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AzTrials

Cognitive DeclineDIINNCT03228446

The Effects of Attentional Filter Training on Working Memory

A study testing filter training and memory training in people with Cognitive Decline and Healthy, run by German Center for Neurodegenerative Diseases (DZNE) at 1 site in Germany.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The investigators are interested in how attentional filter training/ distractor inhibition training could influence cognitive functions like working memory, executive control, problem solving, decision making and attentional control. Read more about this study

Who is it for?
Ages 18 to 80 yearsHealthy volunteers can take part
What is being tested?
filter training and memory training
Could I receive a placebo?
No, everyone receives an active treatment
How many people
60 participants
Where
1 siteGermany
Study dates
26 Sep 2012to Jan 2019
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 80 years
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Who may be able to join

  • right-hander
  • aged between 18-30 or 60-80years

Who cannot join

  • severe visual impairments (e.g. dyschromatopsia, very low vision)
  • diseases or medication that might impair test performance
  • Montreal Cognitive Assessment Score (MoCA) < 26 points

Trial locations and contacts

1 site in 1 country.

Germany1 site

  • DZNE

    Magdeburg, Saxony-Anhalt, 39120

Other trials in Germany

About this study

Official title: Improving Cognitive Functions by Training Distractor Inhibition (DIIN) in Younger and Older Healthy Adults

The investigators are interested in how attentional filter training/ distractor inhibition training could influence cognitive functions like working memory, executive control, problem solving, decision making and attentional control.

Read the detailed description

Two different computer based trainings were applied: an attentional filter training and a working memory training.

Being tested
filter training, memory training, no training (control)
Keywords
training intervention, filter training, distractor inhibition
Medical subject headings
Cognitive Dysfunction

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • filter trainingBehavioural

    one-week filter training on the computer: computerized visual change detection experiment (selective attention )

  • memory trainingBehavioural

    one-week storage training on the computer: computerized visual change detection experiment (memory storage)

  • no training (control)Other

    no training applied

Study groups in NCT03228446
Study groupRoleWhat they receive
Young subjectsExperimentalWorking memory training \& attentional filter training for participants (18-30 years)
Receives: Behavioral: filter training; Behavioral: memory training
Old subjectsExperimentalWorking memory training, attentional filter training and no training (control) for participants (60-80 years)
Receives: Behavioral: filter training; Behavioral: memory training; Other: no training (control)

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Improvements in test performance

    Working memory and filtering performance (in %), effects of distractor interference and reaction times for trials with and without distractors with 4, 5 \& 6 targets

    Measured: 45min pre / post

Secondary outcomes (14)

  1. Rey Complex Figure Test

    Copying complex figures and reproduce it from memory

    Measured: 30min pre / post

  2. Memory from TAP (Test battery of Attentional Performance)

    Working Memory (n-back)

    Measured: 45min pre / post

  3. Attention from TAP (Test battery of Attentional Performance)

    divided attention, Go-NoGo, Flexibility, Incompatibility, Visual scanning

    Measured: 45min pre / post

  4. Performance in repeating numbers

    Repeating numbers in forward \& backward conditions

    Measured: 10min pre / post

  5. Subtest from CANTAB (Cambridge Neuropsychological Test Automated Battery)

    Spatial Span Test

    Measured: 10min pre / post

  6. Iowa Gambling Task

    Decision making

    Measured: 5min on each training day (1-5)

  7. Daily Questionnaires

    subjective performance in the training paradigm

    Measured: 2 min on each training day (1-5)

  8. Daily Questionnaires

    Assessing external circumstances of daily influences

    Measured: 2min on each training day (1-5)

  9. Memory performance without distractors among different setsizes

    Working memory performance (in %) for trials with 4, 5 \& 6 targets and averaged performance for all conditions without distractors

    Measured: 45min pre / post

  10. Memory performance with distractors among different setsizes

    Working memory performance (in %) for trials with 4, 5 \& 6 targets and distractors and averaged performance for all conditions with distractors

    Measured: 45min pre / post

  11. Filtering performance without distractors among different setsizes

    Filtering performance (in %) for trials with 4, 5 \& 6 targets and averaged performance for all conditions without distractors

    Measured: 45min pre / post

  12. Filtering performance with distractors among different setsizes

    Filtering performance (in %) for trials with 4, 5 \& 6 targets and distractors and averaged performance for all conditions with distractors

    Measured: 45min pre / post

  13. Reaction times

    Reaction times in each condition

    Measured: 45min pre / post

  14. Values of distractor inhibition

    Distractor inhibition (DIIN) = Mean of conditions without distractors - Mean of conditions with distractors

    Measured: 45min pre / post

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted25 Jul 2017
  2. Study start26 Sep 2012
  3. Primary completionDec 2018
  4. Study completionJan 2019

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Non-randomised
Intervention model
Parallel groups
Masking
Single blind
Who is masked
Participant
Enrolment
60 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT03228446
Sponsor's protocol ID
MD021
Acronym
DIIN
Status last verified
Feb 2019
First submitted
12 Jul 2017
Last updated
15 Feb 2019
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Schmicker M, Schwefel M, Vellage AK, Muller NG. Training of Attentional Filtering, but Not of Memory Storage, Enhances Working Memory Efficiency by Strengthening the Neuronal Gatekeeper Network. J Cogn Neurosci. 2016 Apr;28(4):636-42. doi: 10.1162/jocn_a_00922. Epub 2016 Jan 14.

    PubMed 26765946

  • Schmicker M, Muller P, Schwefel M, Muller NG. Attentional Filter Training but Not Memory Training Improves Decision-Making. Front Hum Neurosci. 2017 Mar 23;11:138. doi: 10.3389/fnhum.2017.00138. eCollection 2017.

    PubMed 28386225

Questions about this trial

What is this clinical trial studying?

A study testing filter training and memory training in people with Cognitive Decline and Healthy, run by German Center for Neurodegenerative Diseases (DZNE) at 1 site in Germany.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 15 Feb 2019. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Germany. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Improvements in test performance (time frame: 45min pre / post). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT03228446, which also lists 2 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Feb 2019.

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