Corneal TransplantationNCT03381794
The German Keratoplasty Registry of the German Ophthalmological Society (DOG)
An observational study of Corneal Transplantation, run by Universität des Saarlandes at 1 site in Germany.
Trial summary
Aim of this study is to reflect on the changing trends in absolute numbers, surgical techniques and indications of corneal transplantations being performed in Germany. The Section Cornea of the German Ophthalmological Society provides interim-assessments on a regular basis about the most up-to-date results of this… Read more about this study
- Who is it for?
- Ages 1 year to 100 years
- Conditions the study is for
- Corneal Transplantation
- What is being tested?
- Corneal transplantation
- Type of treatment
- Surgery or procedure
- How many people
- 100,000 participants
- Where
- 1 siteGermany
- Study dates
- 1 Jan 2001to 1 Jan 2036
- How long will I take part?
- 16 Years
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 1 year to 100 years
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: All patients in Germany treated with the different types of corneal transplantation since 2001.
Who may be able to join
- All patients in Germany treated with the different types of corneal transplantation since 2001.
Who cannot join
- Patients without corneal transplantation.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Germany1 site, 1 recruiting
- Recruiting
Department of Ophthalmology
Homburg, Saarland, 66421
Elias Flockerzi, PD Dr.med., 0049-6841-16-22302, elias.flockerzi@uks.eu
Berthold Seitz, Prof.Dr.med., 0049-6841-16-22387, berthold.seitz@uks.eu
About this study
Official title: Trends in Corneal Transplantation From 2001 in Germany: Reports of the DOG-Section Cornea and Its Keratoplasty Registry
Aim of this study is to reflect on the changing trends in absolute numbers, surgical techniques and indications of corneal transplantations being performed in Germany.
The Section Cornea of the German Ophthalmological Society provides interim-assessments on a regular basis about the most up-to-date results of this long-term study.
- Conditions
- Corneal Transplantation
- Being tested
- Corneal transplantation
- Keywords
- Keratoplasty Registry, PKP, DSAEK, DMEK, DALK
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Corneal transplantationProcedure or surgery
Also called PKP, DALK, DMEK, DSAEK
PKP: Penetrating Keratoplasty DALK: Deep Anterior Lamellar Keratoplasty DMEK: Descemet Membrane Endothelial Keratoplasty DSAEK: Descemet's Stripping Automated Endothelial Keratoplasty
| Study group | Role | What they receive |
|---|---|---|
| Patients with corneal transplantation | Aim is to include all patients in Germany treated with the different types of corneal transplantation. Receives: Procedure: Corneal transplantation |
What is being measured
The primary outcome is the main question the study is designed to answer.
An overview about absolute numbers of corneal transplantation in Germany.
A questionnaire about absolute numbers of corneal transplantation per year was sent to the 111 ophthalmological departments in Germany performing corneal transplantation. Data has been and is collected annually since 2001.
Measured: 01/01/2001 to 31/12/2031
An overview about trends in the various types of corneal transplantation in Germany.
The questionnaire also records the types of corneal transplantation (i.e. penetrating keratoplasty, deep anterior lamellar keratoplasty, Descemet membrane endothelial keratoplasty (DMEK) and Descemet's stripping automated endothelial keratoplasty DSAEK) allowing a discussion of trends in corneal transplantation. Data has been and is collected annually since 2001.
Measured: 01/01/2001 to 31/12/2031
An overview about indications for corneal transplantation in Germany.
The questionnaire also records the indications for corneal transplantation (e.g. Fuchs' endothelial corneal dystrophy, pseudophakic corneal decompensation, repeated keratoplasty after graft failure, keratoconus and corneal scarring). Data has been and is collected annually since 2001.
Measured: 01/01/2001 to 31/12/2031
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Dec 2017
- Study start1 Jan 2001
- Primary completion1 Jan 2036 (estimated)
- Study completion1 Jan 2036 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Corneal TransplantationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Other
- Enrolment
- 100,000 participants (estimated)
- Target duration
- 16 Years
Sponsor and investigators
- Lead sponsor
- Universität des Saarlandes
- Sponsor type
- University, hospital or other
- Collaborators
- University Eye Hospital, Freiburg, University of Erlangen-Nürnberg, University of Cologne, Heinrich-Heine University, Duesseldorf, Charite University, Berlin, Germany
- Responsible party
- Principal investigator, Elias Flockerzi, University Hospital, Saarland
- Investigators
- Berthold Seitz, Prof.Dr.med., Study director, Universität des Saarlandes
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03381794
- Sponsor's protocol ID
- GeKeR
- Status last verified
- Apr 2026
- First submitted
- 11 Dec 2017
- Last updated
- 27 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Flockerzi E, Turner C, Seitz B, Collaborators GSG; GeKeR Study Group. Descemet's membrane endothelial keratoplasty is the predominant keratoplasty procedure in Germany since 2016: a report of the DOG-section cornea and its keratoplasty registry. Br J Ophthalmol. 2024 May 21;108(5):646-653. doi: 10.1136/bjo-2022-323162.
PubMed 37586835Flockerzi E, Maier P, Bohringer D, Reinshagen H, Kruse F, Cursiefen C, Reinhard T, Geerling G, Torun N, Seitz B; all German Keratoplasty Registry Contributors. Trends in Corneal Transplantation from 2001 to 2016 in Germany: A Report of the DOG-Section Cornea and its Keratoplasty Registry. Am J Ophthalmol. 2018 Apr;188:91-98. doi: 10.1016/j.ajo.2018.01.018. Epub 2018 Feb 2.
PubMed 29410297