Anorexia NervosaNEW FED TRNCT02852538
Outcomes of a Skill-Based Program for Eating Disorders
A study testing NEW FED TR in people with Anorexia Nervosa, run by University of California, San Diego at 2 sites in United States.
Trial summary
This study aims to measure the effect of a neurobiologically-guided intensive family based treatment for adults with anorexia nervosa. Read more about this study
- Who is it for?
- Ages 18 to 50 years, women only
- Conditions the study is for
- Anorexia Nervosa
- What is being tested?
- NEW FED TR
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 93 participants
- Where
- 2 sitesUnited States
- Study dates
- Feb 2015to 8 May 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- Women only
- No healthy volunteers
- Adult
Who may be able to join
- Current diagnosis of anorexia nervosa
- Illness onset at least 2 years prior to study
- Medically stable
- Identified carer to participate in treatment with participant
Who cannot join
- Developmental or intellectual disorder
- Diagnosis of substance abuse or dependence in 3 months prior to study
- Current suicidal thoughts
- Severe comorbid psychiatric disorder (e.g., psychotic disorder, bipolar disorder)
Trial locations and contacts
2 sites in 1 country.
United States2 sites
The Center for Balanced Living
Columbus, Ohio, 43235
University of California San Diego
San Diego, California, 92121
About this study
Official title: An Innovative Family Based Treatment for Adults With Anorexia Nervosa Using Insights From Neurobiology
This study aims to measure the effect of a neurobiologically-guided intensive family based treatment for adults with anorexia nervosa.
- Conditions
- Anorexia Nervosa
- Being tested
- NEW FED TR
- Medical subject headings
- Anorexia Nervosa
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
NEW FED TRBehavioural
Also called Intensive Temperament Based Treatment
NEW FED TR is a five day treatment for adults with anorexia nervosa. It is a neurobiologically informed, interactive, family-based treatment that draws upon the specific etiological traits characterizing anorexia nervosa. It stands for Neurobiological research findings Enhanced With Family/Friends of those with Eating Disorders, addressing Trait Responses that both create a vulnerability to the illness and serve as markers for recovery through treatment (formerly reported as Temperament-Based Treatment).
| Study group | Role | What they receive |
|---|---|---|
| NEW FED TR for Anorexia | Experimental | NEW FED TR Receives: Behavioral: NEW FED TR |
What is being measured
The primary outcome is the main question the study is designed to answer.
Body Mass Index
Measured: 3 months post-treatment
Secondary outcomes (1)
Eating Disorder Examination Total Score
Clinical symptoms
Measured: 3 months post-treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Aug 2016 (estimated)
- Study startFeb 2015
- Primary completion8 May 2026
- Study completion8 May 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Anorexia NervosaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 93 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of California, San Diego
- Sponsor type
- University, hospital or other
- Collaborators
- National Eating Disorders Association
- Responsible party
- Principal investigator, Christina Wierenga, University of California, San Diego
- Investigators
- Christina Wierenga, PhD, Principal investigator, University of California, San DiegoLaura Hill, PhD, Study chair, The Center for Balanced Living
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02852538
- Sponsor's protocol ID
- 110659
- Acronym
- NEW FED TR
- Status last verified
- May 2026
- First submitted
- 26 Jul 2016
- Last updated
- 13 May 2026
- Results posted
- No
- Data monitoring committee
- Yes
- Individual data sharing
- No
Publications
Knatz S, Wierenga CE, Murray SB, Hill L, Kaye WH. Neurobiologically informed treatment for adults with anorexia nervosa: a novel approach to a chronic disorder. Dialogues Clin Neurosci. 2015 Jun;17(2):229-36. doi: 10.31887/DCNS.2015.17.2/sknatz.
PubMed 26246796Kaye WH, Wierenga CE, Knatz S, Liang J, Boutelle K, Hill L, Eisler I. Temperament-based treatment for anorexia nervosa. Eur Eat Disord Rev. 2015 Jan;23(1):12-8. doi: 10.1002/erv.2330. Epub 2014 Nov 6.
PubMed 25377622Hill L, Peck SK, Wierenga CE, Kaye WH. Applying neurobiology to the treatment of adults with anorexia nervosa. J Eat Disord. 2016 Dec 5;4:31. doi: 10.1186/s40337-016-0119-x. eCollection 2016.
PubMed 27980771
Study at a glance
From the registry record, last updated by the sponsor on 13 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- An Innovative Family Based Treatment for Adults With Anorexia Nervosa Using Insights From Neurobiology
- ClinicalTrials.gov ID
- NCT02852538
- Acronym / sponsor ID
- NEW FED TR / 110659
- Conditions
- Anorexia Nervosa
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 93 participants (actual)
- Lead sponsor
- University of California, San DiegoUniversity, hospital or other
- Collaborators
- National Eating Disorders Association
- Study start
- Feb 2015
- Primary completion
- 8 May 2026 (actual)
- Study completion
- 8 May 2026 (actual)
- First posted
- 2 Aug 2016 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to measure the effect of a neurobiologically-guided intensive family based treatment for adults with anorexia nervosa.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| NEW FED TR for Anorexia | Experimental | Behavioral: NEW FED TRNEW FED TR |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Current diagnosis of anorexia nervosa
- Illness onset at least 2 years prior to study
- Medically stable
- Identified carer to participate in treatment with participant
Key exclusion criteria (4 listed)
- Developmental or intellectual disorder
- Diagnosis of substance abuse or dependence in 3 months prior to study
- Current suicidal thoughts
- Severe comorbid psychiatric disorder (e.g., psychotic disorder, bipolar disorder)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| NEW FED TRAlso: Intensive Temperament Based TreatmentNEW FED TR is a five day treatment for adults with anorexia nervosa. It is a neurobiologically informed, interactive, family-based treatment that draws upon the specific etiological traits characterizing anorexia nervosa. It stands for Neurobiological research findings Enhanced With Family/Friends of those with Eating Disorders, addressing Trait Responses that both create a vulnerability to the illness and serve as markers for recovery through treatment (formerly reported as Temperament-Based Treatment). | Behavioural | NEW FED TR for Anorexia |
Primary outcome
Body Mass Index
Time frame: 3 months post-treatment
1 secondary outcome
Eating Disorder Examination Total Score
Time frame: 3 months post-treatment
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 May 2026.
- Background: PubMed 26246796Knatz S, Wierenga CE, Murray SB, Hill L, Kaye WH. Neurobiologically informed treatment for adults with anorexia nervosa: a novel approach to a chronic disorder. Dialogues Clin Neurosci. 2015 Jun;17(2):229-36. doi: 10.31887/DCNS.2015.17.2/sknatz.
- Background: PubMed 25377622Kaye WH, Wierenga CE, Knatz S, Liang J, Boutelle K, Hill L, Eisler I. Temperament-based treatment for anorexia nervosa. Eur Eat Disord Rev. 2015 Jan;23(1):12-8. doi: 10.1002/erv.2330. Epub 2014 Nov 6.
- Derived from this study: PubMed 27980771Hill L, Peck SK, Wierenga CE, Kaye WH. Applying neurobiology to the treatment of adults with anorexia nervosa. J Eat Disord. 2016 Dec 5;4:31. doi: 10.1186/s40337-016-0119-x. eCollection 2016.
- UCSD Eating Disorder Treatment and Research ProgramLink provided by the sponsor.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Christina Wierenga, PhD principal investigator
University of California, San Diego
Laura Hill, PhD study chair
The Center for Balanced Living
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing NEW FED TR in people with Anorexia Nervosa, run by University of California, San Diego at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Body Mass Index (time frame: 3 months post-treatment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02852538, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 May 2026.