Acute Ischemic StrokeGSR-ETNCT03356392
German Stroke Registry - Endovascular Treatment
An observational study of Acute Ischemic Stroke, run by Universitätsklinikum Hamburg-Eppendorf at 1 site in Germany.
Trial summary
The German Stroke Registry (GSR) Endovascular Treatment is an academic, independent, prospective, multicentre, observational registry study. Consecutive patients treated with endovascular stroke treatment will be enrolled in German stroke centers. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Acute Ischemic Stroke
- What is being tested?
- telephone call d90
- How many people
- 10,000 participants
- Where
- 1 siteGermany
- Study dates
- Jun 2015to Jun 2027
- How long will I take part?
- 90 Days
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: all acute stroke patients with the clinical diagnosis of acute ischemic stroke, eligible for IVT and IVT initiated within 4.5 hours after stroke onset, Age >18 years
Who may be able to join
- Clinical diagnosis of acute ischemic stroke
- Eligible for intravenous thrombolysis (IVT) and IVT initiated within 4.5 hours after stroke onset
- Confirmed diagnosis of persistent occlusion of terminal carotid artery, middle cerebral artery (M1 or M2), or basilar artery consistent with symptoms
- Age >18 years
- Ethic approval in process
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Germany1 site, 1 recruiting
- Recruiting
University Medical Center Hamburg-Eppendorf (UKE)
Hamburg, Free and Hanseatic City of Hamburg, 20251
Maximilian Schell, +49 (0)1522/2834807, m.schell@uke.de
Götz Thomalla, Prof. Dr. med., +49 (0)40/7410-0, thomalla@uke.de
About this study
The German Stroke Registry (GSR) Endovascular Treatment is an academic, independent, prospective, multicentre, observational registry study. Consecutive patients treated with endovascular stroke treatment will be enrolled in German stroke centers. Patients receive regular care and data will be collected as part of clinical routine. Baseline clinical and procedural information as well clinical follow-up information during in-hospital stay, and up to 90 days of stroke onset are collected. Data collected include demographics, National Institute of Health Stroke Scale (NIHSS) on admission, pre-treatment ASPECTS, information on timing and success of interventional treatment, procedural complications, intracranial hemorrhage, and functional outcome.
- Conditions
- Acute Ischemic Stroke
- Being tested
- telephone call d90
- Keywords
- acute stroke, thrombectomy, endovascular treatment
- Medical subject headings
- Ischemic Stroke, Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
telephone call d90Other
telephone call on day 90 to assess the primary outcome (mRs d90)
| Study group | Role | What they receive |
|---|---|---|
| stroke patients | acute stroke patients treated with endovascular treatment combined with or without Receives: Other: telephone call d90 |
What is being measured
The primary outcome is the main question the study is designed to answer.
modified Ranking Scale (mRS) on day 90
The scale is a commonly used measurement for the degree of disability or dependence in the daily activities of people who have suffered a stroke;
scale range 0-6; with 0 - No symptoms. 1 - No significant disability. Able to carry out all usual activities, despite some symptoms. 2 - Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities. 3 - Moderate disability. Requires some help, but able to walk unassisted. 4 - Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted. 5 - Severe disability. Requires constant nursing care and attention, bedridden, incontinent. 6 - Dead. publication: van Swieten J, Koudstaal P, Visser M, Schouten H, et al. (1988). "Interobserver agreement for the assessment of handicap in stroke patients". Stroke. 19 (5): 604-607. doi:10.1161/01.str.19.5.604. PMID 3363593.
Measured: 90 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Nov 2017
- Study startJun 2015
- Primary completionJun 2027 (estimated)
- Study completionJun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (29)Papers the sponsor has linked to this study.
- Other trials for Acute Ischemic StrokeStudies of the same condition, open and under way.
- More trials run by Universitätsklinikum Hamburg-EppendorfThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 10,000 participants (estimated)
- Target duration
- 90 Days
Sponsor and investigators
- Lead sponsor
- Universitätsklinikum Hamburg-Eppendorf
- Sponsor type
- University, hospital or other
- Collaborators
- University Hospital of Cologne, Technical University of Munich, RWTH Aachen University, University Hospital Tuebingen, Charite University, Berlin, Germany, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Sana Klinikum Offenbach, Goethe University, Klinikum Dortmund, KRH Klinikum Nordstadt, Asklepios Klinik Altona, Klinikum Altenburger Land, Klinikum Stadt Hanau, Klinikum Lüneburg, Ludwig-Maximilians - University of Munich, University of Göttingen, Krankenhaus Buchholz, Klinikum Osnabrück, Wuerzburg University Hospital, University of Giessen and Marburg, Sana Kliniken Lübeck, Mühlenkreiskliniken Minden, radprax MVZ Nordrhein, University Hospital Muenster, University Medical Center Rostock, Asklepios Klinik Wandsbek, Elbe Kliniken, Städtische Klinikum Braunschweig, Allgemeines Krankenhaus Celle, Bezirkskrankenhaus Günzburg, Klinikum Bremen-Mitte, gGmbH, University Medical Center Mainz, Klinikum Köln-Merheim, University Hospital, Bonn
- Responsible party
- Sponsor
- Investigators
- Martin Dichgans, Prof. Dr. med., Principal investigator, LMU, Munich, GermanyChristian Gerloff, Prof. Dr. med., Principal investigator, UKE, Hamburg, Germany
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03356392
- Sponsor's protocol ID
- GSR-ET
- Acronym
- GSR-ET
- Status last verified
- Dec 2024
- First submitted
- 22 Nov 2017
- Last updated
- 11 Dec 2024
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Deb-Chatterji M, Pinho J, Flottmann F, Meyer L, Broocks G, Brekenfeld C, Reich A, Fiehler J, Gerloff C, Thomalla G; GSR-ET Investigators. Health-related quality of life after thrombectomy in young-onset versus older stroke patients: a multicenter analysis. J Neurointerv Surg. 2022 Nov;14(11):1145-1150. doi: 10.1136/neurintsurg-2021-017991. Epub 2021 Dec 7.
PubMed 34876497Kniep H, Bechstein M, Broocks G, Brekenfeld C, Flottmann F, van Horn N, Geest V, Faizy TD, Deb-Chatterji M, Alegiani A, Thomalla G, Gellissen S, Fiehler J, Hanning U, Meyer L; German Stroke Registry-Endovascular Treatment (GSR-ET). Early surrogates of outcome after thrombectomy in posterior circulation stroke. Eur J Neurol. 2022 Nov;29(11):3296-3306. doi: 10.1111/ene.15519. Epub 2022 Aug 28.
PubMed 35933692Wischmann J, Nolte CH, Riegler C, Siebert E, Boeckh-Behrens T, Wunderlich S, Berndt MT, Rattenberger A, Hafner F, Hoffmann V, Mohlenbruch MA, Purrucker J, Fischer TD, Kellert L; GSR-ET investigators. Nimodipine in catheter flush solutions is associated with reduced vasospasm risk in endovascular stroke treatment. J Neurointerv Surg. 2026 Sep 11:jnis-2026-025972. doi: 10.1136/jnis-2026-025972. Online ahead of print.
PubMed 42728086Ahmad B, Maier IL, Wasser K, Dakna M, Behme D, Schnieder M, Tsogkas I, Ernst M, Brehm A, Bahr M, Psychogios MN, Liman J; German Stroke Registry-Endovascular Treatment (GSR-ET). One-Stop Management Improves Outcome for Large Vessel Occlusion Stroke. Stroke Vasc Interv Neurol. 2025 Dec 18;6(1):e001941. doi: 10.1161/SVIN.125.001941. eCollection 2026 Jan.
PubMed 41816517Asperger H, Bode F, Ebrahimi T, Kindler C, Layer J, Meissner JN, Nitsch L, Shirvani O, Thielscher C, von Danwitz NM, Weller J, Dorn F, Petzold GC, Stosser S; GSR-ET Investigators. Impact of Severe Prestroke Disability on Outcomes After Mechanical Thrombectomy: A Multicenter Analysis. Stroke Vasc Interv Neurol. 2026 Jan 6;6(1):e002055. doi: 10.1161/SVIN.125.002055. eCollection 2026 Jan.
PubMed 41816510Hahn M, Groschel S, Lang LS, Othman AE, Groschel K, Uphaus T; German Stroke Registry - Endovascular Treatment (GSR-ET) investigators. Mortality within three months after nonfatal ischemic stroke treated by mechanical thrombectomy in routine care-data from the German Stroke Registry. Neurol Res Pract. 2025 Oct 1;7(1):71. doi: 10.1186/s42466-025-00427-7.
PubMed 41035079Tong X, Jia B, Ma G, Zhang X, Fiehler J, Flottmann F, Bechstein M, Broocks G, Hanning U, Kniep HC, Thomalla G, Deb-Chatterji M, Schon G, Zhang Y, Gao F, Ma N, Mo D, Miao Z, Meyer L; as the ANGEL-ACT & GSR-ET study group. Relationship Between Thrombolysis-to-Puncture Time and Outcomes of Endovascular Thrombectomy in Acute Ischemic Stroke. Neurol Clin Pract. 2025 Aug;15(4):e200434. doi: 10.1212/CPJ.0000000000200434. Epub 2025 Jul 11.
PubMed 40656129Heitkamp A, Hierholzer SM, Heitkamp C, Winkelmeier L, Meyer L, Bechstein M, Geest V, Broocks G, Brekenfeld C, Flottmann F, Schell M, Thomalla G, Faizy T, Fiehler J, Kniep HC, Gellissen S; German Stroke Registry -Endovascular Treatment (GSR-ET). Key to better outcomes in stroke intervention: early versus complete reperfusion in first pass recanalization. J Neurol. 2025 Jul 11;272(8):504. doi: 10.1007/s00415-025-13235-5.
PubMed 40646337Single C, Mengel A, Laichinger K, Sartor-Pfeiffer J, Selo N, Hennersdorf F, Bender B, Deb-Chatterji M, Thomalla G, Mbroh J, Poli S, Ziemann U, Ernemann U, Feil K; German Stroke Registry-Endovascular Treatment (GSR). Sex-Related Differences in Outcomes of Endovascular Treatment in Large Vessel Occlusion Stroke-Analyses From the German Stroke Registry-Endovascular Treatment. Eur J Neurol. 2025 Mar;32(3):e70092. doi: 10.1111/ene.70092.
PubMed 40008680Beckonert NM, Weller JM, Alegiani AC, Boeckh-Behrens T, Deb-Chatterji M, Hamann GF, Krause LU, Lehnen NC, Nitsch L, Poli S, Riedel C, Tiedt S, Zweynert S, Petzold GC, Dorn F, Bode FJ; GSR-ET investigators. Endovascular treatment of primary M3 occlusion stroke in clinical practice: analysis of the German Stroke Registry. Neurol Res Pract. 2024 Jul 18;6(1):36. doi: 10.1186/s42466-024-00330-7.
PubMed 39020409Heitkamp C, Heitkamp A, Winkelmeier L, Thaler C, Flottmann F, Schell M, Kniep HC, Broocks G, Heit JJ, Albers GW, Thomalla G, Fiehler J, Faizy TD. Predictors of futile recanalization in ischemic stroke patients with low baseline NIHSS. Int J Stroke. 2024 Dec;19(10):1102-1112. doi: 10.1177/17474930241264737. Epub 2024 Nov 19.
PubMed 38888031Winkelmeier L, Heitkamp C, Faizy TD, Broocks G, Kniep H, Meyer L, Bester M, Brekenfeld C, Schell M, Hanning U, Thomalla G, Fiehler J, Flottmann F. Prognostic value of recanalization attempts in endovascular therapy for M2 segment middle cerebral artery occlusions. Int J Stroke. 2024 Apr;19(4):422-430. doi: 10.1177/17474930231214769. Epub 2023 Nov 22.
PubMed 37935652Kniep H, Meyer L, Broocks G, Bechstein M, Guerreiro H, Winkelmeier L, Brekenfeld C, Flottmann F, Deb-Chatterji M, Alegiani A, Hanning U, Thomalla G, Fiehler J, Gellissen S; German Stroke Registry - Endovascular Treatment (GSR - ET). Predictors of functional outcome after thrombectomy for M2 occlusions: a large scale experience from clinical practice. Sci Rep. 2023 Oct 31;13(1):18740. doi: 10.1038/s41598-023-45232-x.
PubMed 37907482Winkelmeier L, Faizy TD, Brekenfeld C, Heitkamp C, Broocks G, Bechstein M, Steffen P, Schell M, Gellissen S, Kniep H, Thomalla G, Fiehler J, Flottmann F; German Stroke Registry - Endovascular Treatment (GSR). Comparison of Thrombolysis In Cerebral Infarction (TICI) 2b and TICI 3 reperfusion in endovascular therapy for large ischemic anterior circulation strokes. J Neurointerv Surg. 2024 Oct 14;16(11):1076-1082. doi: 10.1136/jnis-2023-020724.
PubMed 37777256Winkelmeier L, Faizy TD, Broocks G, Meyer L, Heitkamp C, Brekenfeld C, Thaler C, Steffen P, Schell M, Deb-Chatterji M, Hanning U, Kniep H, Maros ME, Thomalla G, Fiehler J, Flottmann FA; German Stroke Registry. Association Between Recanalization Attempts and Functional Outcome After Thrombectomy for Large Ischemic Stroke. Stroke. 2023 Sep;54(9):2304-2312. doi: 10.1161/STROKEAHA.123.042794. Epub 2023 Jul 26.
PubMed 37492970
Study at a glance
From the registry record, last updated by the sponsor on 11 Dec 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- German Stroke Registry - Endovascular Treatment
- ClinicalTrials.gov ID
- NCT03356392
- Acronym / sponsor ID
- GSR-ET / GSR-ET
- Conditions
- Acute Ischemic Stroke
- Keywords
- acute stroke, thrombectomy, endovascular treatment
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 10,000 participants (estimated)
- Lead sponsor
- Universitätsklinikum Hamburg-EppendorfUniversity, hospital or other
- Collaborators
- University Hospital of Cologne, Technical University of Munich, RWTH Aachen University, University Hospital Tuebingen, Charite University, Berlin, Germany, Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Sana Klinikum Offenbach, Goethe University, Klinikum Dortmund, KRH Klinikum Nordstadt, Asklepios Klinik Altona, Klinikum Altenburger Land, Klinikum Stadt Hanau, Klinikum Lüneburg, Ludwig-Maximilians - University of Munich, University of Göttingen, Krankenhaus Buchholz, Klinikum Osnabrück, Wuerzburg University Hospital, University of Giessen and Marburg, Sana Kliniken Lübeck, Mühlenkreiskliniken Minden, radprax MVZ Nordrhein, University Hospital Muenster, University Medical Center Rostock, Asklepios Klinik Wandsbek, Elbe Kliniken, Städtische Klinikum Braunschweig, Allgemeines Krankenhaus Celle, Bezirkskrankenhaus Günzburg, Klinikum Bremen-Mitte, gGmbH, University Medical Center Mainz, Klinikum Köln-Merheim, University Hospital, Bonn
- Study start
- Jun 2015 (actual)
- Primary completion
- Jun 2027 (estimated)
- Study completion
- Jun 2027 (estimated)
- First posted
- 29 Nov 2017 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The German Stroke Registry (GSR) Endovascular Treatment is an academic, independent, prospective, multicentre, observational registry study. Consecutive patients treated with endovascular stroke treatment will be enrolled in German stroke centers. Patients receive regular care and data will be collected as part of clinical routine. Baseline clinical and procedural information as well clinical follow-up information during in-hospital stay, and up to 90 days of stroke onset are collected. Data collected include demographics, National Institute of Health Stroke Scale (NIHSS) on admission, pre-treatment ASPECTS, information on timing and success of interventional treatment, procedural complications, intracranial hemorrhage, and functional outcome.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 90 Days
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| stroke patients | – | Other: telephone call d90acute stroke patients treated with endovascular treatment combined with or without |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- all acute stroke patients with the clinical diagnosis of acute ischemic stroke, eligible for IVT and IVT initiated within 4.5 hours after stroke onset, Age >18 years
Key inclusion criteria (5 listed)
- Clinical diagnosis of acute ischemic stroke
- Eligible for intravenous thrombolysis (IVT) and IVT initiated within 4.5 hours after stroke onset
- Confirmed diagnosis of persistent occlusion of terminal carotid artery, middle cerebral artery (M1 or M2), or basilar artery consistent with symptoms
- Age >18 years
- Ethic approval in process
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| telephone call d90telephone call on day 90 to assess the primary outcome (mRs d90) | Other | stroke patients |
Primary outcome
modified Ranking Scale (mRS) on day 90
Time frame: 90 days
The scale is a commonly used measurement for the degree of disability or dependence in the daily activities of people who have suffered a stroke; scale range 0-6; with 0 - No symptoms. 1 - No significant disability. Able to carry out all usual activities, despite some symptoms. 2 - Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities. 3 - Moderate disability. Requires some help, but able to walk unassisted. 4 - Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted. 5 - Severe disability. Requires constant nursing care and attention, bedridden, incontinent. 6 - Dead. publication: van Swieten J, Koudstaal P, Visser M, Schouten H, et al. (1988). "Interobserver agreement for the assessment of handicap in stroke patients". Stroke. 19 (5): 604-607. doi:10.1161/01.str.19.5.604. PMID 3363593.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Dec 2024.
- Background: PubMed 34876497Deb-Chatterji M, Pinho J, Flottmann F, Meyer L, Broocks G, Brekenfeld C, Reich A, Fiehler J, Gerloff C, Thomalla G; GSR-ET Investigators. Health-related quality of life after thrombectomy in young-onset versus older stroke patients: a multicenter analysis. J Neurointerv Surg. 2022 Nov;14(11):1145-1150. doi: 10.1136/neurintsurg-2021-017991. Epub 2021 Dec 7.
- Background: PubMed 35933692Kniep H, Bechstein M, Broocks G, Brekenfeld C, Flottmann F, van Horn N, Geest V, Faizy TD, Deb-Chatterji M, Alegiani A, Thomalla G, Gellissen S, Fiehler J, Hanning U, Meyer L; German Stroke Registry-Endovascular Treatment (GSR-ET). Early surrogates of outcome after thrombectomy in posterior circulation stroke. Eur J Neurol. 2022 Nov;29(11):3296-3306. doi: 10.1111/ene.15519. Epub 2022 Aug 28.
- Derived from this study: PubMed 42728086Wischmann J, Nolte CH, Riegler C, Siebert E, Boeckh-Behrens T, Wunderlich S, Berndt MT, Rattenberger A, Hafner F, Hoffmann V, Mohlenbruch MA, Purrucker J, Fischer TD, Kellert L; GSR-ET investigators. Nimodipine in catheter flush solutions is associated with reduced vasospasm risk in endovascular stroke treatment. J Neurointerv Surg. 2026 Sep 11:jnis-2026-025972. doi: 10.1136/jnis-2026-025972. Online ahead of print.
- Derived from this study: PubMed 41816517Ahmad B, Maier IL, Wasser K, Dakna M, Behme D, Schnieder M, Tsogkas I, Ernst M, Brehm A, Bahr M, Psychogios MN, Liman J; German Stroke Registry-Endovascular Treatment (GSR-ET). One-Stop Management Improves Outcome for Large Vessel Occlusion Stroke. Stroke Vasc Interv Neurol. 2025 Dec 18;6(1):e001941. doi: 10.1161/SVIN.125.001941. eCollection 2026 Jan.
- Derived from this study: PubMed 41816510Asperger H, Bode F, Ebrahimi T, Kindler C, Layer J, Meissner JN, Nitsch L, Shirvani O, Thielscher C, von Danwitz NM, Weller J, Dorn F, Petzold GC, Stosser S; GSR-ET Investigators. Impact of Severe Prestroke Disability on Outcomes After Mechanical Thrombectomy: A Multicenter Analysis. Stroke Vasc Interv Neurol. 2026 Jan 6;6(1):e002055. doi: 10.1161/SVIN.125.002055. eCollection 2026 Jan.
- Derived from this study: PubMed 41035079Hahn M, Groschel S, Lang LS, Othman AE, Groschel K, Uphaus T; German Stroke Registry - Endovascular Treatment (GSR-ET) investigators. Mortality within three months after nonfatal ischemic stroke treated by mechanical thrombectomy in routine care-data from the German Stroke Registry. Neurol Res Pract. 2025 Oct 1;7(1):71. doi: 10.1186/s42466-025-00427-7.
- Derived from this study: PubMed 40656129Tong X, Jia B, Ma G, Zhang X, Fiehler J, Flottmann F, Bechstein M, Broocks G, Hanning U, Kniep HC, Thomalla G, Deb-Chatterji M, Schon G, Zhang Y, Gao F, Ma N, Mo D, Miao Z, Meyer L; as the ANGEL-ACT & GSR-ET study group. Relationship Between Thrombolysis-to-Puncture Time and Outcomes of Endovascular Thrombectomy in Acute Ischemic Stroke. Neurol Clin Pract. 2025 Aug;15(4):e200434. doi: 10.1212/CPJ.0000000000200434. Epub 2025 Jul 11.
- Derived from this study: PubMed 40646337Heitkamp A, Hierholzer SM, Heitkamp C, Winkelmeier L, Meyer L, Bechstein M, Geest V, Broocks G, Brekenfeld C, Flottmann F, Schell M, Thomalla G, Faizy T, Fiehler J, Kniep HC, Gellissen S; German Stroke Registry -Endovascular Treatment (GSR-ET). Key to better outcomes in stroke intervention: early versus complete reperfusion in first pass recanalization. J Neurol. 2025 Jul 11;272(8):504. doi: 10.1007/s00415-025-13235-5.
- Derived from this study: PubMed 40008680Single C, Mengel A, Laichinger K, Sartor-Pfeiffer J, Selo N, Hennersdorf F, Bender B, Deb-Chatterji M, Thomalla G, Mbroh J, Poli S, Ziemann U, Ernemann U, Feil K; German Stroke Registry-Endovascular Treatment (GSR). Sex-Related Differences in Outcomes of Endovascular Treatment in Large Vessel Occlusion Stroke-Analyses From the German Stroke Registry-Endovascular Treatment. Eur J Neurol. 2025 Mar;32(3):e70092. doi: 10.1111/ene.70092.
- Derived from this study: PubMed 39020409Beckonert NM, Weller JM, Alegiani AC, Boeckh-Behrens T, Deb-Chatterji M, Hamann GF, Krause LU, Lehnen NC, Nitsch L, Poli S, Riedel C, Tiedt S, Zweynert S, Petzold GC, Dorn F, Bode FJ; GSR-ET investigators. Endovascular treatment of primary M3 occlusion stroke in clinical practice: analysis of the German Stroke Registry. Neurol Res Pract. 2024 Jul 18;6(1):36. doi: 10.1186/s42466-024-00330-7.
- Derived from this study: PubMed 38888031Heitkamp C, Heitkamp A, Winkelmeier L, Thaler C, Flottmann F, Schell M, Kniep HC, Broocks G, Heit JJ, Albers GW, Thomalla G, Fiehler J, Faizy TD. Predictors of futile recanalization in ischemic stroke patients with low baseline NIHSS. Int J Stroke. 2024 Dec;19(10):1102-1112. doi: 10.1177/17474930241264737. Epub 2024 Nov 19.
- Derived from this study: PubMed 37935652Winkelmeier L, Heitkamp C, Faizy TD, Broocks G, Kniep H, Meyer L, Bester M, Brekenfeld C, Schell M, Hanning U, Thomalla G, Fiehler J, Flottmann F. Prognostic value of recanalization attempts in endovascular therapy for M2 segment middle cerebral artery occlusions. Int J Stroke. 2024 Apr;19(4):422-430. doi: 10.1177/17474930231214769. Epub 2023 Nov 22.
- Homepage of German Stroke RegistryLink provided by the sponsor.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Martin Dichgans, Prof. Dr. med. principal investigator
LMU, Munich, Germany
Christian Gerloff, Prof. Dr. med. principal investigator
UKE, Hamburg, Germany
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Acute Ischemic Stroke, run by Universitätsklinikum Hamburg-Eppendorf at 1 site in Germany.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 11 Dec 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Germany. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Maximilian Schell (+49 (0)1522/2834807, m.schell@uke.de), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
modified Ranking Scale (mRS) on day 90 (time frame: 90 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03356392, which also lists 29 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Dec 2024.