AzTrials
AzTrials

Ulcerative Colitis (UC)Phase 3U-ACTIVATENCT03006068

A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC)

A Phase 3 study testing Upadacitinib (ABT-494) in people with Ulcerative Colitis (UC), run by AbbVie at 492 sites in 46 countries.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
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Trial summary

This study is designed to evaluate the long-term safety and efficacy of Upadacitinib in participants with ulcerative colitis (UC) who have not responded at the end of the induction period in Study M14-234 Substudy 1, who have had loss of response during the maintenance period of Study M14-234 Substudy 3, or who have… Read more about this study

Who is it for?
Ages 16 to 75 years
Conditions the study is for
Ulcerative Colitis (UC)
What is being tested?
Upadacitinib (ABT-494)
Type of treatment
Pill or oral medicine
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
950 participants
Where
492 sitesin 46 countries
Study dates
31 Jan 2017to Jul 2027
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 16 to 75 years
  • All sexes
  • No healthy volunteers
  • Child, Adult, Older adult

Who may be able to join

  • Note: Participants aged 16 or 17 may enroll in M14-234 or M14-675 where locally permissible
  • Participant has not achieved clinical response at the end of the induction period (Week 8) in Study M14-234 Substudy 1, has had loss of response during the maintenance period of Study M14-234 Substudy 3, or has successfully completed Study M14-234 Substudy 3. During the COVID-19 pandemic, for participants with missing endoscopy at Week 8, Week 16 or Week 52 due to the COVID-19 pandemic in Studies M14-234 Substudy 2, M14-234 Substudy 3 and M14-675, participants may be enrolled if certain criteria are met.
  • If female, participant must meet the contraception criteria.
  • Women of childbearing potential must have a negative urine pregnancy test at Week 0 visit.
  • Participant is judged to be in otherwise good health as determined by the principal investigator based upon clinical evaluations performed during the preceding study (Study M14-234).
  • Must be able and willing to give written informed consent and to comply with the requirements of this study protocol.

Who cannot join

  • For any reason participant is considered by the investigator to be an unsuitable candidate.
  • Female participant with a positive pregnancy test at the final visit of Study M14-234 or who is considering becoming pregnant during the study or within 30 days after the last dose of study drug.
  • Known hypersensitivity to upadacitinib or its excipients or had any adverse event (AE) during the preceding studies, that in the investigator's judgment makes the participant unsuitable for this study.
  • Participant with an active or recurrent infection that based on the investigator's clinical assessment makes the participant an unsuitable candidate for the study. Participants with ongoing infections undergoing treatment may be enrolled BUT NOT dosed until the infection has been successfully treated.
  • Current evidence of active tuberculosis (TB); current evidence of latent tuberculosis and for any reason the participant cannot take full course of TB prophylaxis treatment as required per protocol.
  • Participant with a poorly controlled medical condition, such as uncontrolled diabetes, unstable ischemic heart disease, moderate or severe congestive heart failure (New York Heart Association class III or IV), recent cerebrovascular accidents and any other condition which, in the opinion of the investigator or sponsor, would put the subject at risk by participation in this study.
  • Participants have malignancy, high-grade dysplasia, un-removed low-grade dysplasia of the gastrointestinal tract diagnosed at the endoscopy performed at the final visit of Study M14-234.
  • History of any malignancy except for successfully treated nonmelanoma skin cancer (NMSC) or localized carcinoma in situ of the cervix from evaluations performed in Study M14-234.

Trial locations and contacts

492 sites in 46 countries.

492 sites in 46 countries

United States147 sites

  • Duplicate_University of New Mexico Department of Internal Medicine /ID# 214399

    Albuquerque, New Mexico, 87131

  • University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 151158

    Ann Arbor, Michigan, 48109

  • Huron Gastroenterology Assoc /ID# 152712

    Ann Arbor, Michigan, 48197

  • TX Clinical Research Institute /ID# 151528

    Arlington, Texas, 76012

  • Digestive Health Partners - Biltmore Office /ID# 167238

    Asheville, North Carolina, 28801

  • University of Maryland, Baltimore /ID# 150529

    Baltimore, Maryland, 21201

  • Inquest Clinical Research /ID# 164636

    Baytown, Texas, 77521-2415

  • Texas Digestive Disease Consultants, PLLC dba GI Alliance /ID# 163630

    Bellevue, Washington, 98004

  • Massachusetts General Hospital /ID# 165678

    Boston, Massachusetts, 02114

  • HP Clinical Research /ID# 163941

    Bountiful, Utah, 84010

  • NY Scientific /ID# 152708

    Brooklyn, New York, 11235

  • Texas Digestive Disease Consultants /ID# 209949

    Cedar Park, Texas, 78613-5028

  • GI Alliance /ID# 209806

    Cedar Park, Texas, 78613

  • Delsol Research Management, Ll /Id# 170130

    Chandler, Arizona, 85224

  • Pharmacorp Clinical Trials /ID# 153363

    Charleston, South Carolina, 29412

  • Atrium Health Carolinas Medical Center /ID# 157060

    Charlotte, North Carolina, 28203

  • Charlotte Gastroenterology and Hepatology, PLLC /ID# 150561

    Charlotte, North Carolina, 28207

  • Clin Res Inst of Michigan, LLC /ID# 153031

    Chesterfield, Michigan, 48047

  • Clin Res Inst of Michigan, LLC /ID# 161983

    Chesterfield, Michigan, 48047

  • Next Innovative Clinical Research - Chicago /ID# 217323

    Chicago, Illinois, 60605-2168

  • Duplicate_The University of Chicago DCAM /ID# 150564

    Chicago, Illinois, 60637

  • Gastro Health Research /ID# 151683

    Cincinnati, Ohio, 45219

  • University Of Cincinnati Medical Center /ID# 164584

    Cincinnati, Ohio, 45219

  • West Central Gastroenterology /ID# 155242

    Clearwater, Florida, 33762

  • Delta Waves, Inc. /ID# 151727

    Colorado Springs, Colorado, 80918

  • Gastro Center of Maryland /ID# 200024

    Columbia, Maryland, 21045

  • The Ohio State University /ID# 169417

    Columbus, Ohio, 43210

  • Optimed Research, Ltd. /ID# 169697

    Columbus, Ohio, 43235

  • Gastro One /ID# 151154

    Cordova, Tennessee, 38018

  • Citrus Valley Gastroenterology /ID# 151915

    Covina, California, 91722-3797

  • Tri-State Gastroenterology /ID# 169812

    Crestview Hills, Kentucky, 41017

  • Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 200771

    Dallas, Texas, 75246

  • Duplicate_Western Connecticut Medical Group /ID# 169211

    Danbury, Connecticut, 06810

  • Hometown Urgent Care and Resea /ID# 200066

    Dayton, Ohio, 45424

  • Moonshine Research Center, Inc /ID# 152534

    Doral, Florida, 33166

  • Universal Axon Clinical Research /ID# 213463

    Doral, Florida, 33166

  • Cooper Gastroenterology at Fire Road /ID# 153048

    Egg Harbor, New Jersey, 08234

  • Dayton Gastroenterology, Inc. /ID# 167632

    Englewood, Ohio, 45415

  • Duplicate_NorthShore University HealthSystem /ID# 150570

    Evanston, Illinois, 60201

  • MediSphere Medical Research Center /ID# 152080

    Evansville, Indiana, 47714-8011

  • Plains Clinical Research Center, LLC /ID# 170291

    Fargo, North Dakota, 58104-5925

  • Ctr for Gastrointestinal Healt /ID# 153369

    Franklin, Virginia, 23851

  • Digestive Health Associates of Texas (DHAT) Research Institute - Garland /ID# 151221

    Garland, Texas, 75044

  • Aurora Medical Center - Grafto /ID# 151726

    Grafton, Wisconsin, 53024

  • Duplicate_NYU Langone Long Island Clinical Research Association /ID# 155271

    Great Neck, New York, 11021

  • Atlantic Gastroenterology Clinical Research /ID# 151901

    Greenville, North Carolina, 27834

  • Gastroenterology Associates, P.A. of Greenville /ID# 150557

    Greenville, South Carolina, 29607

  • Gastroenterology Center of Connecticut /ID# 150534

    Hamden, Connecticut, 06518

  • Palmetto Research, LLC /ID# 151724

    Hialeah, Florida, 33016

  • Northwest Health Care Associates /ID# 151591

    Hoffman Estates, Illinois, 60169

  • Houma Digestive Health Special /ID# 151851

    Houma, Louisiana, 70360

  • Vilo Research Group Inc /ID# 212626

    Houston, Texas, 77017-2337

  • CliniCore International, LLC /ID# 152078

    Houston, Texas, 77027-6812

  • Duplicate_Baylor College of Medicine - Baylor Medical Center /ID# 150538

    Houston, Texas, 77030-3411

  • Centex Studies, Inc. - Houston /ID# 201217

    Houston, Texas, 77058

  • GI Specialists of Houston /ID# 202337

    Houston, Texas, 77070-4347

  • Newport Huntington Medical Group /ID# 217006

    Huntington Beach, California, 92648-5994

  • Indianapolis Gastroenterology /ID# 162914

    Indianapolis, Indiana, 46237

  • Nature Coast Clinical Research - Inverness /ID# 154070

    Inverness, Florida, 34452-4717

  • University of Iowa Hospitals and Clinics /ID# 157059

    Iowa City, Iowa, 52242

  • University of Mississippi Medical Center /ID# 213140

    Jackson, Mississippi, 39216-4500

  • Southern Therapy and Advanced Research (STAR) LLC /ID# 170713

    Jackson, Mississippi, 39216

  • Encore Borland-Groover Clinical Research /Id# 170913

    Jacksonville, Florida, 32256

  • Duplicate_East Tennessee Research Institute /ID# 203611

    Johnson City, Tennessee, 37604

  • SIH Research Mumtaz, Inc /ID# 163199

    Kissimmee, Florida, 34741-4161

  • UC San Diego Health System /ID# 155187

    La Jolla, California, 92037

  • Vector Clinical Trials /ID# 153052

    Las Vegas, Nevada, 89128

  • Dartmouth-Hitchcock Medical Center /ID# 150566

    Lebanon, New Hampshire, 03756

  • South Denver Gastroenterology /ID# 151224

    Lone Tree, Colorado, 80124

  • United Medical Doctors /ID# 207467

    Los Alamitos, California, 90720-3309

  • TLC Clinical Research Inc /ID# 216830

    Los Angeles, California, 90048

  • Gastrointestinal Biosciences Clinical Trials, LLC /ID# 157082

    Los Angeles, California, 90067-2001

  • Duplicate_Caprock Gastro Research, LLC /ID# 215116

    Lubbock, Texas, 79424-3017

  • Gastroenterology Associates of Central Georgia, LLC /ID# 165783

    Macon, Georgia, 31201

  • Cfagi Llc /Id# 202018

    Maitland, Florida, 32751-6108

  • Great Lakes Gastroenterology Research, LLC /ID# 201773

    Mentor, Ohio, 44060-6211

  • Ohio Clinical Research Partner /ID# 154074

    Mentor, Ohio, 44060

  • Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211886

    Mesa, Arizona, 85206

  • Duplicate_University of Miami /ID# 215443

    Miami, Florida, 33136

  • Advanced Pharma CR, LLC /ID# 151723

    Miami, Florida, 33147

  • New Horizon Research Center /ID# 152475

    Miami, Florida, 33165-3372

  • Crystal Pharmacology Research /ID# 151848

    Miami, Florida, 33165

  • Coral Research Clinic /ID# 150524

    Miami, Florida, 33186-4643

  • Wisconsin Center for Advanced Research /ID# 151845

    Milwaukee, Wisconsin, 53215

  • Duplicate_Medical College of Wisconsin /ID# 151850

    Milwaukee, Wisconsin, 53226-3522

  • Facey Medical Foundation /ID# 203135

    Mission Hills, California, 91345

  • East View Medical Research, LLC /ID# 171184

    Mobile, Alabama, 36606

  • CB Flock Research Corporation /ID# 165986

    Mobile, Alabama, 36608

  • Atlantic Digestive Health Inst /ID# 150527

    Morristown, New Jersey, 07960

  • United Medical Doctors - Murrieta /ID# 151213

    Murrieta, California, 92563

  • Quality Medical Research /ID# 203427

    Nashville, Tennessee, 37211

  • Vanderbilt University Medical Center /ID# 153364

    Nashville, Tennessee, 37232-0011

  • Rutgers Robert Wood Johnson /ID# 155247

    New Brunswick, New Jersey, 08901

  • Nola Research Works, LLC /ID# 153365

    New Orleans, Louisiana, 70115

  • Advanced Research Institute, Inc /ID# 163093

    New Port Richey, Florida, 34653

  • Columbia Univ Medical Center /ID# 163409

    New York, New York, 10032-3725

  • Duplicate_DiGiovanna Institute for Medical Education & Research /ID# 201534

    North Massapequa, New York, 11758

  • Advanced Research Institute /ID# 162640

    Ogden, Utah, 84405

  • Hightower Clinical /ID# 216338

    Oklahoma City, Oklahoma, 73102

  • Digestive Disease Specialists /ID# 201057

    Oklahoma City, Oklahoma, 73112

  • Endoscopic Research, Inc. /ID# 151725

    Orlando, Florida, 32803

  • Omega Research Group /ID# 200271

    Orlando, Florida, 32808

  • Ventura County Gastroenterology Medical Group /ID# 163417

    Oxnard, California, 93030-0190

  • Northwest Gastroenterology Clinic /ID# 152528

    Portland, Oregon, 97210

  • Premier Medical Group - GI Division /ID# 153366

    Poughkeepsie, New York, 12601

  • Inland Empire Clinical Trials, LLC /ID# 216163

    Rialto, California, 92377

  • Infinite Clinical Trials /ID# 215342

    Riverdale, Georgia, 30274

  • Mayo Clinic - Rochester /ID# 151681

    Rochester, Minnesota, 55905-0001

  • Gastoenterology Group of Rochester /ID# 151080

    Rochester, New York, 14618-5703

  • Minnesota Gastroenterology PA /ID# 151682

    Saint Paul, Minnesota, 55114

  • Utah Gastroenternology - St. Mark's Office /ID# 163097

    Salt Lake City, Utah, 84124

  • Clinical Associates in Research Therapeutics of America, LLC /ID# 167954

    San Antonio, Texas, 78212

  • Southern Star Research Institute, LLC /ID# 169397

    San Antonio, Texas, 78229-5390

  • San Diego Clinical Trials /ID# 212121

    San Diego, California, 92120

  • Medical Assoc Research Grp /ID# 169149

    San Diego, California, 92123

  • Univ of California San Francis /ID# 164583

    San Francisco, California, 94158

  • Guthrie Medical Group, PC /ID# 150533

    Sayre, Pennsylvania, 18840

  • Virginia Mason Hospital & Medical Center /ID# 153030

    Seattle, Washington, 98101

  • The Polyclinic /ID# 165117

    Seattle, Washington, 98122-4201

  • Louisiana Research Center, LLC /ID# 150526

    Shreveport, Louisiana, 71105-6800

  • Revival Research Institute, LLC /ID# 207281

    Southfield, Michigan, 48034-1659

  • Washington University-School of Medicine /ID# 150537

    St Louis, Missouri, 63110

  • Penn State Health Colonnade /ID# 150267

    State College, Pennsylvania, 16803-2309

  • Richmond University Medical Center /ID# 201860

    Staten Island, New York, 10310-1664

  • Carl R. Meisner Medical Clinic /ID# 171270

    Sugar Land, Texas, 77478

  • Duplicate_Arizona Arthritis & Rheumatology Research, PLLC /ID# 169823

    Sun City, Arizona, 85306

  • Atlanta Gastroenterology Spec /ID# 150565

    Suwanee, Georgia, 30024

  • Clinical Research Trials of Florida, Inc. /ID# 201791

    Tampa, Florida, 33607

  • Duplicate_University of South Florida /ID# 214494

    Tampa, Florida, 33612

  • Duplicate_AdventHealth Tampa /ID# 200274

    Tampa, Florida, 33613-4680

  • Baylor Scott & White Center for Diagnostic Medicine /ID# 204777

    Temple, Texas, 76508

  • Montefiore Medical Center - Moses Campus /ID# 150559

    The Bronx, New York, 10467

  • Advantage Clinical Trials /ID# 163940

    The Bronx, New York, 10468

  • Cotton O'Neil Clinical Research Center, Digestive Health /ID# 167183

    Topeka, Kansas, 66606

  • Adobe Clinical Research LLC /ID# 155249

    Tucson, Arizona, 85712

  • Duplicate_University of Arizona /ID# 150568

    Tucson, Arizona, 85724

  • Options Health Research, LLC /ID# 150569

    Tulsa, Oklahoma, 74104

  • Healthcare Research Consultant /ID# 163096

    Tulsa, Oklahoma, 74135

  • Tyler Research Institute, LLC /ID# 169147

    Tyler, Texas, 75701

  • Carle Foundation Hospital /ID# 151155

    Urbana, Illinois, 61801

  • The Vancouver Clinic, INC. PS /ID# 162334

    Vancouver, Washington, 98664

  • Gastro Health & Nutrition - Victoria /ID# 167764

    Victoria, Texas, 77904

  • Duplicate_Velocity Clinical Research - Salt Lake City /ID# 163180

    West Jordan, Utah, 84088

  • Western States Clinical Res /ID# 158078

    Wheat Ridge, Colorado, 80033-2896

  • Clinical Trials of America /ID# 153453

    Winston-Salem, North Carolina, 27103

  • Duplicate_Atrium Health Wake Forest Baptist Medical Center /ID# 150528

    Winston-Salem, North Carolina, 27157-0001

  • Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 157487

    Wyoming, Michigan, 49519

Other trials in United States

Japan74 sites

  • Tokatsu Tsujinaka Hospital /ID# 214964

    Abiko-shi, Chiba, 270-1168

  • Duplicate_Asahikawa Medical University Hospital /ID# 170281

    Asahikawa-shi, Hokkaido, 078-8510

  • Institute of Science Tokyo Hospital /ID# 152017

    Bunkyo-ku, Tokyo, 113-8519

  • Fukuoka University Chikushi Hospital /ID# 152627

    Chikushino-shi, Fukuoka, 818-8502

  • St. Lukes International Hospital /ID# 208075

    Chuo-ku, Tokyo, 104-8560

  • Fukui Prefectural Hospital /ID# 210450

    Fukui-shi, Fukui, 910-8526

  • Saiseikai Fukuoka Genaral Hospital /ID# 209481

    Fukuoka, Fukuoka, 810-0001

  • Kyushu University Hospital /ID# 152525

    Fukuoka, Fukuoka, 812-8582

  • National Hospital Organization Fukuyama Medical Center /ID# 206294

    Fukuyama-shi, Hiroshima, 720-8520

  • Tokai University Hachioji Hospital /ID# 152584

    Hachioji-shi, Tokyo, 192-0032

  • Hamamatsu University Hospital /ID# 205709

    Hamamatsu, Shizuoka, 431-3192

  • Duplicate_National Hospital Organization Mito Medical Center /ID# 152626

    Higashi Ibaraki-gun, Ibaraki, 311-3193

  • National Hospital Organization Higashi-Ohmi General Medical Center /ID# 210711

    Higashi-ohmi-shi, Shiga, 527-8505

  • National Hospital Organization Hirosaki General Medical Center /ID# 152761

    Hirosaki-shi, Aomori, 036-8545

  • Hiroshima University Hospital /ID# 151952

    Hiroshima, Hiroshima, 734-8551

  • Shimane University Hospital /ID# 208906

    Izumo-shi, Shimane, 693-8501

  • Imamura General Hospital /ID# 227138

    Kagoshima, Kagoshima-ken, 890-0064

  • Idzuro Imamura Hospital /ID# 207640

    Kagoshima, Kagoshima-ken, 892-0824

  • Sameshima Hospital /ID# 206673

    Kagoshima, Kagoshima-ken, 892-0846

  • Kagoshima IBD Gastroenterology Clinic /ID# 245222

    Kagoshima, Kagoshima-ken, 8920804

  • Kanazawa University Hospital /ID# 207810

    Kanazawa, Ishikawa-ken, 920-8641

  • Tsujinaka Hospital - Kashiwanoha /ID# 209572

    Kashiwa-shi, Chiba, 277-0871

  • Saitama Medical Center /ID# 152019

    Kawagoe, Saitama, 350-8550

  • St Marianna University School Of Medicine /ID# 209452

    Kawasaki-shi, Kanagawa, 216-8511

  • Duplicate_Kitakyushu Municipal Medical Center /ID# 152589

    Kitakyushu, Fukuoka, 8020077

  • Aoyama Clinic /ID# 152048

    Kobe, Hyōgo, 650-0015

  • Yamanashi Prefectural Central Hospital /ID# 151909

    Kofu, Yamanashi, 400-8506

  • Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 157820

    Kurashiki-shi, Okayama-ken, 710-0142

  • Kurume University Hospital /ID# 151977

    Kurume-shi, Fukuoka, 830-0011

  • Japanese Red Cross Kyoto Daiichi Hosital /ID# 152358

    Kyoto, Kyoto, 605-0981

  • Kyoto University Hospital /ID# 211808

    Kyoto, Kyoto, 606-8507

  • Kitasato University Kitasato Institute Hospital /ID# 152687

    Minato-ku, Tokyo, 108-8642

  • Kyorin University Hospital /ID# 153195

    Mitaka-shi, Tokyo, 181-8611

  • Iwate Medical University Uchimaru Medical Center /ID# 203412

    Morioka, Iwate, 020-8505

  • Aichi Medical University Hospital /ID# 151994

    Nagakute, Aichi-ken, 480-1195

  • Nagoya University Hospital /ID# 152728

    Nagoya, Aichi-ken, 466-8560

  • Nagoya City University Hospital /ID# 151949

    Nagoya, Aichi-ken, 467-8602

  • Saiseikai Niigata Hospital /ID# 209923

    Niigata, Niigata, 950-1104

  • Duplicate_Niigata University Medical & Dental Hospital /ID# 218050

    Niigata, Niigata, 951-8520

  • Duplicate_Hyogo Medical University Hospital /ID# 152433

    Nishinomiya-shi, Hyōgo, 663-8501

  • Obihiro kosei Hospital /ID# 210425

    Obihiro-shi, Hokkaido, 080-0024

  • Ogaki Municipal Hospital /ID# 208226

    Ogaki-shi, Gifu, 503-8502

  • Ishida Clinic of IBD and Gastroenterology /ID# 210118

    Ōita, Oita Prefecture, 870-0823

  • Duplicate_Okayama University Hospital /ID# 217924

    Okayama, Okayama-ken, 700-8558

  • NHO Nagasaki Medical Center /ID# 210821

    Omura-shi, Nagasaki, 856-8562

  • Kinshukai Infusion Clinic /ID# 207866

    Osaka, Osaka, 530-0011

  • Kitano Hospital, Tazuke Kofukai Medical Research Institute /ID# 210396

    Osaka, Osaka, 530-8480

  • Osaka City General Hospital /ID# 152703

    Osaka, Osaka, 534-0021

  • Osaka Red Cross Hospital /ID# 209477

    Osaka, Osaka, 543-8555

  • Osaka Metropolitan University Hospital /ID# 152681

    Osaka, Osaka, 545-8586

  • Duplicate_Saga University Hospital /ID# 209272

    Saga, Saga-ken, 849-8501

  • Tokitokai Tokito clinic /ID# 152676

    Saitama-shi, Saitama, 336-0963

  • Toho University Sakura Medical Center /ID# 151935

    Sakura-shi, Chiba, 285-8741

  • Sapporo Tokushukai Hospital /ID# 209449

    Sapporo, Hokkaido, 004-0041

  • Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 151705

    Sapporo, Hokkaido, 060-0033

  • Sapporo Medical University Hospital /ID# 206493

    Sapporo, Hokkaido, 060-8543

  • Sapporo Higashi Tokushukai Hospital /ID# 208495

    Sapporo, Hokkaido, 065-0033

  • National Hospital Organization Sendai Medical Center /ID# 209529

    Sendai, Miyagi, 983-8520

  • Duplicate_Center hospital of the National Center for Global Health and Medicine /ID# 209533

    Shinjuku-ku, Tokyo, 162-8655

  • Duplicate_Tokyo Women's Medical University Hospital /ID# 205978

    Shinjuku-ku, Tokyo, 162-8666

  • Tokuyama Central Hospital /ID# 216995

    Shunan-shi, Yamaguchi, 745-8522

  • NHO Shizuoka Medical Center /ID# 163571

    Sunto-gun, Shizuoka, 411-8611

  • Shoyukai Fujita Gastroenterological Hospital /ID# 216494

    Takatsuki-shi, Osaka, 569-0086

  • Teikyo University Hospital /ID# 209865

    Tokyo, 173-8605

  • Toyohashi Municipal Hospital /ID# 171470

    Toyohashi, Aichi-ken, 441-8570

  • Toyonaka Municipal Hospital /ID# 217083

    Toyonaka-shi, Osaka, 560-0055

  • Ieda Hospital /ID# 157782

    Toyota-shi, Aichi-ken, 470-1219

  • Mie University Hospital /ID# 207253

    Tsu, Mie-ken, 514-8507

  • Juntendo University Urayasu Hospital /ID# 208783

    Urayasu-shi, Chiba, 279-0021

  • Yamagata University Hospital /ID# 171468

    Yamagata, Yamagata, 990-9585

  • Kenseikai Dongo Hospital /ID# 208102

    Yamatotakada-shi, Nara, 635-0022

  • Yokkaichi Hazu Medical Center /ID# 214349

    Yokkaichi-shi, Mie-ken, 510-0016

  • SHOWA Medical University Fujigaoka Hospital /ID# 208223

    Yokohama, Kanagawa, 227-8501

  • Yokohama City University Medical Center /ID# 169900

    Yokohama, Kanagawa, 232-0024

Other trials in Japan

Canada16 sites

  • University of Calgary /ID# 151818

    Calgary, Alberta, T2N 4Z6

  • Allen Whey Khye Lim Professional Corporation /ID# 211169

    Edmonton, Alberta, T5R 1W2

  • University of Alberta Hospital /ID# 151824

    Edmonton, Alberta, T6G 2B7

  • Covenant Health /ID# 158931

    Edmonton, Alberta, T6K 4B2

  • Medicor Research Inc /ID# 151825

    Greater Sudbury, Ontario, P3A 1W8

  • CISSS de la Monteregie /ID# 159271

    Greenfield Park, Quebec, J4V 2H1

  • Duplicate_Hamilton Health Sciences -McMaster University Medical Centre /ID# 150477

    Hamilton, Ontario, L8S 4K1

  • OCT Research ULC /ID# 153179

    Kelowna, British Columbia, V1Y 1Z9

  • Duplicate_CISSS de Chaudière-Appalaches, Hôpital Hotel-Dieu de Lévis /ID# 150473

    Lévis, Quebec, G6V 3Z1

  • Recherche GCP Research /ID# 151819

    Montreal, Quebec, H1M 1B1

  • Centre Hospitalier de l'Universite de Montreal - CRCHUM /ID# 167170

    Montreal, Quebec, H2X 0A9

  • Montreal General Hospital - McGill University Health Centre /ID# 170013

    Montreal, Quebec, H3G 1A4

  • Ottawa Hospital Research Institute /ID# 151817

    Ottawa, Ontario, K1H 8L6

  • CIUSSS de l'Estrie - CHUS /ID# 150478

    Sherbrooke, Quebec, J1G 2E8

  • Toronto Digestive Disease Associates /ID# 150475

    Vaughan, Ontario, L4L 4Y7

  • Percuro Clinical Research, Ltd /ID# 150479

    Victoria, British Columbia, V8V 3M9

Other trials in Canada

China16 sites

  • The First Hospital of Jilin University /ID# 210087

    Changchun, Jilin, 130021

  • Duplicate_Xiangya Hospital Central South University /ID# 167230

    Changsha, Hunan, 410008

  • West China Hospital, Sichuan University /ID# 167041

    Chengdu, Sichuan, 610041

  • The First Affiliated Hospital, Sun Yat-sen University /ID# 150517

    Guangzhou, Guangdong, 510080

  • The Sixth Affiliated Hospital of Sun Yat-sen University /ID# 150518

    Guangzhou, Guangdong, 510655

  • The Second Affiliated Hospital of Zhejiang University School of Medicine /ID# 165813

    Hangzhou, Zhejiang, 310009

  • Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 150516

    Hangzhou, Zhejiang, 310018

  • The First Affiliated Hospital of Nanchang University /ID# 212185

    Nanchang, Jiangxi, 330006

  • Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 150523

    Shanghai, Shanghai Municipality, 200065

  • Shanghai Tenth People's Hospital /ID# 150522

    Shanghai, Shanghai Municipality, 200072

  • Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 165826

    Shanghai, Shanghai Municipality, 200127

  • Shengjing Hospital of China Medical University /ID# 166921

    Shenyang, Liaoning, 110022

  • Affiliated Taihe Hospital of Hubei University of Medicine /ID# 216407

    Shiyan, Hubei, 442700

  • Tianjin Medical University General Hospital /ID# 170605

    Tianjin, Tianjin Municipality, 300052

  • Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 167089

    Wuhan, Hubei, 430022

  • Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 167079

    Wuhan, Hubei, 430022

Other trials in China

Germany10 sites

  • MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 151697

    Berlin, 10825

  • Duplicate_Agaplesion Markus Krankenhaus /ID# 161870

    Frankfurt am Main, Hesse, 60431

  • Gastroenterologische Gemeinschaftspraxis Herne /ID# 214575

    Herne, North Rhine-Westphalia, 44623

  • Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 161871

    Kiel, Schleswig-Holstein, 24105

  • Universitatsklinikum Mannheim /ID# 150405

    Mannheim, Baden-Wurttemberg, 68167

  • Duplicate_Universitaetsklinikum Muenster /ID# 150402

    Munster, Lower Saxony, 48149

  • Medizinisches Versorgungszentrum Portal 10 /ID# 207136

    Münster, 48155

  • Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 215812

    Saarbrücken, Saarland, 66111

  • Universitaetsklinikum Tuebingen /ID# 151698

    Tübingen, Baden-Wurttemberg, 72076

  • Praxis medicum /ID# 150404

    Wiesbaden, 65189

Other trials in Germany

Italy10 sites

  • Duplicate_IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 150424

    Bologna, Emilia-Romagna, 40138

  • ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico /ID# 150605

    Milan, Milano, 20122

  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico /ID# 150421

    Milan, 20122

  • IRCCS Ospedale Sacro Cuore Don Calabria /ID# 201726

    Negrar, Verona, 37024

  • Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 150263

    Palermo, 90146

  • ASST Rhodense/Presidio Ospedaliero di Rho /ID# 216673

    Rho, Milano, 20017

  • Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 150425

    Rome, Roma, 00133

  • Duplicate_Azienda Ospedaliera San Camillo Forlanini /ID# 151362

    Rome, Roma, 00152

  • Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 150420

    Rome, Roma, 00168

  • IRCCS Istituto Clinico Humanitas /ID# 151363

    Rozzano, Lombardy, 20089

Other trials in Italy

Russia10 sites

  • Immanuel Kant Baltic Federal University /ID# 202129

    Kaliningrad, Kaliningrad Oblast, 236016

  • Kazan State Medical University /ID# 166040

    Kazan', Tatarstan, Respublika, 420012

  • Olla-Med Clinic /ID# 215334

    Moscow, 105554

  • Perm Clinical Center of the Federal Medical and Biological Agency /ID# 150634

    Perm, Permskiy Kray, 614109

  • Republican hospital named after V.A. Baranov /ID# 206508

    Petrozavodsk, Murmansk Oblast, 185019

  • Euromedservice /ID# 208968

    Pushkin, 196603

  • LLC Novaya Klinika /ID# 208106

    Pyatigorsk, Stavropol Kray, 357500

  • NW State Medical Univ na Mechn /ID# 169332

    Saint Petersburg, Leningradskaya Oblast', 191015

  • Medical Company Hepatology /ID# 200208

    Samara, Samara Oblast, 443011

  • Duplicate_Stavropol State Medical Univ /ID# 150635

    Stavropol, 355017

Other trials in Russia

South Korea10 sites

  • Dong-A University Medical Center /ID# 161568

    Busan, Busan Gwang Yeogsi, 49201

  • Pusan National University Hospital /ID# 161569

    Busan, Busan Gwang Yeogsi, 49241

  • Yeungnam University Medical Center /ID# 150432

    Daegu, 42415

  • Duplicate_Hanyang University Gurihospital /ID# 150431

    Guri-si, Gyeonggido, 11923

  • Duplicate_CHA University Bundang Medical Center /ID# 161567

    Seongnam, Gyeonggido, 13496

  • Kangbuk Samsung Hospital /ID# 150435

    Seoul, Seoul Teugbyeolsi, 03181

  • Asan Medical Center /ID# 159155

    Seoul, Seoul Teugbyeolsi, 05505

  • Samsung Medical Center /ID# 150433

    Seoul, Seoul Teugbyeolsi, 06351

  • Yonsei University Health System Severance Hospital /ID# 161566

    Seoul, 03722

  • The Catholic University Of Korea St. Vincent's Hospital /ID# 150434

    Suwon, Gyeonggido, 16247

Other trials in South Korea

Spain10 sites

  • Complejo Hospitalario Universitario A Coruña /ID# 203912

    A Coruña, A Coruna, 15006

  • Hospital Clinic de Barcelona /ID# 150598

    Barcelona, 08036

  • Duplicate_Hospital Universitario Reina Sofia /ID# 154031

    Córdoba, 14004

  • Hospital Universitario Dr. Negrin /ID# 203965

    Las Palmas de Gran Canaria, Las Palmas, 35019

  • Hospital Universitario Ramon y Cajal /ID# 171491

    Madrid, 28034

  • Hospital Universitario La Paz /ID# 214541

    Madrid, 28046

  • Hospital Universitario de Salamanca /ID# 150590

    Salamanca, 37711

  • Hospital Universitario Marques de Valdecilla /ID# 216621

    Santander, Cantabria, 39008

  • Duplicate_Hospital Clínico Universitario de Santiago-CHUS /ID# 171492

    Santiago de Compostela, A Coruna, 15706

  • Hospital Universitario y Politecnico La Fe /ID# 150591

    Valencia, 46026

Other trials in Spain

Ukraine10 sites

  • Municipal Enterprise "I.I. Mechnikov Dnipropetrovsk Regional Clinical Hospital" /ID# 207731

    Dnipro, 49005

  • CNCE of Kharkiv Regional Council Regional Clinical Hospital /ID# 206941

    Kharkiv, Kharkiv Oblast, 61058

  • PE PMC Acinus, Medical and Diagnostic Center /ID# 217219

    Kropyvnytskyi, 25006

  • Kyiv City Clinical Hospital No.18 /ID# 150505

    Kyiv, 01030

  • Medical Center of LLC "Medical Center "Consilium Medical" /ID# 217448

    Kyiv, 04050

  • CNPE of Kyiv Regional Council Kyiv Regional Hospital /ID# 217374

    Kyiv, 04073

  • Lviv Regional Clinical Hospital /ID# 150508

    Lviv, Lviv Oblast, 79010

  • Municipal Non-Commercial Enterprise Odesa Regional Clinical Hospital of the Od /ID# 162502

    Odesa, Odesa Oblast, 65025

  • Medical Center of the “Health /ID# 162501

    Vinnytsia, Vinnytsia Oblast, 21009

  • MNE Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrogov /ID# 216302

    Vinnytsia, Vinnytsia Oblast, 21018

Other trials in Ukraine

Croatia8 sites

  • Duplicate_Poliklinika Solmed /ID# 211567

    Grad Zagreb, City of Zagreb, 10000

  • Duplicate_Klinicki bolnicki centar Osijek /ID# 150229

    Osijek, County of Osijek-Baranja, 31000

  • Klinicki bolnicki centar Rijeka /ID# 150714

    Rijeka, Primorje-Gorski Kotar County, 51000

  • Klinicki Bolnicki Centar (KBC) Split /ID# 213989

    Split, Split-Dalmatia County, 21000

  • Zadar General Hospital /ID# 150261

    Zadar, 23000

  • Klinicka bolnica Dubrava Zagreb /ID# 150228

    Zagreb, City of Zagreb, 10000

  • Klinicki bolnicki centar Zagreb /ID# 150262

    Zagreb, City of Zagreb, 10000

  • Klinicki bolnicki centar Zagreb /ID# 150715

    Zagreb, City of Zagreb, 10000

Other trials in Croatia

Portugal8 sites

  • Duplicate_Hospital Garcia de Orta, EPE /ID# 151622

    Almada, Setúbal District, 2805-267

  • 2CA-Braga, Hospital de Braga /ID# 151617

    Braga, 4710-243

  • Duplicate_Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 151616

    Guimarães, Braga District, 4835-044

  • Duplicate_Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Cap /ID# 151620

    Lisbon, 1169-050

  • Unidade Local de Saude de Santa Maria, EPE /ID# 151615

    Lisbon, 1649-035

  • Unidade Local de Saude Sao Joao, EPE /ID# 151619

    Porto, 4200-319

  • Centro Hospitalar de Entre Douro e Vouga /ID# 152336

    Santa Maria DA Feira, Porto District, 4520-211

  • Unidade Local de Saude do Alto Minho, EPE /ID# 151618

    Viana do Castelo, 4904-858

Other trials in Portugal

Serbia8 sites

  • Clinical Hosp Center Zvezdara /ID# 150641

    Belgrade, Beograd, 11000

  • Military Medical Academy /ID# 150643

    Belgrade, Beograd, 11000

  • University Clinical Center Serbia /ID# 150642

    Belgrade, Beograd, 11000

  • Clin Hosp Ctr Bezanijska Kosa /ID# 150640

    Belgrade, Beograd, 11080

  • University Clinical Center Kragujevac /ID# 150644

    Kragujevac, Sumadijski Okrug, 34000

  • General Hospital Leskovac /ID# 217882

    Leskovac, Jablanicki Okrug, 16000

  • Duplicate_University Clinical Center of Nis /ID# 151902

    Niš, Nisavski Okrug, 18000

  • University Clinical Center Vojvodina /ID# 150759

    Novi Sad, 21000

Other trials in Serbia

South Africa8 sites

  • MD Search /ID# 157524

    Boksburg North, Gauteng, 1460

  • Kingsbury Hospital /ID# 150587

    Cape Town, Western Cape, 7708

  • Private Practice Dr MN Rajabally /ID# 155145

    Cape Town, Western Cape, 7800

  • Spoke Research Inc /ID# 162203

    CAPE TOWN Milnerton, Western Cape, 7441

  • Clinresco Centers /ID# 163625

    Johannesburg, Gauteng, 1619

  • Lenasia Clinical Trial Centre /ID# 214361

    Johannesburg, Gauteng, 1820

  • Wits Clinical Research /ID# 150586

    Johannesburg, Gauteng, 1864

  • Wits Clinical Research , Wits Health Consortium (PTY) Ltd /ID# 157730

    Johannesburg, Gauteng, 2193

Other trials in South Africa

United Kingdom8 sites

  • Hampshire Hospitals NHS Foundation Trust /ID# 150511

    Basingstoke, Essex, RG24 9NA

  • Duplicate_Royal United Hospitals Bath /ID# 154211

    Bath, Bath And North East Somerset, BA1 3NG

  • University Hospitals Birmingham NHS Foundation Trust /ID# 150513

    Birmingham, B15 2TH

  • Royal Devon & Exeter Hospital /ID# 150510

    Exeter, Devon, EX2 5DW

  • Queen Elizabeth University Hospital - NHS Greater Glasgow and Clyde /ID# 163788

    Glasgow, Lanarkshire, G51 4TF

  • Calderdale and Huddersfield NHS Foundation Trust /ID# 217659

    Huddersfield, HX3 0PW

  • Disc_Barts Health NHS Trust - The Royal London Hospital /ID# 150515

    London, Greater London, E1 2ES

  • Duplicate_St George's University Hospitals NHS Foundation Trust /ID# 208376

    London, Greater London, SW17 0QT

Other trials in United Kingdom

Brazil7 sites

  • Upeclin Fmb - Unesp /Id# 152493

    Botucatu, São Paulo, 18618-686

  • Hospital Nossa Senhora das Graças /ID# 152488

    Curitiba, Paraná, 80810-040

  • Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 153744

    Goiânia, Goiás, 74535-170

  • Hospital de Clinicas de Porto Alegre /ID# 153745

    Porto Alegre, Rio Grande do Sul, 90035-903

  • Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto /ID# 152492

    Ribeirão Preto, São Paulo, 14049-900

  • Faculdade de Medicina do ABC /ID# 152489

    Santo André, La Spezia, 09060-870

  • Kaiser Clinica e Hospital Dia /ID# 152491

    São José do Rio Preto, São Paulo, 15015-110

Other trials in Brazil

Czechia7 sites

  • Hepato-Gastroenterologie HK, s.r.o. /ID# 150946

    Hradec Králové, 500 12

  • CTCenter MaVe s.r.o. /ID# 150903

    Olomouc, 779 00

  • ARTROSCAN s.r.o. /ID# 150502

    Ostrava, 722 00

  • Nemocnice Pardubickeho kraje, a.s. /ID# 213541

    Pardubice, 530 03

  • Iscare Klinické Centrum /ID# 209279

    Prague, Praha 9, 190 00

  • Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 216224

    Prague, 118 33

  • Axon Clinical, s.r.o. /ID# 152477

    Prague, 140 00

Other trials in Czechia

Greece7 sites

  • General Hospital of Athens Laiko /ID# 208672

    Athens, Attica, 11527

  • General Hospital of Chest Diseases of Athens SOTIRIA /ID# 202101

    Athens, Attica, 11527

  • General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 150406

    Athens, 10676

  • University General Hospital of Heraklion PA.G.N.I /ID# 150236

    Heraklion, Crete, 71500

  • University General Hospital of Ioannina /ID# 164247

    Ioannina, 45500

  • Theageneio Anticancer Hospital /ID# 164187

    Thessaloniki, 54639

  • General Hospital of Thessaloniki Hippokrateio /ID# 209522

    Thessaloniki, 54642

Other trials in Greece

Poland7 sites

  • Endoskopia Sp. z o.o. /ID# 152940

    Sopot, Pomeranian Voivodeship, 81-756

  • Gastromed Sp. z o.o /ID# 216198

    Torun, Kuyavian-Pomeranian Voivodeship, 87-100

  • Centrum Zdrowia MDM /ID# 150626

    Warsaw, Masovian Voivodeship, 00-189

  • Panstwowy Instytut Medyczny MSWiA w Warszawie /ID# 150627

    Warsaw, Masovian Voivodeship, 02-507

  • Centrum Medyczne Reuma Park /ID# 150624

    Warsaw, Masovian Voivodeship, 02-665

  • Vivamed Sp. z o.o. /ID# 216743

    Warsaw, Masovian Voivodeship, 03-580

  • Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 215733

    Warsaw, Masovian Voivodeship, 04-730

Other trials in Poland

Argentina6 sites

  • Hospital Britanico de Buenos Aires /ID# 209496

    Ciudad Autonoma de Buenos Aire, Buenos Aires, 1280

  • Gedyt /ID# 210016

    Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1115

  • Mautalen Salud e Investigacion /ID# 171174

    Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1128

  • Hospital Privado Universitario - Hospital Privado Centro Medico de Cordoba S.A. /ID# 164186

    Córdoba, 5016

  • Cardio Alem /ID# 211281

    San Isidro, Buenos Aires, 1642

  • Sanatorio 9 de Julio /ID# 150215

    San Miguel de Tucumán, Tucumán Province, 4000

Other trials in Argentina

Australia6 sites

  • Monash Health - Monash Medical Centre /ID# 150218

    Clayton, Victoria, 3168

  • St Vincent's Hospital Melbourne /ID# 152503

    Fitzroy Melbourne, Victoria, 3065

  • Macquarie University Hospital /ID# 211953

    Macquarie University, New South Wales, 2109

  • Fiona Stanley Hospital /ID# 211641

    Murdoch, Western Australia, 6150

  • Mater Misericordiae Limited /ID# 212686

    South Brisbane, Queensland, 4101

  • Griffith University /ID# 211954

    Southport, Queensland, 4222

Other trials in Australia

Chile6 sites

  • Hospital Guillermo Grant Benavente de Concepción /ID# 212425

    Concepción, Biobio, 4070038

  • CTR Estudios Clinicos /ID# 200111

    Providencia, Region Metropolitana Santiago, 7500571

  • M y F Estudios Clínicos /ID# 200112

    Santiago, Region Metropolitana Santiago, 7750495

  • Research Group /ID# 203177

    Santiago, Santiago Metropolitan, 2540364

  • Hospital Clinico Universidad De Los Andes /ID# 207427

    Santiago, 7501504

  • Centro de Investigaciones Clínicas Viña del Mar /ID# 150226

    Viña del Mar, Valparaiso, 2540488

Other trials in Chile

France6 sites

  • Centre Hospitalier Departemental Vendee (Chd Vendee) /ID# 165749

    La Roche-sur-Yon, Vendee, 85925

  • CHRU Lille - Hopital Claude Huriez /ID# 152609

    Lille, Nord, 59037

  • CHU Montpellier - Hopital Saint Eloi /ID# 200088

    Montpellier, Herault, 34295

  • Chu de Nice-Hopital Larchet Ii /Id# 152608

    Nice, Alpes-Maritimes, 06202

  • HCL - Hopital Lyon Sud /ID# 152540

    Pierre-Bénite, Rhone, 69495

  • CHU de Saint-Etienne, Hopital Nord /ID# 165756

    Saint-Etienne, 42270

Other trials in France

Hungary6 sites

  • Bekes Megyei Kozponti Korhaz /ID# 151601

    Békéscsaba, 5600

  • Semmelweis Egyetem /ID# 150409

    Budapest, 1085

  • Meditres Kft. /ID# 151597

    Kecskemét, Bács-Kiskun county, 6000

  • Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet /ID# 151599

    Sopron, 9400

  • Mentahaz Maganorvosi Kozpont /ID# 206977

    Székesfehérvár, 8000

  • Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 150410

    Szombathely, Vas County, 9700

Other trials in Hungary

Slovakia6 sites

  • Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 150869

    Banská Bystrica, Banská Bystrica Region, 975 17

  • Medak s.r.o. /ID# 150550

    Bratislava, 851 01

  • Slovak Research Center Team Me /ID# 150240

    Ilava, 019 01

  • B+B MED, s.r.o. /ID# 150584

    Košice, Košice Region, 040 01

  • Fakultna nemocnica s poliklinikou Nove Zamky /ID# 211371

    Nové Zámky, Nitra Region, 940 34

  • Gastro I., s.r.o. /ID# 150585

    Prešov, Presov, 080 01

Other trials in Slovakia

Taiwan6 sites

  • Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 150606

    Kaohsiung City, 807

  • Duplicate_Chung Shan Medical University Hospital /ID# 150603

    Taichung, 40201

  • China Medical University Hospital /ID# 150600

    Taichung, 40447

  • National Cheng Kung University Hospital /ID# 151751

    Tainan, 704

  • Taipei Veterans General Hosp /ID# 151750

    Taipei, 11217

  • National Taiwan University Hospital /ID# 150604

    Taipei City, Taipei, 100

Other trials in Taiwan

Turkey (Türkiye)6 sites

  • Istanbul University Cerrahpasa Faculty of Medicine /ID# 150491

    Cerrahpaşa, 34098

  • Umraniye Training and Res Hosp /ID# 163136

    Istanbul, 34764

  • Marmara University Medical Fac /ID# 214573

    Istanbul, 34899

  • Duplicate_Erciyes University Medical Fac /ID# 150495

    Melikgazi, Kayseri, 38030

  • Mersin University Medical /ID# 163135

    Mersin, 33343

  • Gazi Universitesi Tip Fakultes /ID# 150493

    Yenimahalle, Ankara, 06560

Other trials in Turkey (Türkiye)

Bosnia and Herzegovina5 sites

  • Duplicate_University Clinical Centre of the Republic of Srpska /ID# 150223

    Banja Luka, Republika Srpska, 78000

  • Duplicate_University Clinical Centre of the Republic of Srpska /ID# 150712

    Banja Luka, Republika Srpska, 78000

  • University Clinical Hospital Mostar /ID# 150711

    Mostar, 88000

  • Clinical Center University of Sarajevo /ID# 150222

    Sarajevo, 71000

  • University Clinical Center Tuzla /ID# 150224

    Tuzla, Tuzlanski, 75000

Other trials in Bosnia and Herzegovina

Finland5 sites

  • Duplicate_Helsinki Univ Central Hospital /ID# 154283

    Helsinki, 00290

  • Keski-Suomen Sairaala Nova /ID# 155665

    Jyväskylä, 40620

  • Laakarikeskus Ikioma /ID# 150377

    Mikkeli, 50100

  • Tampereen yliopistollinen sairaala /ID# 150376

    Tampere, Pirkanmaa, 33520

  • Turku University Hospital /ID# 169895

    Turku, Southwest Finland, 20520

Other trials in Finland

Ireland5 sites

  • Mercy University Hospital /ID# 153794

    Cork, T12 WE28

  • St James Hospital /ID# 150413

    Dublin, Dublin, D08 NHY1

  • Beaumont Hospital /ID# 150414

    Dublin, D09 XR63

  • St Vincents University Hospital /ID# 150411

    Elm Park, Dublin, D04 T6F4

  • University Hospital Galway /ID# 150412

    Galway, H91 YR71

Other trials in Ireland

Netherlands5 sites

  • Amsterdam UMC, locatie AMC /ID# 150617

    Amsterdam, North Holland, 1105 AZ

  • Leids Universitair Medisch Centrum /ID# 152625

    Leiden, South Holland, 2333 ZA

  • Radboud Universitair Medisch Centrum /ID# 151701

    Nijmegen, Gelderland, 6525 GA

  • Duplicate_Erasmus Medisch Centrum /ID# 150619

    Rotterdam, South Holland, 3015 GD

  • Universitair Medisch Centrum Utrecht /ID# 152776

    Utrecht, 3584 CX

Other trials in Netherlands

Austria4 sites

  • Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 150462

    Linz, Upper Austria, 4010

  • Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 150463

    Salzburg, 5020

  • Klinik Landstrasse /ID# 162867

    Vienna, State of Vienna, 1030

  • Medizinische Universitaet Wien /ID# 150616

    Vienna, State of Vienna, 1090

Other trials in Austria

Estonia4 sites

  • North Estonia Medical Centre /ID# 160871

    Mustamäe, Harju, 13419

  • West Tallinn Central Hospital /ID# 150490

    Tallinn, Harju, 10617

  • East Tallinn Central Hospital - Magdaleena Unit /ID# 150488

    Tallinn, Harju, 11312

  • Tartu University Hospital /ID# 150489

    Tartu, 50406

Other trials in Estonia

Israel4 sites

  • Soroka University Medical Center /ID# 156562

    Beersheba, Southern District, 8410101

  • Rambam Health Care Campus /ID# 150416

    Haifa, 3109601

  • Shaare Zedek Medical Center /ID# 163139

    Jerusalem, Jerusalem, 91031

  • Hadassah Medical Center-Hebrew University /ID# 165119

    Jerusalem, Jerusalem, 91120

Other trials in Israel

Lithuania4 sites

  • Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 150439

    Kaunas, 50161

  • Klaipeda university hospital /ID# 163501

    Klaipėda, 92288

  • Klaipeda University Hospital /ID# 163719

    Klaipėda, 92288

  • Duplicate_Vilnius University Hospital /ID# 164172

    Vilnius, LT-08661

Other trials in Lithuania

Malaysia4 sites

  • Hospital Sultanah Bahiyah /ID# 152310

    Alor Star, Kedah, 05460

  • Hospital Ampang /ID# 152311

    Ampang, Selangor, 68000

  • Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 152313

    Kuala Lumpur, Selangor, 56000

  • Uni Malaya MC /ID# 150440

    Kuala Lumpur, 59100

Other trials in Malaysia

Switzerland4 sites

  • University Hospital Basel /ID# 161732

    Basel Town, Canton of Basel-City, 4031

  • Inselspital, Universitaetsspital Bern /ID# 152602

    Bern, 3010

  • Kantonsspital St. Gallen /ID# 152601

    Sankt Gallen, Canton of St. Gallen, 9007

  • University Hospital Zurich /ID# 152603

    Zurich, Canton of Zurich, 8091

Other trials in Switzerland

Belgium3 sites

  • AZ Maria Middelares /ID# 150466

    Ghent, 9000

  • Universitair Ziekenhuis Leuven /ID# 150468

    Leuven, Vlaams-Brabant, 3000

  • AZ-Delta /ID# 150467

    Roeselare, West-Vlaanderen, 8800

Other trials in Belgium

Colombia3 sites

  • Coorp Hosp Juan Ciudad Sede Hospital Universitario Mayor Mederi /ID# 152811

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  • Imat Oncomedica /ID# 207052

    Montería, Departamento de Córdoba, 230018

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Mexico3 sites

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  • Centro Regiomontano de Estudios Clínicos ROMA S.C /ID# 150265

    Monterrey, Nuevo León, 64610

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Singapore3 sites

  • National University Hospital /ID# 150583

    Singapore, 119074

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    Singapore, 258499

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    Singapore, 308433

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Latvia2 sites

  • VCA Polyclinic Aura /ID# 150436

    Riga, 1035

  • Pauls Stradins Clinical University Hospital /ID# 153183

    Riga, LV-1002

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Norway2 sites

  • Akershus Universitetssykehus_MAIN /ID# 150622

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  • Universitetssykehuset I Nord-Norge /ID# 152836

    Tromsø, Troms, 9019

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Belarus1 site

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    Vitebsk, 210001

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Puerto Rico1 site

  • School of Medicine University of Puerto Rico-Medical Science Campus /ID# 150629

    San Juan, 00935

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Sweden1 site

  • Duplicate_Sahlgrenska University Hospital /ID# 152326

    Gothenburg, Västra Götaland County, 413 45

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About this study

Official title: A Phase 3 Multicenter, Long-Term Extension Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) in Subjects With Ulcerative Colitis

This study is designed to evaluate the long-term safety and efficacy of Upadacitinib in participants with ulcerative colitis (UC) who have not responded at the end of the induction period in Study M14-234 Substudy 1, who have had loss of response during the maintenance period of Study M14-234 Substudy 3, or who have successfully completed Study M14-234 Substudy 3.

Being tested
Upadacitinib (ABT-494), Placebo
Keywords
Ulcerative Colitis (UC), Upadacitinib (ABT-494), Long Term Extension (LTE), Safety, Efficacy, RINVOQ
Medical subject headings
Colitis, Ulcerative

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Upadacitinib (ABT-494)Drug

    Also called RINVOQ

    Upadacitinib (ABT-494) will be administered orally.

  • PlaceboDrug

    Placebo will be administered orally.

Study groups in NCT03006068
Study groupRoleWhat they receive
Participants receiving Upadacitinib (ABT-494) Dose AExperimentalThe participants in this arm will receive Upadacitinib (ABT-494) dose A.
Receives: Drug: Upadacitinib (ABT-494)
Participants receiving Upadacitinib (ABT-494) Dose BExperimentalThe participants in this arm will receive Upadacitinib (ABT-494) dose B.
Receives: Drug: Upadacitinib (ABT-494)
Participants receiving Upadacitinib (ABT-494) Dose A or Dose BExperimentalThe participants in this arm will receive Upadacitinib (ABT-494) dose A or dose B.
Receives: Drug: Upadacitinib (ABT-494)
Participants receiving PlaceboExperimentalThe participants in this arm will receive placebo until study is unblinded.
Receives: Drug: Placebo
Participants receiving Upadacitinib (ABT-494) Dose CExperimentalThe participants in this arm will receive Upadacitinib (ABT-494) dose C.
Receives: Drug: Upadacitinib (ABT-494)

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Assessing Treatment-Emergent Adverse Events

    Treatment-emergent adverse events are defined as events that begin or worsen either on or after the first dose of the study drug and within 30 days after the last dose of the study drug in the analysis period.

    Measured: Up to 288 Weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted30 Dec 2016 (estimated)
  2. Study start31 Jan 2017
  3. Primary completionJul 2027 (estimated)
  4. Study completionJul 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Non-randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
950 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT03006068
Sponsor's protocol ID
M14-533
Other IDs
2023-505699-31-00, 2023
Acronym
U-ACTIVATE
Status last verified
Jan 2026
First submitted
20 Dec 2016
Last updated
12 Jan 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: AbbVie is committed to responsible clinical trial data sharing. This includes access to anonymized, individual and trial-level data (analysis data sets), as well as other information.

Publications

  • Panaccione R, Panes J, Peyrin-Biroulet L, Colombel JF, Lindsay JO, Baert F, Atreya R, Vermeire S, Fujii T, Dubcenco E, Klaff J, Duncan B, Suravaram S, Fish I, Lacerda AP, Vladea R, Ford S, Shah S, Anyanwu SI, Rubin DT. Long-Term Safety of Upadacitinib in Patients With Inflammatory Bowel Disease: Integrated Analysis of Phase 2/3 Studies. Clin Gastroenterol Hepatol. 2026 Feb 27:S1542-3565(26)00145-X. doi: 10.1016/j.cgh.2026.02.018. Online ahead of print.

    PubMed 41763462

  • Panaccione R, Vermeire S, Danese S, Higgins PDR, Lichtenstein GR, Nakase H, Glover S, Colombel JF, Eccleston J, Kujawski M, Remple V, Yao X, Geng Z, Palac H, Sharma D, Suravaram S, Schreiber S. Long-term efficacy and safety of upadacitinib in patients with moderately to severely active ulcerative colitis: an interim analysis of the phase 3 U-ACTIVATE long-term extension study. Lancet Gastroenterol Hepatol. 2025 Jun;10(6):507-519. doi: 10.1016/S2468-1253(25)00017-2.

    PubMed 40347957

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Upadacitinib (ABT-494) in people with Ulcerative Colitis (UC), run by AbbVie at 492 sites in 46 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 12 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 492 sites in United States, Japan, Canada, China, Germany and 41 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Assessing Treatment-Emergent Adverse Events (time frame: Up to 288 Weeks). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT03006068, which also lists 2 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Jan 2026.

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