Healthy AdultsNCT03312920
Investigating Memory Retrieval Improvement in Healthy Subjects
A study testing active anodal tDCS and active cathodal tDCS in people with Healthy Adults, run by The University of Texas at Dallas at 1 site in United States.
Trial summary
The purpose of this study is to investigate whether learning can be accelerated and associative memory performance improved in healthy subjects by applying transcranial Direct Current Stimulation (tDCS) during a Face Name memory task. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy Adults
- What is being tested?
- active anodal tDCS and active cathodal tDCS
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 0 participants
- Where
- 1 siteUnited States
- Study dates
- 27 Sep 2017to 5 Sep 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age: 18-35 years Native English Speaker
Who cannot join
- History of severe head injuries, epileptic insults, or heart disease. Severe psychiatric disorders and severe untreated medical problems. Contraindications for tDCS (pregnant women, implanted devices)
Trial locations and contacts
1 site in 1 country.
United States1 site
University of Texas at Dallas
Richardson, Texas, 75080
About this study
The purpose of this study is to investigate whether learning can be accelerated and associative memory performance improved in healthy subjects by applying transcranial Direct Current Stimulation (tDCS) during a Face Name memory task.
Read the detailed description
Associative memory refers to remembering the association between two items, such as a face and a name or a word in English and the same word in another language. It is not only important for learning, but it is also one of the first aspects of memory performance that is impacted by aging and by Alzheimer׳s disease. For decades, neuroscientists have investigated associative learning and memory and ways to accelerate and enhance associative learning and memory.
Transcranial Direct Current stimulation (tDCS) is a non-invasive and painless electrical stimulation technique that has demonstrated to accelerate learning and improve memory in some studies. To investigate whether learning can be accelerated and associative memory improved by using tDCS, this study will compare the performance in a Face Name Associate memory task from 3 groups. The first group will get active aodal tDCS during the study phase of the Face Name Memory task, whereas the second group will get sham tDCS during the study phase of the task and the third group will get active cathodal tDCS.
- Conditions
- Healthy Adults
- Being tested
- active anodal tDCS, sham tDCS, active cathodal tDCS
- Keywords
- tDCS, accelerated learning, memory
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
active anodal tDCSDevice
active anodal tDCS with memory task
sham tDCSDevice
sham tDCS with memory task
active cathodal tDCSDevice
active cathodal tDCS with memory task
| Study group | Role | What they receive |
|---|---|---|
| active anodal tDCS | Experimental | active anodal tDCS with Face Name associate Memory task Receives: Device: active anodal tDCS |
| Sham tDCS | Sham comparator | sham tDCS with Face Name associate Memory task Receives: Device: sham tDCS |
| active cathodal tDCS | Experimental | active cathodal tDCS with Face Name associate Memory task Receives: Device: active cathodal tDCS |
What is being measured
The primary outcome is the main question the study is designed to answer.
Associative Memory assessed by a Face Name Associate Memory experiment
Changes in performance in the Face Name Associate memory task is compared between the 2 groups (1. Real tDCS+ Face Name Associate memory task \& 2. Sham tDCS+ Face Name Associate memory task) to investigate the influence of tDCS on Associative Memory.
Measured: Associate Memory is assessed after a 10 minutes break following the study phase
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Oct 2017
- Study start27 Sep 2017
- Primary completion6 Oct 2023
- Study completion5 Sep 2024
Why it stopped: Planned changed based on the outcome of another study
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy AdultsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 0 participants (actual)
Sponsor and investigators
- Lead sponsor
- The University of Texas at Dallas
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Sven Vanneste, The University of Texas at Dallas
- Investigators
- Sven Vanneste, PhD, Principal investigator, The University of Texas at Dallas
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03312920
- Sponsor's protocol ID
- 17-132
- Status last verified
- Jan 2025
- First submitted
- 12 Oct 2017
- Last updated
- 10 Jan 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Jan 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigating Memory Retrieval Improvement in Healthy Subjects
- ClinicalTrials.gov ID
- NCT03312920
- Acronym / sponsor ID
- 17-132
- Conditions
- Healthy Adults
- Keywords
- tDCS, accelerated learning, memory
- Study type
- Interventional
- Recruitment status
- WithdrawnReason stopped: Planned changed based on the outcome of another study
- Enrolment
- 0 participants (actual)
- Lead sponsor
- The University of Texas at DallasUniversity, hospital or other
- Study start
- 27 Sep 2017 (actual)
- Primary completion
- 6 Oct 2023 (actual)
- Study completion
- 5 Sep 2024 (actual)
- First posted
- 18 Oct 2017 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to investigate whether learning can be accelerated and associative memory performance improved in healthy subjects by applying transcranial Direct Current Stimulation (tDCS) during a Face Name memory task.
Detailed description
Associative memory refers to remembering the association between two items, such as a face and a name or a word in English and the same word in another language. It is not only important for learning, but it is also one of the first aspects of memory performance that is impacted by aging and by Alzheimer׳s disease. For decades, neuroscientists have investigated associative learning and memory and ways to accelerate and enhance associative learning and memory.
Transcranial Direct Current stimulation (tDCS) is a non-invasive and painless electrical stimulation technique that has demonstrated to accelerate learning and improve memory in some studies. To investigate whether learning can be accelerated and associative memory improved by using tDCS, this study will compare the performance in a Face Name Associate memory task from 3 groups. The first group will get active aodal tDCS during the study phase of the Face Name Memory task, whereas the second group will get sham tDCS during the study phase of the task and the third group will get active cathodal tDCS.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| active anodal tDCS | Experimental | Device: active anodal tDCSactive anodal tDCS with Face Name associate Memory task |
| Sham tDCS | Sham comparator | Device: sham tDCSsham tDCS with Face Name associate Memory task |
| active cathodal tDCS | Experimental | Device: active cathodal tDCSactive cathodal tDCS with Face Name associate Memory task |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Age: 18-35 years Native English Speaker
Key exclusion criteria (1 listed)
- History of severe head injuries, epileptic insults, or heart disease. Severe psychiatric disorders and severe untreated medical problems. Contraindications for tDCS (pregnant women, implanted devices)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| active anodal tDCSactive anodal tDCS with memory task | Device | active anodal tDCS |
| sham tDCSsham tDCS with memory task | Device | Sham tDCS |
| active cathodal tDCSactive cathodal tDCS with memory task | Device | active cathodal tDCS |
Primary outcome
Associative Memory assessed by a Face Name Associate Memory experiment
Time frame: Associate Memory is assessed after a 10 minutes break following the study phase
Changes in performance in the Face Name Associate memory task is compared between the 2 groups (1. Real tDCS+ Face Name Associate memory task \& 2. Sham tDCS+ Face Name Associate memory task) to investigate the influence of tDCS on Associative Memory.
Results and safety
The study was withdrawn before enrolling participants, so there are no results.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Jan 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Sven Vanneste, PhD principal investigator
The University of Texas at Dallas
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing active anodal tDCS and active cathodal tDCS in people with Healthy Adults, run by The University of Texas at Dallas at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: withdrawn, as of the sponsor's last update on 10 Jan 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was withdrawn before enrolling participants, so there are no results.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Associative Memory assessed by a Face Name Associate Memory experiment (time frame: Associate Memory is assessed after a 10 minutes break following the study phase). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Jan 2025.