OsteoarthritisEX-ARTNCT03167502
Performance in Walking in Osteoarthritis Patients
A study testing eccentric work and concentric work in people with Osteoarthritis, run by Centre Hospitalier Universitaire de Nice at 1 site in France.
Trial summary
Few data exist to date on the effect of eccentric muscle building in knee osteoarthritis. No studies have compared the effect of eccentric versus concentric reinforcement in knee osteoarthritis. Our study aims to show the effectiveness of an eccentric reinforcement. This is a randomized, interventional trial. Read more about this study
- Who is it for?
- Ages 40 to 85 years
- Conditions the study is for
- Osteoarthritis
- What is being tested?
- eccentric work and concentric work
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteFrance
- Study dates
- 19 Sep 2017to 17 Jun 2019
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 85 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Autonomous subjects aged 40 to 85
- Subjects meeting ACR criteria for gonarthrosis
- Subjects with a score of Kellgren and Lawrence at least one knee greater than or equal to 2
- Signature of consent form
- Subjects affiliated to social security
Who cannot join
- Subject with a Kellgren and Lawrence stadium at 4 for at least one of his two knees
- Subjects with symptomatic femoro-patellar arthrosis
- Subject with a pathology that makes walking testing impossible.
- Non-autonomous subjects, with a pathology impairing walking
- Subjects with symptomatic osteoarthritis of the hip and / or with a hip or knee prosthesis
- Subject incapable of signing consent and unable to understand information leaflet.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Performance in Walking in Osteoarthritis Patients: the Role of Fatigue and the Effect of an Eccentric Muscle Building Program
Few data exist to date on the effect of eccentric muscle building in knee osteoarthritis. No studies have compared the effect of eccentric versus concentric reinforcement in knee osteoarthritis. Our study aims to show the effectiveness of an eccentric reinforcement. This is a randomized, interventional trial.
Read the detailed description
Few data exist to date on the effect of eccentric muscle building in knee osteoarthritis. No studies have compared the effect of eccentric versus concentric reinforcement in knee osteoarthritis. Our study aims to show the effectiveness of an eccentric reinforcement, the interest of a work supervised by a sports coach to maintain activity over time and to study the effect of this activity at the muscular level. The main objective is to study the effect of an eccentric muscle strengthening program on walking performance in osteoarthritis patients. The secondary objectives are to study: the effect of fatigue on walking, the relationship between fatigue and the level of physical activity, the effect of training on perceived fatigue and the effect of training on the function and at muscular level. This is a randomized, interventional trial. 40 subjects are planned. Inclusion criteria include: age 40-85 years, KL 2 and 3. The subjects are divided into two groups to perform either eccentric or concentric work. 2 sessions per week for 6 weeks. At baseline and at the end of the study a clinical evaluation and MRI will be carried out for evaluation of the criteria of judgment
- Conditions
- Osteoarthritis
- Being tested
- eccentric work, concentric work
- Medical subject headings
- Osteoarthritis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
eccentric workOther
patient will follow 2 eccentric trainings per week during 6 weeks
concentric workOther
patient will follow 2 concentric trainings per week during 6 weeks
| Study group | Role | What they receive |
|---|---|---|
| concentric work | Active comparator | patient suffering from knee osteoarthritis will follow a concentric work. This training is 2 sessions per week for 6 weeks Receives: Other: concentric work |
| eccentric work | Experimental | patient suffering from knee osteoarthritis will follow an eccentric work. This training is 2 sessions per week for 6 weeks Receives: Other: eccentric work |
What is being measured
The primary outcome is the main question the study is designed to answer.
Walking performance
6-minute walk test
Measured: after 6 training weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 May 2017
- Study start19 Sep 2017
- Primary completion25 Nov 2017
- Study completion17 Jun 2019
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for OsteoarthritisStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire de NiceThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire de Nice
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Christian H ROUX, PhD, Principal investigator, service de Rhumatologie, CHU de NICE
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03167502
- Sponsor's protocol ID
- 16-AOIP-03
- Acronym
- EX-ART
- Status last verified
- Mar 2026
- First submitted
- 24 May 2017
- Last updated
- 24 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Trojani MC, Chorin F, Gerus P, Breuil V, Michel C, Guis S, Bendahan D, Roux C. Concentric or eccentric physical activity for patients with symptomatic osteoarthritis of the knee: a randomized prospective study. Ther Adv Musculoskelet Dis. 2022 Jul 7;14:1759720X221102805. doi: 10.1177/1759720X221102805. eCollection 2022.
PubMed 35832351
Study at a glance
From the registry record, last updated by the sponsor on 24 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Performance in Walking in Osteoarthritis Patients: the Role of Fatigue and the Effect of an Eccentric Muscle Building Program
- ClinicalTrials.gov ID
- NCT03167502
- Acronym / sponsor ID
- EX-ART / 16-AOIP-03
- Conditions
- Osteoarthritis
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- Centre Hospitalier Universitaire de NiceUniversity, hospital or other
- Study start
- 19 Sep 2017 (actual)
- Primary completion
- 25 Nov 2017 (actual)
- Study completion
- 17 Jun 2019 (actual)
- First posted
- 30 May 2017 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Few data exist to date on the effect of eccentric muscle building in knee osteoarthritis. No studies have compared the effect of eccentric versus concentric reinforcement in knee osteoarthritis. Our study aims to show the effectiveness of an eccentric reinforcement. This is a randomized, interventional trial.
Detailed description
Few data exist to date on the effect of eccentric muscle building in knee osteoarthritis. No studies have compared the effect of eccentric versus concentric reinforcement in knee osteoarthritis. Our study aims to show the effectiveness of an eccentric reinforcement, the interest of a work supervised by a sports coach to maintain activity over time and to study the effect of this activity at the muscular level. The main objective is to study the effect of an eccentric muscle strengthening program on walking performance in osteoarthritis patients. The secondary objectives are to study: the effect of fatigue on walking, the relationship between fatigue and the level of physical activity, the effect of training on perceived fatigue and the effect of training on the function and at muscular level. This is a randomized, interventional trial. 40 subjects are planned. Inclusion criteria include: age 40-85 years, KL 2 and 3. The subjects are divided into two groups to perform either eccentric or concentric work. 2 sessions per week for 6 weeks. At baseline and at the end of the study a clinical evaluation and MRI will be carried out for evaluation of the criteria of judgment
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| concentric work | Active comparator | Other: concentric workpatient suffering from knee osteoarthritis will follow a concentric work. This training is 2 sessions per week for 6 weeks |
| eccentric work | Experimental | Other: eccentric workpatient suffering from knee osteoarthritis will follow an eccentric work. This training is 2 sessions per week for 6 weeks |
Who may qualify
- Ages
- 40 to 85 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Autonomous subjects aged 40 to 85
- Subjects meeting ACR criteria for gonarthrosis
- Subjects with a score of Kellgren and Lawrence at least one knee greater than or equal to 2
- Signature of consent form
- Subjects affiliated to social security
Key exclusion criteria (6 listed)
- Subject with a Kellgren and Lawrence stadium at 4 for at least one of his two knees
- Subjects with symptomatic femoro-patellar arthrosis
- Subject with a pathology that makes walking testing impossible.
- Non-autonomous subjects, with a pathology impairing walking
- Subjects with symptomatic osteoarthritis of the hip and / or with a hip or knee prosthesis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| eccentric workpatient will follow 2 eccentric trainings per week during 6 weeks | Other | eccentric work |
| concentric workpatient will follow 2 concentric trainings per week during 6 weeks | Other | concentric work |
Primary outcome
Walking performance
Time frame: after 6 training weeks
6-minute walk test
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Mar 2026.
- Results publication: PubMed 35832351Trojani MC, Chorin F, Gerus P, Breuil V, Michel C, Guis S, Bendahan D, Roux C. Concentric or eccentric physical activity for patients with symptomatic osteoarthritis of the knee: a randomized prospective study. Ther Adv Musculoskelet Dis. 2022 Jul 7;14:1759720X221102805. doi: 10.1177/1759720X221102805. eCollection 2022.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Christian H ROUX, PhD principal investigator
service de Rhumatologie, CHU de NICE
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing eccentric work and concentric work in people with Osteoarthritis, run by Centre Hospitalier Universitaire de Nice at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Walking performance (time frame: after 6 training weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03167502, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Mar 2026.