Healthy VolunteerSCENESNCT02840305
Brain Bases of Natural Scenes's Visual Perception of Natural Scenes
A study testing Evaluation of visual function and Magnetic Resonance Imaging in people with Healthy Volunteer, run by University Hospital, Grenoble at 1 site in France.
Trial summary
Using the available data from psychophysics, cellular electrophysiology and functionnal neuroanatomy of visual pathway, current models of visual recognition suppose that the perception of scenes start with a parallel extraction of differents elementary visual characteristics to different spatial frequencies according… Read more about this study
- Who is it for?
- Ages 4 years and olderHealthy volunteers can take part
- Conditions the study is for
- Healthy Volunteer
- What is being tested?
- Evaluation of visual function and Magnetic Resonance Imaging
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 141 participants
- Where
- 1 siteFrance
- Study dates
- Apr 2012to Aug 2016
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 4 years and older
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- Subjet over 18 years and less than 30 years
- Affiliation to a social security
- Free signed consent
- Medical exam done before participation to the study
- Normal or corrected visual acuity
- Subjet over 50 years
Show all 15Show fewer
- Affiliation to a social security
- Free signed consent
- Medical exam done before participation to the study
- Normal or corrected visual acuity
- Children between 4 and 12 years
- Affiliation to a social security
- Free signed consent
- Medical exam done before participation to the study
- Normal or corrected visual acuity
Who cannot join
- Counter-argument to MRI
- Pregnant, breast-feeding or parturient women
- Adults non protected or unable to express their consent
- Adults protected
- Important earing or visual disorder
- Neuropsychiatric disorder current or past passée ou présente (exept benign epilepsy)
Show all 22Show fewer
- Severe affection on a general level (cardiac, respiratory, hematologic, renal, hépatic, cancerous)
- Drug treatment in progress (exept anti-epileptic drug) likely to de modulate brain activity
- Counter-argument to MRI
- Pregnant, breast-feeding or parturient women
- Adults non protected or unable to express their consent
- Adults protected
- Important earing or visual disorder
- Neuropsychiatric disorder current or past passée ou présente (exept benign epilepsy)
- Severe affection on a general level (cardiac, respiratory, hematologic, renal, hépatic, cancerous)
- Drug treatment in progress (exept anti-epileptic drug) likely to de modulate brain activity
- Counter-argument to MRI
- Important earing or visual disorder
- Important development disorder and/or acquisitions identified by parents and/or school teachers
- Neuropsychiatric disorder current or past passée ou présente (exept benign epilepsy)
- Severe affection on a general level (cardiac, respiratory, hematologic, renal, hépatic, cancerous)
- Drug treatment in progress (exept anti-epileptic drug) likely to de modulate brain activity
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Brain Bases of Visual Perceptionnatural Scenes of Natural Scenes.
Using the available data from psychophysics, cellular electrophysiology and functionnal neuroanatomy of visual pathway, current models of visual recognition suppose that the perception of scenes start with a parallel extraction of differents elementary visual characteristics to different spatial frequencies according to a default processing principle named : 'coarse-to-fine'.
According to this principle, the visual scene's analysis would be decomposed in two steps. Fisrt, the fast analysis of the global information borne by low frequency of the scene will provide an overview of the scene's structure and would enable a first perceptive categorisation which would be then refined, approved or denied by the latest analysis of the most local, detailed and precise information, carried by the very high spatial frequency of the scene.
Read more
The research carried out since several years is preparing a biologically plausible model and to find brain bases by different imaging techniques among healthy subjects but also patients with a brain lesion and patients with a peripheral lesion.
The main goal of this Magnetic Resonance Imaging study is to find brain bases of natural scenes's visual perception of the natural scenes.
Three studies in Magnetic Resonance Imaging will be conducted, during which subjects will have to categorize pictures of natural scenes filtered in spatial frequencies. The outcome of this study will allow to refine models of visual recognition, most of them based on analysis of spatial frequencies.
- Conditions
- Healthy Volunteer
- Being tested
- Evaluation of visual function, Magnetic Resonance Imaging
- Keywords
- Natural scenes, Brain bases, Visual perception, MRI
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Evaluation of visual functionOther
Magnetic Resonance ImagingOther
Also called MRI
| Study group | Role | What they receive |
|---|---|---|
| Expérience 1 | Other | Brain bases of spatial frequencies treatment 30 young adults, 20 old adults 20 children between 4 and 6 years, 20 children between 6 and 12 years and 20 young adults Receives: Other: Evaluation of visual function; Other: Magnetic Resonance Imaging |
| Expérience 2 | Other | Brain bases of Computer to Film (CtF) analysis 30 young adults, 20 old adults Receives: Other: Evaluation of visual function; Other: Magnetic Resonance Imaging |
| Expérience 3 | Other | Part of parahippocampal gyrus in Computer to Film (CtF) analysis 30 young adults, 20 old adults. Receives: Other: Evaluation of visual function; Other: Magnetic Resonance Imaging |
What is being measured
The primary outcome is the main question the study is designed to answer.
Identify brain bases of natural scenes's visual perception of the natural scenes
Evaluation 1 = Visual tasks Experience 1 : Brain bases of spatial frequencies treatment Experience 2 : Brain bases of Computer to Film (CtF) natural scenes analysis MRI exam Experience 3 : Part of parahippocampal gyrus in Computer to Film (CtF) natural scenes analysis MRI exam About 30 minutes
Evaluation 2 = Retinotopy : only adults that have shown activations inside occipital cortex during evaluation 1 MRI exam about 50 minutes
Measured: About 80 minutes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Jul 2016 (estimated)
- Study startApr 2012
- Primary completionMar 2016
- Study completionAug 2016
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (38)Papers the sponsor has linked to this study.
- Other trials for Healthy VolunteerStudies of the same condition, open and under way.
- More trials run by University Hospital, GrenobleThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 141 participants (actual)
Sponsor and investigators
- Lead sponsor
- University Hospital, Grenoble
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Alexandre Krainik, Professor, Principal investigator, Grenoble Hospital University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02840305
- Sponsor's protocol ID
- 38RC11.221
- Acronym
- SCENES
- Status last verified
- Jan 2017
- First submitted
- 18 Jul 2016
- Last updated
- 18 Jan 2017
- Results posted
- No
- Data monitoring committee
- No
Publications
Epstein R, Kanwisher N. A cortical representation of the local visual environment. Nature. 1998 Apr 9;392(6676):598-601. doi: 10.1038/33402.
PubMed 9560155Bar M, Aminoff E, Schacter DL. Scenes unseen: the parahippocampal cortex intrinsically subserves contextual associations, not scenes or places per se. J Neurosci. 2008 Aug 20;28(34):8539-44. doi: 10.1523/JNEUROSCI.0987-08.2008.
PubMed 18716212Epstein RA, Ward EJ. How reliable are visual context effects in the parahippocampal place area? Cereb Cortex. 2010 Feb;20(2):294-303. doi: 10.1093/cercor/bhp099. Epub 2009 May 20.
PubMed 19457939Guérin-Dugué, A., & Oliva, A. (1999). Natural images classification from distributions of local dominant orientations, 11th Scandinavian Conference on Image Analysis SCIA'99.
Guérin-Dugué, A., & Oliva, A. (2000). Classification of scene photographs from local orientations features. Pattern Recognition Letters, 21, 1135-1140.
Hegde J. Time course of visual perception: coarse-to-fine processing and beyond. Prog Neurobiol. 2008 Apr;84(4):405-39. doi: 10.1016/j.pneurobio.2007.09.001. Epub 2007 Sep 29.
PubMed 17976895Houde O, Pineau A, Leroux G, Poirel N, Perchey G, Lanoe C, Lubin A, Turbelin MR, Rossi S, Simon G, Delcroix N, Lamberton F, Vigneau M, Wisniewski G, Vicet JR, Mazoyer B. Functional magnetic resonance imaging study of Piaget's conservation-of-number task in preschool and school-age children: a neo-Piagetian approach. J Exp Child Psychol. 2011 Nov;110(3):332-46. doi: 10.1016/j.jecp.2011.04.008. Epub 2011 Jun 1.
PubMed 21636095Hérault, J., Oliva, A., & Guérin-Dugué, A. (1997). Scene categorisation by curvilinear component analysis of low frequency spectra. Paper presented at the IANN'97, Bruges
Hubel DH, Wiesel TN. Ferrier lecture. Functional architecture of macaque monkey visual cortex. Proc R Soc Lond B Biol Sci. 1977 Jul 28;198(1130):1-59. doi: 10.1098/rspb.1977.0085. No abstract available.
PubMed 20635Hughes HC, Nozawa G, Kitterle F. Global precedence, spatial frequency channels, and the statistics of natural images. J Cogn Neurosci. 1996 Summer;8(3):197-230. doi: 10.1162/jocn.1996.8.3.197.
PubMed 23968149Kimchi R. Primacy of wholistic processing and global/local paradigm: a critical review. Psychol Bull. 1992 Jul;112(1):24-38. doi: 10.1037/0033-2909.112.1.24.
PubMed 1529037Lamb MR, Yund EW. The role of spatial frequency in the processing of hierarchically organized stimuli. Percept Psychophys. 1993 Dec;54(6):773-84. doi: 10.3758/bf03211802.
PubMed 8134247Lux S, Marshall JC, Thimm M, Fink GR. Differential processing of hierarchical visual stimuli in young and older healthy adults: implications for pathology. Cortex. 2008 Jan;44(1):21-8. doi: 10.1016/j.cortex.2005.08.001. Epub 2007 Nov 17.
PubMed 18387528Monoyer, F. (1875). Echelle typographique pour la détermination de l'acuité visuelle. (Acad. des Sciences, Comptes rendus). Gaz. Méd. De Paris, 80, 113.
Musel B, Chauvin A, Guyader N, Chokron S, Peyrin C. Is coarse-to-fine strategy sensitive to normal aging? PLoS One. 2012;7(6):e38493. doi: 10.1371/journal.pone.0038493. Epub 2012 Jun 4.
PubMed 22675568
Study at a glance
From the registry record, last updated by the sponsor on 18 Jan 2017. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Brain Bases of Visual Perceptionnatural Scenes of Natural Scenes.
- ClinicalTrials.gov ID
- NCT02840305
- Acronym / sponsor ID
- SCENES / 38RC11.221
- Conditions
- Healthy Volunteer
- Keywords
- Natural scenes, Brain bases, Visual perception, MRI
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 141 participants (actual)
- Lead sponsor
- University Hospital, GrenobleUniversity, hospital or other
- Study start
- Apr 2012
- Primary completion
- Mar 2016 (actual)
- Study completion
- Aug 2016 (actual)
- First posted
- 21 Jul 2016 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Using the available data from psychophysics, cellular electrophysiology and functionnal neuroanatomy of visual pathway, current models of visual recognition suppose that the perception of scenes start with a parallel extraction of differents elementary visual characteristics to different spatial frequencies according to a default processing principle named : 'coarse-to-fine'.
According to this principle, the visual scene's analysis would be decomposed in two steps. Fisrt, the fast analysis of the global information borne by low frequency of the scene will provide an overview of the scene's structure and would enable a first perceptive categorisation which would be then refined, approved or denied by the latest analysis of the most local, detailed and precise information, carried by the very high spatial frequency of the scene.
The research carried out since several years is preparing a biologically plausible model and to find brain bases by different imaging techniques among healthy subjects but also patients with a brain lesion and patients with a peripheral lesion.
The main goal of this Magnetic Resonance Imaging study is to find brain bases of natural scenes's visual perception of the natural scenes.
Three studies in Magnetic Resonance Imaging will be conducted, during which subjects will have to categorize pictures of natural scenes filtered in spatial frequencies. The outcome of this study will allow to refine models of visual recognition, most of them based on analysis of spatial frequencies.
Study design
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Expérience 1 | Other | Other: Evaluation of visual function, Other: Magnetic Resonance ImagingBrain bases of spatial frequencies treatment 30 young adults, 20 old adults 20 children between 4 and 6 years, 20 children between 6 and 12 years and 20 young adults |
| Expérience 2 | Other | Other: Evaluation of visual function, Other: Magnetic Resonance ImagingBrain bases of Computer to Film (CtF) analysis 30 young adults, 20 old adults |
| Expérience 3 | Other | Other: Evaluation of visual function, Other: Magnetic Resonance ImagingPart of parahippocampal gyrus in Computer to Film (CtF) analysis 30 young adults, 20 old adults. |
Who may qualify
- Ages
- 4 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (15 listed)
- Subjet over 18 years and less than 30 years
- Affiliation to a social security
- Free signed consent
- Medical exam done before participation to the study
- Normal or corrected visual acuity
Key exclusion criteria (22 listed)
- Counter-argument to MRI
- Pregnant, breast-feeding or parturient women
- Adults non protected or unable to express their consent
- Adults protected
- Important earing or visual disorder
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Evaluation of visual function | Other | Expérience 1, Expérience 2, Expérience 3 |
| Magnetic Resonance ImagingAlso: MRI | Other | Expérience 1, Expérience 2, Expérience 3 |
Primary outcome
Identify brain bases of natural scenes's visual perception of the natural scenes
Time frame: About 80 minutes
Evaluation 1 = Visual tasks Experience 1 : Brain bases of spatial frequencies treatment Experience 2 : Brain bases of Computer to Film (CtF) natural scenes analysis MRI exam Experience 3 : Part of parahippocampal gyrus in Computer to Film (CtF) natural scenes analysis MRI exam About 30 minutes Evaluation 2 = Retinotopy : only adults that have shown activations inside occipital cortex during evaluation 1 MRI exam about 50 minutes
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Jan 2017.
- Background: PubMed 9560155Epstein R, Kanwisher N. A cortical representation of the local visual environment. Nature. 1998 Apr 9;392(6676):598-601. doi: 10.1038/33402.
- Background: PubMed 18716212Bar M, Aminoff E, Schacter DL. Scenes unseen: the parahippocampal cortex intrinsically subserves contextual associations, not scenes or places per se. J Neurosci. 2008 Aug 20;28(34):8539-44. doi: 10.1523/JNEUROSCI.0987-08.2008.
- Background: PubMed 19457939Epstein RA, Ward EJ. How reliable are visual context effects in the parahippocampal place area? Cereb Cortex. 2010 Feb;20(2):294-303. doi: 10.1093/cercor/bhp099. Epub 2009 May 20.
- BackgroundGuérin-Dugué, A., & Oliva, A. (1999). Natural images classification from distributions of local dominant orientations, 11th Scandinavian Conference on Image Analysis SCIA'99.
- BackgroundGuérin-Dugué, A., & Oliva, A. (2000). Classification of scene photographs from local orientations features. Pattern Recognition Letters, 21, 1135-1140.
- Background: PubMed 17976895Hegde J. Time course of visual perception: coarse-to-fine processing and beyond. Prog Neurobiol. 2008 Apr;84(4):405-39. doi: 10.1016/j.pneurobio.2007.09.001. Epub 2007 Sep 29.
- Background: PubMed 21636095Houde O, Pineau A, Leroux G, Poirel N, Perchey G, Lanoe C, Lubin A, Turbelin MR, Rossi S, Simon G, Delcroix N, Lamberton F, Vigneau M, Wisniewski G, Vicet JR, Mazoyer B. Functional magnetic resonance imaging study of Piaget's conservation-of-number task in preschool and school-age children: a neo-Piagetian approach. J Exp Child Psychol. 2011 Nov;110(3):332-46. doi: 10.1016/j.jecp.2011.04.008. Epub 2011 Jun 1.
- BackgroundHérault, J., Oliva, A., & Guérin-Dugué, A. (1997). Scene categorisation by curvilinear component analysis of low frequency spectra. Paper presented at the IANN'97, Bruges
- Background: PubMed 20635Hubel DH, Wiesel TN. Ferrier lecture. Functional architecture of macaque monkey visual cortex. Proc R Soc Lond B Biol Sci. 1977 Jul 28;198(1130):1-59. doi: 10.1098/rspb.1977.0085. No abstract available.
- Background: PubMed 23968149Hughes HC, Nozawa G, Kitterle F. Global precedence, spatial frequency channels, and the statistics of natural images. J Cogn Neurosci. 1996 Summer;8(3):197-230. doi: 10.1162/jocn.1996.8.3.197.
- Background: PubMed 1529037Kimchi R. Primacy of wholistic processing and global/local paradigm: a critical review. Psychol Bull. 1992 Jul;112(1):24-38. doi: 10.1037/0033-2909.112.1.24.
- Background: PubMed 8134247Lamb MR, Yund EW. The role of spatial frequency in the processing of hierarchically organized stimuli. Percept Psychophys. 1993 Dec;54(6):773-84. doi: 10.3758/bf03211802.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Alexandre Krainik, Professor principal investigator
Grenoble Hospital University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Evaluation of visual function and Magnetic Resonance Imaging in people with Healthy Volunteer, run by University Hospital, Grenoble at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 15 inclusion and 22 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Jan 2017. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Identify brain bases of natural scenes's visual perception of the natural scenes (time frame: About 80 minutes). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02840305, which also lists 38 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Jan 2017.