Limbus CorneaeSILOGNCT02886611
Limbal Stem Cell Deficiency of Genetic Origin: Genotype-phenotype Correlation
An observational study of Limbus Corneae, run by Fondation Ophtalmologique Adolphe de Rothschild at 1 site in France.
Trial summary
The study aims at searching for a genotype-phenotype correlation in patients with a genetic pathology of the ocular surface, in order to identify genetic abnormalities associated with the most severe clinical situations. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Limbus Corneae
- How many people
- 60 participants
- Where
- 1 siteFrance
- Study dates
- 15 Dec 2015to Dec 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: Patients with decreased visual acuity of corneal origin will be selected and genetic analysis will be performed.
Who may be able to join
- genetic pathology of ocular surface
Who cannot join
- Agonal glaucoma
- Low vision mostly related to retinal pathology
- Pregnant or breast feeding patient
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
Fondation Ophtalmologique Adolphe de Rothschild
Paris, 75019
Eric GABISON, Pr
About this study
The study aims at searching for a genotype-phenotype correlation in patients with a genetic pathology of the ocular surface, in order to identify genetic abnormalities associated with the most severe clinical situations.
- Conditions
- Limbus Corneae
What is being measured
The primary outcome is the main question the study is designed to answer.
Genotype-phenotype Correlation
Measured: baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Sep 2016 (estimated)
- Study start15 Dec 2015
- Primary completionDec 2025 (estimated)
- Study completionDec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Limbus CorneaeStudies of the same condition, open and under way.
- More trials run by Fondation Ophtalmologique Adolphe de RothschildThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
- Sponsor type
- Research network
- Responsible party
- Sponsor
- Investigators
- Anna GEMAHLING, MD, Principal investigator, Hôpital Fondation Adolphe de RothschildEric GABISON, MD, Principal investigator, Hôpital Bichat (AP-HP)Dominique BREMOND-GIGNAC, MD, Principal investigator, Hopital Necker-enfants malades (AP-HP)
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02886611
- Sponsor's protocol ID
- EGN_2015_36
- Acronym
- SILOG
- Status last verified
- Dec 2025
- First submitted
- 29 Aug 2016
- Last updated
- 3 Dec 2025
- Results posted
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Limbal Stem Cell Deficiency of Genetic Origin: Genotype-phenotype Correlation
- ClinicalTrials.gov ID
- NCT02886611
- Acronym / sponsor ID
- SILOG / EGN_2015_36
- Conditions
- Limbus Corneae
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Fondation Ophtalmologique Adolphe de RothschildResearch network
- Study start
- 15 Dec 2015 (actual)
- Primary completion
- Dec 2025 (estimated)
- Study completion
- Dec 2026 (estimated)
- First posted
- 1 Sep 2016 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study aims at searching for a genotype-phenotype correlation in patients with a genetic pathology of the ocular surface, in order to identify genetic abnormalities associated with the most severe clinical situations.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Patients with decreased visual acuity of corneal origin will be selected and genetic analysis will be performed.
Key inclusion criteria (1 listed)
- genetic pathology of ocular surface
Key exclusion criteria (3 listed)
- Agonal glaucoma
- Low vision mostly related to retinal pathology
- Pregnant or breast feeding patient
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Genotype-phenotype Correlation
Time frame: baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Dec 2025.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Anna GEMAHLING, MD principal investigator
Hôpital Fondation Adolphe de Rothschild
Eric GABISON, MD principal investigator
Hôpital Bichat (AP-HP)
Dominique BREMOND-GIGNAC, MD principal investigator
Hopital Necker-enfants malades (AP-HP)
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Limbus Corneae, run by Fondation Ophtalmologique Adolphe de Rothschild at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 3 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Amélie YAVCHITZ, MD, PhD (0033148036454, ayavchitz@for.paris), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Genotype-phenotype Correlation (time frame: baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Dec 2025.