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ObesityQFSNCT03355729

The Quebec Family Study (QFS): Role of Genetic Factors in Obesity and Its Related Risk Factors and Diseases

An observational study of Obesity and Physical Fitness, run by Louis Pérusse.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The Quebec Family Study (QFS) is an observational study that was planned to investigate the role of genetic factors in physical fitness, body composition, risk factors for common disease and health-related behaviour. Read more about this study

Who is it for?
Ages 10 years and older
Conditions the study is for
Obesity, Physical Fitness
How many people
951 participants
Where
No sites listed yet
Study dates
Jun 1978to 5 Sep 2002
Phase
Observational
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 10 years and older
  • All sexes
  • Child, Adult, Older adult

Study population: The QFS cohort is a mixture of random sampling and ascertainment through obese individuals. In Phase 1 of the study, subjects were randomly selected from French-Canadian families living in the Quebec city area, In Phases 2 and 3 of the study, families with a least one obese parent and one obese offspring were recruited.

Who may be able to join

  • Age over 10 years

Who cannot join

  • Not applicable

About this study

Official title: The Quebec Family Study: an Observational Study Aimed at Investigating the Role of Genetic Factors in Physical Fitness, Obesity and Risk Factors for Common Diseases and Health-related Behaviours

The Quebec Family Study (QFS) is an observational study that was planned to investigate the role of genetic factors in physical fitness, body composition, risk factors for common disease and health-related behaviour.

Read the detailed description

The Quebec Family Study was an observational study with three cycles of data collection between 1978 and 1992. During the first cycle of data collection (Phase 1: 1978-1982), a total of 1,650 subjects from 375 families were recruited. During the second cycle (Phase 2: 1989-1997), 385 subjects from 105 phase 1 families were retested and an additional 372 subject from 74 families were recruited. During the third cycle (Phase 3: 1998-2002), 204 subjects from phase 1 were tested a third time, 113 subjects from phase 2 were tested a second time and 194 new subjects from 44 families were recruited.

Medical subject headings
Obesity

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Body composition

    Body composition as assessed by underwater weighing

    Measured: Through study completion, an average of 24 years

  2. Body mass index (kg/m^2)

    Body mass index assessed from height and weight

    Measured: Through study completion, an average of 24 years

  3. Abdominal fat

    Abdominal fat as assessed by commuted tomography

    Measured: Through study completion, an average of 24 years

  4. Waist and hip circumferences (cm)

    Waist and hip circumferences (cm)

    Measured: Through study completion, an average of 24 years

Secondary outcomes (14)

  1. Caloric intake

    Total caloric intake and macronutrient intake using a 3-day dietary record

    Measured: Through study completion, an average of 24 years

  2. Eating behaviour

    Eating behaviour assessed using the Three-Factor Eating questionnaire

    Measured: Through study completion, an average of 24 years

  3. Energy expenditure

    Oxygen consumption at rest and during exercise

    Measured: Through study completion, an average of 24 years

  4. Physical activity level

    Physical activity level assessed by questionnaire

    Measured: Through study completion, an average of 24 years

  5. Blood pressure (mm Hg)

    Systolic and diastolic blood pressure

    Measured: Through study completion, an average of 24 years

  6. Plasma lipid levels (mmol/L)

    Fasting levels of triglycerides, LDL-cholesterol and HDL-cholesterol in mmo/L

    Measured: Through study completion, an average of 24 years

  7. Glucose levels (mmol/L)

    Plasma glucose levels in a fasting state and following an oral glucose tolerance test, inflammatory markers.

    Plasma glucose levels in a fasting state and during an oral glucose tolerance test

    Measured: Through study completion, an average of 24 years

  8. Insulin levels (pmol/L)

    Plasma insulin levels in a fasting state and following an oral glucose tolerance test.

    Measured: Through study completion, an average of 24 years

  9. C-reactive protein (CRP in mg/ml)

    C-reactive protein (CRP in mg/ml)

    Measured: Through study completion, an average of 24 years

  10. Adiponectin levels (in micrograms/ml)

    Adiponectin levels (in micrograms/ml)

    Measured: Through study completion, an average of 24 years

  11. Interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-alpha) in pg/ml

    Interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-alpha) in pg/ml

    Measured: Through study completion, an average of 24 years

  12. Smoking habits (nb of cigarettes per day)

    Smoking habits (nb of cigarettes per day)

    Measured: Through study completion, an average of 24 years

  13. Sleeping (hours/day)

    Sleeping (hours/day)

    Measured: Through study completion, an average of 24 years

  14. Alcohol consumption

    Alcohol consumption (nb of drinks per week)

    Measured: Through study completion, an average of 24 years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted28 Nov 2017
  2. Study startJun 1978
  3. Primary completion5 Sep 2002
  4. Study completion5 Sep 2002

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Family based
Time perspective
Cross-sectional
Enrolment
951 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT03355729
Sponsor's protocol ID
2010-075 CG
Acronym
QFS
Status last verified
Nov 2017
First submitted
16 Nov 2017
Last updated
28 Nov 2017
Results posted
No
FDA-regulated drug
No
FDA-regulated device
No

Publications

  • Chaput JP, Perusse L, Despres JP, Tremblay A, Bouchard C. Findings from the Quebec Family Study on the Etiology of Obesity: Genetics and Environmental Highlights. Curr Obes Rep. 2014 Jan 4;3(1):54-66. doi: 10.1007/s13679-013-0086-3. eCollection 2014.

    PubMed 24533236

  • Jacob R, Drapeau V, Tremblay A, Provencher V, Bouchard C, Perusse L. The role of eating behavior traits in mediating genetic susceptibility to obesity. Am J Clin Nutr. 2018 Sep 1;108(3):445-452. doi: 10.1093/ajcn/nqy130.

    PubMed 29982344

Questions about this trial

What is this clinical trial studying?

An observational study of Obesity and Physical Fitness, run by Louis Pérusse.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 28 Nov 2017. Status can change between updates, so confirm with the study contact before making plans.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Body composition (time frame: Through study completion, an average of 24 years). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT03355729, which also lists 2 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Nov 2017.

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