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Sedentary LifestyleNCT02863731

Effect of Alternating Postures on Cognitive Performance

A study testing Alternating working postures, first day and Alternating working postures, second day in people with Sedentary Lifestyle, run by University of Applied Sciences Upper Austria at 1 site in Austria.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

Prolonged sitting is a risk factor for cardiovascular and musculoskeletal diseases, diabetes, several types of cancer and all-cause mortality. In combination with static and awkward postures, the prevalence of musculoskeletal diseases can increase further. Read more about this study

Who is it for?
Ages 18 to 39 yearsHealthy volunteers can take part
Conditions the study is for
Sedentary Lifestyle
What is being tested?
Alternating working postures, first day and Alternating working postures, second day
Could I receive a placebo?
No, everyone receives an active treatment
How many people
46 participants
Where
1 siteAustria
Study dates
Jan 2014to Mar 2015
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 39 years
  • All sexes
  • Healthy volunteers accepted
  • Adult

Who may be able to join

  • Healthy Caucasian (no acute or chronic diseases)
  • Normal weight or overweight (BMI: 18.5 - 30.0 kg/m²)
  • Regular computer users
  • Fluent German speakers
  • Consented to participate

Who cannot join

  • Obesity (BMI > 30.0 kg/m²)
  • Experience in sit-to-stand workstations
  • Acute or chronic diseases
  • Inability to stand
  • Visual impairments that had not been corrected
  • Color blindness
  • Regular heavy smokers (> 10 cigarettes /day)
  • Not consented to participate

Trial locations and contacts

1 site in 1 country.

Austria1 site
  • University of Applied Sciences Upper Austria

    Linz, Upper Austria, 4020

Other trials in Austria

About this study

Prolonged sitting is a risk factor for cardiovascular and musculoskeletal diseases, diabetes, several types of cancer and all-cause mortality. In combination with static and awkward postures, the prevalence of musculoskeletal diseases can increase further. Although the implementation of sit-to-stand or active workstations can help to reduce sitting time, improve physical activity at work and promote health benefits, it might also lead to changes in cognitive functions such as productivity. The purpose of this study is to evaluate the short-term effect of alternating working postures on cognitive performance for healthy people.

Read the detailed description

Measurements were made in a laboratory. They were made on two different days with an interval of 7 days between sessions. Laboratory tests were conducted in a controlled, simulated work-space located at the University of Applied Sciences Campus Linz. All laboratory measurements were made in a controlled laboratory at the campus site Linz of the University of Applied Sciences Upper Austria. Temperature, air flow, humidity, lighting conditions (artificial light only) and noise level were controlled and set to be consistent with the subjects' typical working environment.

During the laboratory measurements, subjects either stood or sat upright in an ergonomic office chair, according to the study protocol. Subjects were encouraged to work as fast and as accurately as they could. To ensure identical testing conditions between subjects and to not unduly influence physiological parameters such as heart rate variability (HRV), subjects were required to minimize excessive movement (e.g. standing up during the sitting periods).

In the first (initial) phase participants were familiarized with the study protocol. Sitting time and weekly physical activity were determined via the long version of the International Physical Activity Questionnaire (IPAQ, only on the first day of measurement). Examples of each cognitive test implemented in the cognitive phase were executed according to their guidelines. A 30 minute break in a sitting posture was used to ascertain baseline heart-rate level. Baseline heart-rate was calculated after a 20 minute rest for a 5 minute interval.

In the second (cognitive) phase subjects participated in a test battery containing five blocks. Each block consisted of a working speed test (text editing task), an attentional test (d2R-test of attention) and a reaction time test (Stroop-test). These tests lasted for 30 minutes to fulfill recommendations regarding postural changes. To simulate "common" working conditions (computer based and non-computer based tasks), digital (text editing task, Stroop-test) as well as pen \& paper (d2R-test) versions of the implemented tests were used.

For the intervention group, the cognitive blocks were executed in an alternating posture (sit - stand - sit - stand - sit) either on the first or the second day of measurement (cross-over design). To generate control periods, this procedure was executed in an sitting posture only (sit - sit - sit - sit - sit) for the non-interventional day. For the control group, both days of measurement were executed in sitting posture only (sit - sit - sit - sit - sit ).

In the third (final) phase participants were asked to estimate their workload by means of the Task Load Index questionnaire developed by the National Aeronautics and Space Administration (NASA-TLX), followed by a 30 minutes resting phase in a sitting posture. During both 30 min resting phases (initial \& final) participants watched documentaries and were encouraged not to talk.

Heart-rate and trunk movements were measured from the start of the study protocol until the next morning by means of an mobile ECG-recorder.

Being tested
Alternating working postures, first day, Alternating working postures, second day
Keywords
postural changes, alternating postures, Cognitive performance, Height-adjustable desk, Worksite
Medical subject headings
Sedentary Behavior

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Alternating working postures, first dayOther

    On the first day of measurement participants execute five test battery trials in alternating postures (sit/stand/sit/stand/sit). On the second day of measurement participants execute the test battery in a sitting posture (sit/sit/sit/sit/sit).

  • Alternating working postures, second dayOther

    On the first day of measurement participants execute five test battery trials in a sitting posture (sit/sit/sit/sit/sit). On the second day of measurement participants execute the test battery in alternating postures (sit/stand/sit/stand/sit).

Study groups in NCT02863731
Study groupRoleWhat they receive
Alternating postures: first dayExperimentalAlternating body postures on the first day of measurement. Sitting body posture on the second day of measurement.
Receives: Other: Alternating working postures, first day
Alternating postures: second dayExperimentalAlternating body postures on the second day of measurement. Sitting body posture on the first day of measurement.
Receives: Other: Alternating working postures, second day
Control groupNo interventionSitting body posture on both days of measurement.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Reaction time

    Reaction time is a commonly measured parameter to describe mental states, fatigue or performance in ergonomic research. As the effect of alternating postures on reaction time is still unclear, a digital version of the Color-Word-Conflict-Stroop-Test has been implemented.

    It contained 190 congruent, incongruent and neutral tasks and required approximately 10 min to simulate long-lasting monotonous office screen work. The reaction time was measured and recorded automatically. Outliers (values outside of the limits of 3 standard deviations) have been automatically eliminated. The Stroop-Test is characterized by a high test-retest reliability.

    Due to the cross-over design of the study two days were necessary to determine the interventional effect. According to the group allocation the participants executed the Stroop-test either in an alternating or sitting posture. Differences in reaction time and accuracy between "alternating" and "sitting" days will be analyzed.

    Measured: 2 experimental days

  2. Attentional performance

    As the effect of alternating postures on attentional performance is still unclear, an attentional performance test called "d2R-test of attention" has been implemented. The d2R-test was executed as a pen and paper version. Therefore, it enabled screen breaks during the test protocol and simulated paper-related office work. The d2R-Test is characterized by a high test-retest reliability and do not require any specific previous knowledge except of rudimentary language skills. Normative values for the d2R-test are available for different countries.

    Attentional performance and accuracy were manually determined according to the d2R-guidelines.

    Due to the cross-over design of the study two days were necessary to determine the interventional effect. According to the group allocation the participants executed the d2R-test either in an alternating or sitting posture. Differences in attentional performance and accuracy between "alternating" and "sitting" days will be analyzed.

    Measured: 2 experimental days

  3. Working speed

    Physical efforts when performing standardized tests (e.g. standing or walking) can negatively influence cognitive parameters as well as working speed. To determine the effect of alternating postures on working speed a digital text editing task encouraging participants to fill in spaces in an ergonomic guideline text for 10 min was used.

    Working speed (words per minute) and accuracy (relative error) have been manually calculated.

    Due to the cross-over design of the study two days were necessary to determine the interventional effect. According to the group allocation the participants executed the text editing task either in an alternating or sitting posture. Differences in working speed between "alternating" and "sitting" days will be analyzed.

    Measured: 2 experimental days

  4. Workload perception

    Sit-to-stand workstations can evoke positive as well as negative associations. A common method to rate workload perception is the NASA-TLX questionnaire (Task Load Index, National Aeronautics and Space Administration). For reasons of simplicity and unmodified sensitivity, the short version of this questionnaire (RTLX, raw task load index), consisting of six major items, was used. Influences on workload perception based on unweighted items in the RTLX were negated due to the cross-over design.

    Due to the cross-over design of the study two days were necessary to determine the interventional effect. According to the group allocation the participants scored their perceived workload after executing several cognitive tests in an alternating or sitting posture. Differences in workload perception between "alternating" and "sitting" days will be analyzed.

    Measured: 2 experimental days

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted11 Aug 2016 (estimated)
  2. Study startJan 2014
  3. Primary completionMar 2015
  4. Study completionMar 2015

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Allocation
Randomised
Intervention model
Crossover
Masking
None (open label)
Enrolment
46 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT02863731
Sponsor's protocol ID
AO-8735-2
Other IDs
834185
Status last verified
Aug 2016
First submitted
14 Jul 2016
Last updated
17 Aug 2016
Results posted
No
Data monitoring committee
No
Individual data sharing
No

Publications

  • Neuhaus M, Healy GN, Dunstan DW, Owen N, Eakin EG. Workplace sitting and height-adjustable workstations: a randomized controlled trial. Am J Prev Med. 2014 Jan;46(1):30-40. doi: 10.1016/j.amepre.2013.09.009.

    PubMed 24355669
  • Commissaris DA, Konemann R, Hiemstra-van Mastrigt S, Burford EM, Botter J, Douwes M, Ellegast RP. Effects of a standing and three dynamic workstations on computer task performance and cognitive function tests. Appl Ergon. 2014 Nov;45(6):1570-8. doi: 10.1016/j.apergo.2014.05.003. Epub 2014 Jun 17.

    PubMed 24951234
  • Bates ME, Lemay EP Jr. The d2 Test of attention: construct validity and extensions in scoring techniques. J Int Neuropsychol Soc. 2004 May;10(3):392-400. doi: 10.1017/S135561770410307X.

    PubMed 15147597
  • Best JR, Nagamatsu LS, Liu-Ambrose T. Improvements to executive function during exercise training predict maintenance of physical activity over the following year. Front Hum Neurosci. 2014 May 27;8:353. doi: 10.3389/fnhum.2014.00353. eCollection 2014.

    PubMed 24904387
  • Van der Elst W, Van Boxtel MP, Van Breukelen GJ, Jolles J. The Stroop color-word test: influence of age, sex, and education; and normative data for a large sample across the adult age range. Assessment. 2006 Mar;13(1):62-79. doi: 10.1177/1073191105283427.

    PubMed 16443719
  • Lynch BM. Sedentary behavior and cancer: a systematic review of the literature and proposed biological mechanisms. Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2691-709. doi: 10.1158/1055-9965.EPI-10-0815. Epub 2010 Sep 10.

    PubMed 20833969
  • Owen N, Sparling PB, Healy GN, Dunstan DW, Matthews CE. Sedentary behavior: emerging evidence for a new health risk. Mayo Clin Proc. 2010 Dec;85(12):1138-41. doi: 10.4065/mcp.2010.0444. No abstract available.

    PubMed 21123641
  • Brown WJ, Miller YD, Miller R. Sitting time and work patterns as indicators of overweight and obesity in Australian adults. Int J Obes Relat Metab Disord. 2003 Nov;27(11):1340-6. doi: 10.1038/sj.ijo.0802426.

    PubMed 14574344
  • Schwartz B, Kapellusch JM, Schrempf A, Probst K, Haller M, Baca A. Effect of a novel two-desk sit-to-stand workplace (ACTIVE OFFICE) on sitting time, performance and physiological parameters: protocol for a randomized control trial. BMC Public Health. 2016 Jul 15;16:578. doi: 10.1186/s12889-016-3271-y.

    PubMed 27422158
  • Schwartz B, Kapellusch JM, Schrempf A, Probst K, Haller M, Baca A. Effect of alternating postures on cognitive performance for healthy people performing sedentary work. Ergonomics. 2018 Jun;61(6):778-795. doi: 10.1080/00140139.2017.1417642. Epub 2017 Dec 28.

    PubMed 29235967

Questions about this trial

What is this clinical trial studying?

A study testing Alternating working postures, first day and Alternating working postures, second day in people with Sedentary Lifestyle, run by University of Applied Sciences Upper Austria at 1 site in Austria.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 17 Aug 2016. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Austria. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Reaction time (time frame: 2 experimental days). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT02863731, which also lists 10 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Aug 2016.

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