Weight-Lifting Exercise ProgramNCT02842593
Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men
A study testing Lower-repetition, heavier-load and Higher-repetition, lighter-load in people with Weight-Lifting Exercise Program, run by McMaster University at 1 site in Canada.
Trial summary
This study evaluates the effects of two types of resistance exercise training (higher-repetition, lower load vs lower-repetition, higher load vs control) on regional and local measures of arterial stiffness in trained young men. Read more about this study
- Who is it for?
- Ages 18 to 30 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Weight-Lifting Exercise Program
- What is being tested?
- Lower-repetition, heavier-load and Higher-repetition, lighter-load
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteCanada
- Study dates
- Sep 2014to Aug 2016
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male
- Aged 18-30 years old
- Non-obese (Body mass index less than 30 kg/m2)
- Non-smoker
- Healthy based on questionnaire responses
- Resistance trained (Resistance training > 2 times per week for 2 years, minimum 1 lower body exercise session per week)
Who cannot join
- Allergies to milk proteins (whey or casein)
- Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires
- Arthritic conditions
- Individuals who consume any analgesic or anti-inflammatory drug(s), prescription or non- prescription, chronically will be excluded
- A history of neuromuscular problems
- Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
Trial locations and contacts
1 site in 1 country.
About this study
This study evaluates the effects of two types of resistance exercise training (higher-repetition, lower load vs lower-repetition, higher load vs control) on regional and local measures of arterial stiffness in trained young men.
- Conditions
- Weight-Lifting Exercise Program
- Being tested
- Lower-repetition, heavier-load, Higher-repetition, lighter-load
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Lower-repetition, heavier-loadBehavioural
8-12 reps/set at ~80% 1 repetition maximum
Higher-repetition, lighter-loadBehavioural
20-25 reps/set at ~30% 1 repetition maximum
| Study group | Role | What they receive |
|---|---|---|
| Resistance exercise training | Experimental | Whole-body resistance exercise training 4x/week for 12 weeks. Either 'lower-repetition, heavier-load' or 'higher-repetition, lighter-load' intervention. Receives: Behavioral: Lower-repetition, heavier-load; Behavioral: Higher-repetition, lighter-load |
| Non-exercising control | No intervention | Continue habitual physical activity for 12 weeks. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Carotid-femoral pulse wave velocity
Assessed using applanation tonometry
Measured: 12 weeks post exercise training
Secondary outcomes (2)
Common carotid artery distensibility
Assessed using vascular ultrasound
Measured: 12 weeks post exercise training
Left ventricular mass
Assessed using standard echocardiography
Measured: 12 weeks post exercise training
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Jul 2016 (estimated)
- Study startSep 2014
- Primary completionAug 2016
- Study completionAug 2016
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Weight-Lifting Exercise ProgramStudies of the same condition, open and under way.
- More trials run by McMaster UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- McMaster University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Stuart Phillips, McMaster University
- Investigators
- Stuart M Phillips, PhD, Principal investigator, McMaster University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02842593
- Sponsor's protocol ID
- REB 14-333-1
- Status last verified
- Jan 2017
- First submitted
- 15 Jul 2016
- Last updated
- 16 Jan 2017
- Results posted
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Jan 2017. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men
- ClinicalTrials.gov ID
- NCT02842593
- Acronym / sponsor ID
- REB 14-333-1
- Conditions
- Weight-Lifting Exercise Program
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- McMaster UniversityUniversity, hospital or other
- Study start
- Sep 2014
- Primary completion
- Aug 2016 (actual)
- Study completion
- Aug 2016 (actual)
- First posted
- 25 Jul 2016 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study evaluates the effects of two types of resistance exercise training (higher-repetition, lower load vs lower-repetition, higher load vs control) on regional and local measures of arterial stiffness in trained young men.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Resistance exercise training | Experimental | Behavioral: Lower-repetition, heavier-load, Behavioral: Higher-repetition, lighter-loadWhole-body resistance exercise training 4x/week for 12 weeks. Either 'lower-repetition, heavier-load' or 'higher-repetition, lighter-load' intervention. |
| Non-exercising control | No intervention | –Continue habitual physical activity for 12 weeks. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Male
- Aged 18-30 years old
- Non-obese (Body mass index less than 30 kg/m2)
- Non-smoker
- Healthy based on questionnaire responses
Key exclusion criteria (6 listed)
- Allergies to milk proteins (whey or casein)
- Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires
- Arthritic conditions
- Individuals who consume any analgesic or anti-inflammatory drug(s), prescription or non- prescription, chronically will be excluded
- A history of neuromuscular problems
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Lower-repetition, heavier-load8-12 reps/set at ~80% 1 repetition maximum | Behavioural | Resistance exercise training |
| Higher-repetition, lighter-load20-25 reps/set at ~30% 1 repetition maximum | Behavioural | Resistance exercise training |
Primary outcome
Carotid-femoral pulse wave velocity
Time frame: 12 weeks post exercise training
Assessed using applanation tonometry
2 secondary outcomes
Common carotid artery distensibility
Time frame: 12 weeks post exercise training
Left ventricular mass
Time frame: 12 weeks post exercise training
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jan 2017.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Stuart M Phillips, PhD principal investigator
McMaster University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Lower-repetition, heavier-load and Higher-repetition, lighter-load in people with Weight-Lifting Exercise Program, run by McMaster University at 1 site in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Jan 2017. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Carotid-femoral pulse wave velocity (time frame: 12 weeks post exercise training). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jan 2017.