AgingNCT03206580
Functional Mobility in the Elderly: Influence of Morphological, Neuromuscular and Training Parameters
A study testing Concentric training and Concentric-Eccentric training in people with Aging, run by Federal University of Rio Grande do Sul at 1 site in Brazil.
Trial summary
Life expectancy and elderly population are increasing. Health professionals try to provide longevity with good quality of life for this population, through the functional independence maintenance. In this context, physical exercise has an important role, specially the strength training. Read more about this study
- Who is it for?
- Ages 65 to 85 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Aging
- What is being tested?
- Concentric training and Concentric-Eccentric training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 11 participants
- Where
- 1 siteBrazil
- Study dates
- 15 Oct 2016to 31 Dec 2018
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 to 85 years
- Men only
- Healthy volunteers accepted
- Older adult
Who may be able to join
- Male;
- 65 years of age or more;
- able to walk independently;
- not engaged in regular physical exercise.
Who cannot join
- Auditory, vestibular, visual and/or neuromusculoskeletal impairments that could influence the tests and the training;
- severe cognitive impairment;
- lower limb surgery;
- osteoporosis;
- lower limb pain.
Trial locations and contacts
1 site in 1 country.
Brazil1 site
Exercise Research Laboratory, School of Physical Education, Federal University of Rio Grande do Sul
Porto Alegre, Rio Grande do Sul, 90690-200
About this study
Official title: Functional Mobility in the Elderly: Influence of Morphological, Neuromuscular and Training
Life expectancy and elderly population are increasing. Health professionals try to provide longevity with good quality of life for this population, through the functional independence maintenance. In this context, physical exercise has an important role, specially the strength training. The ability to produce muscle strength is positively associated with the functionality and independence of older people. Different types of strength training can lead to different neuromuscular and functional gains. These types of interventions can help health professionals to determine characteristics of training for the elderly, aiming the maintenance of their functional independence. Thus, the purpose of this study is to determine the effects of a concentric strength training versus a concentric-eccentric strength training for knee flexors and extensors on structural, neuromuscular and functional parameters in older people, as well as to investigate the effect of a detraining period. Additionally, the investigators will try to identify which structural and neuromuscular parameters of lower limbs are better related to the functionality.
- Conditions
- Aging
- Being tested
- Concentric training, Concentric-Eccentric training
- Keywords
- aging, strength training, functionality
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Concentric trainingOther
Subjects will be submitted to 8 weeks (16 sessions) of a concentric training for knee flexors and knee extensors. This training will be performed in an isokinetic dynamometer at 70% of the subject's maximal voluntary isometric contraction.
Concentric-Eccentric trainingOther
Subjects will be submitted to 8 weeks (16 sessions) of a concentric-eccentric training for knee flexors and knee extensors. This training will be performed in an isokinetic dynamometer at 70% of the subject's maximal voluntary isometric contraction.
| Study group | Role | What they receive |
|---|---|---|
| Concentric training | Experimental | Concentric training Receives: Other: Concentric training |
| Concentric-eccentric training | Experimental | Concentric-eccentric training Receives: Other: Concentric-Eccentric training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pennation angle of rectus femoris, vastus lateralis and biceps femoris, bilaterally.
Pennation angle at rest
Measured: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Thickness of rectus femoris, vastus lateralis and biceps femoris, bilaterally.
Muscle thickness at rest
Measured: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Fascicle length of rectus femoris, vastus lateralis and biceps femoris, bilaterally.
Fascicle length at rest
Measured: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Echo intensity of rectus femoris, vastus lateralis and biceps femoris, bilaterally.
Echo intensity determined from a gray scale analysis of the muscles at rest
Measured: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Countermovement vertical jump
Maximal vertical height in the countermovement jump
Measured: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Timed-up-&-go
Time to rise from a chair, walk 3 meters, turn, walk back and sit again
Measured: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Unipodal static balance
Range in anterior-posterior and medio-lateral center of pressure movement during unipodal evaluation during 30 seconds
Measured: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Gait speed
Gait speed for walking 10 meters at self-selected speed
Measured: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Stair ascent and descent time
Time to stair ascent and descent stairs
Measured: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
6-minutes walking test
The distance that the subjects can walk during 6 minutes
Measured: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Sit-to-stand
Maximal number of repetitions during 30 seconds
Measured: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Power of knee extensors and knee flexors
Power during maximal concentric and eccentric contractions
Measured: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Rate of torque production of knee extensors and knee flexors
Rate of torque production during maximal isometric contractions
Measured: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Strength of knee extensors and knee flexors
Maximal isometric strength
Measured: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Strength of knee extensors and knee flexors
Maximal concentric strength
Measured: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Strength of knee extensors and knee flexors
Maximal eccentric strength
Measured: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Jul 2017
- Study start15 Oct 2016
- Primary completion31 Dec 2018
- Study completion31 Dec 2018
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AgingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 11 participants (actual)
Sponsor and investigators
- Lead sponsor
- Federal University of Rio Grande do Sul
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Marco Aurélio Vaz, PhD, Federal University of Rio Grande do Sul
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03206580
- Sponsor's protocol ID
- UFRGS 2.034.508
- Status last verified
- Jun 2024
- First submitted
- 22 Jun 2017
- Last updated
- 10 Jun 2024
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Jun 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Functional Mobility in the Elderly: Influence of Morphological, Neuromuscular and Training
- ClinicalTrials.gov ID
- NCT03206580
- Acronym / sponsor ID
- UFRGS 2.034.508
- Conditions
- Aging
- Keywords
- aging, strength training, functionality
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 11 participants (actual)
- Lead sponsor
- Federal University of Rio Grande do SulUniversity, hospital or other
- Study start
- 15 Oct 2016 (actual)
- Primary completion
- 31 Dec 2018 (actual)
- Study completion
- 31 Dec 2018 (actual)
- First posted
- 2 Jul 2017 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Life expectancy and elderly population are increasing. Health professionals try to provide longevity with good quality of life for this population, through the functional independence maintenance. In this context, physical exercise has an important role, specially the strength training. The ability to produce muscle strength is positively associated with the functionality and independence of older people. Different types of strength training can lead to different neuromuscular and functional gains. These types of interventions can help health professionals to determine characteristics of training for the elderly, aiming the maintenance of their functional independence. Thus, the purpose of this study is to determine the effects of a concentric strength training versus a concentric-eccentric strength training for knee flexors and extensors on structural, neuromuscular and functional parameters in older people, as well as to investigate the effect of a detraining period. Additionally, the investigators will try to identify which structural and neuromuscular parameters of lower limbs are better related to the functionality.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Concentric training | Experimental | Other: Concentric trainingConcentric training |
| Concentric-eccentric training | Experimental | Other: Concentric-Eccentric trainingConcentric-eccentric training |
Who may qualify
- Ages
- 65 to 85 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Older adult
Key inclusion criteria (4 listed)
- Male;
- 65 years of age or more;
- able to walk independently;
- not engaged in regular physical exercise.
Key exclusion criteria (5 listed)
- Auditory, vestibular, visual and/or neuromusculoskeletal impairments that could influence the tests and the training;
- severe cognitive impairment;
- lower limb surgery;
- osteoporosis;
- lower limb pain.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Concentric trainingSubjects will be submitted to 8 weeks (16 sessions) of a concentric training for knee flexors and knee extensors. This training will be performed in an isokinetic dynamometer at 70% of the subject's maximal voluntary isometric contraction. | Other | Concentric training |
| Concentric-Eccentric trainingSubjects will be submitted to 8 weeks (16 sessions) of a concentric-eccentric training for knee flexors and knee extensors. This training will be performed in an isokinetic dynamometer at 70% of the subject's maximal voluntary isometric contraction. | Other | Concentric-eccentric training |
Primary outcome
Pennation angle of rectus femoris, vastus lateralis and biceps femoris, bilaterally.
Time frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Pennation angle at rest
Thickness of rectus femoris, vastus lateralis and biceps femoris, bilaterally.
Time frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Muscle thickness at rest
Fascicle length of rectus femoris, vastus lateralis and biceps femoris, bilaterally.
Time frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Fascicle length at rest
Echo intensity of rectus femoris, vastus lateralis and biceps femoris, bilaterally.
Time frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Echo intensity determined from a gray scale analysis of the muscles at rest
Countermovement vertical jump
Time frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Maximal vertical height in the countermovement jump
Timed-up-&-go
Time frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Time to rise from a chair, walk 3 meters, turn, walk back and sit again
Unipodal static balance
Time frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Range in anterior-posterior and medio-lateral center of pressure movement during unipodal evaluation during 30 seconds
Gait speed
Time frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Gait speed for walking 10 meters at self-selected speed
Stair ascent and descent time
Time frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Time to stair ascent and descent stairs
6-minutes walking test
Time frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
The distance that the subjects can walk during 6 minutes
Sit-to-stand
Time frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Maximal number of repetitions during 30 seconds
Power of knee extensors and knee flexors
Time frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Power during maximal concentric and eccentric contractions
Rate of torque production of knee extensors and knee flexors
Time frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Rate of torque production during maximal isometric contractions
Strength of knee extensors and knee flexors
Time frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Maximal isometric strength
Strength of knee extensors and knee flexors
Time frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Maximal concentric strength
Strength of knee extensors and knee flexors
Time frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
Maximal eccentric strength
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Jun 2024.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Concentric training and Concentric-Eccentric training in people with Aging, run by Federal University of Rio Grande do Sul at 1 site in Brazil.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 10 Jun 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Brazil. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pennation angle of rectus femoris, vastus lateralis and biceps femoris, bilaterally. (time frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining). The study lists 16 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Jun 2024.