Acute Myocardial InfarctionNCT02880436
Association of Air Quality and Myocardial Infarction
An observational study of Acute Myocardial Infarction, run by Medical University of Graz at 1 site in Austria.
Trial summary
Besides classical cardiovascular risk factors such as smoking, obesity, elevated cholesterol levels and diabetes there are also acute factors potentially triggering acute coronary events. The impact of various substances and air pollution are described. Read more about this study
- Who is it for?
- Ages 18 to 99 years
- Conditions the study is for
- Acute Myocardial Infarction
- What is being tested?
- air pollution
- How many people
- 12,000 participants
- Where
- 1 siteAustria
- Study dates
- Jan 2007to 30 Jun 2017
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 99 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: All patients with myocardial infarction being transfered to a cath lab either at the medical university of Graz or the department of cardiology at the state hospital Graz West
Who may be able to join
- myocardial infarction being confirmed or treated in the cathlab
Who cannot join
- none
Trial locations and contacts
1 site in 1 country.
About this study
Besides classical cardiovascular risk factors such as smoking, obesity, elevated cholesterol levels and diabetes there are also acute factors potentially triggering acute coronary events. The impact of various substances and air pollution are described.
Particulate matter, especially with small particle size (<2.5µm) has been shown to have a positive correlation with myocardial infarctions. However, other studies failed to show this correlation.
Read more
With respect to nitric oxydes the majority of published studies detected a significant correlation with myocardial infarction, too, although a highly ranked publication failed to show the same result. In addition data on the impact of sulfur dioxide and carbon monoxide concentration on cardiac events is very heterogeneous.
Published data indicates additive effects of age and other epidemiological variables suggesting the need of a multivariate analysis.
The rationale of the study is to test if the above mentioned air pollution factors have a significant and independent impact on the incidence of myocardial infarctions
Read the detailed description
The analysis will be performed in a well characterized patient cohort of 12.000 myocardial infarctions within 10 years being invasively diagnosed at the catheterisation centers of the styrian capital Graz.
- Conditions
- Acute Myocardial Infarction
- Being tested
- air pollution
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
air pollutionOther
impact of various pollution agents above threshold and their correlation with acute myocardial infarctions are analyzed
What is being measured
The primary outcome is the main question the study is designed to answer.
myocardial infarction
the number of myocardial infarctions of every day analysed in this study will be correlated with the respective values of air polluting substances
Measured: 1 day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Aug 2016 (estimated)
- Study startJan 2007
- Primary completion30 Jun 2017
- Study completion30 Jun 2017
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Acute Myocardial InfarctionStudies of the same condition, open and under way.
- More trials run by Medical University of GrazThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 12,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Medical University of Graz
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Dirk von Lewinski, MD, Principal investigator, Dirk von Lewinski
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02880436
- Sponsor's protocol ID
- 28-292ex15/16
- Status last verified
- Aug 2017
- First submitted
- 16 Aug 2016
- Last updated
- 25 Aug 2017
- Results posted
- No
- Data monitoring committee
- No
- Individual data sharing
- Undecided
Publications
Bhaskaran K, Hajat S, Haines A, Herrett E, Wilkinson P, Smeeth L. Effects of air pollution on the incidence of myocardial infarction. Heart. 2009 Nov;95(21):1746-59. doi: 10.1136/hrt.2009.175018. Epub 2009 Jul 26.
PubMed 19635723Sen T, Astarcioglu MA, Asarcikli LD, Kilit C, Kafes H, Parspur A, Yaymaci M, Pinar M, Tufekcioglu O, Amasyali B. The effects of air pollution and weather conditions on the incidence of acute myocardial infarction. Am J Emerg Med. 2016 Mar;34(3):449-54. doi: 10.1016/j.ajem.2015.11.068. Epub 2015 Dec 4.
PubMed 26742457Ruidavets JB, Cournot M, Cassadou S, Giroux M, Meybeck M, Ferrieres J. Ozone air pollution is associated with acute myocardial infarction. Circulation. 2005 Feb 8;111(5):563-9. doi: 10.1161/01.CIR.0000154546.32135.6E.
PubMed 15699276Barnett AG, Williams GM, Schwartz J, Best TL, Neller AH, Petroeschevsky AL, Simpson RW. The effects of air pollution on hospitalizations for cardiovascular disease in elderly people in Australian and New Zealand cities. Environ Health Perspect. 2006 Jul;114(7):1018-23. doi: 10.1289/ehp.8674.
PubMed 16835053
Study at a glance
From the registry record, last updated by the sponsor on 25 Aug 2017. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Association of Air Quality and Myocardial Infarction
- ClinicalTrials.gov ID
- NCT02880436
- Acronym / sponsor ID
- 28-292ex15/16
- Conditions
- Acute Myocardial Infarction
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 12,000 participants (estimated)
- Lead sponsor
- Medical University of GrazUniversity, hospital or other
- Study start
- Jan 2007
- Primary completion
- 30 Jun 2017 (actual)
- Study completion
- 30 Jun 2017 (actual)
- First posted
- 26 Aug 2016 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Besides classical cardiovascular risk factors such as smoking, obesity, elevated cholesterol levels and diabetes there are also acute factors potentially triggering acute coronary events. The impact of various substances and air pollution are described.
Particulate matter, especially with small particle size (<2.5µm) has been shown to have a positive correlation with myocardial infarctions. However, other studies failed to show this correlation.
With respect to nitric oxydes the majority of published studies detected a significant correlation with myocardial infarction, too, although a highly ranked publication failed to show the same result. In addition data on the impact of sulfur dioxide and carbon monoxide concentration on cardiac events is very heterogeneous.
Published data indicates additive effects of age and other epidemiological variables suggesting the need of a multivariate analysis.
The rationale of the study is to test if the above mentioned air pollution factors have a significant and independent impact on the incidence of myocardial infarctions
Detailed description
The analysis will be performed in a well characterized patient cohort of 12.000 myocardial infarctions within 10 years being invasively diagnosed at the catheterisation centers of the styrian capital Graz.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
Who may qualify
- Ages
- 18 to 99 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- All patients with myocardial infarction being transfered to a cath lab either at the medical university of Graz or the department of cardiology at the state hospital Graz West
Key inclusion criteria (1 listed)
- myocardial infarction being confirmed or treated in the cathlab
Key exclusion criteria (1 listed)
- none
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| air pollutionimpact of various pollution agents above threshold and their correlation with acute myocardial infarctions are analyzed | Other | – |
Primary outcome
myocardial infarction
Time frame: 1 day
the number of myocardial infarctions of every day analysed in this study will be correlated with the respective values of air polluting substances
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Aug 2017.
- Background: PubMed 19635723Bhaskaran K, Hajat S, Haines A, Herrett E, Wilkinson P, Smeeth L. Effects of air pollution on the incidence of myocardial infarction. Heart. 2009 Nov;95(21):1746-59. doi: 10.1136/hrt.2009.175018. Epub 2009 Jul 26.
- Background: PubMed 26742457Sen T, Astarcioglu MA, Asarcikli LD, Kilit C, Kafes H, Parspur A, Yaymaci M, Pinar M, Tufekcioglu O, Amasyali B. The effects of air pollution and weather conditions on the incidence of acute myocardial infarction. Am J Emerg Med. 2016 Mar;34(3):449-54. doi: 10.1016/j.ajem.2015.11.068. Epub 2015 Dec 4.
- Background: PubMed 15699276Ruidavets JB, Cournot M, Cassadou S, Giroux M, Meybeck M, Ferrieres J. Ozone air pollution is associated with acute myocardial infarction. Circulation. 2005 Feb 8;111(5):563-9. doi: 10.1161/01.CIR.0000154546.32135.6E.
- Background: PubMed 16835053Barnett AG, Williams GM, Schwartz J, Best TL, Neller AH, Petroeschevsky AL, Simpson RW. The effects of air pollution on hospitalizations for cardiovascular disease in elderly people in Australian and New Zealand cities. Environ Health Perspect. 2006 Jul;114(7):1018-23. doi: 10.1289/ehp.8674.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Dirk von Lewinski, MD principal investigator
Dirk von Lewinski
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Acute Myocardial Infarction, run by Medical University of Graz at 1 site in Austria.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Aug 2017. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Austria. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
myocardial infarction (time frame: 1 day). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02880436, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Aug 2017.