LungcancerRexochirNCT03020251
Effects of Preoperative Rehabilitation in Patients Resected for Lung Cancer
A study testing preoperative chest physiotherapy and preoperative rehabilitation program in people with Lungcancer, run by Centre Jean Perrin at 6 sites in France.
Trial summary
This randomized controlled trial will evaluate the effect of a preoperative rehabilitation program at home in patients resected for lung cancer, comparing a control group (C group) receiving only chest physiotherapy and a rehabilitation group (R group) receiving both a training program at home and chest physiotherapy Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Lungcancer
- What is being tested?
- preoperative chest physiotherapy and preoperative rehabilitation program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 90 participants
- Where
- 6 sitesFrance
- Study dates
- 12 May 2017to 13 Feb 2026
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients diagnosed for lung cancer (or highly suspicious for cancer tumor) eligible for resection surgery (lobectomy or pneumonectomy)
- Age > 18 years
- Presence of Chronic Obstructive Pulmonary Disease (COPD) stages 2-4 of Gold (forced expiratory volume (FEV )/ forced vital capacity (FVC) <70%, FEV <80% of predicted) and Exertional dyspnea stage MMRC (Medical Research Council) > 1
- Patients must provide written consent
- Member of social security scheme
Who cannot join
- Patients refusing to participate
- COPD stage 1 Gold (VEMS >= 80% of the theoretical value)
- Presenting an operating contraindication during the initial maximal exercise test
- Presenting cardiac or vascular contraindication to achieve the readaptation program
- Patient living alone at home
- Patient with ventilatory assistance at home (oxygen therapy or noninvasive ventilation (NIV))
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- With exercise hypoventilation (PaCO2 >45 mmHg)
- Cognitive difficulty
- unable major
- pregnancy,
- patients deprived of liberty by a court or administrative decision
Trial locations and contacts
6 sites in 1 country.
6 sites in 1 country
France6 sites
CHU Clermont Ferrand, Gabriel Montpied, service de médecine du sport et explorations fonctionnelles,
Clermont-Ferrand, 63000
Centre de Recherche en Nutrition Humaine
Clermont-Ferrand, 63009
Centre Jean Perrin
Clermont-Ferrand, 63011
CHU Grenoble, Hôpital Michallon
Grenoble, 38700
Hospices Civiles de Lyon, groupement hospitalier Est, Hopital Louis Pradel
Lyon, 69677
CHU Saint-Etienne, CHU Hopital Nord
Saint-Etienne, 42055
About this study
This randomized controlled trial will evaluate the effect of a preoperative rehabilitation program at home in patients resected for lung cancer, comparing a control group (C group) receiving only chest physiotherapy and a rehabilitation group (R group) receiving both a training program at home and chest physiotherapy
- Conditions
- Lungcancer
- Being tested
- preoperative chest physiotherapy, preoperative rehabilitation program
- Keywords
- preoperative rehabilitation program, chest physiotherapy, lung cancer resection
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
preoperative chest physiotherapyOther
preoperative chest physiotherapy : 5 sessions per week during 3 weeks
preoperative rehabilitation programOther
exercise training at home : 5 sessions per week during 3 weeks
| Study group | Role | What they receive |
|---|---|---|
| control group (C group) | Active comparator | patient will receive preoperative chest physiotherapy (standard supportive care) Receives: Other: preoperative chest physiotherapy |
| rehabilitation group (R group) | Experimental | patient will receive preoperative chest physiotherapy and a preoperative rehabilitation program at home (exercise training) Receives: Other: preoperative chest physiotherapy; Other: preoperative rehabilitation program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Hospital length of stay after resection for lung cancer
the date of discharge will be the real day of discharge from surgery department or the day where the patient will be medically considered as outgoing
Measured: time from the date of the surgery (Day 0) until the date of discharge (Day n) (assessed up to 56 days)
Secondary outcomes (8)
the number of complications
Measured: during the stay in the surgery department or the intensive care unit (up to 56 days)
peak oxygen consumption
evaluation N°1 before intervention : during the week before the first date of the intervention (week 1) (intervention : preoperative chest physiotherapy +/- rehabilitation program will be realized on weeks 2, 3, and 4).
evaluation N°2 after intervention and before surgery : during the week before the date of surgery (week 5)
Measured: evaluation N°1 : during the week before the first date of the intervention (week 1). evaluation N°2: during the week before the date of surgery (week 5)
6 minutes walking distance
evaluation N°1 before intervention : during the week before the first date of the intervention (week 1) (intervention : preoperative chest physiotherapy +/- rehabilitation program will be realized on weeks 2, 3, and 4).
evaluation N°2 after intervention and before surgery : during the week before the date of surgery (week 5)
Measured: evaluation N°1 : during the week before the first date of the intervention (week 1). evaluation N°2: during the week before the date of surgery (week 5)
maximal voluntary quadriceps strength
evaluation N°1 before intervention : during the week before the first date of the intervention (week 1) (intervention : preoperative chest physiotherapy +/- rehabilitation program will be realized on weeks 2, 3, and 4).
evaluation N°2 after intervention and before surgery : during the week before the date of surgery (week 5)
Measured: evaluation N°1 : during the week before the first date of the intervention (week 1). evaluation N°2: during the week before the date of surgery (week 5)
maximal inspiratory and expiratory strength
evaluation N°1 before intervention : during the week before the first date of the intervention (week 1) (intervention : preoperative chest physiotherapy +/- rehabilitation program will be realized on weeks 2, 3, and 4).
evaluation N°2 after intervention and before surgery : during the week before the date of surgery (week 5)
Measured: evaluation N°1 : during the week before the first date of the intervention (week 1). evaluation N°2: during the week before the date of surgery (week 5)
real length of stay
the real day of discharge from surgery department
Measured: between the first postoperative day (Day 1) and the real discharge date (up to 56 days)
body composition (bioimpedancemetry)
evaluation N°1 before intervention : during the week before the first date of the intervention (week 1) (intervention : preoperative chest physiotherapy +/- rehabilitation program will be realized on weeks 2, 3, and 4).
evaluation N°2 after intervention and before surgery : during the week before the date of surgery (week 5)
Measured: evaluation N°1 : during the week before the first date of the intervention (week 1). evaluation N°2: during the week before the date of surgery (week 5)
oxidative adaptations of the muscle
optional ancillary study on quadricipal and intercostal muscle biopsies.
Measured: evaluation N°1 : during the week before the first date of the intervention (week 1). evaluation N°2 after intervention : at the date of surgery (during the surgical time at Day 0 week 6)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Jan 2017 (estimated)
- Study start12 May 2017
- Primary completion13 Feb 2026
- Study completion13 Feb 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for LungcancerStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 90 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre Jean Perrin
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Marc FILAIRE, Pr, Principal investigator, Centre Jean Perrin
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03020251
- Sponsor's protocol ID
- 2016-A00622-49
- Acronym
- Rexochir
- Status last verified
- Mar 2026
- First submitted
- 20 Dec 2016
- Last updated
- 13 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Laurent H, Galvaing G, Thivat E, Coudeyre E, Aubreton S, Richard R, Kwiatkowski F, Costes F, Filaire M. Effect of an intensive 3-week preoperative home rehabilitation programme in patients with chronic obstructive pulmonary disease eligible for lung cancer surgery: a multicentre randomised controlled trial. BMJ Open. 2017 Nov 12;7(11):e017307. doi: 10.1136/bmjopen-2017-017307.
PubMed 29133320