AzTrials
AzTrials

Dermatitis, AtopicPhase 3JADE EXTENDNCT03422822

Study to Evaluate Efficacy and Safety of PF-04965842 With or Without Topical Medications in Subjects Aged 12 Years and Older With Moderate to Severe Atopic Dermatitis

A Phase 3 study testing Abrocitinib 100 mg and Abrocitinib 200 mg in people with Dermatitis, Atopic, run by Pfizer at 539 sites in 28 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
Search all trials

Trial summary

B7451015 is a Phase 3 study to evaluate Abrocitinib with or without Topical Medications in patients aged 12 years and older who have moderate to severe atopic dermatitis and have completed a qualifying parent study. Read more about this study

Who is it for?
Ages 12 years and older
Conditions the study is for
Dermatitis, Atopic
What is being tested?
Abrocitinib 100 mg and Abrocitinib 200 mg
Type of treatment
Pill or oral medicine
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
3,166 participants
Where
539 sitesin 28 countries
Study dates
8 Mar 2018to 22 Dec 2025
Phase
Phase 3
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 12 years and older
  • All sexes
  • No healthy volunteers
  • Child, Adult, Older adult

Who may be able to join

  • Evidence of a personally signed and dated informed consent document indicating that the subject or their parent(s)/legal guardian, if applicable, have been informed of all pertinent aspects of the study.
  • Male or female subjects of 12 years of age or older, at the time of informed consent and meets inclusion criterion for minimum body weight (if applicable) from qualifying Parent study. Adolescent subjects below the age of 18 years old (or country-specific age of majority) will only be enrolled in this study if instructed by the sponsor and approved by the country or regulatory/health authority. If these approvals have not been granted, only subjects aged 18 years (or country-specific age of majority) and older will be enrolled.
  • Willing and able to comply with scheduled visits, treatment plan, laboratory tests and other study procedures.
  • Must have completed the full treatment period of a qualifying Parent study OR must have completed the full rescue treatment period of a qualifying Parent study (if applicable) OR must have completed the full open-label run-in period in B7451014 and did not meet the protocol-specified response criteria at Week 12.
  • Female subjects who are of childbearing potential (which includes all female subjects aged 12 years and older, regardless of whether they have experienced menarche) must ot be intending to become pregnant, currently pregnant, or lactating. The following onditions apply:
  • Female subjects of childbearing potential must have a confirmed negative pregnancy test prior to allocation to treatment.
Show all 21Show fewer
  • Female subjects of childbearing potential must agree to use a highly effective method of contraception (as per Section 4.4.1) for the duration of the active treatment period and for at least 28 days after the last dose of investigational product.
  • For Czech Republic only, 5 b. is revised and 5 c. is added to require:
  • Female subjects of childbearing potential 15 years of age who are at risk of pregnancy must agree to use a highly effective method of contraception for the duration of the active treatment period and for at least 28 days after the last dose of investigational product.
  • Female subjects less than 15 years of age must not be sexually active, and abstinence per the below definition should be confirmed prior to enrollment. NOTE: Sexual abstinence, defined as completely and persistently refraining from all heterosexual intercourse (including during the entire period of risk associated with the study treatments) may obviate the need for contraception ONLY if this is the preferred and usual lifestyle of the subject.
  • 6. Female subjects of non-childbearing potential must meet at least 1 of the following criteria:
  • Have undergone a documented hysterectomy and/or bilateral oophorectomy;
  • Have medically confirmed ovarian failure; or
  • Achieved postmenopausal status, defined as follows: cessation of regular menses for at least 12 consecutive months with no alternative pathological or physiological cause and have a serum follicle-stimulating hormone (FSH) level confirming the postmenopausal state. All other female subjects (including female subjects with tubal ligations) are considered to be of childbearing potential. 7. Must agree to avoid prolonged exposure to the sun and not to use tanning booths, sun lamps or other ultraviolet light sources during the study.
  • 8. Must agree to avoid use of prohibited medications throughout the duration of the study. Exclusion Criteria
  • Other acute or chronic medical or psychiatric condition including recent (within the past year) or active suicidal ideation or behavior or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the subject inappropriate for entry into this study.
  • Currently have active forms of other inflammatory skin diseases, ie, not AD or have evidence of skin conditions (eg, psoriasis, seborrheic dermatitis, Lupus) at the time of Day -1 that would interfere with evaluation of atopic dermatitis or response to treatment.
  • Discontinued from treatment (or rescue treatment period/open-label run-in period, if applicable) early in a qualifying Parent study OR triggered a discontinuation criterion at any point during the qualifying Parent study which in the opinion of the investigator, or sponsor, is an ongoing safety concern.
  • Ongoing adverse event in the qualifying Parent study which in the opinion of the investigator, or sponsor, is an ongoing safety concern.
  • Investigator site staff members directly involved in the conduct of the study and their family members, site staff members otherwise supervised by the investigator, or subjects who are Pfizer employees, including their family members, directly involved in the conduct of the study.
  • There are also additional separate inclusion and exclusion criteria to assess eligibility specifically for the B7451015 MRI sub-study.

Who cannot join

None listed.

Trial locations and contacts

539 sites in 28 countries.

539 sites in 28 countries

United States156 sites

  • Emmaus Research Center, Inc.

    Anaheim, California, 92804

  • Synexus Clinical Research US, Inc.

    Anderson, South Carolina, 29621

  • Arlington Research Center, Inc.

    Arlington, Texas, 76011

  • Meridian Clinical Research, LLC

    Baton Rouge, Louisiana, 70808

  • The University of Texas Health Science Center Houston

    Bellaire, Texas, 77401

  • Bexley Dermatology Research

    Bexley, Ohio, 43209

  • Total Skin and Beauty Dermatology Center, PC

    Birmingham, Alabama, 35205

  • Clinical Research Center of Alabama, LLC

    Birmingham, Alabama, 35209

  • University of Alabama at Birmingham - Dermatology Research Clinic

    Birmingham, Alabama, 35233

  • University of Alabama at Birmingham Hospital Outreach Lab

    Birmingham, Alabama, 35233

  • Clinical Research Center of Alabama, LLC

    Birmingham, Alabama, 35244

  • The University of Alabama at Birmingham, Department of Dermatology

    Birmingham, Alabama, 35294

  • Skin Care Research

    Boca Raton, Florida, 33486

  • Tufts Medical Center

    Boston, Massachusetts, 02111

  • Massachusetts General Hospital - Clinical Unit for Research Trials in Skin (CURTIS)

    Boston, Massachusetts, 02114

  • MetroBoston Clinical Partners, LLC

    Brighton, Massachusetts, 02135

  • Renaissance Research and Medical Group, Inc

    Cape Coral, Florida, 33991

  • Cary Dermatology Center, PA

    Cary, North Carolina, 27511

  • Accellacare - Cary

    Cary, North Carolina, 27518

  • MUSC SCTR Research Nexus Clinic and Laboratory

    Charleston, South Carolina, 29425

  • Institute for Asthma and Allergy

    Chevy Chase, Maryland, 20815

  • Portland Clinical Research dba Columbia Asthma & Allergy Clinic

    Clackamas, Oregon, 97015

  • Clarkston Skin Research

    Clarkston, Michigan, 48346

  • Ds Research

    Clarksville, Indiana, 47129

  • Asthma and Allergy Associates, PC

    Colorado Springs, Colorado, 80907

  • Colorado Springs Dermatology Clinic, PC

    Colorado Springs, Colorado, 80910

  • Columbus Regional Research Institute

    Columbus, Georgia, 31904

  • IACT Health

    Columbus, Georgia, 31904

  • The Ohio State University Wexner Medical Center

    Columbus, Ohio, 43210

  • Florida Academic Centers Research and Education, LLC

    Coral Gables, Florida, 33134

  • Skin Research Institute

    Coral Gables, Florida, 33146

  • Avant Research Associates LLC

    Crowley, Louisiana, 70526

  • Menter Dermatology Research Institute

    Dallas, Texas, 75246

  • Henry Ford Medical Center, New Center One

    Detroit, Michigan, 48202

  • Moonshine Research Center, Inc.

    Doral, Florida, 33166

  • California Dermatology & Clinical Research Institute

    Encinitas, California, 92024

  • Onyx Clinical Research

    Flint, Michigan, 48507

  • Hamzavi Dermatology

    Fort Gratiot, Michigan, 48059

  • First OC Dermatology Research Inc

    Fountain Valley, California, 92708

  • Summit Clinical Research, LLC

    Franklin, Virginia, 23851

  • The Ohio State University Dermatology East

    Gahanna, Ohio, 43230

  • Medication Management, LLC

    Greensboro, North Carolina, 27408

  • Homestead Research Institute

    Homestead, Florida, 33030

  • Center for Clinical Studies, LTD. LLP

    Houston, Texas, 77004

  • Marvel Research, LLC

    Huntington Beach, California, 92647

  • Ventavia Research Group

    Hurst, Texas, 76054

  • Dawes Fretzin Clinical Research Group, LLC

    Indianapolis, Indiana, 46250

  • Tilda Research Inc.

    Irvine, California, 92612

  • Clinical Neuroscience Solutions, Inc.

    Jacksonville, Florida, 32256

  • Solutions Through Advanced Research, Inc.

    Jacksonville, Florida, 32256

  • One Health Research Clinic Atlanta, LLC

    Johns Creek, Georgia, 30097

  • C & R Research Services USA, Inc

    Kendall, Florida, 33183

  • Forest Hills Dermatology Group

    Kew Gardens, New York, 11415

  • Pace Dermatology Associates

    Lakewood, Washington, 98499

  • Beach Allergy and Asthma Specialty Group, A Medical Corporation

    Long Beach, California, 90808

  • Keck School of Medicine of University of Southern California

    Los Angeles, California, 90033

  • Wallace Medical Group, Inc

    Los Angeles, California, 90056

  • Skin Sciences, PLLC

    Louisville, Kentucky, 40217

  • Dermatologic Surgery Specialists, PC

    Macon, Georgia, 31217

  • Velocity Clinical Research, Medford

    Medford, Oregon, 97504

  • Tanenbaum Dermatology Center

    Memphis, Tennessee, 38117

  • Clinical Neuroscience Solutions, Inc.

    Memphis, Tennessee, 38119

  • Clinical Trials Solutions

    Miami, Florida, 33126

  • Global Health Clinical Trials Corp

    Miami, Florida, 33135

  • Baumann Cosmetic and Research Institute

    Miami, Florida, 33137

  • Suncoast Research Associates

    Miami, Florida, 33144

  • La Salud Research Clinic, Inc.

    Miami, Florida, 33155

  • Nicklaus Children's Hospital

    Miami, Florida, 33155

  • South Miami Medical & Research Group, Inc.

    Miami, Florida, 33155

  • Ciocca Dermatology, PA

    Miami, Florida, 33173

  • Miami Dermatology & Laser Research, LLC

    Miami, Florida, 33173

  • INTERMED Medical Research Center, Inc

    Miami, Florida, 33175

  • Suncoast Research Associates

    Miami, Florida, 33184

  • Savin Medical Group LLC

    Miami Lakes, Florida, 33014

  • Wellness Clinical Research, LLC

    Miami Lakes, Florida, 33016

  • Children's Hospital of Wisconsin Investigational Drug Service

    Milwaukee, Wisconsin, 53226

  • Children's Hospital of Wisconsin Translational Research Unit

    Milwaukee, Wisconsin, 53226

  • Clinical Research Institute, Inc.

    Minneapolis, Minnesota, 55402

  • Allergy & Asthma Associates of Southern California dba Southern California Research

    Mission Viejo, California, 92691

  • International Clinical Research - Tennessee LLC

    Murfreesboro, Tennessee, 37130

  • ASR, LLC

    Nampa, Idaho, 83687

  • Tulane University Health Sciences Center

    New Orleans, Louisiana, 70112

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029

  • Virginia Clinical Research, Inc

    Norfolk, Virginia, 23502

  • Virginia Dermatology and Skin Cancer Center

    Norfolk, Virginia, 23502

  • Fort Norfolk Diagnostic Center

    Norfolk, Virginia, 23510

  • Midwest Allergy Sinus Asthma, SC

    Normal, Illinois, 61761

  • Dermatology Specialists, Inc.

    Oceanside, California, 92056

  • Lynn Health Science Institute

    Oklahoma City, Oklahoma, 73112

  • Newton Clinical Research

    Oklahoma City, Oklahoma, 73120

  • Skin Specialists PC

    Omaha, Nebraska, 68144

  • Park Avenue Dermatology

    Orange Park, Florida, 32073

  • Clinical Neuroscience Solutions, Inc.

    Orlando, Florida, 32801

  • AdventHealth Orlando

    Orlando, Florida, 32803

  • AdventHealth Pediatric Dermatology Orlando

    Orlando, Florida, 32803

  • Advent Health Orlando - Investigational Drug Services

    Orlando, Florida, 32804

  • Outpatient Services Center - AdventHealth Orlando

    Orlando, Florida, 32804

  • Pediatric Outpatient Procedures and Sedation

    Orlando, Florida, 32804

  • Accel Research Sites - Nona Pediatric Center

    Orlando, Florida, 32829

  • Kansas City Dermatology, PA

    Overland Park, Kansas, 66215

  • Qualmedica Research, LLC.

    Owensboro, Kentucky, 42301

  • Owensboro Dermatology Associates

    Owensboro, Kentucky, 42303

  • Austin Institute for Clinical Research, Inc.

    Pflugerville, Texas, 78660

  • Paddington Testing Co, Inc.

    Philadelphia, Pennsylvania, 19103

  • The Indiana Clinical Trials Center

    Plainfield, Indiana, 46168

  • Oregon Medical Research Center

    Portland, Oregon, 97201

  • Oregon Health & Science University

    Portland, Oregon, 97239

  • M3-Wake Research, Inc.

    Raleigh, North Carolina, 27612

  • Health Concepts

    Rapid City, South Dakota, 57702

  • Mayo Clinic

    Rochester, Minnesota, 55905

  • UR Dermatology Clinical Trials Unit at College Town

    Rochester, New York, 14620

  • Investigational Drug Service

    Rochester, New York, 14642

  • DermAssociates, LLC

    Rockville, Maryland, 20850

  • Peninsula Headlands LLC

    Rolling Hills Estates, California, 90274

  • UC Davis Health

    Sacramento, California, 95816

  • MediSearch Clinical Trials

    Saint Joseph, Missouri, 64506

  • Texas Dermatology and Laser Specialists

    San Antonio, Texas, 78218

  • Dermatology Clinical Research Center of San Antonio

    San Antonio, Texas, 78229

  • MedDerm Associates

    San Diego, California, 92103

  • University of California San Diego Dermatology

    San Diego, California, 92122

  • Synergy Dermatology

    San Francisco, California, 94132

  • San Luis Dermatology and Laser Clinic

    San Luis Obispo, California, 93405

  • Southern California Dermatology, Inc.

    Santa Ana, California, 92701

  • Wolverine Clinical Trials, Llc

    Santa Ana, California, 92705

  • Mosaic Dermatology

    Santa Monica, California, 90403

  • Clinical Science Institute

    Santa Monica, California, 90404

  • Meridian Clinical Research

    Savannah, Georgia, 31406

  • Dermatology Associates of Seattle

    Seattle, Washington, 98101

  • Carolina Research Center, Inc.

    Shelby, North Carolina, 28150

  • NorthShore University HealthSystem - Dermatology

    Skokie, Illinois, 60077

  • NorthShore University HealthSystem Dermatology Clinical Trials Unit

    Skokie, Illinois, 60077

  • The South Bend Clinic Center for Research

    South Bend, Indiana, 46617

  • Dermatology Specialists of Spokane

    Spokane, Washington, 99202

  • Principle Research Solutions

    Spokane, Washington, 99204

  • Saint Louis University Dermatology

    St Louis, Missouri, 63104

  • Olympian Clinical Research

    St. Petersburg, Florida, 33709

  • MultiCare Allenmore Hospital

    Tacoma, Washington, 98405

  • Multicare Institute for Research and Innovation

    Tacoma, Washington, 98405

  • Pace Dermatology Associates

    Tacoma, Washington, 98405

  • Clinical Research Trials of Florida, Inc.

    Tampa, Florida, 33607

  • Clinical Research Trials of Florida

    Tampa, Florida, 33607

  • ForCare Clinical Research

    Tampa, Florida, 33613

  • University of South Florida; Asthma, Allergy and Immunology Clinical Research Unit

    Tampa, Florida, 33613

  • Olympian Clinical Research

    Tampa, Florida, 33615

  • Revival Research Institute, LLC

    Troy, Michigan, 48084

  • Somerset Skin Centre

    Troy, Michigan, 48084

  • Vital Prospects Clinical Research Institute, P.C.

    Tulsa, Oklahoma, 74136

  • Center for Clinical Studies, LTD.LLP

    Webster, Texas, 77598

  • Henry Ford Medical Center - Farmington Road

    West Bloomfield, Michigan, 48322

  • Dundee Dermatology

    West Dundee, Illinois, 60118

  • Integrated Clinical Research

    West Palm Beach, Florida, 33406

  • Chesapeake Clinical Research, Inc.

    White Marsh, Maryland, 21162

  • PMG Research of Wilmington LLC

    Wilmington, North Carolina, 28411

  • PMG Research of Wilmington, LLC

    Wilmington, North Carolina, 28411

  • PMG Research of Winston-Salem, LLC

    Winston-Salem, North Carolina, 27103

  • Winston-Salem Dermatology and Surgery Center, PLLC

    Winston-Salem, North Carolina, 27103

Other trials in United States

Poland57 sites

  • NZOZ Specjalistyczny Osrodek Dermatologiczny DERMAL s.c.

    Bialystok, 15-453

  • KLIMED Marek Klimkiewicz

    Bialystok, 15-704

  • Clinica Dermatoestetica Prywatny Gabinet Dermatologiczny i Alergologiczny

    Bydgoszcz, 85-650

  • DERMAPOLIS Medical Dermatology Center dr n. med. Edyta Gębska

    Chorzów, 41-500

  • Synexus Polska Sp. z o.o. Oddzial w Czestochowie

    Częstochowa, 42-202

  • Uniwersyteckie Centrum Kliniczne Klinika Dermatologii, Wenerologii i Alergologii

    Gdansk, 80-214

  • Neutrum Lekarze M. Hlebowicz i Partnerzy Spolka Partnerska

    Gdansk, 80-462

  • Szpital Sw. Wojciecha

    Gdansk, 80-462

  • Synexus Polska Sp. z o.o. Oddzial w Gdyni

    Gdynia, 81-537

  • MCBK

    Grodzisk Mazowiecki, 05-825

  • Synexus Polska Sp. z o.o. Oddzial w Katowicach

    Katowice, 40-040

  • MULTIKLINIKA Salute Sp. z o.o.

    Katowice, 40-123

  • Silmedic Sp. z o.o., Oddzial w Katowicach

    Katowice, 40-282

  • Care Clinic Centrum Medyczne

    Katowice, 40-568

  • Centrum Medyczne Angelius Provita

    Katowice, 40-611

  • Pro Familia Altera Sp. z o.o.

    Katowice, 40-648

  • Gabinet Dermatologiczny Beata Krecisz

    Kielce, 25-217

  • Malopolskie Centrum Kliniczne

    Krakow, 30-149

  • Centrum Badan Klinicznych JCI

    Krakow, 30-348

  • Centrum Medyczne Plejady

    Krakow, 30-363

  • Centrum Nowoczesnych Terapii "DOBRY LEKARZ" sp. z o.o.

    Krakow, 31-011

  • AWP Klinika Dermatologii Pod Fortem Anna Wojas-Pelc

    Krakow, 31-302

  • Centrum Medyczne Promed

    Krakow, 31-411

  • Krakowskie Centrum Medyczne Sp. z o.o.

    Krakow, 31-501

  • Prywatna Praktyka Lekarska - Adam Smialowski INTERMED KSAWEROW

    Ksawerów, 95-054

  • NZOZ "DERMED" Centrum Medyczne Sp. z o.o. - Oddzial w Lodzi

    Lodz, 90-265

  • Centrum Terapii Wspolczesnej J.M. Jasnorzewska Spolka Komandytowo-Akcyjna

    Lodz, 90-338

  • Osrodek badan klinicznych AppleTree Clinics

    Lodz, 90-349

  • Dermoklinika-Centrum Medyczne s.c. M. Kierstan, J. Narbutt, A. Lesiak

    Lodz, 90-436

  • KO-MED Centra Kliniczne Lublin II

    Lublin, 20-362

  • NZOZ "Med-Laser" Borzecki Spolka Jawna

    Lublin, 20-406

  • Dermedic Jacek Zdybski

    Ostrowiec Świętokrzyski, 27-400

  • Synexus Polska Sp. z o.o. Oddzial w Poznaniu

    Poznan, 60-702

  • Clinical Research Center Sp. z o.o. MEDIC-R Sp. k.

    Poznan, 60-848

  • Gabinety Lekarskie Rivermed

    Poznan, 61-441

  • LIFT-MED Spolka Akcyjna

    Rybnik, 44-200

  • Kliniczny Szpital Wojewodzki nr 1 im. F. Chopina, Klinika Dermatologii

    Rzeszów, 35-055

  • EMED Centrum Uslug Medycznych Ewa Smialek

    Rzeszów, 35-205

  • Andrzej Krolicki, Tomasz Kochanowski "Laser Clinic" S.C.

    Szczecin, 70-332

  • Twoja Przychodnia Szczecinskie Centrum Medyczne

    Szczecin, 71-500

  • Alergo-Med Specjalistyczna Przychodnia Lekarska Sp. z o.o.

    Tarnów, 33-100

  • MICS Centrum Medyczne Warszawa

    Warsaw, 00-874

  • Centrum Medyczne AMED

    Warsaw, 01-518

  • MTZ Clinical Research Powered by Pratia

    Warsaw, 02-172

  • Centralny Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji w Warszawie

    Warsaw, 02-507

  • RCMed Oddzial Warszawa

    Warsaw, 02-657

  • Carpe Diem Centrum Medycyny Estetycznej

    Warsaw, 02-661

  • REUMATIKA - "Centrum Reumatologii" NZOZ 2

    Warsaw, 02-665

  • Synexus Polska Sp. z o.o. Oddzial w Warszawie

    Warsaw, 02-672

  • ETG Warszawa

    Warsaw, 02-793

  • Klinika Ambroziak Sp. z o.o.

    Warsaw, 02-953

  • Wojskowy Instytut Medyczny, Klinika Dermatologiczna

    Warsaw, 04-141

  • EMC Instytut Medyczny S.A. Przychodnia przy ul. Lowieckiej

    Wroclaw, 50-220

  • Synexus Polska Sp. z o.o. Oddzial we Wroclawiu

    Wroclaw, 50-381

  • Lukasz Matusiak "4Health"

    Wroclaw, 50-566

  • Centrum Medyczne Oporow

    Wroclaw, 52-416

  • Kliniczny Oddzial Chorob Wewnetrznych, Dermatologii i Alergologii

    Zabrze, 41-800

Other trials in Poland

Canada41 sites

  • CCA Medical Research

    Ajax, Ontario, L1S 7K8

  • SimcoDerm Medical and Surgical Dermatology Center

    Barrie, Ontario, L4M 7G1

  • Dermatology Research Institute

    Calgary, Alberta, T1Y0B4

  • Dermatology Research Institute

    Calgary, Alberta, T2J7E1

  • Beacon Dermatology

    Calgary, Alberta, T3E 0B2

  • Clinique de Radiologie du Saguenay Enr.

    Chicoutimi, Quebec, G7H 6B9

  • Intermed groupe santé

    Chicoutimi, Quebec, G7H 7Y8

  • Stratica Medical

    Edmonton, Alberta, T5K 1X3

  • Alberta Dermasurgery Centre

    Edmonton, Alberta, T6G 1C3

  • Kingsway Clinical Research

    Etobicoke, Ontario, M8X 1Y9

  • Medicor Research Inc

    Greater Sudbury, Ontario, P3C 1X3

  • Sudbury Skin Clinique

    Greater Sudbury, Ontario, P3C 1X8

  • Derm Effects

    London, Ontario, N6H 5L5

  • Lynderm Research Inc.

    Markham, Ontario, L3P 1X2

  • DermEdge Research

    Mississauga, Ontario, L4Y 4C5

  • Innovaderm Research Inc.

    Montreal, Quebec, H2X 2V1

  • North Bay Dermatology Centre

    North Bay, Ontario, P1B 3Z7

  • The Centre for Clinical Trials

    Oakville, Ontario, L6J 7W5

  • Oshawa Clinic Dermatology Trials

    Oshawa, Ontario, L1H 1B9

  • Dermatology Ottawa Research Centre

    Ottawa, Ontario, K2C 3N2

  • SKiN Centre for Dermatology

    Peterborough, Ontario, K9J 5K2

  • Centre de Recherche Dermatologique du Quebec metropolitain (CRDQ)

    Québec, Quebec, G1V 4X7

  • Centre de Recherche Saint-Louis inc.

    Québec, G1W 4R4

  • CARE Clinic Ltd

    Red Deer, Alberta, T4P-1K4

  • Dr. Rachel Asiniwasis, Medical Professional Corp.

    Regina, Saskatchewan, S4V1R9

  • The Centre for Dermatology

    Richmond Hill, Ontario, L4B 1A5

  • York Dermatology Clinic and Research Centre

    Richmond Hill, Ontario, L4C 9M7

  • Diex Research Sherbrooke Inc.

    Sherbrooke, Quebec, J1L 0H8

  • Karma Clinical Trials, Inc.

    St. John's, Newfoundland and Labrador, A1A 4Y3

  • Dr. Chih-ho Hong Medical Inc

    Surrey, British Columbia, V3R 6A7

  • North York Research Inc.

    Toronto, Ontario, M2N3A6

  • Toronto Research Centre

    Toronto, Ontario, M3H5Y8

  • Research Toronto

    Toronto, Ontario, M4W 2N4

  • AvantDerm

    Toronto, Ontario, M5A 3R6

  • Manna Research Inc.(Toronto)

    Toronto, Ontario, M9W 4L6

  • University of British Columbia Department of Dermatology and Skin Science

    Vancouver, British Columbia, V5Z 4E8

  • Pacific Dermaesthetics Inc.

    Vancouver, British Columbia, V6H4E1

  • K.Papp Clinical Research Inc.

    Waterloo, Ontario, N2J 1C4

  • XLR8 Medical Research Inc.

    Windsor, Ontario, N8T 1E6

  • Winnipeg Clinic

    Winnipeg, Manitoba, R3C 0N2

  • Wiseman Dermatology Research Inc.

    Winnipeg, Manitoba, R3M 3Z4

Other trials in Canada

Germany28 sites

  • Dermazentrum Augsburg

    Augsburg, 86179

  • Licca Clinical Research Institute

    Augsburg, 86179

  • Fachklinik Bad Bentheim

    Bad Bentheim, 48455

  • Charite-Universitaetsmedizin Berlin

    Berlin, 10117

  • Hautzentrum Friedrichshain Studien

    Berlin, 10247

  • Rothhaar Studien GmbH

    Berlin, 10783

  • ISA GmbH

    Berlin, 10789

  • Klinikum Bielefeld Rosenhoehe

    Bielefeld, 33647

  • Universitaetsklinikum Bonn

    Bonn, 53105

  • Klinische Forschung Dresden GmbH

    Dresden, 01069

  • Universitaetsklinikum Carl Gustav Carus der Technischen Universitaet Dresden

    Dresden, 01307

  • Universitätsklinikum Erlangen

    Erlangen, 91054

  • IKF Pneumologie GmbH & Co KG; Institut für klinische Forschung

    Frankfurt, 60596

  • SRH Wald-Klinikum Gera GmbH

    Gera, 07548

  • Klinische Forschung Hamburg GmbH

    Hamburg, 20253

  • MENSINGDERMA research GmbH

    Hamburg, 22391

  • Medizinische Hochschule Hannover

    Hanover, 30625

  • Universitaetsklinikum Schleswig-Holstein, Campus Kiel

    Kiel, 24105

  • Praxis Dr. med. Beate Schwarz

    Langenau, 89129

  • Velocity Clinical Research Germany GmbH

    Leipzig, 04103

  • Universitaetsklinikum Schleswig-Holstein, Campus Luebeck

    Lübeck, 23538

  • Dermatologische Gemeinschaftspraxis

    Mahlow, 15831

  • Dermatologische Gemeinschaftspraxis Dres. Quist

    Mainz, 55128

  • Universitätsklinikum Marburg

    Marburg, 35043

  • Ludwig-Maximilians-University Munich

    Munich, 80337

  • University of Muenster

    Münster, 48149

  • Klinische Forschung Schwerin GmbH

    Schwerin, 19055

  • Hautaerztliche Gemeinschaftspraxis Dres. Leitz und Kollegen

    Stuttgart, 70178

Other trials in Germany

China25 sites

  • Peking University First Hospital

    Beijing, Beijing Municipality, 100034

  • Beijing Friendship Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100050

  • The second Xiangya Hospital,Central South University

    Changsha, Hunan, 410011

  • The Third Xiangya Hospital of Central South University, Dermatological department

    Changsha, Hunan, 410013

  • The Second Affiliated Hospital of Army Medical University,PLA

    Chongqing, 400037

  • The First Affiliated Hospital Of Fujian Medical University

    Fuzhou, Fujian, 350005

  • The First Affiliated Hospital, Sun Yat-sen University

    Guangzhou, Guangdong, 510080

  • The Third Affiliated Hospital, Sun Yat-sen University

    Guangzhou, Guangdong, 510630

  • The First Affiliated Hospital of Zhejiang University School of Medicine/Dermatology and STD Dept

    Hangzhou, Zhejiang, 310003

  • Hangzhou Third Hospital

    Hangzhou, Zhejiang, 310009

  • The Second Affiliated Hospital of Zhejiang University School of Medicine/Dermatology Dept

    Hangzhou, Zhejiang, 310009

  • Zhejiang Provincial People's Hospital/Dermatology Department

    Hangzhou, Zhejiang, 310014

  • Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University

    Hangzhou, Zhejiang, 310016

  • Jinan Central Hospital

    Jinan, Shandong, 250013

  • Shandong Provincial Institute of Dermatology and Venereology & Shandong Provincial Hospital for Skin

    Jinan, Shandong, 250022

  • First Affiliated Hospital of Kunming Medical University

    Kunming, Yunnan, 650032

  • Dermatology Hospital of Jiangxi Province

    Nanchang, Jiangxi, 330000

  • The First Affiliated Hospital With Nanjing University

    Nanjing, Jiangsu, 210000

  • Huashan Hospital Fudan University

    Shanghai, Shanghai Municipality, 200040

  • Dermatology Department, Shanghai Changzheng Hospital

    Shanghai, 200003

  • Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine/Dermatology

    Shanghai, 200092

  • Shanghai Dermatology Hospital

    Shanghai, 200443

  • The University of Hong Kong - Shenzhen Hospital

    Shenzhen, Guangdong, 518053

  • Tianjin Medical University General Hospital, Dermatological Department

    Tianjin, Tianjin Municipality, 300052

  • Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, Hubei, 430030

Other trials in China

Czechia21 sites

  • Lekarna Pod Kankem

    Kunta Hora, 284 01

  • Kozni ambulance Kutna Hora, s.r.o

    Kutná Hora, 28401

  • Dermamedica S.R.O.

    Náchod, 547 01

  • Lekarna U Stribrneho orla (Pharmacy)

    Náchod, 547 01

  • CCR Ostrava, s.r.o.

    Ostrava, 702 00

  • Lekarna Rezidence Nova Karolina

    Ostrava, 702 00

  • Apavar Lekarna

    Ostrava, 70200

  • Lekarna Fakultni Nemocnice Ostrava

    Ostrava - Poruba, 708 52

  • Fakultni Nemocnice Ostrava, Kozni oddeleni

    Ostrava - Poruba, 70852

  • BENU Lekarna

    Pardubice, 530 02

  • PRATIA Pardubice a.s.

    Pardubice, 530 02

  • Lekarna, Nemocnice Pardubickeho kraje, a.s. , Pardubicka nemocnice

    Pardubice, 532 03

  • Nemocnice Pardubickeho kraje, a.s., Pardubicka nemocnice

    Pardubice, 53203

  • Lekarna Pod Platany (Pharmacy)

    Prague, 101 00

  • Prof. MUDr.Petr Arenberger, DrSc. MBA

    Prague, 11000

  • Lekarna U Spasitele

    Prague, 12800

  • PRATIA Prague s.r.o.

    Prague, 130 00

  • Dermatovenerologicka ambulance

    Svitavy, 56802

  • Lekarna na Hranicni (Pharmacy)

    Svitavy, 56802

  • Krajska zdravotni a.s., Masarykova nemocnice o.z.

    Ústí nad Labem, 401 13

  • Lekarna Masarykovy nemocnice v Usti nad Labem, o.z.

    Ústí nad Labem, 401 13

Other trials in Czechia

Spain20 sites

  • Hospital Universitario Fundacion Alcorcon

    Alcorcón, Madrid, 28922

  • Hospital General Universitario de Alicante

    Alicante, 03010

  • Hospital Universitari Germans Trias i Pujol

    Badalona, Barcelona, 08916

  • Hospital Clinic de Barcelona

    Barcelona, 08036

  • Hospital de la Santa Creu i Sant Pau Servicio de Dermatologia

    Barcelona, 08041

  • Hospital Universitario Reina Sofia

    Córdoba, 14004

  • Hospital Sant Joan de Deu

    Esplugues de Llobregat, Barcelona, 08950

  • Hospital Universitario de Gran Canaria Dr. Negrin

    Las Palmas de Gran Canaria, LAS Palmas, 35010

  • Hospital Universitario de La Princesa

    Madrid, 28006

  • Hospital General Universitario Gregorio Maranon

    Madrid, 28007

  • Hospital del Nino Jesus

    Madrid, 28009

  • Hospital Universitario 12 de octubre

    Madrid, 28041

  • Hospital Universitario La Paz

    Madrid, 28046

  • Hospital Universitario Puerta de Hierro de Majadahonda

    Majadahonda, Madrid, 28222

  • Centro de Especialidades Mollabao (Area Sanitaria de Pontevedra e O Salnes)

    Pontevedra, 36001

  • Hospital de Montecelo

    Pontevedra, 36071

  • Hospital Universitario Virgen de la Macarena

    Seville, 41009

  • Consorcio Hospital General Universitario de Valencia

    Valencia, 46014

  • Hospital Universitario y Politecnico La Fe

    Valencia, 46026

  • Hospital Universitario Miguel Servet

    Zaragoza, 50009

Other trials in Spain

United Kingdom18 sites

  • Barnsley Hospital NHS Foundation Trust

    Barnsley, South Yorkshire, S75 2EP

  • MAC Clinical Research

    Blackpool, FY2 0JH

  • University Hospital Bristol NHS Foundation Trust

    Bristol, BS2 8HW

  • MAC Clinical Research

    Cannock, WS11 0BN

  • Accellacare Warwickshire

    Coventry, CV3 4FJ

  • West Glasgow Ambulatory Care Hospital

    Glasgow, G3 8SJ

  • Royal free London NHS Foundation Trust

    London, Greater London, NW3 2QG

  • Guy's Hospital-Guy's and St Thomas NHS Foundation Trust

    London, SE1 9RT

  • MAC Clinical Research Ltd

    Manchester, M13 9NQ

  • Accellacare North London

    Northwood, Middlesex, HA6 2RN

  • MeDiNova South London Quality Research Site

    Orpington, KENT, BR5 3QG

  • Accellacare South London

    Orpington, BR5 3QG

  • Plymouth Hospitals NHS Trust, Derriford Hospital

    Plymouth, Devon, PL6 8DH

  • Sheffield Children's NHS Foundation Trust

    Sheffield, South Yorkshire, S10 2TH

  • Sheffield Teaching Hospitals NHS Foundation Trust, Northern General Hospital

    Sheffield, South Yorkshire, S5 7AU

  • Accellacare Yorkshire

    Shipley, BD18 3SA

  • Medinova Research

    Wokingham, Berkshire, RG40 1XS

  • MeDiNova West London Quality Research Sites

    Wokingham, Berkshire, RG40 1XS

Other trials in United Kingdom

Mexico17 sites

  • Derma Norte del Bajio S.C.

    Aguascalientes, 20127

  • Centro de Investigacion Integral MEDIVEST, S.C.

    Chihuahua City, 31203

  • Servicios Hospitalarios de Mexico S.A. de C.V. (Hospital Ángeles Chihuahua)

    Chihuahua City, 31238

  • Phylasis Clinicas Research S. de R.L. de C.V.

    Cuautitlán Izcalli, 54769

  • JM Research SC

    Cuernavaca, Morelos, 62290

  • Hospital Infantil de Mexico Federico Gomez

    Del. Cuauhtemoc, Mexico City, 06720

  • Unidad de Atención Médica e Investigación en Salud

    Mérida, Yucatán, 97000

  • Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan

    Mérida, Yucatán, 97130

  • Hospital de Jesus, I.A.P.

    Mexico City, 06090

  • Cryptex Investigación Clínica, S.A. de C.V.

    Mexico City, 06100

  • Arke Estudios Clinicos Sa De Cv

    Mexico City, 06700

  • Trials in Medicine S.C.

    Mexico City, 06700

  • Centro de Dermatologia de Monterrey

    Monterrey, Nuevo León, 64460

  • Eukarya Pharmasite S.C.

    Monterrey, 64718

  • SMIQ, S. de R. L. de C.V.

    Querétaro, 76070

  • Clinical Research Institute S.C.

    Saltillo, Coahuila, 25020

  • Sociedad de Metabolismo y Corazon S.C.

    Veracruz, 91900

Other trials in Mexico

Australia16 sites

  • The Skin Centre

    Benowa, Queensland, 4217

  • Eastern Health - Box Hill Hospital

    Box Hill, Victoria, 3128

  • Emeritus Research

    Camberwell, VIC 3124

  • North Eastern Health Specialists

    Campbelltown, South Australia, 5074

  • Skin Health Institute Inc.

    Carlton, Victoria, 3053

  • Sinclair Dermatology

    East Melbourne, Victoria, 3002

  • St George Dermatology & Skin Cancer Centre

    Kogarah, New South Wales, 2217

  • Australian Clinical Research Network

    Maroubra, New South Wales, 2035

  • Royal Melbourne Hospital

    Parkville, Victoria, 3050

  • The Royal Children's Hospital

    Parkville, Victoria, 3052

  • Royal Melbourne Hospital

    Parkville, 3052

  • Woden Dermatology

    Phillip, Australian Capital Territory, 2606

  • Royal North Shore Hospital

    Saint Leonards NSW, 2065

  • Royal North Shore Hospital

    St Leonards, New South Wales, 2065

  • The Skin Hospital

    Westmead, New South Wales, 2145

  • Veracity Clinical Research Pty Ltd

    Woolloongabba, Queensland, 4102

Other trials in Australia

Japan16 sites

  • Iidabashi Skin Clinic

    Chiyoda-ku, Tokyo, 102-0072

  • Fukuwa Clinic

    Chuo-ku, Tokyo, 104-0031

  • Sumire Dermatology Clinic

    Edogawa-ku, Tokyo, 133-0052

  • Hoshikuma Dermatology・Allergy Clinic

    Fukuoka, 814-0171

  • Matsuda Tomoko Dermatological Clinic

    Fukuoka, 819-0167

  • Osaka Habikino Medical Center

    Habikino, Osaka, 583-8588

  • Kawashima Dermatology Clinic

    Ichikawa, Chiba, 272-0033

  • Noguchi Dermatology Clinic

    Kamimashiki-gun, Kumamoto, 861-3106

  • Dermatology Shimizu Clinic

    Kobe, Hyōgo, 657-0846

  • Matsuyama Dermatology Clinic

    Nakano-ku, Tokyo, 165-0026

  • Yoshioka Dermatology Clinic

    Neyagawa, Osaka, 572-0838

  • Takagi Dermatological Clinic

    Obihiro, Hokkaido, 080-0013

  • Sanrui Hifuka

    Saitama, 330-0854

  • Dermatology and Ophthalmology Kume Clinic

    Sakai, Osaka, 593-8324

  • Tokyo Medical University Hospital

    Shinjyuku-ku, Tokyo, 160-0023

  • Queen's square Medical Facilities Queen's square Dermatology and Allergology

    Yokohama, Kanagawa, 220-6208

Other trials in Japan

Hungary15 sites

  • Clinexpert Kft.

    Budapest, 1033

  • SE AOK Bor, Nemikortani es Boronkologiai Klinika

    Budapest, 1085

  • Bp. Főváros XIX. Kerület Önkormányzat Kispesti Eü. Intézete

    Budapest, 1195

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032

  • CRU Hungary Kft.

    Encs, 3860

  • Bugát Pál Kórház, Bőrgyógyászati Szakrendelés

    Gyöngyös, 3200

  • Trial Pharma Kft.

    Győr, 9026

  • Synexus Magyarország Egészségügyi Szolgáltató Kft. Synexus Gyula DRS

    Gyula, 5700

  • Trial Pharma Kft.

    Kaposvár, 7400

  • Borsod-Abaúj-Zemplén Megyei Központi Kórház és Gyermek Gasztroenterológia II. emelet

    Miskolc, 3526

  • Pecsi Tudomanyegyetem Klinikai Kozpont, Bor-,Nemikortani es Onkodermatologiai Klinika

    Pécs, 7632

  • Trial Pharma Kft.

    Püspökladány, 4150

  • Szegedi Tudomanyegyetem Szent-Györgyi Albert

    Szeged, 6720

  • ALLERGO-DERM BAKOS Kft.

    Szolnok, 5000

  • Medmare Bt

    Veszprém, 8200

Other trials in Hungary

Russia14 sites

  • SBIH "Chelyabinsk Regional Clinical Dermatovenerology dispensary"

    Chelyabinsk, 454048

  • Limited Liability Company "Medical Center "Rheuma-Med"

    Kemerovo, 650070

  • Clinic of FSBEI HE Kirov SMU MOH Russia

    Kirov, 610014

  • FSBI "State Research Centre of Dermatovenereology and Cosmetology" MoH RF

    Moscow, 107076

  • NRC Institute of Immunology FMBA of Russia

    Moscow, 115522

  • SBI RR "Skin and Venereal Dispensary"

    Rostov-on-Don, 344007

  • SBI RR "Regional Clinical Skin and Veneral Dispensary"

    Ryazan, 390046

  • LLC "Pierre Wolkenstein Clinic of Skin Diseases"

    Saint Petersburg, 191123

  • Vitiligo center

    Saint Petersburg, 191123

  • FSBEI HE "St. Petersburg State Pediatric Medical University" MoH RF

    Saint Petersburg, 194100

  • Limited Liability Company "Sanavita"

    Saint Petersburg, 194214

  • "Medical Research Institute", LLC

    Saint Petersburg, 196084

  • FSBEI HE I.P.Pavlov SPbSMU MOH Russia

    Saint Petersburg, 197022

  • RSBIH "Smolensk Regional Clinical Hospital"

    Smolensk, 214018

Other trials in Russia

Bulgaria13 sites

  • MHAT Dobrich AD

    Dobrich, 9300

  • MC Asklepii" OOD

    Dupnitsa, 2600

  • MHAT ''Dr. Tota Venkova'' AD

    Gabrovo, 5300

  • "Acibadem City Clinic MHAT Tokuda" EAD

    Sofia, 1407

  • "DCC Aleksandrovska" EOOD

    Sofia, 1431

  • "DCC Fokus-5-Medical Establishment for OutpatientCare"EOOD

    Sofia, 1463

  • Military Medical Academy MHAT Sofia

    Sofia, 1606

  • Dermatology Clinic "Sofia" - group practice for specialized outpatient medical care

    Sofia, 1756

  • "Mc Synexus Sofia" Eood

    Sofia, 1784

  • ACIBADEM City Clinic Diagnostic-Consultative Center EOOD

    Sofia, 1784

  • Medical Center Synexus Sofia EOOD-branch Stara Zagora

    Stara Zagora, 6000

  • "ACIBADEM City Clinic Medical Center Varna" EOOD

    Varna, 9000

  • "DCC Mladost-M Varna" OOD

    Varna, 9000

Other trials in Bulgaria

South Korea12 sites

  • Korea University Ansan Hospital

    Ansan-si, Gyeonggi-do, 15355

  • Soon Chun Hyang University Bucheon Hospital

    Bucheon-si, Gyeonggi-do, 14584

  • Kyungpook National University Hospital

    Daegu, 41944

  • Chungnam National University Hospital CNUH

    Daejeon, 35015

  • Chonnam National University Hospital

    Gwangju, 61469

  • The Catholic University of Korea, Incheon St. Mary's Hospital

    Incheon, 21431

  • Inha University Hospital

    Incheon, 22332

  • Korea University Anam Hospital

    Seoul, 02841

  • Severance Hospital, Yonsei Univ. Health System

    Seoul, 03722

  • The Catholic University of Korea, Seoul St. Mary's Hospital

    Seoul, 06591

  • Chung-Ang University Hospital

    Seoul, 06973

  • Hallym University Kangnam Sacred Heart Hospital

    Seoul, 07441

Other trials in South Korea

Slovakia9 sites

  • Narodny ustav detskych chorob

    Bratislava, 833 40

  • BeneDerma s.r.o.

    Bratislava, 841 02

  • Derma therapy spol. s.r.o, Dermatovenerologicka ambulancia

    Bratislava, 85101

  • Summit Clinical Research, s.r.o.

    Bratislava - Mestská Cast Nove Mesto, 831 01

  • SKINKLINIK s.r.o.

    Bratislava- Mestská Časť Nové Mesto, 83101

  • Nemocnica Kosice-Saca, a.s., 1. sukromna nemocnica, Kozna ambulancia

    Kosice-Saca, 040 15

  • Derma-beauty, s.r.o., Dermatovenerologicka ambulancia

    Nitra, 949 01

  • Fakultna nemocnica s poliklinikou Nove Zamky, Dermatovenerologicka klinika

    Nové Zámky, 940 34

  • SANARE spol.s.r.o.

    Svidník, 089 01

Other trials in Slovakia

Taiwan9 sites

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 807

  • Taipei Medical University-Shuang Ho Hospital

    New Taipei City, 23561

  • Chung Shan Medical University Hospital

    Taichung, 402

  • Taichung Veterans General Hospital

    Taichung, 40705

  • National Cheng-Kung University Hospital

    Tainan, 704

  • Taipei Veterans General Hospital

    Taipei, Taiwan (r.o.c), 11217

  • National Taiwan University Hospital

    Taipei, 100

  • Mackay Memorial Hospital

    Taipei, 10449

  • Chang Gung Memorial Hospital Linkou Branch

    Taoyuan City, 333

Other trials in Taiwan

Brazil8 sites

  • Hospital de Clinicas de Porto Alegre (HCPA)

    Porto Alegre, Rio Grande do Sul, 90035-903/90035-003

  • Associacao dos Funcionarios Públicos do Estado do Rio Grande do Sul - Hospital Ernesto Dornelles

    Porto Alegre, Rio Grande do Sul, 90160-093

  • Instituto de Dermatologia e Estética do Brasil LTDA

    Rio de Janeiro, Rio de Janeiro, 22470-220

  • IBPClin Pesquisa Clinica

    Rio de Janeiro, 20241-180

  • Fundacao do ABC - Faculdade de Medicina do ABC

    Santo André, São Paulo, 09060-870

  • Tecnolab Medicina Diagnostica

    Santo André, São Paulo, 09070-230

  • Pesquisare Saude S/S Ltda

    Santo André, São Paulo, 09080-110

  • Tecnolab - Unidade Matriz

    São Bernardo do Campo, São Paulo, 09750-670

Other trials in Brazil

Italy8 sites

  • AOU Policlinico Sant'Orsola Malpighi

    Bologna, BO, 40138

  • Universita degli Studi G. D'Annunzio -CeSi-MeT

    Chieti, CH, 66100

  • Ospedale Policlinico San Martino

    Genova, GE, 16132

  • Istituto Clinico Humanitas IRCSS - UOC di Dermatologia

    Milan, 20089

  • ASST Fatebenefratelli Sacco

    Milan, 20157

  • AOU Policlinico di Modena Struttura complessa di Dermatologia

    Modena, MO, 41124

  • IFO lstituto Dermatologico San Gallicano IRCCS

    Roma, 00144

  • Universita del Sacro Cuore, Policlinico Agostino Gemelli, Istituto Di Dermatologia

    Rome, 00168

Other trials in Italy

Latvia7 sites

  • Riga 1st Hospital, Clinic of Dermatology and STD

    Riga, LV - 1001

  • Aesthetic dermatology clinic of Prof. J. Kisis

    Riga, LV-1003

  • Health Centre 4 Ltd. Diagnostics Centre

    Riga, LV-1003

  • Childrens Clinical University Hospital State SLLC

    Riga, LV-1004

  • Health and Aesthetics Ltd

    Riga, LV-1009

  • Health Centre 4 Ltd, Dermatology Clinics

    Riga, LV-1013

  • Outpatient Clinic Of Ventspils

    Ventspils, LV3601

Other trials in Latvia

Argentina6 sites

  • CINME Centro de Investigaciones Metabolicas

    C.a.b.a, C1027AAP

  • Psoriahue Medicina Interdisciplinaria

    C.a.b.a., C1425DKG

  • CONEXA Investigación Clínica S.A.

    CABA, Buenos Aires, C1012AAY

  • Framingham Centro Medico

    La Plata, Buenos Aires, B1902COS

  • Hospital Universitario Austral

    Pilar, Buenos Aires, B1629ODT

  • Servicio de Investigacion de Patolog-ias Alergicas del Instituto ABC - Rosario

    Rosario, Santa Fe Province, 2000

Other trials in Argentina

Chile6 sites

  • Centro Medico SkinMed Limitada

    Santiago, Santiago Metropolitan, 7580206

  • Clinica Dermacross S.A.

    Santiago, Santiago Metropolitan, 7640881

  • CEC Spa

    Santiago, Santiago Metropolitan, 7750495

  • MIRES (M Y F Estudios Clínicos Limitada)

    Santiago, Santiago Metropolitan, 7750495

  • Hospital Clinico Universidad de Chile

    Santiago, Santiago Metropolitan, 8380456

  • Centro Internacional de Estudios Clinicos - CIEC

    Santiago, Santiago Metropolitan, 8420383

Other trials in Chile

Israel4 sites

  • Soroka University Medical Center

    Beersheba, 8410101

  • Rabin Medical Center

    Petah Tikva, 4941492

  • The Chaim Sheba Medical Center

    Ramat Gan, 5265601

  • Tel-Aviv Sourasky Medical Center

    Tel Aviv, 6423906

Other trials in Israel

Belgium3 sites

  • University Hospital Brussels

    Brussels, 1090

  • Cliniques Universitaires Saint-Luc

    Brussels, B 1200

  • University Hospital Antwerp

    Edegem, 2650

Other trials in Belgium

Finland3 sites

  • Terveystalo Tampere

    Tampere, 33100

  • Mehiläinen Neo

    Turku, 20520

  • Turun yliopistollinen keskussairaala

    Turku, 20520

Other trials in Finland

Romania3 sites

  • SC Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL

    Brasov, JUD. Brasov, 500283

  • SC Delta Health Care SRL

    Bucharest, 014142

  • Cabinet Medical de Dermatovenerologie Prof. Dr. Orasan Remus Ioan

    Cluj-Napoca, JUD. CLUJ, 400105

Other trials in Romania

Serbia3 sites

  • Military Medical Academy

    Belgrade, 11000

  • Clinical Centre Nis

    Niš, 18000

  • General Hospital Pancevo

    Pančevo, 26000

Other trials in Serbia

Netherlands1 site

  • Universitair Medisch Centrum (UMC) Utrecht

    Utrecht, 3584 CX

Other trials in Netherlands

About this study

Official title: A PHASE 3 MULTI-CENTER, LONG-TERM EXTENSION STUDY INVESTIGATING THE EFFICACY AND SAFETY OF ABROCITINIB, WITH OR WITHOUT TOPICAL MEDICATIONS, ADMINISTERED TO SUBJECTS AGED 12 YEARS AND OLDER WITH MODERATE TO SEVERE ATOPIC DERMATITIS

B7451015 is a Phase 3 study to evaluate Abrocitinib with or without Topical Medications in patients aged 12 years and older who have moderate to severe atopic dermatitis and have completed a qualifying parent study. The efficacy and safety of two dosage strengths of Abrocitinib, 100 mg and 200 mg taken orally once daily, will be evaluated over variable lengths of study participation. The study consists of a 92 week initial treatment period followed by a variable length secondary treatment period during which subjects will receive treatment with open-label abrocitinib until availability of commercial product in their country, or until the sponsor terminates the study in that country.

The B7451015 study also includes a sub-study evaluating whether abrocitinib has any potential effects on adolescent bone with regard to abnormal bone findings in knee MRI. The sub-study will be conducted in selected countries at selected sites. Eligible subjects are those who were 12 to <18 years of age at the screening visit of the qualifying parent study and who are currently participating in the main B7451015 study. The sub-study will include serial Magnetic Resonance Imaging (MRI) annually and continue until all enrolled subjects are 18 years of age and have been imaged at least once or have discontinued/withdrawn.

Being tested
Abrocitinib 100 mg, Abrocitinib 200 mg, Placebo
Keywords
atopic dermatitis, atopic eczema, eczema, JAK, janus kinase, Magnetic Resonance Imaging, MRI
Medical subject headings
Dermatitis, Atopic, Eczema

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Abrocitinib 100 mgDrug

    In the initial treatment period, Abrocitinib 100 mg, administered as two tablets to be taken orally once daily.

  • Abrocitinib 200 mgDrug

    In the initial treatment period, Abrocitinib 200 mg, administered as two tablets to be taken orally once daily.

  • PlaceboDrug

    For subjects whose dose was changed from 100 mg Abrocitinib to placebo, one tablet will be administered to be taken orally once daily for the remainder of the study.

  • Abrocitinib 100 mgDrug

    For subjects whose dose was changed from 200 mg Abrocitinib to 100 mg PF-04965842, one tablet will be administered to be taken orally once daily for the remainder of the study.

  • Abrocitinib 100 mgDrug

    In the secondary treatment period, Abrocitinib 100 mg, administered as one tablet to be taken orally once daily.

  • Abrocitinib 200 mgDrug

    In the secondary treatment period, Abrocitinib 200 mg, administered as two tablets to be taken orally once daily.

Study groups in NCT03422822
Study groupRoleWhat they receive
Abrocitinib 100 mgExperimentalAbrocitinib 100 mg QD PO
Receives: Drug: Abrocitinib 100 mg; Drug: Placebo
Abrocitinib 200 mgExperimentalAbrocitinib 200 mg QD PO
Receives: Drug: Abrocitinib 200 mg; Drug: Abrocitinib 100 mg

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Treatment emergent adverse events

    The incidence of treatment emergent adverse events

    Measured: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years

  2. Serious adverse events and adverse events leading to discontinuation

    The incidence of serious adverse events and adverse events leading to discontinuation

    Measured: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years

  3. Change from baseline in clinical laboratory values

    Change from baseline in clinical laboratory values

    Measured: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years

  4. Change from baseline in electrocardiogram (ECG) measurements

    Change from baseline in electrocardiogram (ECG) measurements

    Measured: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years

  5. Change from baseline in vital signs

    Change from baseline in vital signs

    Measured: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years

Secondary outcomes (13)

  1. Investigator's Global Assessment (IGA)

    Response based on the IGA score of clear (0) or almost clear (1) (on a 5 point scale) and a reduction from baseline of >=2 points at all scheduled time points

    Measured: Baseline, Week 2, Week 4, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92

  2. Eczema Area and Severity Index (EASI)

    Response based on greater than or equal to 50%, 75% and 90% improvement from baseline in the EASI total score (EASI50, EASI75, and EASI90) at all scheduled time points

    Measured: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years

  3. Pruritus Numerical Rating Scale (NRS)

    Response based on an improvement greater than or equal to 3 points and greater than or equal to 4 points from baseline in the pruritus NRS at all scheduled time points

    Measured: Baseline, Week 2, Week 4, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92

  4. Patient Global Assessment (PtGA)

    Change from baseline of PtGA at all scheduled time points

    Measured: Baseline, Week 2, Week 4, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92

  5. Body Surface Area (BSA) affected

    Change from baseline in the percentage BSA affected at all scheduled time points

    Measured: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years

  6. Dermatology Life Quality Index (DLQI) or Children's DLQI (CDLQI)

    Change from baseline in DLQI or CDLQI at all scheduled time points

    Measured: Baseline, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92

  7. Patient Oriented Eczema Measure (POEM)

    Change from baseline in POEM at all scheduled time points

    Measured: Baseline, Week 12, Week 24, Week 36, Week 48, Week 60, Week 72, Week 84, Week 92

  8. Hospital Anxiety and Depression Scale (HADS)

    Change from baseline in HADS at all scheduled time points

    Measured: Baseline, Week 12, Week 24, Week 36, Week 48, Week 60, Week 64, Week 72, Week 84, Week 92, Week 96

  9. EuroQol Quality of Life 5 Dimension 5 Level Scale (EQ-5D-5L) or EuroQol Quality of Life 5 Dimension Youth Scale (EQ-5D-Y)

    Change from baseline of EQ-5D-5L or EQ-5D-Y at all scheduled time points

    Measured: Baseline, Week 24, Week 48, Week 60, Week 72, Week 92

  10. Steroid-Free Days

    Number of steroid-free days will be assessed throughout the duration of the study.

    Measured: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years

  11. Serum Hs-CRP Levels

    Serum Hs-CRP levels at all scheduled time points

    Measured: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years

  12. Change in height standard deviation score (SDS)

    Change in height standard deviation score (SDS) at all scheduled time points

    Measured: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years

  13. Proportion of abnormal findings in knee MRI in adolescent subjects exposed to abrocitinib 100mg and 200mg QD

    Proportion of abnormal findings in knee MRI in adolescent subjects exposed to abrocitinib 100mg and 200mg QD

    Measured: Throughout sub-study until all enrolled subjects are 18 years of age and have been imaged at least once or have discontinued or withdrawn; an estimated maximum of 4 years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted6 Feb 2018
  2. Study start8 Mar 2018
  3. Primary completion22 Dec 2025
  4. Study completion22 Dec 2025

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
3,166 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT03422822
Sponsor's protocol ID
B7451015
Other IDs
JADE EXTEND, 2023-508955-37-00, 2023
Acronym
JADE EXTEND
Status last verified
Jan 2026
First submitted
20 Dec 2017
Last updated
15 Jan 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical\_trials/trial\_data\_and\_results/data\_requests.
Expanded access
Available

Publications

  • Pink AE, Rice ZP, Gooderham MJ, Wang F, Wollenberg A, Biswas P, Chan G, Alderfer J, Watkins M. Does Baseline Severity of Atopic Dermatitis Impact the Long-Term Efficacy of Abrocitinib? Post-hoc Analysis of Two Randomized Trials. Dermatol Ther (Heidelb). 2026 Oct 8. doi: 10.1007/s13555-026-01937-1. Online ahead of print.

    PubMed 42844558

  • Weidinger S, Reich K, Issa N, Hong HC, Bunick CG, Biswas P, Chan G, Guler E, Watkins M, Alderfer J. Abrocitinib Achieves Early and Complete/Near-Complete Skin Clearance Plus Itch-Free State in Atopic Dermatitis: Phase 3 Pooled Post Hoc Analysis. Dermatol Ther (Heidelb). 2026 Aug;16(8):4217-4225. doi: 10.1007/s13555-026-01833-8. Epub 2026 Jun 27.

    PubMed 42365219

  • Silverberg JI, Simpson EL, Farooqui SA, Chan G, Biswas P, Guler E. Efficacy and Safety of Variable-Dose Versus Continuous-Dose Abrocitinib Treatment in Patients with Moderate-to-Severe Atopic Dermatitis: A Pooled Analysis. Dermatol Ther (Heidelb). 2026 May 20. doi: 10.1007/s13555-026-01778-y. Online ahead of print.

    PubMed 42162528

  • Paller AS, Eichenfield LF, Irvine AD, Flohr C, Wollenberg A, Barbarot S, Bangert C, Spergel JM, Selfridge A, Biswas P, Fan H, Alderfer J, Watkins M, Koppensteiner H. Integrated Efficacy and Safety Analysis of Abrocitinib in Adolescents With Moderate-to-Severe Atopic Dermatitis. Allergy. 2025 Aug;80(8):2213-2224. doi: 10.1111/all.16512. Epub 2025 Mar 3.

    PubMed 40028832

  • Silverberg JI, Simpson EL, Pink AE, Weidinger S, Chan G, Biswas P, Clibborn C, Guler E. Switching from Dupilumab to Abrocitinib in Patients With Moderate-to-Severe Atopic Dermatitis: A Post Hoc Analysis of Efficacy After Treatment With Dupilumab in JADE DARE. Dermatol Ther (Heidelb). 2025 Feb;15(2):367-380. doi: 10.1007/s13555-024-01320-y. Epub 2025 Feb 4.

    PubMed 39903335

  • Silverberg JI, Thyssen JP, Lazariciu I, Myers DE, Guler E, Chovatiya R. Abrocitinib may improve itch and quality of life in patients with itch-dominant atopic dermatitis. Skin Health Dis. 2024 May 5;4(4):e382. doi: 10.1002/ski2.382. eCollection 2024 Aug.

    PubMed 39104653

  • Simpson EL, Silverberg JI, Nosbaum A, Winthrop KL, Guttman-Yassky E, Hoffmeister KM, Egeberg A, Valdez H, Zhang M, Farooqui SA, Romero W, Thorpe AJ, Rojo R, Johnson S. Integrated Safety Analysis of Abrocitinib for the Treatment of Moderate-to-Severe Atopic Dermatitis From the Phase II and Phase III Clinical Trial Program. Am J Clin Dermatol. 2021 Sep;22(5):693-707. doi: 10.1007/s40257-021-00618-3. Epub 2021 Aug 18.

    PubMed 34406619

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Abrocitinib 100 mg and Abrocitinib 200 mg in people with Dermatitis, Atopic, run by Pfizer at 539 sites in 28 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 21 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 15 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 539 sites in United States, Poland, Canada, Germany, China and 23 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Treatment emergent adverse events (time frame: Throughout study regardless of availability of commercial product until at least 2024, or until the sponsor terminates the study; an estimated maximum of 8 years). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT03422822, which also lists 7 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Jan 2026.

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