer.
To establish a quality assured platform to improve the understanding of tumor biology and cancer patients care
material (including imaging data) as well as patient-reported outcomes from patients with cancer diagnosis to support biospecimen-based translational research and biomarker discovery to improve the understanding of tumor biology and cancer patients care.
Measured: 5 years
Secondary outcomes (7)
To perform biospecimen and data based high quality research aiming to better understand the biology of cancer, and/or how it is currently managed and/or how to better diagnose and treat it in the future;
Measured: 5 years
To investigate the molecular pathways related to the development of specific tumors from a biological point of view;
Measured: 5 years
To investigate the effect of cancer treatment on the tumor, microenvironment and patients globally;
Measured: 5 years
To collect large series of homogeneous clinical data to analyse the disease course and treatment performed;
Measured: 5 years
To investigate the prevalence and validate the prognostic or predictive value of novel biomarkers in cancers;
Measured: 5 years
To perform biospecimen and data based high quality research aiming to facilitate the discovery of new test for tumor biomarkers or facilitate the establishment of validated tests for tumor biomarkers;
Measured: 5 years
To identify patients with molecular alterations in their tumor that can be matched to biomarker-driven clinical trials, to facilitate enrollment of cancer patients in biomarker-driven clinical trials.
Measured: 5 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Jul 2016 (estimated)
- Study start3 May 2017
- Primary completion29 Aug 2022
- Study completionOct 2031 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for All Tumor TypesStudies of the same condition, open and under way.
- More trials run by European Organisation for Research and Treatment of Cancer - EORTCThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 4,975 participants (estimated)
- Target duration
- 5 Years
Sponsor and investigators
- Sponsor type
- Research network
- Responsible party
- Sponsor
- Investigators
- Benjamin Besse, Pr., Study chair, European Organisation for Research and Treatment of Cancer - EORTC
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02834884
- Sponsor's protocol ID
- EORTC-1553
- Acronym
- SPECTA
- Status last verified
- Jun 2026
- First submitted
- 13 Jul 2016
- Last updated
- 24 Jun 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No