Out-of-Hospital Cardiac ArrestNCT03222999
Korean Cardiac Arrest Research Consortium
An observational study of Out-of-Hospital Cardiac Arrest, run by Korean Cardiac Arrest Research Consortium at 1 site in South Korea.
Trial summary
This study will evaluated the epidemiology and the outcomes of patients suffering out-of-hospital cardiac arrest with presumed cardiac etiology in Korea. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Out-of-Hospital Cardiac Arrest
- How many people
- 30,000 participants
- Where
- 1 siteSouth Korea
- Study dates
- 1 Oct 2015to 31 Dec 2030
- How long will I take part?
- 6 Months
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: EMS treated OHCA who visits study participating ED
Who may be able to join
- OHCA patients who were transported to participating emergency department (ED) by emergency medical service with resuscitation efforts and whose arrest was identified as a presumed cardiac etiology by emergency physicians in ED.
Who cannot join
- OHCA with terminal illness documented by medical record, under hospice care, with pregnancy, with pre-documented 'Do Not Resuscitate' card
- OHCA of definite non-cardiac etiology, including trauma, drowning, poisoning, burn, asphyxia, or hanging
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
South Korea1 site, 1 recruiting
- Recruiting
Korean Cardiac Arrest Resuscitation Consortium
Seoul, 03080
Kyoung Jun Song, MD
About this study
This study will evaluated the epidemiology and the outcomes of patients suffering out-of-hospital cardiac arrest with presumed cardiac etiology in Korea.
Read the detailed description
The Korean Cardiac Arrest Research Consortium (KoCARC) is a collaborative research network developed to comprehend various researches conducted in the field of out-of-cardiac arrest resuscitation and to strengthen the cooperative effort in conducting studies. It was organized in 2014 with recruitment of hospitals willing to participate voluntarily to the consortium.
Not only for emergency medicine, but KoCARC is expanding the research collaboration with cardiology, preventive medicine and epidemiology as well. To enhance the professionalism and effectiveness in research, seven research committees, which consists of Epidemiology and Preventive Research Committee (EPR), Community Resuscitation Research Committee (CRR), EMS Resuscitation Research Committee (ERR), Hospital Resuscitation Research Committee (HRR), Hypothermia and Post-resuscitation Care Research Committee (HPR), Cardiac Care Resuscitation Committee (CCR) and Pediatric Resuscitation Research Committee (PRR). Also Data Safety and Monitoring Board Committee (DSMB) is organized to provide annual review and Security and Ethics Committee to oversight security and ethical issues in research. Monthly meeting of interdisciplinary steering committee, consists of the consortium chair, steering committee chair, each research committee chair and secretary committee, is held to approve the proposed research agendas and to mediate between multi-center trial participating hospitals.
KoCARC registry is a data collecting system composed of OHCA risk and prognostic variables developed to provide the platform to researches conducted in KoCARC.
- Conditions
- Out-of-Hospital Cardiac Arrest
- Being tested
- No intervention planned
- Keywords
- Out-of-Hospital Cardiac Arrest
- Medical subject headings
- Out-of-Hospital Cardiac Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
No intervention plannedOther
No intervention planned
What is being measured
The primary outcome is the main question the study is designed to answer.
Survival at 6 month
Patients will be followed upon hospital discharge and up to 6 month.
Measured: 6 months after cardiac arrest
Secondary outcomes (1)
Good neurological recovery at 6 month
Good neurological recovery: Cerebral Performance Category (CPC) 1 or 2. Patients will be followed upon hospital discharge and up to 6 month.
Measured: 6 months after cardiac arrest
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Jul 2017
- Study start1 Oct 2015
- Primary completion31 Dec 2030 (estimated)
- Study completion31 Dec 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (8)Papers the sponsor has linked to this study.
- Other trials for Out-of-Hospital Cardiac ArrestStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Prospective
- Enrolment
- 30,000 participants (estimated)
- Target duration
- 6 Months
Sponsor and investigators
- Lead sponsor
- Korean Cardiac Arrest Research Consortium
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Chung, Sung-Phil, Korean Cardiac Arrest Research Consortium
- Investigators
- Sung-Pil Chung, MD, PhD, Study chair, Korean Cardiac Arrest Resuscitation Consortium
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03222999
- Sponsor's protocol ID
- KoCARC
- Status last verified
- Aug 2026
- First submitted
- 6 Jul 2017
- Last updated
- 5 Aug 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Choi A, Park I, You JS, Chung SP, Park YS. Non-Linear Relationship Between Alcohol Consumption and Neurological Outcomes in Patients With Out-of-Hospital Cardiac Arrest Presenting to the Emergency Department. J Korean Med Sci. 2025 Jun 2;40(21):e96. doi: 10.3346/jkms.2025.40.e96.
PubMed 40461141Lee SH, Cho Y, Oh J, Kang H, Lim TH, Ko BS, Yoo KH, Lee J. Total cholesterol and bilirubin levels are associated with neurologic outcomes in patients with out-of-hospital cardiac arrest. Intern Emerg Med. 2025 Jun;20(4):1185-1193. doi: 10.1007/s11739-024-03742-0. Epub 2024 Nov 8.
PubMed 39516448Lee H, Oh J, Choi HJ, Shin H, Cho Y, Lee J. The Incidence and Outcomes of Out-of-Hospital Cardiac Arrest During the COVID-19 Pandemic in South Korea: Multicenter Registry Study. JMIR Public Health Surveill. 2024 Jun 24;10:e52402. doi: 10.2196/52402.
PubMed 38913998Ko BS, Kim YJ, Han KS, Jo YH, Shin J, Park I, Kang H, Lim TH, Hwang SO, Kim WY. Association between the number of prehospital defibrillation attempts and a sustained return of spontaneous circulation: a retrospective, multicentre, registry-based study. Emerg Med J. 2023 Jun;40(6):424-430. doi: 10.1136/emermed-2021-212091. Epub 2023 Apr 6.
PubMed 37024298Jeong D, Lee GT, Park JE, Chang H, Kim T, Cha WC, Yoon H, Hwang SY, Shin TG, Sim MS, Jo I, Lee SH, Shin SD, Choi JH. Extracorporeal Life-support for Out-of-hospital Cardiac Arrest: A Nationwide Multicenter Study. Shock. 2022 May 1;57(5):680-686. doi: 10.1097/SHK.0000000000001924. Epub 2022 Mar 10.
PubMed 35271541Kim SJ, Kim HS, Hwang SO, Jung WJ, Roh YI, Cha KC, Shin SD, Song KJ; Korean Cardiac Arrest Research Consortium (KoCARC) Investigators. Ionized calcium level at emergency department arrival is associated with return of spontaneous circulation in out-of-hospital cardiac arrest. PLoS One. 2020 Oct 12;15(10):e0240420. doi: 10.1371/journal.pone.0240420. eCollection 2020.
PubMed 33045006Yoon JC, Kim YJ, Ahn S, Jin YH, Lee SW, Song KJ, Shin SD, Hwang SO, Kim WY; Korean Cardiac Arrest Research Consortium KoCARC. Factors for modifying the termination of resuscitation rule in out-of-hospital cardiac arrest. Am Heart J. 2019 Jul;213:73-80. doi: 10.1016/j.ahj.2019.04.003. Epub 2019 May 3.
PubMed 31129440Lee DE, Lee MJ, Ahn JY, Ryoo HW, Park J, Kim WY, Shin SD, Hwang SO; Korean Cardiac Arrest Research Consortium (KoCARC). New Termination-of-Resuscitation Models and Prognostication in Out-of-Hospital Cardiac Arrest Using Electrocardiogram Rhythms Documented in the Field and the Emergency Department. J Korean Med Sci. 2019 May 6;34(17):e134. doi: 10.3346/jkms.2019.34.e134.
PubMed 31050224
Study at a glance
From the registry record, last updated by the sponsor on 5 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Korean Cardiac Arrest Research Consortium
- ClinicalTrials.gov ID
- NCT03222999
- Acronym / sponsor ID
- KoCARC
- Conditions
- Out-of-Hospital Cardiac Arrest
- Keywords
- Out-of-Hospital Cardiac Arrest
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 30,000 participants (estimated)
- Lead sponsor
- Korean Cardiac Arrest Research ConsortiumUniversity, hospital or other
- Study start
- 1 Oct 2015 (actual)
- Primary completion
- 31 Dec 2030 (estimated)
- Study completion
- 31 Dec 2030 (estimated)
- First posted
- 19 Jul 2017 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will evaluated the epidemiology and the outcomes of patients suffering out-of-hospital cardiac arrest with presumed cardiac etiology in Korea.
Detailed description
The Korean Cardiac Arrest Research Consortium (KoCARC) is a collaborative research network developed to comprehend various researches conducted in the field of out-of-cardiac arrest resuscitation and to strengthen the cooperative effort in conducting studies. It was organized in 2014 with recruitment of hospitals willing to participate voluntarily to the consortium.
Not only for emergency medicine, but KoCARC is expanding the research collaboration with cardiology, preventive medicine and epidemiology as well. To enhance the professionalism and effectiveness in research, seven research committees, which consists of Epidemiology and Preventive Research Committee (EPR), Community Resuscitation Research Committee (CRR), EMS Resuscitation Research Committee (ERR), Hospital Resuscitation Research Committee (HRR), Hypothermia and Post-resuscitation Care Research Committee (HPR), Cardiac Care Resuscitation Committee (CCR) and Pediatric Resuscitation Research Committee (PRR). Also Data Safety and Monitoring Board Committee (DSMB) is organized to provide annual review and Security and Ethics Committee to oversight security and ethical issues in research. Monthly meeting of interdisciplinary steering committee, consists of the consortium chair, steering committee chair, each research committee chair and secretary committee, is held to approve the proposed research agendas and to mediate between multi-center trial participating hospitals.
KoCARC registry is a data collecting system composed of OHCA risk and prognostic variables developed to provide the platform to researches conducted in KoCARC.
Study design
- Observational model
- Case only
- Time perspective
- Prospective
- Target follow-up
- 6 Months
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- EMS treated OHCA who visits study participating ED
Key inclusion criteria (1 listed)
- OHCA patients who were transported to participating emergency department (ED) by emergency medical service with resuscitation efforts and whose arrest was identified as a presumed cardiac etiology by emergency physicians in ED.
Key exclusion criteria (2 listed)
- OHCA with terminal illness documented by medical record, under hospice care, with pregnancy, with pre-documented 'Do Not Resuscitate' card
- OHCA of definite non-cardiac etiology, including trauma, drowning, poisoning, burn, asphyxia, or hanging
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| No intervention plannedNo intervention planned | Other | – |
Primary outcome
Survival at 6 month
Time frame: 6 months after cardiac arrest
Patients will be followed upon hospital discharge and up to 6 month.
1 secondary outcome
Good neurological recovery at 6 month
Time frame: 6 months after cardiac arrest
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Aug 2026.
- Derived from this study: PubMed 40461141Choi A, Park I, You JS, Chung SP, Park YS. Non-Linear Relationship Between Alcohol Consumption and Neurological Outcomes in Patients With Out-of-Hospital Cardiac Arrest Presenting to the Emergency Department. J Korean Med Sci. 2025 Jun 2;40(21):e96. doi: 10.3346/jkms.2025.40.e96.
- Derived from this study: PubMed 39516448Lee SH, Cho Y, Oh J, Kang H, Lim TH, Ko BS, Yoo KH, Lee J. Total cholesterol and bilirubin levels are associated with neurologic outcomes in patients with out-of-hospital cardiac arrest. Intern Emerg Med. 2025 Jun;20(4):1185-1193. doi: 10.1007/s11739-024-03742-0. Epub 2024 Nov 8.
- Derived from this study: PubMed 38913998Lee H, Oh J, Choi HJ, Shin H, Cho Y, Lee J. The Incidence and Outcomes of Out-of-Hospital Cardiac Arrest During the COVID-19 Pandemic in South Korea: Multicenter Registry Study. JMIR Public Health Surveill. 2024 Jun 24;10:e52402. doi: 10.2196/52402.
- Derived from this study: PubMed 37024298Ko BS, Kim YJ, Han KS, Jo YH, Shin J, Park I, Kang H, Lim TH, Hwang SO, Kim WY. Association between the number of prehospital defibrillation attempts and a sustained return of spontaneous circulation: a retrospective, multicentre, registry-based study. Emerg Med J. 2023 Jun;40(6):424-430. doi: 10.1136/emermed-2021-212091. Epub 2023 Apr 6.
- Derived from this study: PubMed 35271541Jeong D, Lee GT, Park JE, Chang H, Kim T, Cha WC, Yoon H, Hwang SY, Shin TG, Sim MS, Jo I, Lee SH, Shin SD, Choi JH. Extracorporeal Life-support for Out-of-hospital Cardiac Arrest: A Nationwide Multicenter Study. Shock. 2022 May 1;57(5):680-686. doi: 10.1097/SHK.0000000000001924. Epub 2022 Mar 10.
- Derived from this study: PubMed 33045006Kim SJ, Kim HS, Hwang SO, Jung WJ, Roh YI, Cha KC, Shin SD, Song KJ; Korean Cardiac Arrest Research Consortium (KoCARC) Investigators. Ionized calcium level at emergency department arrival is associated with return of spontaneous circulation in out-of-hospital cardiac arrest. PLoS One. 2020 Oct 12;15(10):e0240420. doi: 10.1371/journal.pone.0240420. eCollection 2020.
- Derived from this study: PubMed 31129440Yoon JC, Kim YJ, Ahn S, Jin YH, Lee SW, Song KJ, Shin SD, Hwang SO, Kim WY; Korean Cardiac Arrest Research Consortium KoCARC. Factors for modifying the termination of resuscitation rule in out-of-hospital cardiac arrest. Am Heart J. 2019 Jul;213:73-80. doi: 10.1016/j.ahj.2019.04.003. Epub 2019 May 3.
- Derived from this study: PubMed 31050224Lee DE, Lee MJ, Ahn JY, Ryoo HW, Park J, Kim WY, Shin SD, Hwang SO; Korean Cardiac Arrest Research Consortium (KoCARC). New Termination-of-Resuscitation Models and Prognostication in Out-of-Hospital Cardiac Arrest Using Electrocardiogram Rhythms Documented in the Field and the Emergency Department. J Korean Med Sci. 2019 May 6;34(17):e134. doi: 10.3346/jkms.2019.34.e134.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Sung-Pil Chung, MD, PhD study chair
Korean Cardiac Arrest Resuscitation Consortium
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Out-of-Hospital Cardiac Arrest, run by Korean Cardiac Arrest Research Consortium at 1 site in South Korea.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 5 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in South Korea. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact KoCARC Coordination Center (82-2-2072-4052, kocarc_cc@naver.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Survival at 6 month (time frame: 6 months after cardiac arrest). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03222999, which also lists 8 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Aug 2026.